DE60022188D1 - Amorphe salpetersäureester und deren pharmazeutische zusammensetzungen - Google Patents

Amorphe salpetersäureester und deren pharmazeutische zusammensetzungen

Info

Publication number
DE60022188D1
DE60022188D1 DE60022188T DE60022188T DE60022188D1 DE 60022188 D1 DE60022188 D1 DE 60022188D1 DE 60022188 T DE60022188 T DE 60022188T DE 60022188 T DE60022188 T DE 60022188T DE 60022188 D1 DE60022188 D1 DE 60022188D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
amorphic
acid esters
nitric acid
ono2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60022188T
Other languages
English (en)
Other versions
DE60022188T2 (de
Inventor
Francesca Benedini
Patrizia Antognazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of DE60022188D1 publication Critical patent/DE60022188D1/de
Application granted granted Critical
Publication of DE60022188T2 publication Critical patent/DE60022188T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60022188T 1999-06-24 2000-06-21 Amorphe salpetersäureester und deren pharmazeutische zusammensetzungen Expired - Fee Related DE60022188T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI001402A IT1312115B1 (it) 1999-06-24 1999-06-24 Composti amorfi e relative composizioni farmaceutiche
ITMI991402 1999-06-24
PCT/EP2000/005723 WO2001000563A1 (en) 1999-06-24 2000-06-21 Amorphous nitric esters and their pharmaceutical compositions

Publications (2)

Publication Number Publication Date
DE60022188D1 true DE60022188D1 (de) 2005-09-29
DE60022188T2 DE60022188T2 (de) 2006-06-08

Family

ID=11383219

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60022188T Expired - Fee Related DE60022188T2 (de) 1999-06-24 2000-06-21 Amorphe salpetersäureester und deren pharmazeutische zusammensetzungen

Country Status (23)

Country Link
US (1) US6753442B1 (de)
EP (1) EP1187803B1 (de)
JP (1) JP2003503380A (de)
KR (1) KR100672001B1 (de)
CN (1) CN1187312C (de)
AT (1) ATE302746T1 (de)
AU (1) AU781479B2 (de)
BR (1) BR0011831A (de)
CA (1) CA2377132A1 (de)
DE (1) DE60022188T2 (de)
DK (1) DK1187803T3 (de)
ES (1) ES2246878T3 (de)
HU (1) HUP0201721A3 (de)
IL (1) IL146789A0 (de)
IT (1) IT1312115B1 (de)
MX (1) MXPA01013273A (de)
NO (1) NO321523B1 (de)
NZ (1) NZ515757A (de)
PL (1) PL195557B1 (de)
RU (1) RU2248963C2 (de)
TR (1) TR200103624T2 (de)
WO (1) WO2001000563A1 (de)
ZA (1) ZA200109862B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319202B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
US6706724B2 (en) 2000-12-21 2004-03-16 Nitromed, Inc. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1219306A1 (de) * 2000-12-29 2002-07-03 Nicox S.A. Zyklodextrin und NO-abgebende Arzneimittlen enthaltende Zusammensetzungen
WO2003103602A2 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP2005538110A (ja) 2002-07-29 2005-12-15 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
ES2258760T3 (es) 2003-07-22 2006-09-01 Arena Pharmaceuticals, Inc. Derivados de diaril y de la urea de arileteroaril usados como moduladores del receptor de la serotonina 5-ht2a utiles para la profilaxis y el tratamiento de desordenes a ellos asociados.
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
WO2009023253A2 (en) 2007-08-15 2009-02-19 Arena Pharmaceuticals Inc. IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
SG185309A1 (en) * 2007-10-17 2012-11-29 Todd F Ovokaitys Room temperature stable non-crystalline aspirin
EA023338B1 (ru) 2007-10-17 2016-05-31 Тодд Ф. Овокайтис Способ модификации твердого состояния соединения и соаморфные композиции, полученные этим способом
ES2324007A1 (es) * 2007-10-25 2009-07-28 Ferrer Internacional, S.A. Una forma amorfa de un compuesto antiinflamatorio.
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
ES2666324T3 (es) 2008-10-28 2018-05-04 Arena Pharmaceuticals, Inc. Composiciones de un modulador del receptor de serotonina 5-HT2A útiles para el tratamiento de trastornos relacionados con el mismo
CN102186933B (zh) 2008-11-04 2014-06-25 帝斯曼知识产权资产管理有限公司 光纤用的d 1413 ht可辐射固化涂层
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
MX2017016413A (es) 2015-06-12 2018-08-01 Axovant Sciences Gmbh Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamineto de un trastorno conductual del sueño rem.
AU2016291673A1 (en) 2015-07-15 2018-01-25 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
EP0759899B1 (de) * 1994-05-10 1999-09-15 Nicox S.A. Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
KR19990001564A (ko) 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
IT1307928B1 (it) 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Also Published As

Publication number Publication date
TR200103624T2 (tr) 2002-04-22
MXPA01013273A (es) 2003-07-14
US6753442B1 (en) 2004-06-22
KR100672001B1 (ko) 2007-01-19
HUP0201721A3 (en) 2003-08-28
ITMI991402A0 (it) 1999-06-24
ES2246878T3 (es) 2006-03-01
DK1187803T3 (da) 2005-11-28
IL146789A0 (en) 2002-07-25
NO321523B1 (no) 2006-05-15
NZ515757A (en) 2004-02-27
HUP0201721A2 (en) 2002-10-28
CN1187312C (zh) 2005-02-02
ITMI991402A1 (it) 2000-12-24
ZA200109862B (en) 2003-05-28
JP2003503380A (ja) 2003-01-28
NO20016232D0 (no) 2001-12-19
AU781479B2 (en) 2005-05-26
NO20016232L (no) 2001-12-19
CA2377132A1 (en) 2001-01-04
EP1187803A1 (de) 2002-03-20
DE60022188T2 (de) 2006-06-08
KR20020008220A (ko) 2002-01-29
ATE302746T1 (de) 2005-09-15
AU6264400A (en) 2001-01-31
PL195557B1 (pl) 2007-10-31
EP1187803B1 (de) 2005-08-24
BR0011831A (pt) 2002-03-19
IT1312115B1 (it) 2002-04-04
PL352529A1 (en) 2003-08-25
WO2001000563A1 (en) 2001-01-04
CN1356975A (zh) 2002-07-03
RU2248963C2 (ru) 2005-03-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NICOX S.A., SOPHIA ANTIPOLIS, FR

8339 Ceased/non-payment of the annual fee