BR0012443A - Lipolìmero neutro e composições de lipossoma contendo o mesmo - Google Patents
Lipolìmero neutro e composições de lipossoma contendo o mesmoInfo
- Publication number
- BR0012443A BR0012443A BR0012443-5A BR0012443A BR0012443A BR 0012443 A BR0012443 A BR 0012443A BR 0012443 A BR0012443 A BR 0012443A BR 0012443 A BR0012443 A BR 0012443A
- Authority
- BR
- Brazil
- Prior art keywords
- neutral
- lipopolymers
- liposomes
- lipolymer
- compositions containing
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 5
- 230000007935 neutral effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- -1 aryl carbamate Chemical compound 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Patente de Invenção: "LIPOLìMERO NEUTRO E COMPOSIçõES DE LIPOSSOMA CONTENDO O MESMO". Lipossomas contendo lipopolímeros neutros substituídos por PEG fornecem tempos de circulação similares os lipossomas que incorporam fosfolipídeos substituídos por PEG negativamente carregados convencionais. O uso dos lipopolímeros não carregados pode também apresentar vantagens em termos de interações com as superfícies celulares e vazamento reduzido de substâncias carregadas, particularmente drogas catiónicas, dos lipossomas. Os lipopolímeros são da fórmula (1) em que cada um de R^ 1^ e R^ 2^ é uma cadeia de alquila ou alquenila tendo entre cerca de 8 a cerca de 24 átomos de carbono; n é de cerca de 10 a cerca de 300, Z é selecionado do grupo que consiste em hidróxi, alcóxi, benzilóxi, éster carboxílico, éster suifónico, carbamato de alquila ou de arila, amino e alquilamino e a ligação L é selecionada do grupo que consiste em (i) -X-(C=O)-Y-CH~ 2~-, (ii) X-(C=O)- e (iii) -X-CH~ 2~-, em que X e Y são independentemente selecionados de oxigênio, NH, e uma ligação direta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14381099P | 1999-07-14 | 1999-07-14 | |
| PCT/US2000/018949 WO2001005873A1 (en) | 1999-07-14 | 2000-07-12 | Neutral lipopolymer and liposomal compositions containing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012443A true BR0012443A (pt) | 2002-04-02 |
Family
ID=22505748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012443-5A BR0012443A (pt) | 1999-07-14 | 2000-07-12 | Lipolìmero neutro e composições de lipossoma contendo o mesmo |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6586001B1 (pt) |
| EP (1) | EP1198490B1 (pt) |
| JP (1) | JP2003505401A (pt) |
| KR (2) | KR100758158B1 (pt) |
| CN (1) | CN1193059C (pt) |
| AT (1) | ATE317869T1 (pt) |
| AU (1) | AU769517B2 (pt) |
| BR (1) | BR0012443A (pt) |
| CA (1) | CA2379060A1 (pt) |
| CY (1) | CY1105466T1 (pt) |
| CZ (1) | CZ2002140A3 (pt) |
| DE (1) | DE60026030T2 (pt) |
| DK (1) | DK1198490T3 (pt) |
| ES (1) | ES2255501T3 (pt) |
| HK (1) | HK1048484B (pt) |
| HU (1) | HUP0202177A3 (pt) |
| IL (2) | IL147564A0 (pt) |
| MX (1) | MXPA02000402A (pt) |
| NO (1) | NO20020175L (pt) |
| PL (1) | PL352711A1 (pt) |
| PT (1) | PT1198490E (pt) |
| RU (1) | RU2250911C2 (pt) |
| WO (1) | WO2001005873A1 (pt) |
| ZA (1) | ZA200200303B (pt) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1347743T3 (da) * | 2000-12-07 | 2006-07-03 | Univ Utrecht Holding Bv | Præparat til behandling af inflammatoriske lidelser |
| US20030077829A1 (en) * | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
| AU2003238929A1 (en) | 2002-06-07 | 2003-12-22 | Rutgers, The State University | Micelle assemblies |
| CA2491164C (en) | 2002-06-28 | 2012-05-08 | Cory Giesbrecht | Method and apparatus for producing liposomes |
| JP2006519262A (ja) * | 2003-02-28 | 2006-08-24 | アルザ・コーポレーシヨン | リポソームにより誘導される補体活性化の減少のためのリポソーム組成物 |
| CN100379404C (zh) * | 2003-02-28 | 2008-04-09 | 阿尔扎公司 | 用于减少脂质体诱导的补体激活的脂质体组合物 |
