MY173212A - Recombinant production of steviol glycosides - Google Patents

Recombinant production of steviol glycosides

Info

Publication number
MY173212A
MY173212A MYPI2014000343A MYPI2014000343A MY173212A MY 173212 A MY173212 A MY 173212A MY PI2014000343 A MYPI2014000343 A MY PI2014000343A MY PI2014000343 A MYPI2014000343 A MY PI2014000343A MY 173212 A MY173212 A MY 173212A
Authority
MY
Malaysia
Prior art keywords
steviol glycosides
recombinant production
rebaudioside
plants
plant cells
Prior art date
Application number
MYPI2014000343A
Other languages
English (en)
Inventor
M Hicks Paula
Jens Houghton-Larsen
Michael Naesby
Tange Thomas Ostergaard
Jorgen Hansen
Mikkelsen Michael Dalgaard
Hansen Esben Halkjaer
Ernesto Simon
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46724642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY173212(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of MY173212A publication Critical patent/MY173212A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Seasonings (AREA)
MYPI2014000343A 2011-08-08 2012-08-08 Recombinant production of steviol glycosides MY173212A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161521051P 2011-08-08 2011-08-08
US201161521203P 2011-08-08 2011-08-08
US201161521084P 2011-08-08 2011-08-08
US201161523487P 2011-08-15 2011-08-15
US201161567929P 2011-12-07 2011-12-07
US201261603639P 2012-02-27 2012-02-27
PCT/US2012/050021 WO2013022989A2 (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Publications (1)

Publication Number Publication Date
MY173212A true MY173212A (en) 2020-01-06

Family

ID=46724642

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2014000343A MY173212A (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Country Status (11)

Country Link
US (5) US9631215B2 (enExample)
EP (3) EP3792350A1 (enExample)
JP (5) JP6262653B2 (enExample)
KR (2) KR102114493B1 (enExample)
CN (2) CN108396044A (enExample)
AU (5) AU2012294452C1 (enExample)
BR (4) BR122021015508B1 (enExample)
CA (2) CA3128532A1 (enExample)
MY (1) MY173212A (enExample)
SG (4) SG10201606563PA (enExample)
WO (1) WO2013022989A2 (enExample)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
US8790730B2 (en) 2005-10-11 2014-07-29 Purecircle Usa Process for manufacturing a sweetener and use thereof
US9392799B2 (en) 2011-02-17 2016-07-19 Purecircle Sdn Bhd Glucosyl stevia composition
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US9386797B2 (en) 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
EP2498625B1 (en) 2009-11-12 2018-10-24 Purecircle Usa Inc. Granulation of a stevia sweetener
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
US20150344512A1 (en) 2011-12-19 2015-12-03 Purecircle Usa Inc. Methods of purifying steviol glycosides and uses of the same
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
BR122021005297B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol
MX346137B (es) 2010-12-13 2017-03-08 Purecircle Usa Inc Rebaudiosido d altamente soluble.
US9510611B2 (en) 2010-12-13 2016-12-06 Purecircle Sdn Bhd Stevia composition to improve sweetness and flavor profile
WO2012108894A1 (en) 2011-02-10 2012-08-16 Purecircle Usa Stevia composition
US9603373B2 (en) 2011-02-17 2017-03-28 Purecircle Sdn Bhd Glucosyl stevia composition
US9474296B2 (en) 2011-02-17 2016-10-25 Purecircle Sdn Bhd Glucosyl stevia composition
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9894922B2 (en) 2011-05-18 2018-02-20 Purecircle Sdn Bhd Glucosyl rebaudioside C
WO2012166163A1 (en) 2011-05-31 2012-12-06 Purecircle Usa Stevia composition
BR112013030885B1 (pt) 2011-06-03 2019-01-02 Purecircle Usa Inc processo para produzir uma composição de ingrediente alimentício de stevia compreendendo rebaudiosídeo b
PL2720561T3 (pl) 2011-06-20 2019-05-31 Purecircle Usa Inc Kompozycja stewii
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
JP6262653B2 (ja) 2011-08-08 2018-01-17 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． ステビオール配糖体の組換え生産
US10480019B2 (en) 2011-08-10 2019-11-19 Purecircle Sdn Bhd Process for producing high-purity rubusoside
MX377611B (es) 2011-09-07 2025-03-10 Purecircle Usa Inc Edulcorante de estevia altamente soluble.
EP3735841A1 (en) 2011-12-19 2020-11-11 PureCircle SDN BHD Methods for purifying steviol glycosides and uses of the same
FR2984743B1 (fr) * 2011-12-23 2014-08-22 Oreal Utilisation cosmetique du steviol, d'un derive glycoside du steviol, ou un de leurs isomeres pour stimuler, restaurer ou reguler le metabolisme des cellules de la peau et des semi-muqueuses.
EA201400836A8 (ru) * 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
WO2013137487A1 (ja) * 2012-03-16 2013-09-19 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
EP2832858B1 (en) 2012-03-27 2020-07-08 Suntory Holdings Limited Method for producing steviol glycoside
US20130338348A1 (en) * 2012-03-30 2013-12-19 J.R. Simplot Company Steviol and steviol glycoside formation in plants
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
EP2852296B1 (en) 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
WO2014086890A1 (en) * 2012-12-05 2014-06-12 Evolva Sa Steviol glycoside compositions sensory properties
KR20150115002A (ko) 2013-02-06 2015-10-13 에볼바 에스아 레바우디오시드 ｄ 및 레바우디오시드 ｍ의 개선된 생산 방법
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
KR101404728B1 (ko) * 2013-02-28 2014-06-09 씨제이제일제당 (주) 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
WO2014146084A1 (en) * 2013-03-15 2014-09-18 Cargill, Incorporated Stevia plants with an increased rebaudioside d content
ES2779252T3 (es) * 2013-05-15 2020-08-14 Purecircle Usa Inc Procedimiento para obtener una composición de estevia
AU2014273054A1 (en) * 2013-05-31 2015-12-03 Dsm Ip Assets B.V. Extracellular diterpene production
CA2913876A1 (en) * 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Microorganisms for diterpene production
BR112015030650B1 (pt) 2013-06-07 2021-02-23 Purecircle Usa Inc composição de modificação de sabor e aroma compreendendo glicosídeos de esteviol, seu produto alimentar ou de bebida e seu método para aumentar a intensidade de sabor e aroma ou melhorar a percepção de sal e reduzir o teor de sódio de um produto alimentar ou de bebida
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
