SI2934568T1 - Dual GLP1 / GIP or trigonal agonists GLP1 / GIP / glucagon - Google Patents
Dual GLP1 / GIP or trigonal agonists GLP1 / GIP / glucagon Download PDFInfo
- Publication number
- SI2934568T1 SI2934568T1 SI201330923T SI201330923T SI2934568T1 SI 2934568 T1 SI2934568 T1 SI 2934568T1 SI 201330923 T SI201330923 T SI 201330923T SI 201330923 T SI201330923 T SI 201330923T SI 2934568 T1 SI2934568 T1 SI 2934568T1
- Authority
- SI
- Slovenia
- Prior art keywords
- carboxy
- ethoxy
- butyryl
- butyrylamino
- inhibitors
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title claims 12
- 102000051325 Glucagon Human genes 0.000 title claims 4
- 108060003199 Glucagon Proteins 0.000 title claims 4
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title claims 4
- 229960004666 glucagon Drugs 0.000 title claims 4
- 230000009977 dual effect Effects 0.000 title claims 3
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 2
- 208000008589 Obesity Diseases 0.000 claims abstract 5
- 235000020824 obesity Nutrition 0.000 claims abstract 5
- 208000001145 Metabolic Syndrome Diseases 0.000 claims abstract 4
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 2
- 230000037406 food intake Effects 0.000 claims abstract 2
- 235000012631 food intake Nutrition 0.000 claims abstract 2
- -1 (S) -4-carboxy-4-hexadecanoylamino-butyryl- Chemical group 0.000 claims 50
- 150000001875 compounds Chemical class 0.000 claims 30
- 125000000539 amino acid group Chemical group 0.000 claims 27
- 239000003112 inhibitor Substances 0.000 claims 19
- 239000005557 antagonist Substances 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 7
- 102100040918 Pro-glucagon Human genes 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 5
- 239000013543 active substance Substances 0.000 claims 5
- 108010004460 Gastric Inhibitory Polypeptide Proteins 0.000 claims 4
- 102100039994 Gastric inhibitory polypeptide Human genes 0.000 claims 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 4
- 239000000018 receptor agonist Substances 0.000 claims 4
- 229940044601 receptor agonist Drugs 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- 241000024188 Andala Species 0.000 claims 3
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 108091016366 Histone-lysine N-methyltransferase EHMT1 Proteins 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 229940043355 kinase inhibitor Drugs 0.000 claims 3
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 108010063919 Glucagon Receptors Proteins 0.000 claims 2
- 102100040890 Glucagon receptor Human genes 0.000 claims 2
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims 2
- 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 108010041872 Islet Amyloid Polypeptide Chemical class 0.000 claims 2
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims 2
- PQNASZJZHFPQLE-LURJTMIESA-N N(6)-methyl-L-lysine Chemical compound CNCCCC[C@H](N)C(O)=O PQNASZJZHFPQLE-LURJTMIESA-N 0.000 claims 2
- 206010033307 Overweight Diseases 0.000 claims 2
- 108091006269 SLC5A2 Proteins 0.000 claims 2
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 239000002876 beta blocker Substances 0.000 claims 2
- 229940097320 beta blocking agent Drugs 0.000 claims 2
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims 2
- 229960001058 bupropion Drugs 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 108010036598 gastric inhibitory polypeptide receptor Proteins 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 201000001421 hyperglycemia Diseases 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- DNKCFBJMFIUNRS-UHFFFAOYSA-N mephentermine sulfate Chemical compound OS(O)(=O)=O.CNC(C)(C)CC1=CC=CC=C1.CNC(C)(C)CC1=CC=CC=C1 DNKCFBJMFIUNRS-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229960003512 nicotinic acid Drugs 0.000 claims 2
- 235000001968 nicotinic acid Nutrition 0.000 claims 2
- 239000011664 nicotinic acid Substances 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 1
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
- NGJOFQZEYQGZMB-KTKZVXAJSA-N (4S)-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[2-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NGJOFQZEYQGZMB-KTKZVXAJSA-N 0.000 claims 1
- IGRCWJPBLWGNPX-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1N(C)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl IGRCWJPBLWGNPX-UHFFFAOYSA-N 0.000 claims 1
- SWLAMJPTOQZTAE-UHFFFAOYSA-N 4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]benzoic acid Chemical class COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C(O)=O)C=C1 SWLAMJPTOQZTAE-UHFFFAOYSA-N 0.000 claims 1
- HFDKKNHCYWNNNQ-YOGANYHLSA-N 75976-10-2 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 HFDKKNHCYWNNNQ-YOGANYHLSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 1
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 1
- 229940123208 Biguanide Drugs 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 1
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 claims 1
- PWDLDBWXTVILPC-WGAVTJJLSA-N CC(C)(N)CC1=CC=CC=C1.C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 Chemical compound CC(C)(N)CC1=CC=CC=C1.C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 PWDLDBWXTVILPC-WGAVTJJLSA-N 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 229940127328 Cholesterol Synthesis Inhibitors Drugs 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 claims 1
- 108050004099 Diacylglycerol O-acyltransferase 1 Proteins 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000004930 Fatty Liver Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 claims 1
- 102100040134 Free fatty acid receptor 4 Human genes 0.000 claims 1
- 102100025353 G-protein coupled bile acid receptor 1 Human genes 0.000 claims 1
- 229940100607 GPR119 agonist Drugs 0.000 claims 1
- 108091007911 GSKs Proteins 0.000 claims 1
- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 claims 1
- 101800004295 Glucagon-like peptide 1(7-36) Proteins 0.000 claims 1
- 102000007390 Glycogen Phosphorylase Human genes 0.000 claims 1
- 108010046163 Glycogen Phosphorylase Proteins 0.000 claims 1
- 102000004103 Glycogen Synthase Kinases Human genes 0.000 claims 1
- 101000912510 Homo sapiens Free fatty acid receptor 1 Proteins 0.000 claims 1
- 101000890672 Homo sapiens Free fatty acid receptor 4 Proteins 0.000 claims 1
- 101000857733 Homo sapiens G-protein coupled bile acid receptor 1 Proteins 0.000 claims 1
- 101000876418 Homo sapiens Laforin Proteins 0.000 claims 1
- 101000887427 Homo sapiens Probable G-protein coupled receptor 142 Proteins 0.000 claims 1
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 1
- 102100021711 Ileal sodium/bile acid cotransporter Human genes 0.000 claims 1
- 101710156096 Ileal sodium/bile acid cotransporter Proteins 0.000 claims 1
- 102000000853 LDL receptors Human genes 0.000 claims 1
- 108010001831 LDL receptors Proteins 0.000 claims 1
- 102100035192 Laforin Human genes 0.000 claims 1
- 102000016267 Leptin Human genes 0.000 claims 1
- 108010092277 Leptin Proteins 0.000 claims 1
- 229940127470 Lipase Inhibitors Drugs 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 108010028924 PPAR alpha Proteins 0.000 claims 1
- 102000023984 PPAR alpha Human genes 0.000 claims 1
- 108010016731 PPAR gamma Proteins 0.000 claims 1
- 102000000536 PPAR gamma Human genes 0.000 claims 1
- 102000018886 Pancreatic Polypeptide Human genes 0.000 claims 1
- 101710176384 Peptide 1 Proteins 0.000 claims 1
- 102100038824 Peroxisome proliferator-activated receptor delta Human genes 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 208000005374 Poisoning Diseases 0.000 claims 1
- 102100039861 Probable G-protein coupled receptor 142 Human genes 0.000 claims 1
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 1
- 102000053067 Pyruvate Dehydrogenase Acetyl-Transferring Kinase Human genes 0.000 claims 1
- 108091006277 SLC5A1 Proteins 0.000 claims 1
- 102000058090 Sodium-Glucose Transporter 1 Human genes 0.000 claims 1
- 229940127504 Somatostatin Receptor Agonists Drugs 0.000 claims 1
- 229940100389 Sulfonylurea Drugs 0.000 claims 1
- 101000983124 Sus scrofa Pancreatic prohormone precursor Proteins 0.000 claims 1
- 229940123464 Thiazolidinedione Drugs 0.000 claims 1
- 229940127535 Thyroid Hormone Receptor Agonists Drugs 0.000 claims 1
- 229940121886 Thyroid hormone receptor agonist Drugs 0.000 claims 1
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 1
- 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 claims 1
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 claims 1
- 102400000752 Xenin Human genes 0.000 claims 1
- 101710159466 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial Proteins 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims 1
- 229960004373 acetylcholine Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000670 adrenergic alpha-2 receptor antagonist Substances 0.000 claims 1
- 239000000674 adrenergic antagonist Substances 0.000 claims 1
- 239000003888 alpha glucosidase inhibitor Chemical class 0.000 claims 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 claims 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 150000004283 biguanides Chemical class 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- NOJMTMIRQRDZMT-GSPXQYRGSA-N bromocriptine methanesulfonate Chemical compound CS(O)(=O)=O.C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 NOJMTMIRQRDZMT-GSPXQYRGSA-N 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 229940015838 cycloset Drugs 0.000 claims 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims 1
- 229960004166 diltiazem Drugs 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940127257 dual PPAR agonist Drugs 0.000 claims 1
- 229940125542 dual agonist Drugs 0.000 claims 1