| US20060198882A1 (en) * | 2003-03-21 | 2006-09-07 | Yechezkel Barenholz | Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer |
| MXPA05010926A (es) * | 2003-04-15 | 2005-11-25 | Opperbas Holding Bv | Composicion farmaceutica que comprende proteinas y/o polipeptidos y particulas coloidales. |
| US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
| CA2510040C (en) * | 2003-05-23 | 2012-01-03 | Nektar Therapeutics Al, Corporation | Polymeric reagents and polymer-biomolecule conjugates comprising carbamate linkages |
| KR20060015265A (ko) * | 2003-05-30 | 2006-02-16 | 알자 코포레이션 | 제제의 폐 투여 방법 |
| CA2532228C (en) * | 2003-07-16 | 2017-02-14 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| NZ592917A (en) * | 2003-09-15 | 2012-12-21 | Protiva Biotherapeutics Inc | Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates |
| CA2542804A1 (en) * | 2003-10-24 | 2005-05-06 | Alza Corporation | Preparation of lipid particles |
| US20050191344A1 (en) * | 2004-01-15 | 2005-09-01 | Samuel Zalipsky | Liposome composition for delivery of therapeutic agents |
| JP4796062B2 (ja) | 2004-06-07 | 2011-10-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 脂質封入干渉ｒｎａ |
| TW200618820A (en) * | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
| CA2587470A1 (en) * | 2004-11-15 | 2006-05-18 | Yissum Research Development Company Of The Hebrew University Of Jerusale M | Combination therapy associating preferably a ceramide with a cytotoxic drug |
| WO2007005754A2 (en) * | 2005-07-01 | 2007-01-11 | Alza Corporation | Liposomal delivery vehicle for hydrophobic drugs |
| US20070055199A1 (en) | 2005-08-10 | 2007-03-08 | Gilbert Scott J | Drug delivery device for buccal and aural applications and other areas of the body difficult to access |
| ES2611924T3 (es) * | 2006-10-03 | 2017-05-11 | Arbutus Biopharma Corporation | Formulaciones que contienen lípidos |
| CN101583380B (zh) * | 2006-11-30 | 2013-07-10 | 尼克塔治疗公司 | 用于制备聚合物轭合物的方法 |
| US8466255B2 (en) | 2007-02-05 | 2013-06-18 | Nippon Shinyaku Co., Ltd. | Polyethylene glycol derivative |
| JP5415283B2 (ja) | 2007-02-07 | 2014-02-12 | グラダリス インク． | シアル酸産生を調節し、遺伝性封入体ミオパチーを治療する方法及び組成物 |
| US20110097720A1 (en) * | 2008-01-02 | 2011-04-28 | Alnylam Pharmaceuticals, Inc. | Screening method for selected amino lipid-containing compositions |
| DK2279254T3 (en) | 2008-04-15 | 2017-09-18 | Protiva Biotherapeutics Inc | PRESENT UNKNOWN LIPID FORMS FOR NUCLEIC ACID ADMINISTRATION |
| KR100967833B1 (ko) | 2008-05-20 | 2010-07-05 | 아이디비켐(주) | 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법 |
| US9173840B2 (en) | 2008-10-09 | 2015-11-03 | Northeastern University | Multifunctional self-assembling polymeric nanosystems |
| CN102439151A (zh) | 2009-03-19 | 2012-05-02 | 默沙东公司 | 使用短干扰核酸（siNA）的RNA干扰介导的BTB和CNC同系物1，碱性亮氨酸拉链转录因子1（Bach1）基因表达的抑制 |
| EP2408458A1 (en) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (STAT6) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP2012520685A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたＧＡＴＡ結合タンパク質３（ＧＡＴＡ３）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| US20120016011A1 (en) | 2009-03-19 | 2012-01-19 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| WO2010111468A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
| WO2010111497A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP2012521764A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いた胸腺間質性リンパ球新生因子（ＴＳＬＰ）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| EP2411019A2 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2010111464A1 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2011000106A1 (en) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Improved cationic lipids and methods for the delivery of therapeutic agents |
