SG10201606567TA - Recombinant production of steviol glycosides - Google Patents

Recombinant production of steviol glycosides

Info

Publication number
SG10201606567TA
SG10201606567TA SG10201606567TA SG10201606567TA SG10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA
Authority
SG
Singapore
Prior art keywords
recombinant production
steviol glycosides
steviol
glycosides
recombinant
Prior art date
Application number
SG10201606567TA
Other languages
English (en)
Inventor
Jens Houghton-Larsen
Paula M Hicks
Michael Naesby
Tange Thomas Ostergaard
Jorgen Hansen
Mikkelsen Michael Dalgaard
Hansen Esben Halkjaer
Ernesto Simon
Andrade Pereira Tavares Sabina De
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46724642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201606567T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of SG10201606567TA publication Critical patent/SG10201606567TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Seasonings (AREA)
SG10201606567TA 2011-08-08 2012-08-08 Recombinant production of steviol glycosides SG10201606567TA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161521203P 2011-08-08 2011-08-08
US201161521084P 2011-08-08 2011-08-08
US201161521051P 2011-08-08 2011-08-08
US201161523487P 2011-08-15 2011-08-15
US201161567929P 2011-12-07 2011-12-07
US201261603639P 2012-02-27 2012-02-27

Publications (1)

Publication Number Publication Date
SG10201606567TA true SG10201606567TA (en) 2016-10-28

Family

ID=46724642

Family Applications (4)

Application Number Title Priority Date Filing Date
SG10201606567TA SG10201606567TA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606563PA SG10201606563PA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606569VA SG10201606569VA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606565XA SG10201606565XA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Family Applications After (3)

Application Number Title Priority Date Filing Date
SG10201606563PA SG10201606563PA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606569VA SG10201606569VA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606565XA SG10201606565XA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Country Status (11)

