LT2644206T - Peg dariniai, susidedantys iš dviejų peg grandinių - Google Patents
Peg dariniai, susidedantys iš dviejų peg grandiniųInfo
- Publication number
- LT2644206T LT2644206T LTEP13162374.6T LT13162374T LT2644206T LT 2644206 T LT2644206 T LT 2644206T LT 13162374 T LT13162374 T LT 13162374T LT 2644206 T LT2644206 T LT 2644206T
- Authority
- LT
- Lithuania
- Prior art keywords
- peg
- derivatives containing
- chains
- peg derivatives
- peg chains
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33344—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carbamate group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47321303P | 2003-05-23 | 2003-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2644206T true LT2644206T (lt) | 2019-05-27 |
Family
ID=33551443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP13162374.6T LT2644206T (lt) | 2003-05-23 | 2004-05-21 | Peg dariniai, susidedantys iš dviejų peg grandinių |
Country Status (22)
Country | Link |
---|---|
US (1) | US7887789B2 (lt) |
EP (3) | EP1626741A2 (lt) |
JP (1) | JP5048332B2 (lt) |
KR (1) | KR101128320B1 (lt) |
CN (1) | CN1747748B (lt) |
AU (1) | AU2004251602B2 (lt) |
CA (1) | CA2510040C (lt) |
CY (1) | CY1121759T1 (lt) |
DK (1) | DK2644206T3 (lt) |
EA (1) | EA011351B1 (lt) |
ES (1) | ES2725808T3 (lt) |
HU (1) | HUE043911T2 (lt) |
IL (1) | IL169165A (lt) |
LT (1) | LT2644206T (lt) |
MX (1) | MXPA05007628A (lt) |
NZ (1) | NZ541374A (lt) |
PL (1) | PL2644206T3 (lt) |
PT (1) | PT2644206T (lt) |
SI (1) | SI2644206T1 (lt) |
TR (1) | TR201907313T4 (lt) |
WO (1) | WO2005000360A2 (lt) |
ZA (1) | ZA200505157B (lt) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL210412B1 (pl) | 2002-05-24 | 2012-01-31 | Schering Corp | Izolowane przeciwciało anty-IGFR lub jego fragment, kompozycja farmaceutyczna, zastosowanie, kwas nukleinowy, zrekombinowany wektor, komórka gospodarza, kompleks, polipeptyd i sposób jego wytwarzania |
EP1596887B1 (en) | 2003-02-26 | 2022-03-23 | Nektar Therapeutics | Polymer-factor viii moiety conjugates |
US7947261B2 (en) * | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
EP1626741A2 (en) | 2003-05-23 | 2006-02-22 | Nektar Therapeutics Al, Corporation | Peg derivatives having an amidocarbonate linkage |
AR046639A1 (es) * | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
CA2549011A1 (en) | 2003-12-10 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Compositions comprising two different populations of polymer-active agent conjugates |
US9446139B2 (en) | 2004-03-15 | 2016-09-20 | Nektar Therapeutics | Polymer-based compositions and conjugates of HIV entry inhibitors |
US7579444B2 (en) * | 2004-06-30 | 2009-08-25 | Nektar Therapeutics Al, Corporation | Polymer-factor IX moiety conjugates |
DE602005025355D1 (de) * | 2004-07-16 | 2011-01-27 | Nektar Therapeutics San Carlos | Konjugate enthaltend gm-csf und ein polymer |
KR20070042567A (ko) * | 2004-08-31 | 2007-04-23 | 파마시아 앤드 업존 캄파니 엘엘씨 | 글리세롤 분지쇄 폴리에틸렌 글리콜 인간 성장 호르몬공액체, 이의 제조 방법 및 이의 사용 방법 |
RU2423380C2 (ru) | 2004-11-12 | 2011-07-10 | БАЙЕР ХЕЛСКЕА ЛЛСи | Сайт-направленная модификация fviii |
EP1848461A2 (en) | 2005-02-16 | 2007-10-31 | Nektar Therapeutics Al, Corporation | Conjugates of an epo moiety and a polymer |
US20060233740A1 (en) * | 2005-03-23 | 2006-10-19 | Bossard Mary J | Conjugates of an hGH moiety and a polymer |
