DE60106619D1 - Pharmazeutische zusammensetzungen enthaltend tobramycin und xanthangummi - Google Patents

Pharmazeutische zusammensetzungen enthaltend tobramycin und xanthangummi

Info

Publication number
DE60106619D1
DE60106619D1 DE60106619T DE60106619T DE60106619D1 DE 60106619 D1 DE60106619 D1 DE 60106619D1 DE 60106619 T DE60106619 T DE 60106619T DE 60106619 T DE60106619 T DE 60106619T DE 60106619 D1 DE60106619 D1 DE 60106619D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
compositions containing
xanthan gum
containing tobramycin
tobramycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106619T
Other languages
English (en)
Other versions
DE60106619T2 (de
Inventor
Perdiguer Nuria Carreras
Mas Jose Alberto Vallet
Cabello Gemma Torrella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DE60106619D1 publication Critical patent/DE60106619D1/de
Publication of DE60106619T2 publication Critical patent/DE60106619T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE60106619T 2000-07-28 2001-06-26 Pharmazeutische zusammensetzungen enthaltend tobramycin und xanthangummi Expired - Lifetime DE60106619T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22166000P 2000-07-28 2000-07-28
US221660P 2000-07-28
PCT/EP2001/007267 WO2002009724A1 (en) 2000-07-28 2001-06-26 Pharmaceutical compositions containing tobramycin and xanthan gum

Publications (2)

Publication Number Publication Date
DE60106619D1 true DE60106619D1 (de) 2004-11-25
DE60106619T2 DE60106619T2 (de) 2005-03-17

Family

ID=22828757

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106619T Expired - Lifetime DE60106619T2 (de) 2000-07-28 2001-06-26 Pharmazeutische zusammensetzungen enthaltend tobramycin und xanthangummi

Country Status (18)

Country Link
US (1) US6352978B1 (de)
EP (1) EP1305033B1 (de)
CN (1) CN1218689C (de)
AR (1) AR029965A1 (de)
AT (1) ATE279927T1 (de)
AU (1) AU2001270593A1 (de)
BR (1) BR0112787B1 (de)
CA (1) CA2414737C (de)
CO (1) CO5300418A1 (de)
DE (1) DE60106619T2 (de)
DK (1) DK1305033T3 (de)
ES (1) ES2225573T3 (de)
MX (1) MXPA03000813A (de)
PL (1) PL199321B1 (de)
PT (1) PT1305033E (de)
TW (1) TWI282278B (de)
WO (1) WO2002009724A1 (de)
ZA (1) ZA200300110B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006035969A1 (ja) * 2004-09-28 2006-04-06 Senju Pharmaceutical Co., Ltd. キサンタンガムおよびアミノ酸を含有する眼科用組成物
US7795316B1 (en) 2007-12-19 2010-09-14 Alcon Research, Ltd. Topical ophthalmic compositions containing tobramycin and dexamethasone
TWI495469B (zh) 2008-06-09 2015-08-11 Alcon Res Ltd 含有氟喹諾酮抗生素藥物之經改良藥學組成物
WO2011162752A1 (en) * 2010-06-23 2011-12-29 Alcon Research, Ltd. Topical ophthalmic suspensions containing tobramycin and dexamethasone
US9480696B2 (en) 2011-05-04 2016-11-01 Trustees Of Boston University Proton-motive force stimulation to potentiate aminoglycoside antibiotics against persistent bacteria

Family Cites Families (49)