Country Link
US (5) US9631215B2 (enExample)
EP (4) EP2742142B2 (enExample)
JP (5) JP6262653B2 (enExample)
KR (2) KR20200057799A (enExample)
CN (2) CN103732753B (enExample)
AU (5) AU2012294452C1 (enExample)
BR (4) BR112014003037B1 (enExample)
CA (2) CA3128532A1 (enExample)
MY (1) MY173212A (enExample)
SG (4) SG10201606567TA (enExample)
WO (1) WO2013022989A2 (enExample)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9386797B2 (en) 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
WO2016130609A1 (en) * 2015-02-10 2016-08-18 Purecircle Usa Inc. Rebaudioside m biosynthetic production and recovery methods
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US8790730B2 (en) 2005-10-11 2014-07-29 Purecircle Usa Process for manufacturing a sweetener and use thereof
US9392799B2 (en) 2011-02-17 2016-07-19 Purecircle Sdn Bhd Glucosyl stevia composition
ES2707280T3 (es) 2009-11-12 2019-04-03 Purecircle Usa Inc Granulación de un edulcorante a base de estevia
US10888099B2 (en) 2009-11-12 2021-01-12 Purecircle Sdn Bhd. Granulation of a Stevia sweetener
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
US20150344512A1 (en) 2011-12-19 2015-12-03 Purecircle Usa Inc. Methods of purifying steviol glycosides and uses of the same
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
WO2013036366A1 (en) 2011-09-07 2013-03-14 Purecircle Usa Inc. Highly soluble stevia sweetener
US9510611B2 (en) 2010-12-13 2016-12-06 Purecircle Sdn Bhd Stevia composition to improve sweetness and flavor profile
BR112013014589B1 (pt) 2010-12-13 2019-04-02 Purecircle Usa Inc. Método para preparar uma composição de rebaudiosídeo d altamente solúvel
US10362797B2 (en) 2011-02-10 2019-07-30 Purecircle Sdn Bhd Stevia composition
US9474296B2 (en) 2011-02-17 2016-10-25 Purecircle Sdn Bhd Glucosyl stevia composition
US9603373B2 (en) 2011-02-17 2017-03-28 Purecircle Sdn Bhd Glucosyl stevia composition
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9894922B2 (en) 2011-05-18 2018-02-20 Purecircle Sdn Bhd Glucosyl rebaudioside C
BR112013030701B1 (pt) 2011-05-31 2021-07-20 Purecircle Usa Inc Processo para produzir uma composição de estévia compreendendo rebaudiosídeo b, a qual pode ser utilizada como intensificador de adoçante, um intensificador de sabor e/ou um adoçante
BR112013030885B1 (pt) 2011-06-03 2019-01-02 Purecircle Usa Inc processo para produzir uma composição de ingrediente alimentício de stevia compreendendo rebaudiosídeo b
EP3915394A1 (en) 2011-06-20 2021-12-01 PureCircle USA Inc. Stevia composition
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
EP2742142B2 (en) 2011-08-08 2020-03-25 Evolva SA Recombinant production of steviol glycosides
US10480019B2 (en) 2011-08-10 2019-11-19 Purecircle Sdn Bhd Process for producing high-purity rubusoside
CA3152828A1 (en) 2011-12-19 2013-06-27 The Coca-Cola Company Methods for purifying steviol glycosides and uses of the same
FR2984743B1 (fr) * 2011-12-23 2014-08-22 Oreal Utilisation cosmetique du steviol, d'un derive glycoside du steviol, ou un de leurs isomeres pour stimuler, restaurer ou reguler le metabolisme des cellules de la peau et des semi-muqueuses.
EA201400836A8 (ru) * 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
JP6251669B2 (ja) * 2012-03-16 2017-12-20 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
ES2820518T3 (es) * 2012-03-27 2021-04-21 Suntory Holdings Ltd Método para producir glucósido de esteviol
WO2013148257A1 (en) * 2012-03-30 2013-10-03 J.R. Simplot Company Steviol and steviol glycoside formation in plants
MX395285B (es) * 2012-05-22 2025-03-25 Purecircle Sdn Bhd Glucosidos de esteviol de alta pureza.
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