WO2006110776A2 (en) | 2005-04-12 | 2006-10-19 | Nektar Therapeutics Al, Corporation | Polyethylene glycol cojugates of antimicrobial agents |
MX2007012896A (es) * | 2005-04-15 | 2007-12-10 | Schering Corp | Metodos y composiciones para tratamiento o prevencion de cancer. |
EP1898955A2 (en) | 2005-06-17 | 2008-03-19 | Nektar Therapeutics AL, Corporation | Polymer-based compositions and conjugates of non-steroidal anti-inflammatory drugs |
EP1926768B1 (en) * | 2005-07-18 | 2011-09-14 | Nektar Therapeutics | Branched functionalized polymers using branched polyol cores |
CU23556A1 (es) * | 2005-11-30 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
EP2364735A3 (en) | 2005-12-16 | 2012-04-11 | Nektar Therapeutics | Branched PEG conjugates of GLP-1 |
CN103030801B (zh) * | 2006-02-21 | 2015-07-22 | 尼克塔治疗公司 | 嵌段可降解聚合物及由其制备的轭合物 |
ITMI20060612A1 (it) * | 2006-03-30 | 2007-09-30 | Keryos Spa | New activaded poly-ethylene glycols-and related polymers and their applications |
WO2007117685A2 (en) | 2006-04-07 | 2007-10-18 | Nektar Therapeutics Al, Corporation | Conjugates of an anti-tnf-alpha antibody |
EP2089052A4 (en) * | 2006-05-24 | 2011-02-16 | Peg Biosciences | POLYETHYLENE GLYCOL-BASED LINK COMPOUNDS AND BIOLOGICALLY ACTIVE CONJUGATES BASED ON SAID COMPOUNDS |
CN105820231A (zh) | 2006-08-04 | 2016-08-03 | 普罗龙药品有限责任公司 | 修饰型促红细胞生成素 |
EP2089438B1 (en) * | 2006-11-07 | 2010-03-03 | DSM IP Assets B.V. | Carbamate, thiocarbamate or carbamide comprising a biomolecular moiety |
EP2119738B1 (en) * | 2007-02-05 | 2014-04-16 | Nippon Shinyaku Co., Ltd. | Polyethylene glycol derivative |
US20140011964A1 (en) * | 2007-02-28 | 2014-01-09 | Serina Therapeutics, Inc. | Activated Polyoxazolines and Conjugates and Compositions Comprising the Same |
KR101518079B1 (ko) | 2007-03-12 | 2015-05-06 | 넥타르 테라퓨틱스 | 올리고머-프로테아제 억제제 컨주게이트 |
AU2014200906B2 (en) * | 2007-03-12 | 2016-07-07 | Nektar Therapeutics | Oligomer-protease inhibitor conjugates |
CL2008002399A1 (es) * | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
AU2008317383B2 (en) * | 2007-10-23 | 2013-11-14 | Nektar Therapeutics | Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom |
EP2222329A1 (en) * | 2007-11-09 | 2010-09-01 | Baxter International Inc. | Modified recombinant factor viii and von willebrand factor and methods of use |
TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
WO2009114151A1 (en) * | 2008-03-12 | 2009-09-17 | Nektar Therapeutics | Oligomer-amino acid and olgomer-atazanavir conjugates |
US9233165B2 (en) | 2008-04-11 | 2016-01-12 | Nektar Therapeutics | Oligomer-aryloxy-substituted propanamine conjugates |
TWI421093B (zh) * | 2008-07-31 | 2014-01-01 | Pharmaessentia Corp | 胜肽-聚合物綴合物 |
MX2011001583A (es) | 2008-08-11 | 2011-04-04 | Nektar Therapeutics | Conjugados de alcanoato polimericos de multiples brazos. |
US20110195940A1 (en) | 2008-09-17 | 2011-08-11 | Nektar Therapeutics | Protease Inhibitors Having Enhanced Features |
EP2334333A1 (en) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymer conjugates of v681-like peptides |
US20110237524A1 (en) * | 2008-09-19 | 2011-09-29 | Nektar Therapeutics | Polymer conjugates of aod-like peptides |
EP2334334A1 (en) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymer conjugates of nesiritide peptides |
US20110171164A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of glp-2-like peptides |
EP2344200A2 (en) * | 2008-09-19 | 2011-07-20 | Nektar Therapeutics | Modified therapeutics peptides, methods of their preparation and use |
EP2340045B1 (en) * | 2008-09-19 | 2017-04-12 | Nektar Therapeutics | Polymer conjugates of protegrin peptides |
WO2010033227A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of thymosin alpha 1 peptides |
US20110171160A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
EP2334336A1 (en) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymer conjugates of osteocalcin peptides |
EP2334337A1 (en) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymer conjugates of opioid growth factor peptides |
EP2341942A1 (en) * | 2008-09-19 | 2011-07-13 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
WO2010033204A2 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of c-peptides |
WO2010080720A2 (en) * | 2009-01-12 | 2010-07-15 | Nektar Therapeutics | Conjugates of a lysosomal enzyme moiety and a water soluble polymer |
WO2010132693A2 (en) | 2009-05-13 | 2010-11-18 | Nektar Therapeutics | Oligomer-containing pyrrolidine compounds |
KR20140119165A (ko) * | 2009-06-22 | 2014-10-08 | 와이어쓰 엘엘씨 | 황색포도상구균 혈청형 5 및 8 협막 다당류 접합체 면역원성 조성물 및 이의 제조 방법 |
JP5732053B2 (ja) | 2009-07-31 | 2015-06-10 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 持続型インスリン組成物 |
WO2011012715A1 (en) * | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Biodegradable polyethylene glycol based water-insoluble hydrogels |
US9084743B2 (en) | 2009-09-17 | 2015-07-21 | Baxter International Inc. | Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof |
DK2501413T3 (da) * | 2009-11-18 | 2019-06-11 | Nektar Therapeutics | Syre-saltformer af polymermedikamentkonjugater |
WO2011075185A1 (en) * | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
CA2798518A1 (en) | 2010-05-17 | 2011-11-24 | Cebix, Inc. | Pegylated c-peptide |
US10040761B2 (en) * | 2010-06-25 | 2018-08-07 | Nof Corporation | Branched hetero polyethylene glycol and intermediate |
KR101809878B1 (ko) | 2010-07-20 | 2017-12-15 | 할로자임, 아이엔씨 | 항-히알루로난제 투여와 관련된 유해 부작용의 치료 |
WO2012054822A1 (en) | 2010-10-22 | 2012-04-26 | Nektar Therapeutics | Pharmacologically active polymer-glp-1 conjugates |
IL295201A (en) | 2010-11-12 | 2022-10-01 | Nektar Therapeutics | Conjugations of a part of il-2 and a polymer, preparations containing them and their uses |
US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
EP2654799B1 (en) | 2010-12-23 | 2017-11-08 | Nektar Therapeutics | Polymer-sunitinib conjugates |
US9943605B2 (en) | 2010-12-23 | 2018-04-17 | Nektar Therapeutics | Polymer-semaxanib moiety conjugates |
EP2654797B1 (en) | 2010-12-23 | 2017-11-08 | Nektar Therapeutics | Polymer-des-ethyl sunitinib conjugates |
WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
AU2012271361B2 (en) | 2011-06-17 | 2017-03-02 | Halozyme, Inc. | Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme |
US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
US20180289821A1 (en) * | 2011-08-03 | 2018-10-11 | Anp Technologies, Inc. | Oxazoline Polymer Compositions and Use Thereof |
US20130071394A1 (en) | 2011-09-16 | 2013-03-21 | John K. Troyer | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use |