- 238000005265 energy consumption Methods 0.000 claims 1
- 239000002792 enkephalinase inhibitor Substances 0.000 claims 1
- 229940125753 fibrate Drugs 0.000 claims 1
- OKISBDHRUPZLOC-UHFFFAOYSA-N gallin Chemical compound OC(=O)C1=CC=CC=C1C1C2=CC=C(O)C(O)=C2OC2=C(O)C(O)=CC=C21 OKISBDHRUPZLOC-UHFFFAOYSA-N 0.000 claims 1
- 239000003626 gastrointestinal polypeptide Substances 0.000 claims 1
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000004026 insulin derivative Substances 0.000 claims 1
- 238000011835 investigation Methods 0.000 claims 1
- 229940039781 leptin Drugs 0.000 claims 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 1
- 230000037356 lipid metabolism Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229950004994 meglitinide Drugs 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960002748 norepinephrine Drugs 0.000 claims 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 1
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims 1
- 229960001243 orlistat Drugs 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 108091008765 peroxisome proliferator-activated receptors β/δ Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims 1
- 239000003358 phospholipase A2 inhibitor Substances 0.000 claims 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229960003611 pramlintide Drugs 0.000 claims 1
- 108010029667 pramlintide Proteins 0.000 claims 1
- NRKVKVQDUCJPIZ-MKAGXXMWSA-N pramlintide acetate Chemical compound C([C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NRKVKVQDUCJPIZ-MKAGXXMWSA-N 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000036186 satiety Effects 0.000 claims 1
- 235000019627 satiety Nutrition 0.000 claims 1
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims 1
- 229960004425 sibutramine Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 150000001467 thiazolidinediones Chemical class 0.000 claims 1
- 229960004394 topiramate Drugs 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- 239000013585 weight reducing agent Substances 0.000 claims 1
- IDHVLSACPFUBDY-QCDLPZBNSA-N xenin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CN=CN1 IDHVLSACPFUBDY-QCDLPZBNSA-N 0.000 claims 1
- 108010006643 xenin 25 Proteins 0.000 claims 1
- 229960002911 zonisamide Drugs 0.000 claims 1
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 claims 1
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306647 | 2012-12-21 | ||
| EP13811510.0A EP2934568B1 (en) | 2012-12-21 | 2013-12-19 | Dual glp1/gip or trigonal glp1/gip/glucagon agonists |
| PCT/EP2013/077313 WO2014096150A1 (en) | 2012-12-21 | 2013-12-19 | Dual glp1/gip or trigonal glp1/gip/glucagon agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2934568T1 true SI2934568T1 (en) | 2018-03-30 |
Family
ID=47559233
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201330923T SI2934568T1 (en) | 2012-12-21 | 2013-12-19 | Dual GLP1 / GIP or trigonal agonists GLP1 / GIP / glucagon |
| SI201331127T SI2934567T1 (sl) | 2012-12-21 | 2013-12-19 | Derivati eksendina-4 kot dualni GLP1/GIP ali trigonalni agonisti GLP1/GIP/glukagon |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201331127T SI2934567T1 (sl) | 2012-12-21 | 2013-12-19 | Derivati eksendina-4 kot dualni GLP1/GIP ali trigonalni agonisti GLP1/GIP/glukagon |
Country Status (38)
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| CN110684067A (zh) | 2012-12-21 | 2020-01-14 | 艾丽奥斯生物制药有限公司 | 取代的核苷和核苷酸 |
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| MX2015008077A (es) | 2012-12-21 | 2015-10-30 | Sanofi Sa | Derivados de exendina-4 como agonistas dobles de glp1/gip o trigonal de glp1-gip/glucagon. |
| MX388826B (es) | 2013-05-28 | 2025-03-20 | Scohia Pharma Inc | Compuesto peptidico. |
| EA035688B1 (ru) * | 2013-11-06 | 2020-07-27 | Зилэнд Фарма А/С | Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip |
| BR112016009889B1 (pt) | 2013-11-06 | 2023-11-28 | Zealand Pharma A/S | Análogo do gip, composição farmacêutica compreendendo um análogo do gip, ou um sal farmaceuticamente aceitável do mesmo, e seu uso |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| UA118380C2 (uk) | 2014-06-17 | 2019-01-10 | Пфайзер Інк. | Заміщені сполуки дигідроізохінолінону |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| DK3212218T3 (da) | 2014-10-29 | 2021-08-30 | Zealand Pharma As | GIP-agonistforbindelser og fremgangsmåder |
| PE20230304A1 (es) | 2014-12-30 | 2023-02-13 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon como agentes hipoglucemicos y antiobesidad |
| JOP20200119A1 (ar) | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| US10993993B2 (en) | 2015-05-28 | 2021-05-04 | Immunoforge Co., Ltd. | Pharmaceutical composition for treating muscle atrophy or sarcopenia including glucagon-like peptide (GLP-1) or GLP-1 receptor agonist |
| KR101661332B1 (ko) * | 2015-05-28 | 2016-09-29 | (의료)길의료재단 | 글루카곤 유사 펩타이드-1 수용체 항진제를 포함하는 근감소증 치료용 약학 조성물 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198624A1 (en) * | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| CN108025041A (zh) | 2015-06-30 | 2018-05-11 | 韩美药品株式会社 | 胰高血糖素衍生物和包含其长效缀合物的组合物 |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| PL3389697T3 (pl) | 2015-12-14 | 2021-04-19 | Antaros Medical Ab | Selektywni agoniści receptora glukagonu zawierający ugrupowanie chelatujące do celów obrazowania |
| DK3393496T5 (da) | 2015-12-23 | 2024-09-16 | Univ Johns Hopkins | Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions |
| CN113456820B (zh) | 2015-12-29 | 2023-09-08 | 派格生物医药(苏州)股份有限公司 | 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途 |
| HK1258177A1 (en) * | 2015-12-31 | 2019-11-08 | Hanmi Pharm. Co., Ltd. | Persistent conjugate of triple activator activating glucagon, glp-1 and gip receptor |
| EA201891946A1 (ru) * | 2016-03-10 | 2019-04-30 | Медиммун Лимитед | Коагонисты глюкагона и glp-1 для лечения ожирения |
| CN109477094B (zh) | 2016-05-24 | 2022-04-26 | 武田药品工业株式会社 | 肽化合物 |
| SG11201811697SA (en) | 2016-06-29 | 2019-01-30 | Hanmi Pharmaceutical Co Ltd | Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof |
| TW201821434A (zh) * | 2016-10-10 | 2018-06-16 | 法商賽諾菲公司 | 製備包含親脂性修飾的離胺酸側鏈的肽的方法 |
| US10774127B2 (en) * | 2016-10-12 | 2020-09-15 | University Of Copenhagen | Peptide dual agonists of GIPR and GLP2R |
| AR110301A1 (es) * | 2016-12-02 | 2019-03-13 | Sanofi Sa | Compuestos como agonistas peptídicos de receptores de glp1 / glucagón / gip |
| AR110300A1 (es) * | 2016-12-02 | 2019-03-13 | Sanofi Sa | Compuestos como agonistas peptídicos trigonales de los receptores de glp1 / glucagón / gip |
| TW201832783A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 包含ｇｌｐ－１／胰高血糖素雙重激動劑、連接子和透明質酸的接合物 |
| US10392366B2 (en) | 2017-02-21 | 2019-08-27 | Sanofi | Azetidine compounds as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| AR112760A1 (es) * | 2017-07-19 | 2019-12-11 | Novo Nordisk As | Compuestos bifuncionales que comprenden un análogo de glp-1 y un análogo de egf(a) |
| KR102686854B1 (ko) | 2017-08-09 | 2024-07-18 | 사노피 | 지방간 질환 및 지방간염의 치료에서의 glp-1/글루카곤 수용체 작용제 |
| CN115304666B (zh) * | 2017-11-24 | 2025-09-19 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的胰高血糖素类似物 |
| GB201720187D0 (en) | 2017-12-04 | 2018-01-17 | Imperial Innovations Ltd | Novel Compounds |
| DK3774862T3 (da) | 2018-04-05 | 2022-09-05 | Sun Pharmaceutical Ind Ltd | Nye GLP-1-analoger |
| CA3096495A1 (en) | 2018-04-10 | 2019-10-17 | Sanofi-Aventis Deutschland Gmbh | Lixisenatide synthesis with capping |
| US11560402B2 (en) | 2018-04-10 | 2023-01-24 | Sanofi-Aventis Deutschland Gmbh | Method for cleavage of solid phase-bound peptides from the solid phase |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| UY38249A (es) | 2018-05-30 | 2019-12-31 | Sanofi Sa | Productos conjugados que comprenden un agonista del receptor triple de glp-1/glucagón/gip, un conector y ácido hialurónico |
| TWI749381B (zh) * | 2018-11-01 | 2021-12-11 | 美商美國禮來大藥廠 | 蛋白質酪胺酸-酪胺酸類似物及其使用方法 |
| KR102119188B1 (ko) * | 2018-11-13 | 2020-06-08 | 이뮤노포지 주식회사 | 글루카곤 유사 펩타이드-1(glp-1), glp-1 유래 펩타이드, 또는 glp-1 분해 억제제를 포함하는 근감소증 또는 근위축증 치료용 약학 조성물 |
| WO2020130749A1 (ko) * | 2018-12-21 | 2020-06-25 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 및 인슐린을 포함하는 약학 조성물 |
| US20220153853A1 (en) | 2018-12-21 | 2022-05-19 | Jiangsu Hengrui Medicine Co., Ltd. | Bispecific protein |
| JP7324530B2 (ja) * | 2019-01-07 | 2023-08-10 | 鴻緒生物医葯科技（北京）有限公司 | 新型ポリペプチド及びその治療用途 |
| US20220168396A1 (en) * | 2019-04-11 | 2022-06-02 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Multi-receptor agonist and medical use thereof |
| WO2020214012A1 (ko) * | 2019-04-19 | 2020-10-22 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 또는 이의 결합체를 포함하는 고지혈증 예방 또는 치료용 약학적 조성물 및 예방 또는 치료 방법 |
| WO2020214013A1 (ko) * | 2019-04-19 | 2020-10-22 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 또는 이의 결합체의 고지혈증에 대한 치료적 용도 |
| GB201908424D0 (en) | 2019-06-12 | 2019-07-24 | Imp College Innovations Ltd | Novel compounds |
| KR20220066056A (ko) | 2019-08-16 | 2022-05-23 | 어플라이드 몰레큘라 트랜스포트 인크. | 조성물, 제형, 및 인터루킨 제조 및 정제 |
| CN111040022B (zh) * | 2019-12-23 | 2021-12-14 | 万新医药科技(苏州)有限公司 | 针对胰高血糖素样肽-1受体、胰高血糖素受体、以及抑胃肽受体的三重激动剂 |
| BR112022014397A2 (pt) * | 2020-01-23 | 2022-10-11 | Lilly Co Eli | Compostos co-agonistas de gip/glp1 |
| MX2022011089A (es) | 2020-03-06 | 2022-10-03 | Sanofi Sa | Peptidos como agonistas selectivos del receptor de gip. |
| AU2021250319A1 (en) | 2020-03-31 | 2022-12-01 | Antaros Medical Ab | Selective GIP receptor agonists comprising a chelating moiety for imaging and therapy purposes |
| EP4140496A4 (en) * | 2020-04-20 | 2024-05-22 | Hanmi Pharm. Co., Ltd. | PREVENTIVE OR THERAPEUTIC COMPOSITION FOR HYPERLIPIDEMIA WITH TRIPLE AGONIST ACTING ON GLUCAGON, GLP-1 AND GIP RECEPTORS |