EP2928321A1 (en) 2012-12-05 2015-10-14 Evolva SA Steviol glycoside compositions sensory properties
CA2899276C (en) * 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US10017804B2 (en) 2013-02-11 2018-07-10 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
KR101404728B1 (ko) * 2013-02-28 2014-06-09 씨제이제일제당 (주) 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
PE20200961A1 (es) * 2013-03-15 2020-09-24 Cargill Inc Plantas de stevia con un contenido de rebaudiosido d incrementado
BR112015028767B1 (pt) * 2013-05-15 2021-06-01 Purecircle Usa Inc Processo para produzir uma composição de estévia e composição de estévia produzida pelo dito processo
US10689681B2 (en) 2013-05-31 2020-06-23 Dsm Ip Assets B.V. Microorganisms for diterpene production
CN105247064A (zh) * 2013-05-31 2016-01-13 帝斯曼知识产权资产管理有限公司 细胞外的二萜生产
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
EP3003058B2 (en) 2013-06-07 2023-06-28 Purecircle Usa Inc. Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
US10039834B2 (en) 2013-07-12 2018-08-07 The Coca-Cola Company Compositions and methods using rebaudioside X to provide sweetness enhancement
WO2015007748A1 (en) * 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Diterpene production
WO2015011209A1 (en) * 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
CA2917615A1 (en) * 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
JP6530760B2 (ja) * 2013-11-01 2019-06-12 コナゲン インコーポレーテッド ステビオール配糖体の組換え製造
EP3101139A4 (en) * 2014-01-28 2017-08-30 Pepsico, Inc. Rebaudioside m enzymatic preparation method
CN106459880A (zh) * 2014-04-25 2017-02-22 帝斯曼知识产权资产管理有限公司 细胞色素p450还原酶的稳定化
US9522929B2 (en) * 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
MX2017001859A (es) * 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
EP3683315A1 (en) * 2014-08-19 2020-07-22 Purecircle SDN BHD Method for preparing rebaudioside m
CN105850750B (zh) * 2015-01-23 2018-06-12 谱赛科美国公司 甜叶菊新品种814011谱星3号及高rm含量甜菊糖苷的制备
WO2016036578A1 (en) 2014-09-02 2016-03-10 Purecircle Sdn Bhd Stevia extracts
JP2017528134A (ja) * 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの生産
CN104232496B (zh) * 2014-09-18 2017-06-06 广州康琳奈生物科技有限公司 一种重组毕赤酵母工程菌及其在合成莱鲍迪苷a中的应用
BR112017005656A2 (pt) * 2014-09-19 2018-07-31 Purecircle Sdn Bhd glicosídeos de esteviol de alta pureza
US12677849B2 (en) 2014-09-19 2026-07-14 Purecircle Sdn. Bhd. High-purity steviol glycosides
KR102557670B1 (ko) 2014-10-03 2023-07-20 코나겐 인크. 비칼로리 감미료 및 합성 방법
US10463062B2 (en) 2014-11-05 2019-11-05 Manus Bio Inc. Microbial production of steviol glycosides
WO2016100689A1 (en) 2014-12-17 2016-06-23 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
BR112017016338A2 (en) * 2015-01-30 2018-03-27 Evolva Sa production of steviol glycosides in recombinant hosts
WO2016141207A1 (en) 2015-03-03 2016-09-09 The Regents Of The University Of California Protecting group chemistry for clean, reductant-free dyeing
CA3255837A1 (en) 2015-03-16 2025-10-30 Dsm Ip Assets B.V. Udp-glycosyltransferases
US20180057850A1 (en) * 2015-03-23 2018-03-01 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
CN113683712B (zh) 2015-04-03 2022-10-21 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷
AU2016250184B2 (en) * 2015-04-14 2020-07-30 Conagen Inc. Production of non-caloric sweeteners using engineered whole-cell catalysts
WO2016170045A1 (en) * 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthase
AU2016271628B2 (en) * 2015-05-29 2020-01-30 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high pH and compositions obtained therefrom
AU2016271125A1 (en) 2015-05-29 2017-12-21 Cargill, Incorporated Heat treatment to produce glycosides
CN107614677A (zh) 2015-05-29 2018-01-19 嘉吉公司 用于使用多阶段进料生产甜菊醇糖苷的发酵方法
CN105200098A (zh) * 2015-06-30 2015-12-30 苏州汉酶生物技术有限公司 一种利用酿酒酵母酶法制备瑞鲍迪甙m的方法
CA2994288A1 (en) * 2015-08-06 2017-02-09 Cargill, Incorporated Fermentation methods for producing steviol glycosides
JP2018522569A (ja) 2015-08-07 2018-08-16 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組換え宿主内でのステビオールグリコシドの産生
CN107922465B (zh) * 2015-08-13 2021-12-24 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷转运
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
WO2017060318A2 (en) 2015-10-05 2017-04-13 Dsm Ip Assets B.V. Kaurenoic acid hydroxylases
PL3367816T3 (pl) 2015-10-26 2024-05-06 Purecircle Usa Inc. Kompozycje glikozydów stewiolowych
CN108884484A (zh) * 2015-11-30 2018-11-23 谱赛科有限责任公司 用于制备高纯度甜菊醇糖苷的方法
US20190062796A1 (en) * 2015-12-10 2019-02-28 Evolva Sa Production of steviol glycosides in recombinant hosts
RU2764635C2 (ru) 2015-12-15 2022-01-19 ПЬЮРСЁРКЛ ЮЭсЭй ИНК. Композиция стевиол гликозида
US20190021382A1 (en) * 2016-03-01 2019-01-24 Wm. Wrigley Jr. Company Long-lasting sweetener formulations
CN109154010A (zh) * 2016-03-11 2019-01-04 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
MY198001A (en) * 2016-04-13 2023-07-25 Evolva SA Production of steviol glycoside in recombinant hosts
EP3458598A1 (en) * 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3027730A1 (en) * 2016-06-17 2017-12-21 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
WO2018031955A2 (en) * 2016-08-12 2018-02-15 Amyris, Inc. Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
JP7177048B2 (ja) * 2016-10-14 2022-11-22 コナゲン インコーポレイテッド ステビオール配糖体の生合成製造およびそのためのプロセス
CN109890973B (zh) 2016-10-21 2023-05-23 百事可乐公司 一种酶法制备瑞鲍迪甙n的方法
CN117051063A (zh) 2016-10-21 2023-11-14 百事可乐公司 一种酶法制备瑞鲍迪甙c的方法
WO2018072211A1 (zh) * 2016-10-21 2018-04-26 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙j的方法
WO2018078014A1 (en) * 2016-10-27 2018-05-03 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
EP3564369A4 (en) * 2016-12-27 2020-07-29 Suntory Holdings Limited STEVIOL GLYCOSIDE HEXOSE TRANSFERASE AND CODING GENE FOR THIS
KR20260006703A (ko) 2017-02-03 2026-01-13 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법
MY202423A (en) * 2017-03-06 2024-04-28 Conagen Inc Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e
US11284577B2 (en) 2017-03-08 2022-03-29 Purecircle Usa Inc. High rebaudioside M stevia plant cultivars and methods of producing the same
WO2018190378A1 (ja) * 2017-04-12 2018-10-18 サントリーホールディングス株式会社 ステビア由来ラムノース合成酵素及び遺伝子
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
KR102792406B1 (ko) * 2017-06-30 2025-04-08 코나겐 인크. 베타-글루코시다제에 의한 스테비올 글리코시드의 가수분해
JP7487099B2 (ja) 2017-08-11 2024-05-20 アミリス， インコーポレイテッド レバウジオシドの高効率生成のためのエンドウ（ｐｉｓｕｍ ｓａｔｉｖｕｍ）カウレンオキシダーゼ
US11365417B2 (en) * 2017-09-12 2022-06-21 Bio Capital Holdings, LLC Biological devices and methods of use thereof to produce steviol glycosides
CN107446874B (zh) * 2017-09-25 2020-07-28 四川盈嘉合生科技有限公司 重组大肠杆菌及其在合成莱鲍迪苷d中的用途
US20200291442A1 (en) 2017-12-05 2020-09-17 Evolva Sa Production of steviol glycosides in recombinant hosts
JP7365707B2 (ja) * 2018-03-12 2023-10-20 コナゲン インコーポレイテッド ステビオール配糖体レバウジオシドｊ及びレバウジオシドｎの生合成による製造
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
AU2019304965B2 (en) * 2018-07-16 2025-04-24 Manus Bio, Inc. Production of steviol glycosides through whole cell biotransformation
IL319918A (en) 2018-07-30 2025-05-01 Tate & Lyle Solutions Usa Llc Engineered glycosyltransferases and methods for glycosylation of steviol glycoside
CN109393426A (zh) * 2018-09-29 2019-03-01 四川盈嘉合生科技有限公司 一种复合甜味剂
CA3114953A1 (en) * 2018-10-15 2020-04-23 Amyris, Inc. Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides
CA3118924A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
WO2020117792A2 (en) * 2018-12-04 2020-06-11 The Regents Of The University Of California Scalable biosynthesis of the seaweed neurochemical kainic acid
WO2020123877A1 (en) * 2018-12-12 2020-06-18 Conagen Inc. Biosynthetic production of variant steviol glycosides
KR102618015B1 (ko) * 2018-12-21 2023-12-26 주식회사 삼양사 스테비올 또는 이의 전구체의 생산
PH12021551733A1 (en) 2019-01-24 2022-07-25 Amyris Inc Abc transporters for the high efficiency production of rebaudiosides
CN109913380B (zh) * 2019-03-25 2021-12-10 南京工业大学 生产(-)-α-红没药醇的重组解脂耶氏酵母菌及其构建方法和应用
SG11202111698SA (en) 2019-05-03 2021-11-29 Amyris Inc Kaurenoic acid 13-hydroxylase (kah) variants and uses thereof
US12065685B1 (en) 2019-05-13 2024-08-20 Amyris, Inc. UDP-glycosyltransferase variants and uses thereof
WO2020264179A1 (en) * 2019-06-25 2020-12-30 Manus Bio, Inc. Uridine diphosphate-dependent glycosyltransferase enzyme
WO2021074344A1 (en) 2019-10-17 2021-04-22 Dsm Ip Assets B.V. Improved isolation of steviol glycosides
KR102379608B1 (ko) * 2019-10-29 2022-03-29 주식회사 삼양사 개선된 스테비올 배당체 화합물 또는 이의 전구체의 생산
CN111088176B (zh) * 2019-12-30 2022-03-25 北京化工大学 产β-胡萝卜素的基因工程菌及其应用
CN112006035B (zh) * 2020-07-24 2021-07-30 江西新龙生物科技股份有限公司 用于防治植物病害的微生物源杀菌剂及其制备方法
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
WO2022084482A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production
US20240093258A1 (en) 2020-11-24 2024-03-21 Manus Bio Inc. Glycoside product biosynthesis and recovery
JP7210626B2 (ja) * 2021-02-18 2023-01-23 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
US11299700B1 (en) 2021-02-19 2022-04-12 Acequia Biotechnology, Llc Bioreactor containers and methods of growing hairy roots using the same
WO2022187819A1 (en) 2021-03-01 2022-09-09 Cargill, Incorporated Xylosylated steviol glycosides and enzymatic methods for production
KR102600520B1 (ko) * 2021-06-09 2023-11-09 씨제이제일제당 주식회사 제라닐제라닐 피로포스페이트 신타아제 변이체 및 이를 이용한 테트라테르펜, 이의 전구체, 및 테트라테르펜을 전구체로 하는 물질의 생산방법
CN115478060B (zh) * 2021-06-16 2023-11-28 弈柯莱生物科技(集团)股份有限公司 一种糖基转移酶及其应用
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
KR102564619B1 (ko) 2021-08-10 2023-08-07 이재준 사각육면 밀폐형 접이식 스퀘어박스
WO2023044368A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Method for producing glycosylated therapeutics by using an immobilized enzyme preparation
CN113930377B (zh) * 2021-10-14 2023-12-26 广西大学 一株全细胞催化提高莱鲍迪苷a含量的工程菌
CN115975827A (zh) * 2021-10-15 2023-04-18 中国科学院分子植物科学卓越创新中心 用于甜茶素生产的宿主细胞及方法
CN114196696B (zh) * 2021-12-06 2023-10-20 天津大学 一种与特定短肽标签融合能高效催化Reb M生成的重组酶
WO2023122649A1 (en) * 2021-12-21 2023-06-29 Mozhdehi Davoud Temperature-responsive nano-biomaterials from genetically encoded farnesylated proteins
CN114561310B (zh) * 2022-03-17 2022-12-02 江南大学 一种生产甜茶苷的酿酒酵母及其应用
EP4525636A4 (en) * 2022-05-19 2026-06-24 Corn Products Dev Inc IMPROVED COMPOSITIONS AND PRODUCTION PROCESSES OF STEVIOL GLYCOSIDES
CA3261258A1 (en) * 2022-07-07 2024-01-11 Purecircle Sdn Bhd HIGH PURITY STEVIOL GLYCOSIDES
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses
WO2024042405A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the synthesis of bio-based polymers
WO2024042486A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the production of polyurethanes
WO2024118831A1 (en) * 2022-11-30 2024-06-06 Velozbio Company Compositions and methods for protein production
EP4627098A1 (en) 2022-12-02 2025-10-08 Amyris Bio Products Portugal, Unipessoal, LDA Compositions and methods for using previously cultured cells
CN118755690B (zh) * 2024-09-06 2024-11-19 四川盈嘉合生科技有限公司 一种蔗糖合成酶及其在生物合成甜菊糖苷中的应用
CN119265154B (zh) * 2024-12-10 2025-05-13 诸城市浩天药业有限公司 一种糖基转移酶ugt76g4突变体及其应用