US10039834B2 (en) 2013-07-12 2018-08-07 The Coca-Cola Company Compositions and methods using rebaudioside X to provide sweetness enhancement
AU2014292150B2 (en) * 2013-07-15 2019-04-04 Dsm Ip Assets B.V. Diterpene production
WO2015011209A1 (en) * 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
CN105658081A (zh) * 2013-07-31 2016-06-08 帝斯曼知识产权资产管理有限公司 甜菊糖苷
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
JP6530760B2 (ja) * 2013-11-01 2019-06-12 コナゲン インコーポレーテッド ステビオール配糖体の組換え製造
US20170211113A1 (en) * 2014-01-28 2017-07-27 Pepsico, Inc. Method for preparing rebaudioside m by using enzyme method
WO2015162305A1 (en) * 2014-04-25 2015-10-29 Dsm Ip Assets B.V. Stabilization of cytochrome p450 reductase
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3183349B1 (en) * 2014-08-19 2020-03-25 Purecircle SDN BHD Method for preparing rebaudioside i
WO2016034942A1 (en) 2014-09-02 2016-03-10 Purecircle Usa Inc. Stevia extracts enriched in rebaudioside d, e, n and/or o and process for the preparation thereof
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
CN104232496B (zh) * 2014-09-18 2017-06-06 广州康琳奈生物科技有限公司 一种重组毕赤酵母工程菌及其在合成莱鲍迪苷a中的应用
CN113549664B (zh) * 2014-09-19 2025-10-28 谱赛科有限责任公司 高纯度甜菊醇糖苷
AU2015327940B2 (en) * 2014-10-03 2020-04-16 Conagen Inc. Non-caloric sweeteners and methods for synthesizing
CN107109453A (zh) * 2014-11-05 2017-08-29 马努斯生物合成股份有限公司 甜菊醇糖苷的微生物产生
WO2016100689A1 (en) 2014-12-17 2016-06-23 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
CN108522291B (zh) * 2015-01-23 2022-01-04 谱赛科美国公司 利用甜叶菊新品种814011谱星3号制备高rm含量甜菊糖苷的方法
EP4148137A1 (en) * 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
MX2017010311A (es) * 2015-02-10 2017-12-14 Purecircle Usa Inc Metodos de produccion y recuperacion de rebaudiosido m biosintetico.
EP3265577A1 (en) 2015-03-03 2018-01-10 The Regents of the University of California Protecting group chemistry for clean, reductant-free dyeing
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
CA2979957A1 (en) * 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
EP3718417B1 (en) 2015-04-03 2025-09-03 DSM IP Assets B.V. Steviol glycosides
WO2016168413A1 (en) * 2015-04-14 2016-10-20 Conagen Inc. Production of non-caloric sweeteners using engineered whole-cell catalysts
CN107532135A (zh) * 2015-04-21 2018-01-02 帝斯曼知识产权资产管理有限公司 萜类化合物的微生物生产
CA2987587C (en) 2015-05-29 2022-05-03 Cargill, Incorporated Heat treatment to produce glycosides
JP2018521636A (ja) 2015-05-29 2018-08-09 カーギル・インコーポレイテッド 多段階供給を用いる、ステビオール配糖体を生成するための発酵方法
JP2018516600A (ja) 2015-05-29 2018-06-28 カーギル・インコーポレイテッド 高いｐＨを使用してステビオールグリコシドを産生するための発酵方法及びそこから得られる組成物
CN105200098A (zh) * 2015-06-30 2015-12-30 苏州汉酶生物技术有限公司 一种利用酿酒酵母酶法制备瑞鲍迪甙m的方法
CA2994288A1 (en) * 2015-08-06 2017-02-09 Cargill, Incorporated Fermentation methods for producing steviol glycosides
BR112018002564A2 (pt) 2015-08-07 2018-09-25 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
CN107922465B (zh) * 2015-08-13 2021-12-24 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷转运
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
CA2999638A1 (en) 2015-10-05 2017-04-13 Dsm Ip Assets B.V. Kaurenoic acid hydroxylases
CN115336734A (zh) 2015-10-26 2022-11-15 谱赛科美国股份有限公司 甜菊醇糖苷组合物
WO2017093895A1 (en) * 2015-11-30 2017-06-08 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
EP3387136B1 (en) * 2015-12-10 2022-01-05 Evolva SA Production of steviol glycosides in recombinant hosts
CN108712864A (zh) 2015-12-15 2018-10-26 谱赛科美国股份有限公司 甜菊醇糖苷组合物
WO2017151616A1 (en) * 2016-03-01 2017-09-08 Wm. Wrigley Jr. Company Long-lasting sweetener formulations
US20190048356A1 (en) * 2016-03-11 2019-02-14 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109195457A (zh) 2016-04-13 2019-01-11 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017198681A1 (en) * 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017218888A1 (en) * 2016-06-17 2017-12-21 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
MY194280A (en) 2016-08-12 2022-11-25 Amyris Inc Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
BR112019007504B1 (pt) 2016-10-14 2023-05-09 Conagen Inc Método de preparação de uma composição de glicosídeo de esteviol
JP6842800B2 (ja) * 2016-10-21 2021-03-17 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
AU2016427130B2 (en) 2016-10-21 2022-08-18 Pepsico, Inc. Method for preparing rebaudioside N using enzymatic method
EP3530746A4 (en) * 2016-10-21 2020-06-24 Pepsico, Inc. METHOD FOR PRODUCING REBAUDIOSIDE C BY ENZYMATIC METHOD
WO2018078014A1 (en) * 2016-10-27 2018-05-03 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