| JP2023526973A (ja) * | 2020-05-29 | 2023-06-26 | 北京拓界生物医薬科技有限公司 | Ｇｌｐ－１とｇｉｐ受容体二重アゴニスト化合物及びその応用 |
| CN116133677A (zh) * | 2020-07-06 | 2023-05-16 | 鸿绪生物医药科技（北京）有限公司 | 新型多肽制剂及其治疗用途 |
| CA3185229A1 (en) * | 2020-07-06 | 2022-01-13 | Jie Han | Novel polypeptide and therapeutic use thereof |
| TW202315883A (zh) | 2020-07-22 | 2023-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 適用於口服的glp-1及gip受體共促效劑 |
| WO2022018185A1 (en) | 2020-07-22 | 2022-01-27 | Novo Nordisk A/S | Glp-1 and gip receptor co-agonists |
| WO2022034062A1 (en) * | 2020-08-12 | 2022-02-17 | Txp Pharma Ag | Exendin-4 peptide analogues |
| JP2023550594A (ja) | 2020-10-30 | 2023-12-04 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１、ｇｉｐ、およびグルカゴン受容体三重作動薬 |
| CN114617956B (zh) * | 2020-12-10 | 2023-10-03 | 江苏中新医药有限公司 | 一种高效降糖的蛋白质药物 |
| JP2024511107A (ja) * | 2021-03-25 | 2024-03-12 | ブライトジーン バイオ－メディカル テクノロジー カンパニー リミテッド | Ｇｉｐとｇｌｐ－１の二重受容体作動薬、医薬組成物および使用 |
| US12215133B2 (en) | 2021-03-25 | 2025-02-04 | Brightgene Bio-Medical Technology Co., Ltd. | GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use |
| CA3219647A1 (en) * | 2021-05-26 | 2022-12-01 | The United Bio-Technology (Hengqin) Co., Ltd. | Multi agonists and use thereof |
| WO2022262837A1 (zh) * | 2021-06-18 | 2022-12-22 | 北京拓界生物医药科技有限公司 | 胰高血糖素类似物及其医药用途 |
| CN115572326B (zh) * | 2021-06-21 | 2025-01-10 | 广东东阳光药业股份有限公司 | Glp-1、gcg和gip受体的三重激动剂 |
| TW202313667A (zh) * | 2021-07-30 | 2023-04-01 | 大陸商南京明德新藥研發有限公司 | 含內醯胺橋的多肽化合物 |
| JP2024536727A (ja) | 2021-09-06 | 2024-10-08 | サノフイ | 強力で選択的なｇｉｐ受容体アゴニストとしての新規のペプチド |
| CA3237796A1 (en) * | 2021-11-12 | 2023-05-19 | Zhenbin Li | Pharmaceutical composition of glp-1 receptor and gip receptor dual agonist, and use thereof |
| CA3239474A1 (en) * | 2021-12-01 | 2023-06-08 | Hua He | Pharmaceutical composition of glp-1 and gip receptor dual agonist and use thereof |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| CN117603364A (zh) * | 2022-09-30 | 2024-02-27 | 广西医科大学附属肿瘤医院 | 一类GLP-1/glucagon/Y2受体三重激动剂及其应用 |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| KR20250152096A (ko) * | 2023-02-24 | 2025-10-22 | 아이피2아이피오 이노베이션스 리미티드 | 화합물 |
| GB202302686D0 (en) * | 2023-02-24 | 2023-04-12 | Imperial College Innovations Ltd | Novel compounds |
| AU2024291989A1 (en) * | 2023-07-14 | 2026-01-15 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Glp-1, gip and gcg receptor triagonist and use thereof |
| CN120329412A (zh) * | 2023-11-06 | 2025-07-18 | 成都奥达生物科技有限公司 | 一种三激动剂化合物 |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025162423A1 (zh) * | 2024-02-02 | 2025-08-07 | 杭州先为达生物科技股份有限公司 | 针对glp-1r、gipr和gcgr的三激动剂 |
| WO2025176999A2 (en) * | 2024-02-23 | 2025-08-28 | Ip2Ipo Innovations Limited | Novel compounds |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
| WO2025219590A1 (en) | 2024-04-19 | 2025-10-23 | Actimed Therapeutics Ltd | Beta-blockers for preserving muscle mass, bone density, and cardiac function in weight loss treatments |
| CN118440155B (zh) * | 2024-07-11 | 2024-11-22 | 中国药科大学 | 一种双激动多肽化合物及其医药用途 |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (437)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6284727B1 (en) | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| NZ250844A (en) | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US5641757A (en) | 1994-12-21 | 1997-06-24 | Ortho Pharmaceutical Corporation | Stable 2-chloro-2'-deoxyadenosine formulations |
| CA2262647C (en) | 1996-08-08 | 2007-12-04 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
| CA2264243C (en) | 1996-08-30 | 2004-10-05 | Novo Nordisk A/S | Glp-1 derivatives |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| CA2277112C (en) | 1997-01-07 | 2008-08-26 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the reduction of food intake |
| US7312196B2 (en) | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US6410511B2 (en) | 1997-01-08 | 2002-06-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US6723530B1 (en) | 1997-02-05 | 2004-04-20 | Amylin Pharmaceuticals, Inc. | Polynucleotides encoding proexendin, and methods and uses thereof |
| EP1019077B2 (en) | 1997-08-08 | 2010-12-22 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| US7220721B1 (en) | 1997-11-14 | 2007-05-22 | Amylin Pharmaceuticals, Inc. | Exendin agonist peptides |
| US7223725B1 (en) | 1997-11-14 | 2007-05-29 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| DK1032587T4 (da) | 1997-11-14 | 2013-04-08 | Amylin Pharmaceuticals Llc | Hidtil ukendte exendinagonist-forbindelser |
| NZ504258A (en) | 1997-11-14 | 2002-12-20 | Amylin Pharmaceuticals Inc | Exendin 3 and 4 agonist compounds for the treatment of diabetes |
| ES2316161T3 (es) | 1998-01-09 | 2009-04-01 | Amylin Pharmaceuticals, Inc. | Formulaciones para peptidos agonistas de amilina con insulina. |
| US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| EP1950223A3 (en) | 1998-03-09 | 2009-05-13 | Zealand Pharma A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| EP1061947B1 (en) | 1998-03-13 | 2004-06-16 | Novo Nordisk A/S | Stabilized aqueous glucagon solutions comprising detergents |
| US6998387B1 (en) | 1998-03-19 | 2006-02-14 | Amylin Pharmaceuticals, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
| ID28617A (id) | 1998-06-12 | 2001-06-21 | Bionebraska Inc | Peptida jenis-1 glukagon yang meningkatkan respon sel-b terhadap glukosa pada subyek yang mengalami kerusakan toleransi glukosa |
| CA2339326A1 (en) | 1998-08-10 | 2000-02-24 | Josephine Egan | Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof |
| JP2002524514A (ja) | 1998-09-17 | 2002-08-06 | イーライ・リリー・アンド・カンパニー | タンパク質製剤 |
| US6429197B1 (en) | 1998-10-08 | 2002-08-06 | Bionebraska, Inc. | Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain |
| US7259136B2 (en) | 1999-04-30 | 2007-08-21 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating peripheral vascular disease |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| WO2000037098A1 (en) | 1998-12-22 | 2000-06-29 | Eli Lilly And Company | Shelf-stable formulation of glucagon-like peptide-1 |
| US7399489B2 (en) | 1999-01-14 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Exendin analog formulations |
| US6902744B1 (en) | 1999-01-14 | 2005-06-07 | Amylin Pharmaceuticals, Inc. | Exendin agonist formulations and methods of administration thereof |
| ATE460942T1 (de) | 1999-01-14 | 2010-04-15 | Amylin Pharmaceuticals Inc | Exendine zur glucagon suppression |
| US20030087820A1 (en) | 1999-01-14 | 2003-05-08 | Young Andrew A. | Novel exendin agonist formulations and methods of administration thereof |
| WO2000055119A1 (en) | 1999-03-17 | 2000-09-21 | Novo Nordisk A/S | Method for acylating peptides and novel acylating agents |
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| NZ514916A (en) | 1999-04-30 | 2004-06-25 | Amylin Pharmaceuticals Inc | Exendins and exendin agonists linked to polyethylene glycol polymers |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| CA2363712C (en) | 1999-05-17 | 2011-05-10 | Conjuchem Inc. | Long lasting insulinotropic peptides |
| US6482799B1 (en) | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| US6344180B1 (en) | 1999-06-15 | 2002-02-05 | Bionebraska, Inc. | GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| US6972319B1 (en) | 1999-09-28 | 2005-12-06 | Bayer Pharmaceuticals Corporation | Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use |
| GB9930882D0 (en) | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
| CA2396157A1 (en) | 2000-01-10 | 2001-07-19 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia |
| CN1487836A (zh) | 2000-03-14 | 2004-04-07 | 埃米林药品公司 | 胰高糖素样肽1(7-36)对胃窦幽门十二指肠能动性的影响 |
| CA2380423A1 (en) | 2000-05-17 | 2001-11-22 | Bionebraska, Inc. | Peptide pharmaceutical formulations |
| ATE397938T1 (de) | 2000-05-19 | 2008-07-15 | Amylin Pharmaceuticals Inc | Behandlung des akuten koronaren syndroms mit glp- 1 |
| JP4624642B2 (ja) | 2000-08-18 | 2011-02-02 | エミスフェアー・テクノロジーズ・インク | 活性剤デリバリー用化合物および組成物 |
| US7507714B2 (en) | 2000-09-27 | 2009-03-24 | Bayer Corporation | Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use |
| WO2002034285A2 (en) | 2000-10-20 | 2002-05-02 | Coolidge Thomas R | Treatment of hibernating myocardium and diabetic cardiomyopathy with a glp-1 peptide |
| PT1355942E (pt) | 2000-12-07 | 2008-11-21 | Lilly Co Eli | Proteínas de fusão de glp-1 |
| AU3938402A (en) | 2000-12-13 | 2002-06-24 | Lilly Co Eli | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| GB2371227A (en) | 2001-01-10 | 2002-07-24 | Grandis Biotech Gmbh | Crystallisation - resistant aqueous growth hormone formulations |
| US6573237B2 (en) | 2001-03-16 | 2003-06-03 | Eli Lilly And Company | Protein formulations |
| CN1162446C (zh) | 2001-05-10 | 2004-08-18 | 上海华谊生物技术有限公司 | 促胰岛素分泌肽衍生物 |
| EP1542712A2 (en) | 2001-06-01 | 2005-06-22 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| DE60224284T2 (de) | 2001-06-28 | 2008-12-18 | Novo Nordisk A/S | Stabile formulierung von modifiziertem glp-1 |
| US7858560B2 (en) | 2001-07-16 | 2010-12-28 | Caprotec Bioanalytics Gmbh | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| DE60228972D1 (de) | 2001-07-31 | 2008-10-30 | Us Gov Health & Human Serv | Glp 1 exendin 4 peptidanaloga und deren verwendungen |
| MXPA04001560A (es) | 2001-08-28 | 2004-05-17 | Lilly Co Eli | Premezclas de glp-1 e insulina basal. |
| WO2003035099A1 (en) | 2001-10-19 | 2003-05-01 | Eli Lilly And Company | Biphasic mixtures of glp-1 and insulin |
| CA2484556A1 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP5424521B2 (ja) | 2001-12-21 | 2014-02-26 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | アルブミン融合タンパク質 |
| US7105489B2 (en) | 2002-01-22 | 2006-09-12 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating polycystic ovary syndrome |