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) * 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−１，３グリコシルステビオシドの製造方法
JPS59101408A (ja) 1982-12-02 1984-06-12 Junichi Iwamura 植物生長調整剤
US5198360A (en) 1990-01-19 1993-03-30 Eli Lilly And Company Dna sequence conferring a plaque inhibition phenotype
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
CN1129953A (zh) 1993-07-15 1996-08-28 尼奥斯药品公司 糖组分的合成方法
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
WO1999018224A1 (en) * 1997-10-06 1999-04-15 The Centre National De Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
CA2630341C (en) 1998-04-14 2011-07-26 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by microorganisms
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
ATE490332T1 (de) 1998-07-06 2010-12-15 Dcv Inc Verfahren zur vitaminherstellung
JP3277275B2 (ja) 1998-07-28 2002-04-22 有限会社シャトウバッグ バッグ等に用いる模様付き表地材及びその製造方法
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
AU2594300A (en) 1998-12-23 2000-07-12 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
PT1190068E (pt) 1999-04-15 2006-06-30 Calgene Llc Sequencias de acidos nucleicos para proteinas envolvidas na sintese de tocoferol
WO2000063400A2 (en) 1999-04-21 2000-10-26 The Samuel Roberts Noble Foundation Plant transformation process
DE60036477T2 (de) 1999-08-04 2008-06-12 Bacher, Adelbert, Prof. Dr.med. Dr.rer.nat. Isoprenoid biosynthese
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
WO2001083769A2 (en) 2000-05-03 2001-11-08 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
CA2420555C (en) 2000-08-24 2012-10-23 The Scripps Research Institute Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
CA2422730A1 (en) 2000-09-19 2002-03-28 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
US20030219798A1 (en) 2000-09-29 2003-11-27 Gokarn Ravi R. Isoprenoid production
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
WO2002059297A2 (en) 2001-01-25 2002-08-01 Evolva Biotech A/S A library of a collection of cells
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
KR100704072B1 (ko) 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. 개선된 이소프레노이드 제조 방법
WO2003008540A2 (en) * 2001-06-22 2003-01-30 Syngenta Participations Ag Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
JP2005185101A (ja) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
US7514597B2 (en) 2002-08-20 2009-04-07 Suntory Limited Glycosyltransferase gene
AU2003273922A1 (en) 2002-09-27 2004-04-19 Dsm Ip Assets B.V. Squalene synthase 8sqs9 gen
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
ES2323175T3 (es) 2003-06-12 2009-07-08 Dsm Ip Assets B.V. Mevalonato-quinasas resistentes a la retroalimentacion.
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
US20060150283A1 (en) * 2004-02-13 2006-07-06 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
EP1765418B1 (en) 2004-05-21 2011-12-14 The Regents of the University of California Method for enhancing production of isoprenoid compounds
WO2006069610A2 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
JPWO2006016395A1 (ja) 2004-08-09 2008-05-01 国立大学法人東北大学 Ｕｄｐ−グルクロニル基転移酵素およびその遺伝子
EP1778843B1 (en) 2004-08-19 2012-09-19 DSM IP Assets B.V. Production of isoprenoids
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
CN101080490B (zh) 2004-12-14 2012-08-15 帝斯曼知识产权资产管理有限公司 改进的甲羟戊酸激酶
JP4284562B2 (ja) 2005-03-04 2009-06-24 独立行政法人産業技術総合研究所 Ｕｄｐ−キシロースの製造方法
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
US7989677B2 (en) 2005-08-17 2011-08-02 Nestec S. A. Nucleic acids and proteins associated with sucrose accumulation in coffee
AU2006283455A1 (en) 2005-08-22 2007-03-01 Co2 Boost Llc A device and process to generate CO2 used for indoor crop production and underwater gardening
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
KR101374346B1 (ko) 2005-11-23 2014-03-14 더 코카콜라 컴파니 시간 특성 및/또는 향미 특성이 개선된 천연 고효능 감미료조성물, 그 제제 방법 및 용도
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
AU2007299219A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
WO2007136847A2 (en) 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2007147275A1 (en) 2006-06-19 2007-12-27 Givaudan Sa Nucleic acid, polypeptide and its use
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
BRPI0716954B1 (pt) 2006-09-26 2024-04-30 The Regents Of The University Of California Microrganismos geneticamente modificados capazes de produzir um isoprenóide
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) * 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−ｎ−ビオースｉ及びガラクト−ｎ−ビオースの製造方法
MX2009007834A (es) 2007-01-22 2009-09-10 Cargill Inc Metodo para producir composiciones de rebaudiosido a purificado usando cristalizacion en solvente/ antisolvente.
JP2008237110A (ja) * 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
AU2008254423C1 (en) 2007-05-17 2016-06-02 Eastman Renewable Materials, Llc Methods and compositions for producing solvents
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (ja) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc 新規糖転移酵素、及びそれを利用した配糖体の製造