WO2013063155A2 (en) | 2011-10-24 | 2013-05-02 | Halozyme, Inc. | Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof |
MX361727B (es) | 2011-12-30 | 2018-12-14 | Halozyme Inc | Variantes de polipeptido ph20, formulaciones y usos de las mismas. |
AU2013243873B2 (en) | 2012-04-04 | 2016-08-25 | Halozyme, Inc. | Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane |
CN102643420B (zh) * | 2012-05-09 | 2015-05-20 | 中国科学院过程工程研究所 | 一种异端基双官能团聚烷基醚类化合物及其用途 |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
RU2647729C2 (ru) * | 2012-10-11 | 2018-03-19 | Асцендис Фарма Ас | Пролекарства на основе гидрогеля |
WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
UA116553C2 (uk) | 2012-12-21 | 2018-04-10 | Санофі | Пептидна сполука - агоніст рецептора glp-1 i glp |
WO2014110867A1 (zh) * | 2013-01-17 | 2014-07-24 | 厦门赛诺邦格生物科技有限公司 | 一种单一官能化的支化聚乙二醇及其修饰的生物相关物质 |
TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
DK3041513T3 (da) | 2013-09-08 | 2020-10-26 | Kodiak Sciences Inc | Zwitterioniske faktor viii-polymerkonjugater |
EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽-4(exendin-4)胜肽類似物 |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
CN103980494B (zh) * | 2014-04-21 | 2016-04-13 | 国家纳米科学中心 | 一种具有抗肿瘤活性的多肽聚合物及其制备方法和应用 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
TR201907471T4 (tr) | 2014-08-28 | 2019-06-21 | Halozyme Inc | Bir hiyalüronan ayrıştırıcı enzim ve bir bağışıklık kontrol noktası inhibitörüyle kombinasyon terapisi. |
ES2753391T3 (es) | 2014-10-14 | 2020-04-08 | Halozyme Inc | Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas |
BR112017009193A2 (pt) | 2014-11-06 | 2018-01-30 | Pharmaessentia Corporation | método de tratamento de uma doença infecciosa, câncer, ou doença mieloproliferativa em um indivíduo; método de tratamento de uma doença mieloproliferativa em um indivíduo; e; interferon tipo i |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
CN107921143B (zh) | 2015-06-15 | 2021-11-19 | 安吉奥开米公司 | 用于治疗软脑膜癌病的方法 |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
MX2019015402A (es) | 2017-06-22 | 2020-07-20 | Catalyst Biosciences Inc | Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso. |
JP7204078B2 (ja) * | 2018-03-13 | 2023-01-16 | 日油株式会社 | 主鎖および側鎖に単分散ポリエチレングリコールを有するヘテロ二官能性化合物 |
US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
BR112020021564A2 (pt) | 2018-05-21 | 2021-03-02 | Nektar Therapeutics | estimulador de treg seletivo rur20kd-il-2 e composições relacionadas |
AU2019305215A1 (en) * | 2018-07-20 | 2021-02-25 | Hercules Llc | Water soluble or dispersible composition |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
CN113661239A (zh) | 2018-12-28 | 2021-11-16 | 催化剂生物科学公司 | 经修饰的尿激酶型纤溶酶原激活物多肽和使用方法 |
RU2699071C1 (ru) * | 2019-04-16 | 2019-09-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "МИРЭА - Российский технологический университет" | Новый полиэтиленгликольсодержащий глицеролипид |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
WO2023114833A1 (en) | 2021-12-14 | 2023-06-22 | Eli Lilly And Company | Dosing regimens for selective treg stimulator rur20kd-il-2 and related compositions |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856830A (en) | 1971-12-23 | 1974-12-24 | Atlas Chem Ind | Polymerizable urethane compounds |
US3954584A (en) | 1973-06-20 | 1976-05-04 | Kansai Paint Company | Photopolymerizable vinylurethane liquid composition |