| EP2449114B9 (en) | 2009-07-01 | 2017-04-19 | Protiva Biotherapeutics Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| US9018187B2 (en) | 2009-07-01 | 2015-04-28 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| JP5605760B2 (ja) * | 2010-01-18 | 2014-10-15 | セイコーエプソン株式会社 | 吐出用液体、生体試料の吐出方法、及び化合物 |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| WO2012018754A2 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US9029341B2 (en) | 2010-08-17 | 2015-05-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| WO2012027206A1 (en) | 2010-08-24 | 2012-03-01 | Merck Sharp & Dohme Corp. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
| EP2609106A4 (en) | 2010-08-26 | 2014-03-19 | Merck Sharp & Dohme | RNA INTERFERENCE-MEDIATED INHIBITION OF EXPRESSION OF PHD2 GENE (PROLYL HYDROXYLASE DOMAIN 2) USING SMALL INTERFERING NUCLEIC ACID (PANI) |
| US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
| DK3202760T3 (da) * | 2011-01-11 | 2019-11-25 | Alnylam Pharmaceuticals Inc | Pegylerede lipider og deres anvendelse til lægemiddelfremføring |
| US8846850B2 (en) | 2011-02-22 | 2014-09-30 | Rutgers, The State University Of New Jersey | Amphiphilic macromolecules for nucleic acid delivery |
| JP5949036B2 (ja) * | 2011-03-29 | 2016-07-06 | 日油株式会社 | ポリオキシアルキレン修飾脂質およびその製造方法 |
| US8575380B2 (en) | 2011-10-17 | 2013-11-05 | Nof Corporation | Branched polyethylene glycol linked with diacyl glycerol, process for producing the same, and polyethylene glycol modified liposome |
| EP2861558B1 (en) | 2012-06-15 | 2017-01-18 | Rutgers, The State University of New Jersey | Macromolecules for treating atherosclerosis |
| US10138203B2 (en) | 2014-06-16 | 2018-11-27 | Rutgers, The State University Of New Jersey | Antibacterial agents |
| US9630905B2 (en) | 2014-09-08 | 2017-04-25 | Rutgers, The State University Of New Jersey | Amphiphilic macromolecules and methods of use thereof |
| GB201417589D0 (en) | 2014-10-06 | 2014-11-19 | Cantab Biopharmaceuticals Patents Ltd | Pharmaceutical Formulations |
| GB201518170D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for subcutaneous administration with intravenous administration of therapeutic agent |
| GB201518172D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for use in medicine |
| GB201518171D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for topical administration with therapeutic agent |
| US10759740B2 (en) | 2016-03-24 | 2020-09-01 | Rutgers, The State University Of New Jersey | Antibacterial agents |
| US10640725B2 (en) | 2016-08-05 | 2020-05-05 | Rutgers, The State University Of New Jersey | Thermocleavable friction modifiers and methods thereof |
| JP2023553343A (ja) | 2020-11-25 | 2023-12-21 | アカゲラ・メディスンズ，インコーポレイテッド | 核酸を送達するための脂質ナノ粒子および関連する使用方法 |
| GB202111757D0 (en) | 2021-08-17 | 2021-09-29 | Cantab Biopharmaceuticals Patents Ltd | Modified colloidal particles for use in the treatment of haemophilia A |
| GB202111758D0 (en) | 2021-08-17 | 2021-09-29 | Cantab Biopharmaceuticals Patents Ltd | Modified colloidal particles for use in the treatment of haemophilia A |
| GB202111759D0 (en) | 2021-08-17 | 2021-09-29 | Cantab Biopharmaceuticals Patents Ltd | Modified colloidal particles |
| CA3234809A1 (en) | 2021-10-20 | 2023-04-27 | Steven Goldman | Isolated glial progenitor cells for use in the competition treatment of age-related white matter loss |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2694893A1 (fr) * | 1992-08-03 | 1994-02-25 | Oreal | Composition formée d'une dispersion aqueuse de vésicules de lipides amphiphiles non-ioniques stabilisées. |