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
EP2594645A3 (en) 2007-09-21 2013-11-06 BASF Plant Science GmbH Plants with increased yield
JP5584937B2 (ja) 2007-12-03 2014-09-10 ディーエスエム アイピー アセッツ ビー．ブイ． ステビア抽出物またはステビア抽出物構成物質を含有する新規な栄養補給食品組成物およびその使用
CA2710629C (en) 2007-12-27 2016-06-21 Mcneil Nutritionals, Llc Synergistic sweetening compositions
EP2250268A4 (en) 2008-02-20 2011-08-24 Ceres Inc IMPROVED NITROGEN USE OF EFFICIENCY PROPERTIES IN PLANT NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES
TWI475963B (zh) 2008-02-25 2015-03-11 可口可樂公司 甜菊糖苷ａ衍生性產物以及製造彼的方法
US7981647B2 (en) 2008-03-03 2011-07-19 Joule Unlimited, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
WO2009140394A1 (en) 2008-05-13 2009-11-19 Cargill, Incorporated Separation of rebaudioside a from stevia glycosides using chromatography
CN101314776B (zh) * 2008-07-11 2010-11-03 南京农业大学 二磷酸尿核甘葡萄糖基转移酶基因及其所编码的蛋白质
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
ES2592377T3 (es) 2008-10-03 2016-11-29 Morita Kagaku Kogyo Co., Ltd. Nuevos glucósidos de esteviol
CN101720910B (zh) 2008-10-23 2012-07-25 大闽食品（漳州）有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) * 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
MX2011013231A (es) 2009-06-08 2012-01-20 Jennewein Biotechnologie Gmbh Sintesis de hmo.
WO2010146463A2 (en) 2009-06-16 2010-12-23 Cpc (Tianjin) Fine Chemicals Co., Ltd. Process for rebaudioside d
SG178376A1 (en) * 2009-09-04 2012-03-29 Redpoint Bio Corp Sweetness enhancers including rebaudioside a or d
AU2010298437B2 (en) 2009-09-22 2014-06-19 Redpoint Bio Corporation Novel polymorphs of rebaudioside C and methods for making and using the same
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
CA2775732C (en) 2009-10-15 2018-10-09 Purecircle Sdn Bhd High-purity rebaudioside d and applications
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
US8993840B2 (en) 2009-11-23 2015-03-31 E I du Pont de Nemours and Compay Sucrose transporter genes for increasing plant seed lipids
PT2816112T (pt) 2009-12-10 2018-11-20 Univ Iowa State Res Found Inc Modificação do adn modificada pelo efector tal
WO2011090709A1 (en) 2009-12-28 2011-07-28 The Coca-Cola Company Sweetness enhancers, compositions thereof, and methods for use
KR101244315B1 (ko) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 에탄올―저항성 효모 유전자 및 이의 용도
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
WO2011146833A1 (en) 2010-05-20 2011-11-24 Evolva Inc. Method of producing isoprenoid compounds in yeast
EP2575499A2 (en) 2010-05-31 2013-04-10 Vib Vzw The use of transporters to modulate flavor production by yeast
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
CA2819253A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
EP2742142B2 (en) * 2011-08-08 2020-03-25 Evolva SA Recombinant production of steviol glycosides
EP2783009B1 (en) 2011-11-23 2016-04-13 Evolva SA Methods and materials for enzymatic synthesis of mogroside compounds
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
CA3152828A1 (en) 2011-12-19 2013-06-27 The Coca-Cola Company Methods for purifying steviol glycosides and uses of the same
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
CN102559528B (zh) * 2012-02-09 2013-08-21 南京工业大学 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用
JP6251669B2 (ja) 2012-03-16 2017-12-20 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
MX395285B (es) 2012-05-22 2025-03-25 Purecircle Sdn Bhd Glucosidos de esteviol de alta pureza.
WO2014048392A1 (zh) 2012-09-29 2014-04-03 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
EP2928321A1 (en) 2012-12-05 2015-10-14 Evolva SA Steviol glycoside compositions sensory properties
CA2899276C (en) 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US10017804B2 (en) 2013-02-11 2018-07-10 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
CN105247064A (zh) 2013-05-31 2016-01-13 帝斯曼知识产权资产管理有限公司 细胞外的二萜生产
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
WO2015011209A1 (en) 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
CA2917615A1 (en) 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
EP3536697A1 (en) 2013-07-31 2019-09-11 DSM IP Assets B.V. Recovery of steviol glycosides
EP3042953A4 (en) 2013-08-02 2017-07-12 Suntory Holdings Limited Method for using hexenol glycosyl transferase
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
US20160215306A1 (en) 2013-08-30 2016-07-28 Evolva Sa Method for producing modified resveratrol
WO2015132411A2 (en) 2014-03-07 2015-09-11 Evolva Sa Methods for recombinant production of saffron compounds
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの生産
BR112017016338A2 (en) 2015-01-30 2018-03-27 Evolva Sa production of steviol glycosides in recombinant hosts
CA3255837A1 (en) 2015-03-16 2025-10-30 Dsm Ip Assets B.V. Udp-glycosyltransferases
JP2018522569A (ja) 2015-08-07 2018-08-16 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組換え宿主内でのステビオールグリコシドの産生
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts

Also Published As

Publication number Publication date
JP2019205445A (ja) 2019-12-05
CN108396044A (zh) 2018-08-14
BR122021015508B1 (pt) 2022-03-29
CN103732753A (zh) 2014-04-16
EP2742142A2 (en) 2014-06-18
US12416034B2 (en) 2025-09-16
KR20200057799A (ko) 2020-05-26
AU2012294452A1 (en) 2014-02-06
AU2024204171B2 (en) 2026-02-26
US20140329281A1 (en) 2014-11-06
CA2843606A1 (en) 2013-02-14
AU2012294452C1 (en) 2017-11-30
US20220228185A1 (en) 2022-07-21
WO2013022989A3 (en) 2013-07-04
KR20140057322A (ko) 2014-05-12
US20170321238A1 (en) 2017-11-09
US20230407360A1 (en) 2023-12-21
AU2022203048A1 (en) 2022-05-26
BR122020019161B1 (pt) 2022-04-05
AU2024204171A1 (en) 2024-07-11
US20200123583A1 (en) 2020-04-23
BR112014003037A2 (pt) 2018-09-04
EP3009508A1 (en) 2016-04-20
EP3792350B1 (en) 2026-03-25
EP2742142B2 (en) 2020-03-25
EP4726050A2 (en) 2026-04-15
AU2017258907A1 (en) 2017-11-30
SG10201606569VA (en) 2016-09-29
MY173212A (en) 2020-01-06
CA3128532A1 (en) 2013-02-14
JP2024112815A (ja) 2024-08-21
AU2012294452A8 (en) 2014-03-06
SG10201606563PA (en) 2016-10-28
CA2843606C (en) 2021-10-05
JP2022101592A (ja) 2022-07-06
AU2022203048B2 (en) 2024-03-28
BR122021015509B1 (pt) 2022-03-29
JP7057765B2 (ja) 2022-04-20
JP6262653B2 (ja) 2018-01-17
KR102114493B1 (ko) 2020-05-26
EP3009508B1 (en) 2020-11-25
WO2013022989A2 (en) 2013-02-14
EP2742142B1 (en) 2016-06-01
SG10201606565XA (en) 2016-10-28
EP3792350A1 (en) 2021-03-17
CN103732753B (zh) 2018-03-30
BR112014003037B1 (pt) 2022-04-05
US10435730B2 (en) 2019-10-08
JP7803999B2 (ja) 2026-01-21
JP2014524247A (ja) 2014-09-22
EP4726050A3 (en) 2026-07-01
AU2020200157B2 (en) 2022-02-10
JP6554518B2 (ja) 2019-07-31
AU2012294452B2 (en) 2017-08-10
AU2020200157A1 (en) 2020-01-30
JP2018019715A (ja) 2018-02-08
US9631215B2 (en) 2017-04-25

Similar Documents

Publication Publication Date Title
SG10201606565XA (en) Recombinant production of steviol glycosides
SG10201709458QA (en) Recombinant production of steviol glycosides
EP3063286A4 (en) Recombinant production of steviol glycosides
EP2852296A4 (en) GLYCOSIDES OF STÉVIOL OF GREAT PURITY
SG11201506127WA (en) Efficient production of steviol glycosides in recombinant hosts
PL2675294T3 (pl) Glukozylowa kompozycja stewii
PL2720561T3 (pl) Kompozycja stewii
PL2713762T3 (pl) Kompozycja stewii
EP2713763A4 (en) Stevia-COMPOSITION
LT2793618T (lt) Gėrimas, apimantis steviolio glikozidus
PL2486806T3 (pl) Kompozycja stewii
EP2754025A4 (en) PINCH FOR ADJUSTMENT
EP2672840A1 (en) Stevia composition
PL2663346T3 (pl) Wytwarzanie zindywidualizowanego koncentratu
PL3272861T3 (pl) Kompozycje alfa- galaktozydazy
PL2768515T3 (pl) Kompozycja stewii glukozylowanej
SG2014013999A (en) Improved mcm-56 manufacture
IL232418A (en) Process for preparation of cell-c-aryl glucosides
GB2512737B (en) Micro-Fermentation of cocoa
EP2684869A4 (en) PREPARATION OF 3-MERCAPOTOPROPIONATES
GB201101794D0 (en) Protein production
GB201103801D0 (en) Movement of aircraft
AU2011092V (en) WG001 Westringia glabra
TWM433301U (en) Improvement structure of cloth
AU2011901299A0 (en) Preparation of saponin aglycones