TR200103624T2 - Amof bileşikler ve bunların farmasötik bileşimleri. - Google Patents

Amof bileşikler ve bunların farmasötik bileşimleri.

Info

Publication number
TR200103624T2
TR200103624T2 TR2001/03624T TR200103624T TR200103624T2 TR 200103624 T2 TR200103624 T2 TR 200103624T2 TR 2001/03624 T TR2001/03624 T TR 2001/03624T TR 200103624 T TR200103624 T TR 200103624T TR 200103624 T2 TR200103624 T2 TR 200103624T2
Authority
TR
Turkey
Prior art keywords
derivatives
amof
compounds
pharmaceutical compositions
hydroxybenzoic acid
Prior art date
Application number
TR2001/03624T
Other languages
English (en)
Inventor
Benedini Francesca
Antognazza Patrizia
Original Assignee
Nicox S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox S.A. filed Critical Nicox S.A.
Publication of TR200103624T2 publication Critical patent/TR200103624T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Bu bulus, bir tadil edilmis fiziksel biçimde benzoksibenzoik asitin nitroksi türevlerine ve bu türevlerin farmasötik formülasyonlarina iliskindir, bahsedilen türevler asagidaki genel formüle sahiptir: A-X1-NO2(I), bu formülde, A, asagida tanimlandigi sekilde bir hidroksibenzoik asit türevidir, X1, asagida tanimlandigi sekilde bir baglanma iki-degerli radikalidir, bahsedilen formülasyonlar, 2-2.5 saat düzeyinde çok kisa zamanlar dahilinde, A diye tanimlanan hidroksibenzoik asit türevlerinin plazmatik konsantrasyon zirvesini uyarabilmektedir.
TR2001/03624T 1999-06-24 2000-06-21 Amof bileşikler ve bunların farmasötik bileşimleri. TR200103624T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001402A IT1312115B1 (it) 1999-06-24 1999-06-24 Composti amorfi e relative composizioni farmaceutiche

Publications (1)

Publication Number Publication Date
TR200103624T2 true TR200103624T2 (tr) 2002-04-22

Family

ID=11383219

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03624T TR200103624T2 (tr) 1999-06-24 2000-06-21 Amof bileşikler ve bunların farmasötik bileşimleri.

Country Status (23)

Country Link
US (1) US6753442B1 (tr)
EP (1) EP1187803B1 (tr)
JP (1) JP2003503380A (tr)
KR (1) KR100672001B1 (tr)
CN (1) CN1187312C (tr)
AT (1) ATE302746T1 (tr)
AU (1) AU781479B2 (tr)
BR (1) BR0011831A (tr)
CA (1) CA2377132A1 (tr)
DE (1) DE60022188T2 (tr)
DK (1) DK1187803T3 (tr)
ES (1) ES2246878T3 (tr)
HU (1) HUP0201721A3 (tr)
IL (1) IL146789A0 (tr)
IT (1) IT1312115B1 (tr)
MX (1) MXPA01013273A (tr)
NO (1) NO321523B1 (tr)
NZ (1) NZ515757A (tr)
PL (1) PL195557B1 (tr)
RU (1) RU2248963C2 (tr)
TR (1) TR200103624T2 (tr)
WO (1) WO2001000563A1 (tr)
ZA (1) ZA200109862B (tr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
EP1219306A1 (en) * 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US7220749B2 (en) 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
DE602004000260T2 (de) 2003-07-22 2006-08-24 Arena Pharmaceuticals, Inc., San Diego Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
WO2009023253A2 (en) 2007-08-15 2009-02-19 Arena Pharmaceuticals Inc. IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
EA027333B1 (ru) 2007-10-17 2017-07-31 Тодд Ф. Овокайтис Стабильный при комнатной температуре некристаллический аспирин
EA023338B1 (ru) * 2007-10-17 2016-05-31 Тодд Ф. Овокайтис Способ модификации твердого состояния соединения и соаморфные композиции, полученные этим способом
ES2324007A1 (es) * 2007-10-25 2009-07-28 Ferrer Internacional, S.A. Una forma amorfa de un compuesto antiinflamatorio.
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
ES2666324T3 (es) * 2008-10-28 2018-05-04 Arena Pharmaceuticals, Inc. Composiciones de un modulador del receptor de serotonina 5-HT2A útiles para el tratamiento de trastornos relacionados con el mismo
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
EP2344592B1 (en) 2008-11-04 2014-12-17 DSM IP Assets B.V. D 1413 ht radiation curable coatings for optical fiber
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
WO2015187974A1 (en) 2014-06-06 2015-12-10 Ovokaitys Todd Frank Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
JP2018516992A (ja) 2015-06-12 2018-06-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
RU2018103338A (ru) 2015-07-15 2019-08-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
RU2145595C1 (ru) 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
IT1307928B1 (it) 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Also Published As

Publication number Publication date
NO20016232D0 (no) 2001-12-19
NO20016232L (no) 2001-12-19
AU6264400A (en) 2001-01-31
PL195557B1 (pl) 2007-10-31
HUP0201721A3 (en) 2003-08-28
KR100672001B1 (ko) 2007-01-19
JP2003503380A (ja) 2003-01-28
ZA200109862B (en) 2003-05-28
ITMI991402A1 (it) 2000-12-24
DE60022188D1 (de) 2005-09-29
EP1187803A1 (en) 2002-03-20
CA2377132A1 (en) 2001-01-04
DE60022188T2 (de) 2006-06-08
AU781479B2 (en) 2005-05-26
ES2246878T3 (es) 2006-03-01
CN1356975A (zh) 2002-07-03
DK1187803T3 (da) 2005-11-28
BR0011831A (pt) 2002-03-19
KR20020008220A (ko) 2002-01-29
ATE302746T1 (de) 2005-09-15
IL146789A0 (en) 2002-07-25
IT1312115B1 (it) 2002-04-04
RU2248963C2 (ru) 2005-03-27
US6753442B1 (en) 2004-06-22
MXPA01013273A (es) 2003-07-14
NZ515757A (en) 2004-02-27
NO321523B1 (no) 2006-05-15
PL352529A1 (en) 2003-08-25
HUP0201721A2 (en) 2002-10-28
EP1187803B1 (en) 2005-08-24
CN1187312C (zh) 2005-02-02
WO2001000563A1 (en) 2001-01-04
ITMI991402A0 (it) 1999-06-24

Similar Documents

Publication Publication Date Title
TR200103624T2 (tr) Amof bileşikler ve bunların farmasötik bileşimleri.
BR0214343A (pt) Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1
TR200302242T2 (tr) Protein kinaz önleyicileri olarak pirolopirimidinler
AR018175A1 (es) Compuestos de indol-3-glioxilamidas sustituidas, utiles como medicamentos antitumorales, composiciones farmaceuticas formuladas con dichos derivados,utilizacion de dichos derivados para la preparacion de medicamentos antitumorales y los medicamentos asi preparados.
MY141661A (en) 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
EE200100487A (et) Uudsed ühendid ja kompositsioonid proteaasiinhibiitoritena
MY148480A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
SE0001899D0 (sv) New compounds
MXPA04004837A (es) Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1.
MXPA04004842A (es) Inhibidores de 11-(-hidroxiesteroide deshidrogenasa de tipo 1.
TR200103186T2 (tr) MEK enzimlerinin inhibitörleri olarak kinolin türevleri
NO20024177L (no) Farmasöytiske preparater inneholdende azetidinderivater, de nye azetidinderivater og deres fremstilling
IL143545A0 (en) Thrombin inhibitors
ATE232873T1 (de) Phosphonsaürederivate als ptp-1b-inhibitoren
BRPI0408240A (pt) composto, utilização de um composto e composição farmacêutica
IL163625A0 (en) Alkoxy-pyridine derivatives and pharmaceutical compositions containing the same
RS44204A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
BR0307027A (pt) Compostos derivados de nitróxi de compostos esteróides, uso dos compostos, e, formulações farmacêuticas
ATE253359T1 (de) Antithrombotische mittel
RS44304A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EP0974352A4 (en) SUBSTANCES FOR INHIBITING PTERYGIUM EDUCATION AND ITS POSTOPERATIVE RECURRENCE
NO983511D0 (no) Difenylstilbener som pro-legemidler for COX-2-inhibitorer
MXPA03008801A (es) Aril oxima-piperazinas utiles como antagonistas de ccr5.
ATE250610T1 (de) Kaliumkanal-blockierende mittel
ATE286395T1 (de) Antithrombotische mittel