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
DE2632677A1 (de) * | 1976-07-16 | 1978-01-26 | Schering Ag | Verfahren zur herstellung von androstan-17-on-derivaten und deren verwendung |
US4180491A (en) | 1976-12-01 | 1979-12-25 | Rohm And Haas Company | Nonionic polyurethane thickener with surfactant cothickener and organic diluent, clear concentrates, aqueous print pastes, coloring compositions, methods of making and printing |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5290418A (en) | 1992-09-24 | 1994-03-01 | Applied Biosystems, Inc. | Viscous electrophoresis polymer medium and method |
US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
US5650234A (en) | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
AU4510596A (en) * | 1994-12-06 | 1996-06-26 | National Research Council Of Canada | Water soluble ubiquinone compositions, prodrugs, and methods relating thereto |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
TR199701557T2 (xx) | 1995-06-07 | 2002-06-21 | Ortho Pharmaceutical Corporation | Eritropoietin resept�r�ne ba�lanan bile�ikler ve peptidler. |
KR100404774B1 (ko) | 1995-09-06 | 2004-04-01 | 아사히 덴카 고교 가부시키가이샤 | 점성조정제 |
SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
ES2293688T5 (es) | 1997-08-08 | 2011-05-04 | Amylin Pharmaceuticals, Inc. | Nuevos compuestos análogos de la exendina. |
AU1325400A (en) * | 1998-10-26 | 2000-05-15 | University Of Utah Research Foundation | Method for preparation of polyethylene glycol aldehyde derivatives |
AU779887B2 (en) | 1999-06-08 | 2005-02-17 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
BR0012443A (pt) * | 1999-07-14 | 2002-04-02 | Alza Corp | Lipolìmero neutro e composições de lipossoma contendo o mesmo |
RU2269354C2 (ru) | 1999-09-28 | 2006-02-10 | Байер Корпорейшн | Агонисты рецептора-3(r3) пептида-активатора гипофизарной аденилатциклазы(расар) и способы их фармакологического применения |
US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
EP2070968A3 (en) | 1999-12-22 | 2013-07-24 | Nektar Therapeutics | Method for the Preparation of 1-Benzotriazolyl Carbonate Esters of Poly(ethylene glycol) |
CA2414076A1 (en) | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
JP2002003604A (ja) * | 2000-06-21 | 2002-01-09 | Sanyo Chem Ind Ltd | 樹脂改質剤 |
KR100396983B1 (ko) * | 2000-07-29 | 2003-09-02 | 이강춘 | 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체 |
WO2002060978A1 (fr) | 2001-01-30 | 2002-08-08 | Kyowa Hakko Kogyo Co., Ltd. | Polyalkylene glycols ramifies |
DE10114134A1 (de) | 2001-03-19 | 2002-11-28 | Biogenes | Verfahren zur Herstellung modifizierter Hydroxypolymere mit einer oder mehreren funktionellen Gruppen und deren Verwendung |
US7041855B2 (en) | 2001-12-11 | 2006-05-09 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
EP1507755A4 (en) * | 2001-12-11 | 2006-05-17 | Sun Bio Inc | NOVEL MONOFUNCTIONAL POLYETHYLENE GLYCOL ALDEHYDES |
JP4446746B2 (ja) | 2002-04-26 | 2010-04-07 | ソレクサ・インコーポレイテッド | ポリヌクレオチドの並行配列決定のための一定長シグネチャー |
US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
WO2004044224A2 (en) | 2002-11-12 | 2004-05-27 | Enzon Pharmaceuticals, Inc. | Branched polymeric prodrugs of vancomycin |
US7217845B2 (en) * | 2002-11-25 | 2007-05-15 | Sun Bio, Inc. | Bifunctional polyethylene glycol derivatives |