* Cited by examiner, † Cited by third party
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US3700451A (en) 1970-04-06 1972-10-24 Itek Corp Gelable and gelled compositions
US3944427A (en) 1970-04-06 1976-03-16 Itek Corporation Gelable and gelled compositions
US3784712A (en) 1970-12-23 1974-01-08 Gen Foods Corp Gum gelling system xanthan-tara dessert gel
CA1070629A (en) 1975-11-10 1980-01-29 Allen I. Laskin Process for modifying biopolymers
US4135979A (en) 1976-08-24 1979-01-23 Merck & Co., Inc. Treatment of xanthan gum to improve clarity
US4136177A (en) 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4136178A (en) 1977-01-31 1979-01-23 American Home Products Corp. Locust bean gum therapeutic compositions
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
GB8318403D0 (en) 1983-07-07 1983-08-10 Sutherland I W Gel-forming polysaccharides
FR2551087B1 (fr) 1983-08-30 1986-03-21 Rhone Poulenc Spec Chim Procede de traitement d'une solution de polysaccharide et son utilisation
DE3335593A1 (de) 1983-09-30 1985-04-11 Diamalt AG, 8000 München Gelier- und verdickungsmittel auf der basis von cassia-galactomannanen
US4717713A (en) 1983-10-31 1988-01-05 Research Corporation Controlled release liquid pharmaceutical
US4708861A (en) 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US4647470A (en) 1985-11-27 1987-03-03 Merck & Co., Inc. Low-acetyl gellan gum blends
FR2618333B1 (fr) 1987-07-20 1990-07-13 Merck Sharp & Dohme Composition pharmaceutique et/ou cosmetique a usage topique contenant de la gomme rhamsam
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US4814160A (en) 1988-03-01 1989-03-21 Colgate-Palmolive Company Non-bleeding striped dentifrice
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5234957A (en) 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5149694A (en) 1988-03-09 1992-09-22 Alcon Laboratories, Inc. Combination of tobramycin and dexamethasone for topical ophthalmic use
DE3843416A1 (de) 1988-12-23 1990-06-28 Wolff Walsrode Ag Xanthan mit verbesserter loeslichkeit und verfahren zur herstellung
CA2021414C (en) 1989-07-25 2004-09-28 Daniel H. Doherty Genetic control of acetylation and pyruvylation of xanthan gum
US5461081A (en) 1989-09-28 1995-10-24 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
FR2653021A1 (fr) 1989-10-17 1991-04-19 Merck Sharp & Dohme Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
JP2536806B2 (ja) * 1991-03-27 1996-09-25 アルコン ラボラトリーズ インコーポレイテッド ゲル化多糖類と微粉砕された薬剤担体とを組み合わせた局部眼科用組成物
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
DE69224071T2 (de) 1991-09-17 1998-05-07 Alcon Lab Inc Chinolan-antibiotika und polystyrolsulfonat enthaltende zusammensetzungen
US5192802A (en) 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5473062A (en) 1992-10-29 1995-12-05 Takeda Chemical Industries, Ltd. Process for producing purified xanthan gum
JP3228315B2 (ja) 1993-04-23 2001-11-12 信越化学工業株式会社 キサンタンガムの汚染生菌数を減少させる方法
CA2181048C (en) 1994-01-14 2003-05-06 Lee Shahinian, Jr. A method for sustained and extended corneal analgesia
US5422116A (en) 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
ES2171186T3 (es) 1994-04-08 2002-09-01 Atrix Lab Inc Composiciones liquidas de difusion.
US5523301A (en) 1994-08-05 1996-06-04 Merck & Co., Inc. Optic nerve health
EP0725628B1 (de) 1994-08-30 2001-11-07 Alcon Laboratories, Inc. Thermisch gelierende trägerstoffe zur arzneistoffabgabe, die zelluloseether enthalten
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
FR2742336B1 (fr) 1995-12-19 1998-03-06 Chauvin Lab Sa Collyre destine notamment au traitement de l'oeil sec
SE9603480L (sv) 1996-09-23 1998-03-24 Johan Carlfors Beredningsform för svårlösliga läkemedel
FR2754712B1 (fr) 1996-10-17 1999-09-03 Merck Sharp Dohme Chibret Lab Compositions ophtalmiques
US5888493A (en) 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
WO1998053809A1 (en) 1997-05-30 1998-12-03 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
KR20010013377A (ko) * 1997-06-04 2001-02-26 데이비드 엠 모이어 마일드한 잔류성 항균 조성물
JP2002506461A (ja) 1997-06-26 2002-02-26 メルク エンド カンパニー インコーポレーテッド 網膜及び視神経の健康の最適化方法
DE69909768T2 (de) * 1998-04-07 2004-06-17 Alcon Manufacturing Ltd., Fort Worth Xanthangummi enthaltende gelbildende ophthalmische zusammensetzungen
US6174524B1 (en) * 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
US6297337B1 (en) * 1999-05-19 2001-10-02 Pmd Holdings Corp. Bioadhesive polymer compositions

Also Published As

Publication number Publication date
AR029965A1 (es) 2003-07-23
PL199321B1 (pl) 2008-09-30
WO2002009724A1 (en) 2002-02-07
CA2414737C (en) 2009-01-06
PL365154A1 (en) 2004-12-27
EP1305033A1 (de) 2003-05-02
CA2414737A1 (en) 2002-02-07
ATE279927T1 (de) 2004-11-15
DE60106619T2 (de) 2005-03-17
PT1305033E (pt) 2005-01-31
BR0112787A (pt) 2003-09-09
TWI282278B (en) 2007-06-11
US20020035088A1 (en) 2002-03-21
CO5300418A1 (es) 2003-07-31
DK1305033T3 (da) 2005-01-31
CN1444482A (zh) 2003-09-24
ZA200300110B (en) 2004-01-21
ES2225573T3 (es) 2005-03-16
AU2001270593A1 (en) 2002-02-13
CN1218689C (zh) 2005-09-14
EP1305033B1 (de) 2004-10-20
BR0112787B1 (pt) 2013-03-05
US6352978B1 (en) 2002-03-05
MXPA03000813A (es) 2005-08-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition