TR200103624T2 - Amof bileşikler ve bunların farmasötik bileşimleri. - Google Patents

Amof bileşikler ve bunların farmasötik bileşimleri.

Info

Publication number
TR200103624T2
TR200103624T2 TR2001/03624T TR200103624T TR200103624T2 TR 200103624 T2 TR200103624 T2 TR 200103624T2 TR 2001/03624 T TR2001/03624 T TR 2001/03624T TR 200103624 T TR200103624 T TR 200103624T TR 200103624 T2 TR200103624 T2 TR 200103624T2
Authority
TR
Turkey
Prior art keywords
derivatives
amof
compounds
pharmaceutical compositions
hydroxybenzoic acid
Prior art date
Application number
TR2001/03624T
Other languages
English (en)
Inventor
Benedini Francesca
Antognazza Patrizia
Original Assignee
Nicox S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox S.A. filed Critical Nicox S.A.
Publication of TR200103624T2 publication Critical patent/TR200103624T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Bu bulus, bir tadil edilmis fiziksel biçimde benzoksibenzoik asitin nitroksi türevlerine ve bu türevlerin farmasötik formülasyonlarina iliskindir, bahsedilen türevler asagidaki genel formüle sahiptir: A-X1-NO2(I), bu formülde, A, asagida tanimlandigi sekilde bir hidroksibenzoik asit türevidir, X1, asagida tanimlandigi sekilde bir baglanma iki-degerli radikalidir, bahsedilen formülasyonlar, 2-2.5 saat düzeyinde çok kisa zamanlar dahilinde, A diye tanimlanan hidroksibenzoik asit türevlerinin plazmatik konsantrasyon zirvesini uyarabilmektedir.
TR2001/03624T 1999-06-24 2000-06-21 Amof bileşikler ve bunların farmasötik bileşimleri. TR200103624T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001402A IT1312115B1 (it) 1999-06-24 1999-06-24 Composti amorfi e relative composizioni farmaceutiche

Publications (1)

Publication Number Publication Date
TR200103624T2 true TR200103624T2 (tr) 2002-04-22

Family

ID=11383219

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03624T TR200103624T2 (tr) 1999-06-24 2000-06-21 Amof bileşikler ve bunların farmasötik bileşimleri.

Country Status (23)

Country Link
US (1) US6753442B1 (tr)
EP (1) EP1187803B1 (tr)
JP (1) JP2003503380A (tr)
KR (1) KR100672001B1 (tr)
CN (1) CN1187312C (tr)
AT (1) ATE302746T1 (tr)
AU (1) AU781479B2 (tr)
BR (1) BR0011831A (tr)
CA (1) CA2377132A1 (tr)
DE (1) DE60022188T2 (tr)
DK (1) DK1187803T3 (tr)
ES (1) ES2246878T3 (tr)
HU (1) HUP0201721A3 (tr)
IL (1) IL146789A0 (tr)
IT (1) IT1312115B1 (tr)
MX (1) MXPA01013273A (tr)
NO (1) NO321523B1 (tr)
NZ (1) NZ515757A (tr)
PL (1) PL195557B1 (tr)
RU (1) RU2248963C2 (tr)
TR (1) TR200103624T2 (tr)
WO (1) WO2001000563A1 (tr)
ZA (1) ZA200109862B (tr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU782971B2 (en) 1999-12-23 2005-09-15 Nicox S.A. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
AU2002249812B2 (en) 2000-12-21 2005-11-10 Nicox S.A. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1219306A1 (en) * 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004004648A2 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
EP1542972A4 (en) 2002-07-29 2008-01-23 Nitromed Inc CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITION AND METHOD OF USE
WO2005012254A1 (en) 2003-07-22 2005-02-10 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
ES2421237T7 (es) 2007-08-15 2013-09-30 Arena Pharmaceuticals, Inc. Derivados de imidazo[1,2-a]piridin como moduladores del receptor serotoninérgico 5ht2a en el tratamiento de trastornos relacionados con el mismo
WO2009052246A1 (en) 2007-10-17 2009-04-23 Ovokaitys, Todd, F. Process for the modification of the solid state of a compound and co-amorphous compositions produced with same
AP2010005266A0 (en) * 2007-10-17 2010-06-30 Ovokaitys Todd F Room temperature stable non-crystalline aspirin
ES2324007A1 (es) * 2007-10-25 2009-07-28 Ferrer Internacional, S.A. Una forma amorfa de un compuesto antiinflamatorio.
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
TR201805216T4 (tr) * 2008-10-28 2018-06-21 Arena Pharm Inc İlgi̇li̇ bozukluklarin tedavi̇si̇nde faydali bi̇r 5-ht2a serotoni̇n reseptör modülatörünün bi̇leşi̇mleri̇
US8218931B2 (en) 2008-11-04 2012-07-10 Dsm Ip Assets B.V. D 1413 HT radiation curable coatings for optical fiber
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
JP2018516992A (ja) 2015-06-12 2018-06-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
CA2992518A1 (en) 2015-07-15 2017-01-19 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
WO2022126109A1 (en) 2020-12-08 2022-06-16 Ovokaitys Todd Frank Methods and systems for increased production of stem cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
DE69512232T2 (de) * 1994-05-10 2000-02-24 Nicox S.A., Paris Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen
IT1276071B1 (it) 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
IT1307928B1 (it) 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Also Published As

Publication number Publication date
AU781479B2 (en) 2005-05-26
US6753442B1 (en) 2004-06-22
IT1312115B1 (it) 2002-04-04
KR20020008220A (ko) 2002-01-29
NO321523B1 (no) 2006-05-15
RU2248963C2 (ru) 2005-03-27
ES2246878T3 (es) 2006-03-01
WO2001000563A1 (en) 2001-01-04
EP1187803A1 (en) 2002-03-20
AU6264400A (en) 2001-01-31
PL195557B1 (pl) 2007-10-31
ITMI991402A0 (it) 1999-06-24
HUP0201721A3 (en) 2003-08-28
DE60022188T2 (de) 2006-06-08
CN1187312C (zh) 2005-02-02
CA2377132A1 (en) 2001-01-04
BR0011831A (pt) 2002-03-19
EP1187803B1 (en) 2005-08-24
IL146789A0 (en) 2002-07-25
MXPA01013273A (es) 2003-07-14
JP2003503380A (ja) 2003-01-28
ITMI991402A1 (it) 2000-12-24
CN1356975A (zh) 2002-07-03
DE60022188D1 (de) 2005-09-29
KR100672001B1 (ko) 2007-01-19
DK1187803T3 (da) 2005-11-28
NO20016232L (no) 2001-12-19
ATE302746T1 (de) 2005-09-15
NZ515757A (en) 2004-02-27
ZA200109862B (en) 2003-05-28
HUP0201721A2 (en) 2002-10-28
NO20016232D0 (no) 2001-12-19
PL352529A1 (en) 2003-08-25

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