EP1596887B1 (en) * | 2003-02-26 | 2022-03-23 | Nektar Therapeutics | Polymer-factor viii moiety conjugates |
US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
EP1626741A2 (en) | 2003-05-23 | 2006-02-22 | Nektar Therapeutics Al, Corporation | Peg derivatives having an amidocarbonate linkage |
KR102612902B1 (ko) | 2016-04-22 | 2023-12-18 | 삼성디스플레이 주식회사 | 투명 전도막 및 이를 포함하는 전자 소자 |
-
2004
- 2004-05-21 EP EP04753099A patent/EP1626741A2/en not_active Withdrawn
- 2004-05-21 PL PL13162374T patent/PL2644206T3/pl unknown
- 2004-05-21 EP EP13162374.6A patent/EP2644206B1/en active Active
- 2004-05-21 CN CN2004800040643A patent/CN1747748B/zh active Active
- 2004-05-21 EP EP19153793.5A patent/EP3593820A1/en active Pending
- 2004-05-21 MX MXPA05007628A patent/MXPA05007628A/es active IP Right Grant
- 2004-05-21 PT PT13162374T patent/PT2644206T/pt unknown
- 2004-05-21 JP JP2006533335A patent/JP5048332B2/ja active Active
- 2004-05-21 CA CA2510040A patent/CA2510040C/en active Active
- 2004-05-21 DK DK13162374.6T patent/DK2644206T3/da active
- 2004-05-21 WO PCT/US2004/016212 patent/WO2005000360A2/en active Application Filing
- 2004-05-21 EA EA200501863A patent/EA011351B1/ru unknown
- 2004-05-21 KR KR1020057016193A patent/KR101128320B1/ko active IP Right Grant
- 2004-05-21 SI SI200432467T patent/SI2644206T1/sl unknown
- 2004-05-21 ES ES13162374T patent/ES2725808T3/es active Active
- 2004-05-21 LT LTEP13162374.6T patent/LT2644206T/lt unknown
- 2004-05-21 TR TR2019/07313T patent/TR201907313T4/tr unknown
- 2004-05-21 US US10/851,691 patent/US7887789B2/en active Active
- 2004-05-21 HU HUE13162374A patent/HUE043911T2/hu unknown
- 2004-05-21 NZ NZ541374A patent/NZ541374A/en unknown
- 2004-05-21 AU AU2004251602A patent/AU2004251602B2/en active Active
-
2005
- 2005-06-15 IL IL169165A patent/IL169165A/en active IP Right Grant
- 2005-06-24 ZA ZA200505157A patent/ZA200505157B/en unknown
-
2019
- 2019-06-21 CY CY20191100651T patent/CY1121759T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LT2644206T (lt) | Peg dariniai, susidedantys iš dviejų peg grandinių | |
IL169905A0 (en) | Novel 2-pyridinecarboxamide derivatives | |
HK1088326A1 (en) | Piperidine-benzenesulfonamide derivatives | |
HK1089443A1 (en) | Imidazol-4-yl-ethynyl-pyridine derivatives | |
GB0317665D0 (en) | Qinazoline derivatives | |
SI1682493T1 (sl) | Amidoacetonitrilni derivati | |
IL176014A0 (en) | Azepinoindole derivatives as pharmaceutical agents | |
GB2407141B (en) | Link chain | |
IL175189A0 (en) | N-thiazol-2-yl-benzamide derivatives | |
HK1093061A1 (en) | Aminoalkanol derivatives | |
ZA200703674B (en) | Acylated nonadepsipeptides used as lysobactin derivatives | |
SI1706373T1 (sl) | Amidoacetonitrilni derivati | |
TWI340117B (en) | Conveyor | |
GB0312368D0 (en) | Novel ureido- and amido-pyrazolone derivatives | |
GB0319793D0 (en) | Pyridinylmorpholine derivatives | |
AU2003295211A8 (en) | Rotary chain vice | |
PL379168A1 (pl) | Pochodne kaptoprilu | |
TWI341309B (en) | Heteroarylcarbamoylbenzene derivatives | |
GB0229519D0 (en) | Line peg | |
GB0319148D0 (en) | Azaquinazoline derivatives | |
AU2003280822A8 (en) | Beauveriolide derivatives | |
GB0310727D0 (en) | Packaging two | |
GB0329399D0 (en) | Conveyor | |
GB0321840D0 (en) | Packaging seven | |
GB0321841D0 (en) | Packaging eight |