| US5741518A (en) * | 1992-08-03 | 1998-04-21 | L'oreal | Composition composed of an aqueous dispersion of stabilized vesicles of nonionic amphiphilic lipids |
| WO1995025764A1 (fr) * | 1994-03-23 | 1995-09-28 | Meiji Seika Kabushiki Kaisha | Derive bicatenaire de lipide contenant un polyoxyethylene |
| US5820873A (en) * | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| PT957929E (pt) * | 1996-10-25 | 2006-06-30 | Gilead Sciences Inc | Complexos de ligandos de acido nucleico do factor de crescimento endotelial vascular |
-
2000
- 2000-07-12 AT AT00945341T patent/ATE317869T1/de not_active IP Right Cessation
- 2000-07-12 BR BR0012443-5A patent/BR0012443A/pt not_active Application Discontinuation
- 2000-07-12 AU AU59303/00A patent/AU769517B2/en not_active Ceased
- 2000-07-12 IL IL14756400A patent/IL147564A0/xx active IP Right Grant
- 2000-07-12 PT PT00945341T patent/PT1198490E/pt unknown
- 2000-07-12 KR KR1020027000531A patent/KR100758158B1/ko not_active IP Right Cessation
- 2000-07-12 HU HU0202177A patent/HUP0202177A3/hu unknown
- 2000-07-12 MX MXPA02000402A patent/MXPA02000402A/es active IP Right Grant
- 2000-07-12 WO PCT/US2000/018949 patent/WO2001005873A1/en active IP Right Grant
- 2000-07-12 JP JP2001511524A patent/JP2003505401A/ja not_active Abandoned
- 2000-07-12 ES ES00945341T patent/ES2255501T3/es not_active Expired - Lifetime
- 2000-07-12 DK DK00945341T patent/DK1198490T3/da active
- 2000-07-12 KR KR1020077014651A patent/KR20070086708A/ko not_active Application Discontinuation
- 2000-07-12 CN CNB008102988A patent/CN1193059C/zh not_active Expired - Fee Related
- 2000-07-12 PL PL00352711A patent/PL352711A1/xx not_active Application Discontinuation
- 2000-07-12 RU RU2002100651/04A patent/RU2250911C2/ru not_active IP Right Cessation
- 2000-07-12 EP EP00945341A patent/EP1198490B1/en not_active Expired - Lifetime
- 2000-07-12 DE DE60026030T patent/DE60026030T2/de not_active Expired - Fee Related
- 2000-07-12 CZ CZ2002140A patent/CZ2002140A3/cs unknown
- 2000-07-12 CA CA002379060A patent/CA2379060A1/en not_active Abandoned
- 2000-07-13 US US09/615,552 patent/US6586001B1/en not_active Expired - Lifetime
-
2002
- 2002-01-10 IL IL147564A patent/IL147564A/en not_active IP Right Cessation
- 2002-01-14 ZA ZA200200303A patent/ZA200200303B/xx unknown
- 2002-01-14 NO NO20020175A patent/NO20020175L/no not_active Application Discontinuation
-
2003
- 2003-01-24 HK HK03100630.3A patent/HK1048484B/zh not_active IP Right Cessation
-
2006
- 2006-05-05 CY CY20061100593T patent/CY1105466T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1105466T1 (el) | 2010-04-28 |
| IL147564A (en) | 2007-03-08 |
| KR20020012008A (ko) | 2002-02-09 |
| HK1048484B (zh) | 2005-10-14 |
| CN1193059C (zh) | 2005-03-16 |
| US6586001B1 (en) | 2003-07-01 |
| DE60026030T2 (de) | 2006-08-10 |
| CN1360611A (zh) | 2002-07-24 |
| CZ2002140A3 (cs) | 2002-05-15 |
| JP2003505401A (ja) | 2003-02-12 |
| HUP0202177A3 (en) | 2004-05-28 |
| RU2250911C2 (ru) | 2005-04-27 |
| IL147564A0 (en) | 2002-08-14 |
| MXPA02000402A (es) | 2002-07-30 |
| CA2379060A1 (en) | 2001-01-25 |
| PL352711A1 (en) | 2003-09-08 |
| ATE317869T1 (de) | 2006-03-15 |
| EP1198490B1 (en) | 2006-02-15 |
| KR20070086708A (ko) | 2007-08-27 |
| AU769517B2 (en) | 2004-01-29 |
| PT1198490E (pt) | 2006-06-30 |
| KR100758158B1 (ko) | 2007-09-12 |
| EP1198490A1 (en) | 2002-04-24 |
| HK1048484A1 (en) | 2003-04-04 |
| WO2001005873A1 (en) | 2001-01-25 |
| DK1198490T3 (da) | 2006-06-19 |
| DE60026030D1 (de) | 2006-04-20 |
| ES2255501T3 (es) | 2006-07-01 |
| HUP0202177A2 (hu) | 2002-12-28 |
| AU5930300A (en) | 2001-02-05 |
| NO20020175D0 (no) | 2002-01-14 |
| ZA200200303B (en) | 2003-03-26 |
| NO20020175L (no) | 2002-01-14 |
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