| MXPA04008068A (es) | 2002-02-20 | 2004-11-26 | Lilly Co Eli | Metodo para administrar moleculas de glp-1. |
| MXPA04008215A (es) | 2002-02-27 | 2004-11-26 | Immunex Corp | Formulacion polipeptidica. |
| WO2003077851A2 (en) | 2002-03-11 | 2003-09-25 | Hk Pharmaceuticals, Inc. | Compounds and methods for analyzing the proteome |
| US7141240B2 (en) | 2002-03-12 | 2006-11-28 | Cedars-Sinai Medical Center | Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1 |
| WO2003084563A1 (en) | 2002-04-04 | 2003-10-16 | Novo Nordisk A/S | Glp-1 agonist and cardiovascular complications |
| CN1735423A (zh) | 2002-04-10 | 2006-02-15 | 伊莱利利公司 | 胃轻瘫的治疗 |
| US6861236B2 (en) | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
| US20040037826A1 (en) | 2002-06-14 | 2004-02-26 | Michelsen Birgitte Koch | Combined use of a modulator of CD3 and a GLP-1 compound |
| WO2003105897A1 (en) | 2002-06-14 | 2003-12-24 | Novo Nordisk A/S | Combined use of a modulator of cd3 and a glp-1 compound |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| ATE432289T1 (de) | 2002-07-04 | 2009-06-15 | Zealand Pharma As | Glp-1 und behandlungsmethode für diabetes |
| CN1665540A (zh) | 2002-07-09 | 2005-09-07 | 桑多斯股份公司 | 含1,2－丙二醇的高浓度人生长激素液体制剂 |
| US20070065469A1 (en) | 2002-07-09 | 2007-03-22 | Michael Betz | Liquid formulations with high concentration of human growth hormone (high) comprising glycine |
| US20080260838A1 (en) | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| JP4828940B2 (ja) | 2002-08-01 | 2011-11-30 | マンカインド コーポレイション | 細胞輸送組成物およびこれらの使用 |
| US20040038865A1 (en) | 2002-08-01 | 2004-02-26 | Mannkind Corporation | Cell transport compositions and uses thereof |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| CN105001222B (zh) | 2002-08-21 | 2017-11-07 | 勃林格殷格翰制药两合公司 | 8‑[3‑氨基‑哌啶‑1‑基]‑黄嘌呤化合物，其制备方法及作为药物制剂的用途 |
| US7544657B2 (en) | 2002-10-02 | 2009-06-09 | Zealand Pharma A/S | Stabilized Exendin-4 compounds |
| US20050209142A1 (en) | 2002-11-20 | 2005-09-22 | Goran Bertilsson | Compounds and methods for increasing neurogenesis |
| ATE494904T1 (de) | 2002-11-20 | 2011-01-15 | Neuronova Ab | Verbindungen und verfahren zur erhöhung der neurogenese |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| JP2006514035A (ja) | 2002-12-17 | 2006-04-27 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 心不整脈の予防および治療 |
| US20040209803A1 (en) | 2002-12-19 | 2004-10-21 | Alain Baron | Compositions for the treatment and prevention of nephropathy |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| EP1620118B1 (en) | 2003-04-08 | 2014-06-18 | Yeda Research And Development Co., Ltd. | Reversible pegylated drugs |
| WO2004089985A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Stable pharmaceutical compositions |
| CN1822851B (zh) | 2003-05-15 | 2011-04-13 | 塔夫茨大学信托人 | 肽和多肽药物的稳定类似物 |
| US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
| LT2644206T (lt) | 2003-05-23 | 2019-05-27 | Nektar Therapeutics | Peg dariniai, susidedantys iš dviejų peg grandinių |
| WO2005000222A2 (en) | 2003-05-30 | 2005-01-06 | Amylin Pharmaceuticals, Inc. | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| EP1633390B1 (en) | 2003-06-03 | 2012-01-18 | Novo Nordisk A/S | Stabilized pharmaceutical glp-1 peptide compositions |
| CN102940879B (zh) | 2003-06-03 | 2017-06-06 | 诺沃挪第克公司 | 稳定化的药物肽组合物 |
| CN1812808B (zh) | 2003-06-03 | 2012-07-04 | 诺沃挪第克公司 | 稳定化的药物肽组合物 |
| JP2007524592A (ja) | 2003-06-03 | 2007-08-30 | ノボ・ノルデイスク・エー／エス | 安定化された薬学的ペプチド組成物 |
| US8921311B2 (en) | 2003-08-01 | 2014-12-30 | Mannkind Corporation | Method for treating hyperglycemia |
| EP2107069B1 (en) | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Novel insulin derivatives |
| MXPA06001814A (es) | 2003-08-21 | 2006-05-04 | Novo Nordisk As | Separacion de polipeptidos que comprenden un aminoacido racemizado. |
| WO2005021022A2 (en) | 2003-09-01 | 2005-03-10 | Novo Nordisk A/S | Stable formulations of peptides |
| US20060247167A1 (en) | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| JP2007537981A (ja) | 2003-09-19 | 2007-12-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の血漿タンパク質親和性タグ |
| WO2005046716A1 (en) | 2003-11-13 | 2005-05-26 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a glp-1 peptide and a insulin peptide of short time action for treatment of diabetes and bulimia |
| US20060287221A1 (en) | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
| US20050106214A1 (en) | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
| US20050281879A1 (en) | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| WO2005081619A2 (en) | 2003-11-20 | 2005-09-09 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| BRPI0416743A (pt) | 2003-11-20 | 2007-01-16 | Novo Nordisk As | formulação farmacêutica, e, métodos de preparar uma formulação de peptìdeo apropriada para uso em um dispositivo de injeção, para reduzir depósitos em equipamento de produção e no produto final, e para reduzir o entupimento de dispositivos de injeção por uma formulação de peptìdeo |
| AU2004295023A1 (en) | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
| CN1913925A (zh) | 2003-12-10 | 2007-02-14 | 尼克塔治疗亚拉巴马公司 | 含有两组不同聚合物－活性剂缀合物的组合物 |
| US20050143303A1 (en) | 2003-12-26 | 2005-06-30 | Nastech Pharmaceutical Company Inc. | Intranasal administration of glucose-regulating peptides |
| US20060210614A1 (en) | 2003-12-26 | 2006-09-21 | Nastech Pharmaceutical Company Inc. | Method of treatment of a metabolic disease using intranasal administration of exendin peptide |
| WO2007065156A2 (en) | 2005-12-02 | 2007-06-07 | Nastech Pharmaceutical Company Inc. | Pharmaceutical formulation for increased epithelial permeability of glucose-regulating peptide |
| CN1938334A (zh) * | 2004-01-30 | 2007-03-28 | 瓦拉塔药品公司 | Glp－1激动剂和胃泌素化合物的联合使用 |
| KR101427024B1 (ko) | 2004-02-11 | 2014-08-05 | 아스트라제네카 파마수티컬스 엘피 | 선택가능한 특성을 갖는 하이브리드 폴리펩티드 |
| EP1789440A4 (en) | 2004-02-11 | 2008-03-12 | Amylin Pharmaceuticals Inc | REASONS FOR THE FAMILY OF PANCREATIC POLYPEPTIDES AND POLYPEPTIDES CONTAINING THEM |
| JP2008500281A (ja) | 2004-02-11 | 2008-01-10 | アミリン・ファーマシューティカルズ，インコーポレイテッド | アミリンファミリーペプチドおよびそれらを作成し使用するための方法 |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| US7399744B2 (en) | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
| JP5030292B2 (ja) | 2004-04-15 | 2012-09-19 | アミリン・ファーマシューティカルズ，インコーポレイテッド | ポリマーを基にした持続放出性装置 |
| US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
| US20060110423A1 (en) | 2004-04-15 | 2006-05-25 | Wright Steven G | Polymer-based sustained release device |
| US20090069226A1 (en) | 2004-05-28 | 2009-03-12 | Amylin Pharmaceuticals, Inc. | Transmucosal delivery of peptides and proteins |
| WO2005117584A2 (en) | 2004-05-28 | 2005-12-15 | Amylin Pharmaceuticals, Inc | Improved transmucosal delivery of peptides and proteins |
| EP1758575A1 (en) | 2004-06-11 | 2007-03-07 | Novo Nordisk A/S | Counteracting drug-induced obesity using glp-1 agonists |
| JP5220410B2 (ja) | 2004-07-19 | 2013-06-26 | バイオコン・リミテッド | インスリン−オリゴマー複合体、その処方物及び使用 |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| JP2008509153A (ja) | 2004-08-03 | 2008-03-27 | バイオレクシス ファーマシューティカル コーポレイション | Ｇｌｐ−１を含むトランスフェリン融合タンパク質用いた併用療法 |
| CA2577158A1 (en) | 2004-08-16 | 2006-02-23 | Water Un Limited | Apparatus and method for cooling of air |
| JP4965446B2 (ja) | 2004-08-31 | 2012-07-04 | ノヴォ ノルディスク アー／エス | ペプチド、ポリペプチド及びタンパク質の安定化のためのトリス（ヒドロキシメチル）アミノメタンの使用 |
| DE102004043153B4 (de) | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
| WO2006028110A1 (ja) | 2004-09-07 | 2006-03-16 | Chugai Seiyaku Kabushiki Kaisha | 水溶性ヒアルロン酸修飾物の製造方法 |
| JP2008513384A (ja) | 2004-09-17 | 2008-05-01 | ノボ ノルディスク アクティーゼルスカブ | インスリンおよびインスリン分泌性ペプチドを含有する医薬組成物 |
| KR101341359B1 (ko) | 2004-10-01 | 2013-12-13 | 램스코르 인코포레이티드 | 편리하게 이식가능한 서방형 약물 조성물 |
| WO2006037811A2 (en) | 2004-10-07 | 2006-04-13 | Novo Nordisk A/S | Protracted exendin-4 compounds |
| US7595294B2 (en) | 2004-10-08 | 2009-09-29 | Transition Therapeutics, Inc. | Vasoactive intestinal polypeptide pharmaceuticals |
| US20090036355A1 (en) | 2004-10-13 | 2009-02-05 | Sanjay Bhanot | Antisense Modulation of PTP1B Expression |
| US7442682B2 (en) | 2004-10-19 | 2008-10-28 | Nitto Denko Corporation | Transepithelial delivery of peptides with incretin hormone activities |
| EP2494983B1 (en) | 2004-11-12 | 2019-04-24 | Novo Nordisk A/S | Stable formulations of glp-1 |
| US20080125361A1 (en) | 2004-11-12 | 2008-05-29 | Novo Nordisk A/S | Stable Formulations Of Peptides |
| US20090011976A1 (en) | 2004-11-12 | 2009-01-08 | Novo Nordisk A/S | Stable Formulations Of Peptides |
| CA2589800A1 (en) | 2004-12-02 | 2006-06-08 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and glp-1 or pyy |
| PL1824876T3 (pl) | 2004-12-13 | 2016-01-29 | Amylin Pharmaceuticals Llc | Motywy rodziny polipeptydów trzustkowych, polipeptydy i sposoby je obejmujące |
| JP5243041B2 (ja) | 2004-12-21 | 2013-07-24 | ネクター セラピューティックス | 安定化ポリマーチオール試薬 |
| ES2326906T3 (es) | 2004-12-22 | 2009-10-21 | Eli Lilly And Company | Formulaciones de proteinas de fusion analogas al glp-1. |
| AU2005323063B2 (en) | 2004-12-24 | 2011-01-27 | Amylin Pharmaceuticals, Llc | Use of GLP-1 and agonists thereof to prevent cardiac myocyte apoptosis |
| EP2505207B1 (en) | 2005-01-14 | 2015-04-22 | Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. | Modified exendins and uses thereof |
| US8716221B2 (en) | 2005-01-14 | 2014-05-06 | Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. | Modified exendins and uses thereof |
| WO2006082588A2 (en) | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| EA011653B1 (ru) | 2005-02-11 | 2009-04-28 | Амилин Фармасьютикалз, Инк. | Аналоги и гибридные полипептиды gip с избираемыми свойствами |
| US20090286723A1 (en) | 2005-02-11 | 2009-11-19 | Amylin Pharmaceuticals, Inc. | Hybrid Polypeptides with Selectable Properties |
| WO2006097535A2 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Peptide agonists of the glucagon family with secretin like activity |
| EP1888103B1 (en) | 2005-04-11 | 2012-03-21 | Amylin Pharmaceuticals, Inc. | Use of glp-1, exendin and agonists thereof to delay or prevent cardiac remodeling |
| JP4979686B2 (ja) | 2005-04-24 | 2012-07-18 | ノボ・ノルデイスク・エー／エス | 注入デバイス |
| CN101180081B (zh) | 2005-05-25 | 2015-08-26 | 诺沃-诺迪斯克有限公司 | 稳定的多肽制剂 |
| EP1883652A2 (en) | 2005-05-26 | 2008-02-06 | Bristol-Myers Squibb Company | N-terminally modified glp-1 receptor modulators |
| ES2399645T3 (es) | 2005-06-06 | 2013-04-02 | Camurus Ab | Formulaciones de análogos de GLP-1 |
| AU2006258841B2 (en) | 2005-06-13 | 2012-05-03 | Imperial Innovations Limited | Oxyntomodulin analogues and their effects on feeding behaviour |
| GB0511986D0 (en) | 2005-06-13 | 2005-07-20 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| CA2611823C (en) | 2005-06-16 | 2013-07-30 | Nektar Therapeutics Al, Corporation | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| WO2007019331A2 (en) | 2005-08-04 | 2007-02-15 | Nektar Therapeutics Al, Corporation | Conjugates of a g-csf moiety and a polymer |
| EP1924293A4 (en) | 2005-08-06 | 2008-12-24 | Qinghua Wang | COMPOSITION AND METHOD FOR THE PREVENTION AND TREATMENT OF DIABETES TYPE I |
| CN105056211A (zh) | 2005-08-19 | 2015-11-18 | 安米林药品有限责任公司 | 治疗糖尿病和降低体重的毒蜥外泌肽 |
| CN102614131A (zh) | 2005-09-14 | 2012-08-01 | 曼金德公司 | 以提高结晶微粒表面对活性试剂的亲和力为基础的药物配制方法 |
| JP5072848B2 (ja) | 2005-09-20 | 2012-11-14 | ノバルティス アーゲー | 低血糖イベントを低減するためのｄｐｐ−ｉｖ阻害剤の使用 |
| WO2007047834A2 (en) | 2005-10-18 | 2007-04-26 | Biocon Limited | Oral peptide conjugates for metabolic diseases |
| WO2007047922A2 (en) | 2005-10-19 | 2007-04-26 | Smartcells, Inc. | Polymer-drug conjugates |
| CA2628241C (en) | 2005-11-07 | 2016-02-02 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting physiological solubility and stability |
| WO2007053946A1 (en) | 2005-11-09 | 2007-05-18 | Conjuchem Biotechnologies Inc. | Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin |
| CA2632903C (en) | 2005-12-02 | 2015-11-24 | Vianova Labs, Inc. | Treatment of cancer and other diseases |
| WO2007067964A2 (en) | 2005-12-08 | 2007-06-14 | Nastech Pharmaceutical Company Inc. | Mucosal delivery of stabilized formulations of exendin |
| ES2390286T3 (es) | 2005-12-16 | 2012-11-08 | Nektar Therapeutics | Conjugados poliméricos de GLP-1 |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| ES2779992T3 (es) | 2005-12-20 | 2020-08-21 | Univ Duke | Métodos y composiciones para suministrar agentes activos con propiedades farmacológicas potenciadas |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| MX2008009125A (es) | 2006-01-18 | 2008-10-23 | Qps Llc | Composiciones farmaceuticas con estabilidad mejorada. |
| JP2009525986A (ja) | 2006-02-03 | 2009-07-16 | メディミューン，エルエルシー | タンパク質製剤 |
| US7704953B2 (en) | 2006-02-17 | 2010-04-27 | Mdrna, Inc. | Phage displayed cell binding peptides |
| US20090186817A1 (en) | 2006-03-21 | 2009-07-23 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of using same |
| WO2007120899A2 (en) | 2006-04-13 | 2007-10-25 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Pharmaceutical compositions of hglp-1, exendin-4 and analogs thereof |
| MX2008013216A (es) | 2006-04-14 | 2008-10-27 | Mannkind Corp | Formulaciones farmaceuticas de peptido-1 tipo glucagon (glp-1). |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| US8299024B2 (en) | 2006-05-12 | 2012-10-30 | Amylin Pharmaceuticals, Llc | Methods to restore glycemic control |
| WO2007139589A1 (en) | 2006-05-26 | 2007-12-06 | Bristol-Myers Squibb Company | Sustained release glp-1 receptor modulators |
| CA2652907A1 (en) | 2006-05-26 | 2007-12-06 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treatment of diabetes |
| EP2038423B1 (en) | 2006-06-21 | 2012-12-26 | Biocon Limited | A method of producing biologically active polypeptide having insulinotropic activity |
| PL2494959T3 (pl) | 2006-07-05 | 2015-06-30 | Foamix Pharmaceuticals Ltd | Nośnik ze spienialnego kwasu dikarboksylowego oraz kompozycje farmaceutyczne z nośnikiem |
| JP5102833B2 (ja) | 2006-07-24 | 2012-12-19 | バイオレクシス ファーマシューティカル コーポレーション | エキセンディン融合タンパク質 |
| US7928186B2 (en) | 2006-08-02 | 2011-04-19 | Phoenix Pharmaceuticals, Inc. | Cell permeable bioactive peptide conjugates |
| AU2007281433A1 (en) | 2006-08-04 | 2008-02-07 | Nastech Pharmaceutical Company Inc. | Compositions for intranasal delivery of human insulin and uses thereof |
| NZ574524A (en) | 2006-08-09 | 2011-07-29 | Intarcia Therapeutics Inc | Piston assembly for positioning lumen of a reservoir for an osmotic delivery having a columnar body and a spring |
| AU2007284365A1 (en) | 2006-08-17 | 2008-02-21 | Amylin Pharmaceuticals, Inc. | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| WO2008023050A1 (en) * | 2006-08-25 | 2008-02-28 | Novo Nordisk A/S | Acylated exendin-4 compounds |
| CN101125207B (zh) | 2006-11-14 | 2012-09-05 | 上海华谊生物技术有限公司 | 带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途 |
| WO2008073448A2 (en) | 2006-12-12 | 2008-06-19 | Amylin Pharmaceuticals, Inc. | Pharmaceutical formulations and methods for making the same |
| TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
| US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| EP2124974B1 (en) | 2007-01-05 | 2017-03-15 | Indiana University Research and Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological ph buffers |
| CN101663317A (zh) * | 2007-01-05 | 2010-03-03 | CovX科技爱尔兰有限公司 | 胰高血糖素样蛋白-1受体glp-1r激动剂化合物 |
| RU2432361C2 (ru) | 2007-01-05 | 2011-10-27 | КовЭкс Текнолоджиз Айэлэнд Лимитед | Соединения агонисты рецептора глюкагоноподобного белка-1 (glp-1r) |
| WO2008098212A2 (en) | 2007-02-08 | 2008-08-14 | Diobex, Inc. | Extended release formulations of glucagon and other peptides and proteins |
| EP2487184A1 (en) | 2007-02-15 | 2012-08-15 | Indiana University Research and Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| US8420598B2 (en) | 2007-04-20 | 2013-04-16 | B & L Delipharm Corp. | Mono modified exendin with polyethylene glycol or its derivatives and uses thereof |
| HRP20130259T1 (hr) | 2007-04-23 | 2013-04-30 | Intarcia Therapeutics, Inc. | Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe |
| US8236760B2 (en) | 2007-04-27 | 2012-08-07 | Cedars-Sinsai Medical Center | Use of GLP-1 receptor agonists for the treatment of short bowel syndrome |
| US7829664B2 (en) | 2007-06-01 | 2010-11-09 | Boehringer Ingelheim International Gmbh | Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof |
| WO2008148839A2 (en) | 2007-06-08 | 2008-12-11 | Ascendis Pharma As | Long-acting polymeric prodrugs of exendin |
| JP5385266B2 (ja) | 2007-06-15 | 2014-01-08 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| US20100196405A1 (en) | 2007-07-10 | 2010-08-05 | Kingman Ng | GLP-1 Fc FUSION PROTEIN FORMULATION |
| EP2185178B1 (en) | 2007-08-03 | 2017-08-23 | Eli Lilly And Company | Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity |
| CN101366692A (zh) | 2007-08-15 | 2009-02-18 | 江苏豪森药业股份有限公司 | 一种稳定的艾塞那肽制剂 |
| KR20100080519A (ko) | 2007-08-30 | 2010-07-08 | 큐어디엠 인코포레이티드 | 프로섬 펩타이드 및 이의 유사체의 조성물 및 이의 이용 방법 |
| CN101842109B (zh) | 2007-09-05 | 2014-01-29 | 诺沃-诺迪斯克有限公司 | 用a-b-c-d-衍生的肽和它们的治疗用途 |
| WO2009035540A2 (en) | 2007-09-07 | 2009-03-19 | Ipsen Pharma S.A.S. | Analogues of exendin-4 and exendin-3 |
| CN101969928B (zh) | 2007-10-24 | 2014-05-07 | 曼金德公司 | 活性剂的递送 |
| US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
| EP2211842B1 (en) | 2007-10-24 | 2015-08-12 | MannKind Corporation | An inhalable dry powder formulation comprising glp-1 for use in the treatment of hyperglycemia and diabetes by pulmonary administration |
| WO2009058662A2 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Glucagon antagonists |
| WO2009058734A1 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
| HUE030383T2 (en) | 2007-11-16 | 2017-05-29 | Novo Nordisk As | Stable pharmaceutical formulations containing liraglutide and deglates |
| US8710002B2 (en) | 2007-11-23 | 2014-04-29 | Michael Rothkopf | Methods of enhancing diabetes resolution |
| CN101444618B (zh) | 2007-11-26 | 2012-06-13 | 杭州九源基因工程有限公司 | 含有艾塞那肽的药物制剂 |
| US20090186819A1 (en) | 2007-12-11 | 2009-07-23 | Marieve Carrier | Formulation of insulinotropic peptide conjugates |
| ES2613152T3 (es) | 2008-01-09 | 2017-05-22 | Sanofi-Aventis Deutschland Gmbh | Nuevos derivados de insulina con perfil tiempo/acción extremadamente retardado |
| JP2011511778A (ja) | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
| DK2596805T3 (da) | 2008-02-01 | 2021-12-13 | Ascendis Pharma As | Prodrug omfattende et lægemiddel-linker-konjugat |
| RU2595380C2 (ru) | 2008-02-06 | 2016-08-27 | Байокон Лимитид | Ферментационная среда для получения правастатина и способ получения правастатина |
| WO2009114959A1 (zh) | 2008-03-20 | 2009-09-24 | 中国人民解放军军事医学科学院毒物药物研究所 | 可注射用缓释药物制剂及其制备方法 |
| WO2009125423A2 (en) | 2008-04-07 | 2009-10-15 | National Institute Of Immunology | Compositions useful for the treatment of diabetes and other chronic disorder |
| TW200950801A (en) | 2008-05-07 | 2009-12-16 | Merrion Res Iii Ltd | Compositions of peptides and processes of preparation thereof |
| ES2552646T3 (es) | 2008-05-21 | 2015-12-01 | Amylin Pharmaceuticals, Inc. | Exendinas para disminuir el colesterol y los triglicéridos |
| EP2288918A1 (en) | 2008-05-23 | 2011-03-02 | Amylin Pharmaceuticals, Inc. | Glp-1 receptor agonist bioassays |
| CN104491962B (zh) | 2008-06-13 | 2018-10-23 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| AU2009260302B2 (en) | 2008-06-17 | 2014-10-23 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| EP2298801A4 (en) | 2008-06-17 | 2011-08-03 | Otsuka Chemical Co Ltd | GLYCOSYLATED GLP-1 PEPTIDE |
| BRPI0915282A2 (pt) | 2008-06-17 | 2017-02-07 | Univ Indiana Res & Tech Corp | agonistas mistos baseados no gip para o tratamento de distúrbios metabólicos e obesidade |
| KR20110039230A (ko) | 2008-06-17 | 2011-04-15 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 생리학적 ｐＨ 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체 |
| EP3412300A1 (en) | 2008-06-27 | 2018-12-12 | Duke University | Therapeutic agents comprising elastin-like peptides |
| US20110129522A1 (en) | 2008-07-21 | 2011-06-02 | Transpharma Medical Ltd. | Transdermal system for extended delivery of incretins and incretn mimetic peptides |
| WO2010013012A2 (en) | 2008-08-01 | 2010-02-04 | Lund University Bioscience Ab | Novel polypeptides and uses thereof |
| CN101670096B (zh) | 2008-09-11 | 2013-01-16 | 杭州九源基因工程有限公司 | 含有艾塞那肽的药物制剂 |
| ES2772731T3 (es) | 2008-10-17 | 2020-07-08 | Sanofi Aventis Deutschland | Combinación de una insulina y un agonista de GLP-1 |
| SMT201700189T1 (it) | 2008-12-10 | 2017-05-08 | Glaxosmithkline Llc | Composizioni farmaceutiche di albiglutide |
| MX2011006315A (es) | 2008-12-15 | 2011-09-22 | Zealand Pharma As | Analogos de glucagon. |
| KR20110126592A (ko) | 2008-12-15 | 2011-11-23 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
| KR20110126591A (ko) | 2008-12-15 | 2011-11-23 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
| CA2747109A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| SG172291A1 (en) | 2008-12-19 | 2011-07-28 | Univ Indiana Res & Tech Corp | Amide based glucagon superfamily peptide prodrugs |
| CN101538323B (zh) | 2009-01-13 | 2012-05-09 | 深圳翰宇药业股份有限公司 | 一种纯化艾塞那肽的方法 |
| DE102009006602A1 (de) | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| WO2010096052A1 (en) | 2009-02-19 | 2010-08-26 | Merck Sharp & Dohme Corp. | Oxyntomodulin analogs |
| MX2011009251A (es) | 2009-03-04 | 2011-11-18 | Mannkind Corp | Sistema mejorado de suministro de farmaco en polvo seco. |
| AU2010220255B2 (en) | 2009-03-05 | 2014-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with retractable needle |
| EP2413955A4 (en) | 2009-04-01 | 2012-12-26 | Amylin Pharmaceuticals Inc | N-TERMINAL CONFORMATION RESTRICTED GLP-1 RECEPTOR AGONIST COMPOUNDS |
| WO2010118034A2 (en) | 2009-04-06 | 2010-10-14 | Board Of Regents, The University Of Texas System | Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells |
| JP5727459B2 (ja) | 2009-04-22 | 2015-06-03 | アルテオゼン， インクＡｌｔｅｏｇｅｎ， Ｉｎｃ | 体内持続性を維持することにより体内半減期が増加したタンパク質またはペプチド融合体 |
| CN101870728A (zh) | 2009-04-23 | 2010-10-27 | 派格生物医药(苏州)有限公司 | 新型Exendin变体及其缀合物 |
| CN101559041B (zh) | 2009-05-19 | 2014-01-15 | 中国科学院过程工程研究所 | 粒径均一的多肽药物缓释微球或微囊制剂及制备方法 |
| WO2010133676A1 (en) | 2009-05-20 | 2010-11-25 | Sanofi-Aventis Deutschland Gmbh | A system comprising a drug delivery device and a cartridge provided with a bung and a method of identifying the cartridge |
| CA2760760A1 (en) | 2009-05-20 | 2010-11-25 | Sanofi-Aventis Deutschland Gmbh | A bung for drug containing cartridges in drug delivery devices |
| EP2435061A4 (en) | 2009-05-28 | 2013-03-27 | Amylin Pharmaceuticals Inc | DAMPING GLP-1 RECEPTOR AGONIST COMPOUNDS |
| JP2012529463A (ja) | 2009-06-11 | 2012-11-22 | ノヴォ ノルディスク アー／エス | ２型糖尿病を治療するための、ｇｌｐ−１とｆｇｆ２１との組合せ |
| BRPI1014508A2 (pt) | 2009-06-16 | 2016-04-05 | Univ Indiana Res & Tech Corp | análogos de peptídeo de glucagon, dimer de dois peptídeos de glucagon, composição farmacêutica deles derivada e métodos para seu uso" |
| CA2766537A1 (en) | 2009-07-02 | 2011-01-06 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
| HUE026255T2 (en) | 2009-07-13 | 2016-06-28 | Zealand Pharma As | Acylated glucagon analogues |
| CN101601646B (zh) | 2009-07-22 | 2011-03-23 | 南京凯瑞尔纳米生物技术有限公司 | 治疗糖尿病的鼻腔滴剂及其制备方法 |
| WO2011011675A1 (en) | 2009-07-23 | 2011-01-27 | Zelos Therapeutics, Inc. | Pharmaceutically acceptable formulations/compositions for peptidyl drugs |
| CA2769340C (en) | 2009-07-31 | 2018-09-11 | Harald Rau | Prodrugs comprising an insulin linker conjugate |
| WO2011017835A1 (en) | 2009-08-11 | 2011-02-17 | Nanjing University | Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding |
| CN101993485B (zh) | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
| US20120148586A1 (en) | 2009-08-27 | 2012-06-14 | Joyce Ching Tsu Chou | Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders |
| WO2011039096A1 (en) | 2009-09-30 | 2011-04-07 | Glaxo Group Limited | Drug fusions and conjugates with extended half life |
| EP2490708B1 (en) | 2009-10-22 | 2013-03-27 | Biodel Inc. | Stabilized glucagon solutions |
| US20110097386A1 (en) | 2009-10-22 | 2011-04-28 | Biodel, Inc. | Stabilized glucagon solutions |
| US9610329B2 (en) | 2009-10-22 | 2017-04-04 | Albireo Pharma, Inc. | Stabilized glucagon solutions |
| EP2495255A4 (en) | 2009-10-30 | 2013-05-15 | Otsuka Chemical Co Ltd | GLYCOSYLATED FORM OF AN ANTIGENIC GLP-1 ANALOG |
| HRP20150107T1 (xx) | 2009-11-02 | 2015-03-13 | Pfizer Inc. | Derivati dioksabiciklo[3.2.1]oktan-2,3,4-triola |
| WO2011056713A2 (en) | 2009-11-03 | 2011-05-12 | Amylin Pharmaceuticals, Inc. | Glp-1 receptor agonist compounds for obstructive sleep apnea |
| AR078973A1 (es) | 2009-11-13 | 2011-12-14 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1 y metionina |
| MY180661A (en) | 2009-11-13 | 2020-12-04 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
| RU2012130011A (ru) | 2009-12-15 | 2014-01-27 | МЕТАБОЛИК СОЛЮШНЗ ДЕВЕЛОПМЕНТ КОМПАНИ, ЭлЭлСи | Ppar-снижающие тиазолидиндионы и комбинации для лечения сахарного диабета и других нарушений обмена веществ |
| EP2512475A1 (en) | 2009-12-15 | 2012-10-24 | Metabolic Solutions Development Company LLC | Ppar-sparing thiazolidinediones and combinations for the treatment of obesity and other metabolic diseases |
| AU2010331926B2 (en) | 2009-12-15 | 2014-03-27 | Cirius Therapeutics, Inc. | PPAR-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases |
| KR102029560B1 (ko) | 2009-12-15 | 2019-10-07 | 씨리우스 테라퓨틱스, 엘엘씨 | 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염 |
| CN111560060A (zh) | 2009-12-16 | 2020-08-21 | 诺沃—诺迪斯克有限公司 | 双酰化glp-1衍生物 |
| WO2011075623A1 (en) | 2009-12-18 | 2011-06-23 | Latitude Pharmaceuticals, Inc. | One - phase gel compos ition compri s ing phos pholi pids |
| US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| CN101798588B (zh) * | 2009-12-21 | 2015-09-09 | 上海仁会生物制药股份有限公司 | Glp-1受体激动剂生物学活性测定方法 |
| JO2976B1 (en) | 2009-12-22 | 2016-03-15 | ايلي ليلي اند كومباني | Axentomodulin polypeptide |
| AR079344A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
| BR112012018104A2 (pt) | 2010-01-20 | 2017-10-17 | Zeland Pharma As | tratamento de doenças cardíacas |
| CN102834108A (zh) * | 2010-01-27 | 2012-12-19 | 印第安纳大学研究及科技有限公司 | 用于治疗代谢紊乱和肥胖症的胰高血糖素拮抗剂-gip激动剂偶联物和组合物 |
| AU2011209472B2 (en) | 2010-02-01 | 2014-07-24 | Sanofi-Aventis Deutschland Gmbh | Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder |
| WO2011109784A1 (en) | 2010-03-05 | 2011-09-09 | Conjuchem, Llc | Formulation of insulinotropic peptide conjugates |
| CN102917748B (zh) | 2010-03-24 | 2015-04-01 | 施菲姆德控股有限责任公司 | 血管内组织破坏 |
| AR080592A1 (es) * | 2010-03-26 | 2012-04-18 | Lilly Co Eli | Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso |
| WO2011117415A1 (en) | 2010-03-26 | 2011-09-29 | Novo Nordisk A/S | Novel glucagon analogues |
| CN103179976A (zh) | 2010-05-13 | 2013-06-26 | 印第安纳大学研究及科技有限公司 | 呈现g蛋白偶联受体活性的胰高血糖素超家族肽 |
| CN103079587B (zh) | 2010-05-13 | 2016-05-11 | 印第安纳大学研究及科技有限公司 | 呈现核激素受体活性的胰高血糖素超家族肽 |
| AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
| WO2011144751A1 (en) | 2010-05-20 | 2011-11-24 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| WO2011156407A2 (en) | 2010-06-09 | 2011-12-15 | Amylin Pharmaceuticals, Inc. | Glp-1 receptor agonists to treat pancre-atitis |
| CN101891823B (zh) | 2010-06-11 | 2012-10-03 | 北京东方百泰生物科技有限公司 | 一种Exendin-4及其类似物融合蛋白 |
| US8636711B2 (en) | 2010-06-14 | 2014-01-28 | Legacy Emanuel Hospital & Health Center | Stabilized glucagon solutions and uses therefor |
| EP2582421A1 (en) | 2010-06-21 | 2013-04-24 | MannKind Corporation | Dry powder drug delivery system and methods |
| AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
| CN103179979A (zh) | 2010-06-24 | 2013-06-26 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰高血糖素超家族肽前药 |
| US9234023B2 (en) | 2010-06-24 | 2016-01-12 | Biousian Biosystems, Inc. | Glucagon-like peptide-1 glycopeptides |
| WO2011163473A1 (en) | 2010-06-25 | 2011-12-29 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability in physiological ph buffers |
| WO2012012460A1 (en) | 2010-07-19 | 2012-01-26 | Xeris Pharmaceuticals, Inc. | Stable glucagon formulations for the treatment of hypoglycemia |
| US20130137645A1 (en) | 2010-07-19 | 2013-05-30 | Mary S. Rosendahl | Modified peptides and proteins |
| KR20130101005A (ko) | 2010-07-28 | 2013-09-12 | 아밀린 파마슈티칼스, 엘엘씨. | 안정화된 영역을 갖는 glp-1 수용체 효능제 화합물 |
| CN102397558B (zh) | 2010-09-09 | 2013-08-14 | 中国人民解放军军事医学科学院毒物药物研究所 | Exendin-4类似物的定位聚乙二醇化修饰物及其用途 |
| EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
| WO2012050923A2 (en) | 2010-09-28 | 2012-04-19 | Amylin Pharmaceuticals, Inc. | Engineered polypeptides having enhanced duration of action |
| WO2012059762A1 (en) | 2010-11-03 | 2012-05-10 | Arecor Limited | Novel composition comprising glucagon |
| EP2637657B1 (en) | 2010-11-09 | 2019-05-22 | MannKind Corporation | Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines |
| EP2460552A1 (en) | 2010-12-06 | 2012-06-06 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with locking arrangement for dose button |
| CN102552883B (zh) | 2010-12-09 | 2014-02-19 | 天津药物研究院 | 一种多肽复合物、药物组合物、其制备方法和应用 |
| RU2600440C3 (ru) | 2010-12-16 | 2021-12-10 | Ново Нордиск А/С | Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты |
| JP2014504588A (ja) | 2010-12-22 | 2014-02-24 | アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー | 膵島細胞移植のためのｇｌｐ−１受容体アゴニスト |
| EA201390941A1 (ru) | 2010-12-22 | 2013-12-30 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Аналоги глюкагона, проявляющие активность на рецепторе gip |
| CN102532301B (zh) | 2010-12-31 | 2014-09-03 | 上海医药工业研究院 | 一类新型的Exendin-4类似物及其制备方法 |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| CN102100906A (zh) | 2011-02-18 | 2011-06-22 | 深圳翰宇药业股份有限公司 | 一种艾塞那肽的药用制剂及其制备方法 |
| MX342675B (es) | 2011-03-10 | 2016-10-07 | Xeris Pharmaceuticals Inc | Formulaciones estables para inyeccion parenteral de farmacos de peptido. |
| CN102718858B (zh) | 2011-03-29 | 2014-07-02 | 天津药物研究院 | 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用 |
| CN102718868A (zh) | 2011-03-30 | 2012-10-10 | 上海华谊生物技术有限公司 | 定点单取代聚乙二醇化Exendin类似物及其制备方法 |
| EP2694095B1 (en) | 2011-04-05 | 2018-03-07 | Longevity Biotech, Inc. | Compositions comprising glucagon analogs and methods of making and using the same |
| EP2696897A2 (en) | 2011-04-11 | 2014-02-19 | Yeda Research and Development Co. Ltd. | Albumin binding probes and drug conjugates thereof |
| WO2012150503A2 (en) | 2011-05-03 | 2012-11-08 | Zealand Pharma A/S | Glu-glp-1 dual agonist signaling-selective compounds |
| CN102766204B (zh) | 2011-05-05 | 2014-10-15 | 天津药物研究院 | 胰高血糖素样肽-1突变体多肽及其制备方法和其应用 |
| KR102255479B1 (ko) | 2011-05-18 | 2021-05-24 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 제약 |
| JP2014521594A (ja) | 2011-05-25 | 2014-08-28 | アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー | 長持続期間デュアルホルモンコンジュゲート |
| UA113626C2 (xx) | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
| JP5914641B2 (ja) | 2011-06-10 | 2016-05-11 | ベイジン・ハンミ・ファーマシューティカル・カンパニー・リミテッドＢｅｉｊｉｎｇ Ｈａｎｍｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | グルコース依存性インスリン分泌刺激ポリペプチドのアナログ、医薬組成物及びその使用 |
| CA2838503C (en) | 2011-06-10 | 2020-02-18 | Hanmi Science Co., Ltd. | Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same |
| WO2012174478A2 (en) | 2011-06-17 | 2012-12-20 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
| TR201901402T4 (tr) | 2011-06-17 | 2019-02-21 | Hanmi Science Co Ltd | Oksintomodulin ve bir immünoglobulin fragmanı içeren bir konjugat ve onun kullanımı. |
| CN103857408B (zh) | 2011-06-22 | 2017-04-12 | 印第安那大学科技研究公司 | 胰高血糖素/glp‑1受体协同激动剂 |
| BR112013032717A2 (pt) | 2011-06-22 | 2017-01-24 | Univ Indiana Res & Tech Corp | coagonistas do receptor de glucagon/glp-1 |
| EP2723359A4 (en) | 2011-06-24 | 2015-03-11 | Amylin Pharmaceuticals Llc | METHOD FOR THE TREATMENT OF DIABETES WITH THE HELP OF DELAYED RELEASED FORMULATIONS FROM GLP-1 RECEPTOR AGONISTS |
| KR101357117B1 (ko) | 2011-06-28 | 2014-02-06 | 비앤엘델리팜 주식회사 | 폴리에틸렌글라이콜 또는 이의 유도체로 페길화된 엑센딘-4 유사체, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨병 예방 또는 치료용 약학적 조성물 |
| US9944687B2 (en) | 2011-07-04 | 2018-04-17 | Imperial Innovations Limited | Compounds and their effects on feeding behaviour |
| EP2729481B1 (en) | 2011-07-08 | 2018-10-17 | Amylin Pharmaceuticals, LLC | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
| MX2014001190A (es) | 2011-08-10 | 2014-05-12 | Adocia | Solucion inyectable de al menos insulina basal. |
| EP4295858A1 (en) | 2011-08-24 | 2023-12-27 | ImmunoForge Co., Ltd. | Formulations of active agents for sustained release |
| CN103189389B (zh) | 2011-09-03 | 2017-08-11 | 深圳市健元医药科技有限公司 | 新的glp‑ⅰ类似物及其制备方法和用途 |
| US8541368B2 (en) | 2011-09-23 | 2013-09-24 | Novo Nordisk A/S | Glucagon analogues |
| CN107693783A (zh) | 2011-10-28 | 2018-02-16 | 赛诺菲-安万特德国有限公司 | 2型糖尿病的治疗方案 |
| CN102363633B (zh) | 2011-11-16 | 2013-11-20 | 天津拓飞生物科技有限公司 | 胰高血糖素样肽-1突变体多肽及其制备方法、药物组合物和其应用 |
| ES2672880T3 (es) | 2011-11-17 | 2018-06-18 | Indiana University Research And Technology Corporation | Péptidos de la superfamilia de glucagón que muestran actividad de receptor de glucocorticoides |
| AU2012268889B2 (en) | 2011-11-29 | 2013-12-19 | Zoetis Services Llc | Pharmaceutical compositions |
| PL2791160T3 (pl) | 2011-12-16 | 2022-06-20 | Modernatx, Inc. | Kompozycje zmodyfikowanego mrna |
| ES2623786T3 (es) | 2011-12-22 | 2017-07-12 | Pfizer Inc. | Procedimiento de purificación de una muestra de anticuerpo H38C2 |
| MX2014007120A (es) | 2011-12-23 | 2015-03-05 | Boehringer Ingelheim Int | Analogos de glucagon. |
| EP2797585A4 (en) | 2011-12-29 | 2015-10-07 | Latitude Pharmaceuticals Inc | STABILIZED GLUCAGONNANOULULSIONS |
| US9198971B2 (en) | 2012-01-09 | 2015-12-01 | Adocia | Injectable solution at pH 7 comprising at least one basal insulin the pI of which is between 5.8 and 8.5 and a substituted co-polyamino acid |
| US20150133373A1 (en) | 2012-03-28 | 2015-05-14 | Amylin Pharmaceuticals, Llc | Transmucosal delivery of engineered polypeptides |
| WO2013148871A1 (en) | 2012-03-28 | 2013-10-03 | Amylin Pharmaceuticals, Llc | Engineered polypeptides |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| CN104411338A (zh) | 2012-04-02 | 2015-03-11 | 现代治疗公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| CN102649947A (zh) | 2012-04-20 | 2012-08-29 | 无锡和邦生物科技有限公司 | 一种用于测定glp-1及其功能类似物生物活性的细胞株及其应用 |
| WO2013163162A1 (en) | 2012-04-24 | 2013-10-31 | Amylin Pharmaceuticals, Llc | Site-specific enzymatic modification of exendins and analogs thereof |
| US20130289241A1 (en) | 2012-04-26 | 2013-10-31 | Shanghai Ambiopharm, Inc. | Method for preparing exenatide |
| US8901484B2 (en) | 2012-04-27 | 2014-12-02 | Sanofi-Aventis Deutschland Gmbh | Quantification of impurities for release testing of peptide products |
| WO2013182217A1 (en) | 2012-04-27 | 2013-12-12 | Sanofi-Aventis Deutschland Gmbh | Quantification of impurities for release testing of peptide products |
| JP6228187B2 (ja) | 2012-05-03 | 2017-11-08 | ジーランド ファーマ アクティーゼルスカブ | Ｇｉｐ−ｇｌｐ−１デュアルアゴニスト化合物及び方法 |
| CA2872315A1 (en) | 2012-05-03 | 2013-11-07 | Zealand Pharma A/S | Glucagon-like-peptide-2 (glp-2) analogues |
| EP2664374A1 (en) | 2012-05-15 | 2013-11-20 | F. Hoffmann-La Roche AG | Lysin-glutamic acid dipeptide derivatives |
| CN103421094A (zh) | 2012-05-24 | 2013-12-04 | 上海医药工业研究院 | 一种具有epo类似活性的多肽化合物 |
| WO2013177565A1 (en) | 2012-05-25 | 2013-11-28 | Amylin Pharmaceuticals, Llc | Insulin-pramlintide compositions and methods for making and using them |
| AU2013276610A1 (en) | 2012-06-14 | 2015-01-15 | Sanofi | Exendin-4 peptide analogues |
| DK2864350T3 (en) | 2012-06-21 | 2018-05-28 | Univ Indiana Res & Tech Corp | ANALOGUE OF GLUCAGON EXPRESSING GIP RECEPTOR ACTIVITY |
| WO2013192129A1 (en) | 2012-06-21 | 2013-12-27 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting gip receptor activity |
| BR112015000529B1 (pt) | 2012-07-12 | 2022-01-11 | Mannkind Corporation | Inalador de pó seco |
| MY170671A (en) | 2012-07-23 | 2019-08-26 | Zealand Pharma As | Glucagon analogues |
| AR092862A1 (es) | 2012-07-25 | 2015-05-06 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion |
| AR094821A1 (es) | 2012-07-25 | 2015-09-02 | Hanmi Pharm Ind Co Ltd | Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| WO2014027253A1 (en) | 2012-08-14 | 2014-02-20 | Wockhardt Limited | Pharmaceutical microparticulate compositions of polypeptides |
| EP2931300A1 (en) | 2012-08-14 | 2015-10-21 | Wockhardt Limited | Pharmaceutical microparticulate compositions of polypeptides |
| CN102816244A (zh) | 2012-08-23 | 2012-12-12 | 无锡和邦生物科技有限公司 | 一种Exendin-4肽与人血清白蛋白HSA的融合蛋白及其制备方法 |
| CN102827270A (zh) | 2012-09-13 | 2012-12-19 | 无锡和邦生物科技有限公司 | 一种聚乙二醇化艾塞那肽衍生物及其用途 |
| EP2895506A1 (en) | 2012-09-17 | 2015-07-22 | Imperial Innovations Limited | Peptide analogues of glucagon and glp1 |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| AR092873A1 (es) | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR101993393B1 (ko) | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| EP3610856B1 (en) | 2012-11-06 | 2021-08-18 | Hanmi Pharm. Co., Ltd. | Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment |
| JP6525456B2 (ja) | 2012-11-20 | 2019-06-05 | メデリス ダイアビーティーズ，エルエルシー | インスリン抵抗性のための改善されたペプチド製剤 |
| TWI617574B (zh) | 2012-12-11 | 2018-03-11 | 梅迪繆思有限公司 | 用於治療肥胖之升糖素與ｇｌｐ－１共促效劑 |
| MX2015008077A (es) | 2012-12-21 | 2015-10-30 | Sanofi Sa | Derivados de exendina-4 como agonistas dobles de glp1/gip o trigonal de glp1-gip/glucagon. |
| CN103908657A (zh) | 2012-12-31 | 2014-07-09 | 复旦大学附属华山医院 | 胰升糖素样肽-1类似物在制备眼科疾病药物中的用途 |
| JP6538645B2 (ja) | 2013-03-14 | 2019-07-03 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン‐インクレチン複合物 |
| CA2902352A1 (en) | 2013-03-14 | 2014-09-18 | Medimmune Limited | Pegylated glucagon and glp-1 co-agonists for the treatment of obesity |
| JP2016521253A (ja) | 2013-03-15 | 2016-07-21 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | 持続性作用を有するプロドラッグ |
| AU2014255608B2 (en) | 2013-04-18 | 2018-01-25 | Novo Nordisk A/S | Stable, protracted GLP-1/glucagon receptor co-agonists for medical use |
| JP2014227368A (ja) | 2013-05-21 | 2014-12-08 | 国立大学法人帯広畜産大学 | 糖尿病および高血糖状態の処置のためのグルカゴンアナログ |
| CN103304660B (zh) | 2013-07-12 | 2016-08-10 | 上海昂博生物技术有限公司 | 一种利拉鲁肽的合成方法 |
| CN103405753B (zh) | 2013-08-13 | 2016-05-11 | 上海仁会生物制药股份有限公司 | 稳定的促胰岛素分泌肽水针药物组合物 |
| CA2926314C (en) | 2013-10-17 | 2023-08-29 | Zealand Pharma A/S | Acylated glucagon analogues |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| EA035688B1 (ru) | 2013-11-06 | 2020-07-27 | Зилэнд Фарма А/С | Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip |
| EP3080151A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Exendin-4 peptide analogues |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086731A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| CN103665148B (zh) | 2013-12-17 | 2016-05-11 | 中国药科大学 | 一种可口服给药的降糖多肽及其制法和用途 |
| CN103980358B (zh) | 2014-01-03 | 2016-08-31 | 杭州阿诺生物医药科技股份有限公司 | 一种制备利拉鲁肽的方法 |
| EP3091965A1 (en) | 2014-01-09 | 2016-11-16 | Sanofi | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| WO2015104314A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| GB201404002D0 (en) | 2014-03-06 | 2014-04-23 | Imp Innovations Ltd | Novel compounds |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| CN106519015B (zh) | 2014-09-23 | 2020-04-17 | 深圳市图微安创科技开发有限公司 | 胃泌酸调节素类似物 |
| CN107108713A (zh) | 2014-10-10 | 2017-08-29 | 诺和诺德股份有限公司 | 稳定的基于glp‑1的glp‑1/胰高血糖素受体共激动剂 |
| WO2016065090A1 (en) | 2014-10-24 | 2016-04-28 | Merck Sharp & Dohme Corp. | Co-agonists of the glucagon and glp-1 receptors |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| WO2016198604A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as dual glp-1 /glucagon receptor agonists |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
-
2013
- 2013-12-19 MX MX2015008077A patent/MX2015008077A/es unknown
- 2013-12-19 HR HRP20180092TT patent/HRP20180092T1/hr unknown
- 2013-12-19 SI SI201330923T patent/SI2934568T1/en unknown
- 2013-12-19 CN CN201380067043.5A patent/CN104902920A/zh active Pending
- 2013-12-19 AR ARP130104909A patent/AR099912A1/es unknown
- 2013-12-19 WO PCT/EP2013/077310 patent/WO2014096148A1/en not_active Ceased
- 2013-12-19 KR KR1020157018591A patent/KR20150099548A/ko not_active Withdrawn
- 2013-12-19 DK DK13810958.2T patent/DK2934567T3/en active
- 2013-12-19 AU AU2013366692A patent/AU2013366692B2/en not_active Ceased
- 2013-12-19 PT PT13810958T patent/PT2934567T/pt unknown
- 2013-12-19 KR KR1020157017458A patent/KR20150096684A/ko not_active Withdrawn
- 2013-12-19 EP EP18164271.1A patent/EP3400957A1/en not_active Withdrawn
- 2013-12-19 CN CN201380066991.7A patent/CN104902918A/zh active Pending
- 2013-12-19 ES ES13810958.2T patent/ES2688367T3/es active Active
- 2013-12-19 AU AU2013366691A patent/AU2013366691A1/en not_active Abandoned
- 2013-12-19 AR ARP130104911A patent/AR094178A1/es unknown
- 2013-12-19 HR HRP20181300TT patent/HRP20181300T1/hr unknown
- 2013-12-19 SG SG11201503576XA patent/SG11201503576XA/en unknown
- 2013-12-19 EA EA201591174A patent/EA031428B1/ru not_active IP Right Cessation
- 2013-12-19 HK HK15112143.4A patent/HK1211232A1/xx unknown
- 2013-12-19 MX MX2015008099A patent/MX360317B/es active IP Right Grant
- 2013-12-19 SG SG11201503526UA patent/SG11201503526UA/en unknown
- 2013-12-19 AR ARP130104914A patent/AR094181A1/es unknown
- 2013-12-19 EP EP13814892.9A patent/EP2934569A1/en not_active Withdrawn
- 2013-12-19 KR KR1020157015384A patent/KR20150096398A/ko not_active Withdrawn
- 2013-12-19 RU RU2015129788A patent/RU2015129788A/ru not_active Application Discontinuation
- 2013-12-19 LT LTEP13811510.0T patent/LT2934568T/lt unknown
- 2013-12-19 HK HK15112142.5A patent/HK1211231A1/xx unknown
- 2013-12-19 PL PL13810958T patent/PL2934567T3/pl unknown
- 2013-12-19 SI SI201331127T patent/SI2934567T1/sl unknown
- 2013-12-19 CA CA2895875A patent/CA2895875A1/en not_active Abandoned
- 2013-12-19 PE PE2015001035A patent/PE20151239A1/es unknown
- 2013-12-19 JP JP2015548550A patent/JP2016506401A/ja not_active Abandoned
- 2013-12-19 KR KR1020157017459A patent/KR20150096433A/ko not_active Ceased
- 2013-12-19 BR BR112015013809A patent/BR112015013809A2/pt active Search and Examination
- 2013-12-19 AU AU2013360721A patent/AU2013360721A1/en not_active Abandoned
- 2013-12-19 EP EP13810957.4A patent/EP2934566B1/en active Active
- 2013-12-19 PL PL13811510T patent/PL2934568T3/pl unknown
- 2013-12-19 CA CA2895755A patent/CA2895755A1/en not_active Abandoned
- 2013-12-19 JP JP2015548553A patent/JP2016503771A/ja not_active Abandoned
- 2013-12-19 RS RS20180942A patent/RS57531B1/sr unknown
- 2013-12-19 SG SG11201503524PA patent/SG11201503524PA/en unknown
- 2013-12-19 PT PT138115100T patent/PT2934568T/pt unknown
- 2013-12-19 EP EP13811510.0A patent/EP2934568B1/en active Active
- 2013-12-19 SG SG11201504215PA patent/SG11201504215PA/en unknown
- 2013-12-19 RU RU2015129815A patent/RU2652783C2/ru not_active IP Right Cessation
- 2013-12-19 DK DK13811510.0T patent/DK2934568T3/en active
- 2013-12-19 CA CA2894765A patent/CA2894765A1/en not_active Abandoned
- 2013-12-19 EP EP13810958.2A patent/EP2934567B9/en active Active
- 2013-12-19 WO PCT/EP2013/077307 patent/WO2014096145A1/en not_active Ceased
- 2013-12-19 JP JP2015548554A patent/JP6408998B2/ja not_active Expired - Fee Related
- 2013-12-19 MA MA38276A patent/MA38276B1/fr unknown
- 2013-12-19 AR ARP130104913A patent/AR094180A1/es unknown
- 2013-12-19 RU RU2015129696A patent/RU2015129696A/ru not_active Application Discontinuation
- 2013-12-19 ES ES13811510.0T patent/ES2653765T3/es active Active
- 2013-12-19 CN CN201380067038.4A patent/CN104902919B/zh not_active Expired - Fee Related
- 2013-12-19 UA UAA201507199A patent/UA116553C2/uk unknown
- 2013-12-19 MX MX2015008079A patent/MX362190B/es active IP Right Grant
- 2013-12-19 SG SG10201705097PA patent/SG10201705097PA/en unknown
- 2013-12-19 WO PCT/EP2013/077313 patent/WO2014096150A1/en not_active Ceased
- 2013-12-19 AU AU2013366690A patent/AU2013366690B2/en not_active Ceased
- 2013-12-19 JP JP2015548552A patent/JP6391589B2/ja active Active
- 2013-12-19 HK HK16101474.5A patent/HK1213483A1/zh unknown
- 2013-12-19 BR BR112015014800A patent/BR112015014800A2/pt not_active Application Discontinuation
- 2013-12-19 LT LTEP13810958.2T patent/LT2934567T/lt unknown
- 2013-12-19 HU HUE13810958A patent/HUE038748T2/hu unknown
- 2013-12-19 HU HUE13811510A patent/HUE035803T2/en unknown
- 2013-12-19 CA CA2895156A patent/CA2895156A1/en not_active Abandoned
- 2013-12-19 BR BR112015014510A patent/BR112015014510A2/pt not_active Application Discontinuation
- 2013-12-19 MX MX2015008114A patent/MX2015008114A/es unknown
- 2013-12-19 CN CN201380066471.6A patent/CN104870009B/zh active Active
- 2013-12-19 WO PCT/EP2013/077312 patent/WO2014096149A1/en not_active Ceased
- 2013-12-20 UY UY0001035234A patent/UY35234A/es not_active Application Discontinuation
- 2013-12-20 TW TW102147359A patent/TW201441251A/zh unknown
- 2013-12-20 TW TW102147360A patent/TWI602828B/zh not_active IP Right Cessation
- 2013-12-20 US US14/135,756 patent/US20140206608A1/en not_active Abandoned
- 2013-12-20 TW TW102147362A patent/TW201441252A/zh unknown
- 2013-12-20 US US14/135,801 patent/US9670261B2/en active Active
- 2013-12-20 US US14/136,061 patent/US9745360B2/en not_active Expired - Fee Related
- 2013-12-20 UY UY0001035233A patent/UY35233A/es not_active Application Discontinuation
- 2013-12-20 US US14/135,772 patent/US20140213513A1/en not_active Abandoned
- 2013-12-20 TW TW102147363A patent/TWI600663B/zh not_active IP Right Cessation
- 2013-12-20 UY UY0001035231A patent/UY35231A/es not_active Application Discontinuation
- 2013-12-20 UY UY0001035232A patent/UY35232A/es not_active Application Discontinuation
-
2015
- 2015-05-04 IL IL238623A patent/IL238623A0/en unknown
- 2015-05-05 IL IL238650A patent/IL238650A0/en unknown
- 2015-05-07 IL IL238692A patent/IL238692A0/en unknown
- 2015-05-29 ZA ZA2015/03914A patent/ZA201503914B/en unknown
- 2015-05-31 IL IL239101A patent/IL239101A0/en unknown
- 2015-06-05 PH PH12015501291A patent/PH12015501291B1/en unknown
- 2015-06-18 TN TNP2015000283A patent/TN2015000283A1/fr unknown
- 2015-06-18 DO DO2015000156A patent/DOP2015000156A/es unknown
- 2015-06-18 CL CL2015001751A patent/CL2015001751A1/es unknown
- 2015-07-08 CR CR20150358A patent/CR20150358A/es unknown
- 2015-07-20 EC ECIEPI201531141A patent/ECSP15031141A/es unknown
-
2016
- 2016-07-22 AR ARP160102245A patent/AR105816A2/es unknown
- 2016-08-31 CL CL2016002182A patent/CL2016002182A1/es unknown
-
2017
- 2017-04-12 US US15/486,054 patent/US10253079B2/en active Active
-
2018
- 2018-01-17 CY CY20181100056T patent/CY1120030T1/el unknown
- 2018-08-09 CY CY20181100833T patent/CY1121153T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI2934568T1 (en) | Dual GLP1 / GIP or trigonal agonists GLP1 / GIP / glucagon | |
| JP2016503770A5 (enExample) | ||
| JP2016503772A5 (enExample) | ||
| JP2016503771A5 (enExample) | ||
| RU2016143236A (ru) | Двойные агонисты рецепторов glp-1/глюкагона, являющиеся производными от эксендина-4 | |
| JP2016506401A5 (enExample) | ||
| HRP20171726T1 (hr) | Derivati eksendin-4 kao dvostruki glp1/glukagon agonisti | |
| CA2965560A1 (en) | Compositions and peptides having dual glp-1r and glp-2r agonist activity | |
| CA2824397A1 (en) | Combination of acylated glucagon analogues with insulin analogues | |
| JP6769984B2 (ja) | アミリン類似体 | |
| RU2016142018A (ru) | Производные эксендина-4 в качестве двойных пептидных агонистов рецепторов glp-1/глюкагона | |
| JP2019534248A (ja) | アミリン類似体 | |
| RU2016141925A (ru) | Двойные пептидные агонисты рецепторов glp-1/глюкагона, являющиеся производными эксендина-4 | |
| EA028665B1 (ru) | Соединения - двойные агонисты gip-glp-1 и способы | |
| US10800826B2 (en) | Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors | |
| CN117881415A (zh) | 肥胖症和肥胖症相关障碍的治疗 | |
| KR20240034235A (ko) | 대사 장애를 위한 융합 폴리펩타이드 | |
| CN102781458A (zh) | 多肽缀合物 | |
| EP4081243A1 (en) | Stapled triazole co-agonists of the glucagon and glp-1 receptors | |
| EP4081535A1 (en) | Stapled lactam co-agonists of the glucagon and glp-1 receptors | |
| TW202517291A (zh) | 組合療法 | |
| EP4081244A1 (en) | Stapled olefin co-agonists of the glucagon and glp-1 receptors | |
| HK1193042A (en) | Combination of acylated glucagon analogues with insulin analogues | |
| OA16677A (en) | Combination of acylated glucagon analogues with insulin analogues. | |
| JP2015006186A (ja) | グルカゴン類似体 |