WO2018124141A1 (ja) * 2016-12-27 2018-07-05 サントリーホールディングス株式会社 ステビオール配糖体ヘキソース転移酵素およびそれをコードする遺伝子
IL321402A (en) * 2017-02-03 2025-08-01 Tate & Lyle Solutions Usa Llc Engineered glycosyltransferases and steviol glycoside glucosylation methods
JP7194111B2 (ja) * 2017-03-06 2022-12-21 コナゲン インコーポレイテッド ステビオール配糖体レバウジオシドｄ４のレバウジオシドｅからの生合成製造
US11284577B2 (en) 2017-03-08 2022-03-29 Purecircle Usa Inc. High rebaudioside M stevia plant cultivars and methods of producing the same
CN110494564B (zh) * 2017-04-12 2024-03-15 三得利控股株式会社 来自甜菊的鼠李糖合成酶及基因
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3644758A4 (en) * 2017-06-30 2021-03-31 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase
KR20200035981A (ko) 2017-08-11 2020-04-06 아미리스 인코퍼레이티드 레바우디오사이드의 고효율 생산을 위한 피숨 사티붐 카우렌 산화효소
WO2019055325A2 (en) 2017-09-12 2019-03-21 Biocapital Holdings, Llc BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES
CN107446874B (zh) * 2017-09-25 2020-07-28 四川盈嘉合生科技有限公司 重组大肠杆菌及其在合成莱鲍迪苷d中的用途
BR112020009838A2 (pt) 2017-12-05 2020-11-17 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
CN111868252B (zh) * 2018-03-12 2025-06-03 科纳根公司 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3824093B1 (en) * 2018-07-16 2024-11-20 Manus Bio, Inc. Production of steviol glycosides through whole cell biotransformation
MX2021001260A (es) 2018-07-30 2021-04-12 Tate & Lyle Solutions Usa Llc Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol.
CN109393426A (zh) * 2018-09-29 2019-03-01 四川盈嘉合生科技有限公司 一种复合甜味剂
US12221641B2 (en) 2018-10-15 2025-02-11 Amyris, Inc. Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides
US12234464B2 (en) 2018-11-09 2025-02-25 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
WO2020117792A2 (en) * 2018-12-04 2020-06-11 The Regents Of The University Of California Scalable biosynthesis of the seaweed neurochemical kainic acid
BR112021011419A2 (pt) * 2018-12-12 2021-09-08 Conagen Inc. Método de produção de rebaudiosídeo r6-2a e/ou r6-2b, r7-2, r6-1 e r6-4a e/ou r6-4b, rebaudiosídeo sintético e produto de consumo oral
KR102618015B1 (ko) * 2018-12-21 2023-12-26 주식회사 삼양사 스테비올 또는 이의 전구체의 생산
KR20210120027A (ko) 2019-01-24 2021-10-06 아미리스 인코퍼레이티드 레바우디오사이드의 고효율 생산을 위한 abc 수송체
CN109913380B (zh) * 2019-03-25 2021-12-10 南京工业大学 生产(-)-α-红没药醇的重组解脂耶氏酵母菌及其构建方法和应用
AU2020268897A1 (en) 2019-05-03 2021-11-18 Amyris, Inc. Kaurenoic acid 13-hydroxylase (KAH) variants and uses thereof
US12065685B1 (en) 2019-05-13 2024-08-20 Amyris, Inc. UDP-glycosyltransferase variants and uses thereof
US11168309B2 (en) 2019-06-25 2021-11-09 Manus Bio Inc. Uridine diphosphate-dependent glycosyltransferase enzyme
KR102379608B1 (ko) * 2019-10-29 2022-03-29 주식회사 삼양사 개선된 스테비올 배당체 화합물 또는 이의 전구체의 생산
CN111088176B (zh) * 2019-12-30 2022-03-25 北京化工大学 产β-胡萝卜素的基因工程菌及其应用
CN112006035B (zh) * 2020-07-24 2021-07-30 江西新龙生物科技股份有限公司 用于防治植物病害的微生物源杀菌剂及其制备方法
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
EP4232568A1 (en) 2020-10-22 2023-08-30 DSM IP Assets B.V. Microorganisms for diterpene production
CN117203325A (zh) * 2020-11-24 2023-12-08 马努斯生物合成股份有限公司 糖苷产物生物合成和回收
JP7210626B2 (ja) * 2021-02-18 2023-01-23 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
US11299700B1 (en) 2021-02-19 2022-04-12 Acequia Biotechnology, Llc Bioreactor containers and methods of growing hairy roots using the same
US20240182941A1 (en) 2021-03-01 2024-06-06 Cargill, Incorporated Xylosylated steviol glycosides and enzymatic methods for production
CN115478060B (zh) * 2021-06-16 2023-11-28 弈柯莱生物科技(集团)股份有限公司 一种糖基转移酶及其应用
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
KR102564619B1 (ko) 2021-08-10 2023-08-07 이재준 사각육면 밀폐형 접이식 스퀘어박스
WO2023044368A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Method for producing glycosylated therapeutics by using an immobilized enzyme preparation
CN113930377B (zh) * 2021-10-14 2023-12-26 广西大学 一株全细胞催化提高莱鲍迪苷a含量的工程菌
CN114196696B (zh) * 2021-12-06 2023-10-20 天津大学 一种与特定短肽标签融合能高效催化Reb M生成的重组酶
WO2023122649A1 (en) * 2021-12-21 2023-06-29 Mozhdehi Davoud Temperature-responsive nano-biomaterials from genetically encoded farnesylated proteins
CN114561310B (zh) * 2022-03-17 2022-12-02 江南大学 一种生产甜茶苷的酿酒酵母及其应用
EP4551583A1 (en) * 2022-07-07 2025-05-14 PureCircle SDN BHD High-purity steviol glycosides
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses
WO2024042486A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the production of polyurethanes
WO2024042405A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the synthesis of bio-based polymers
EP4627091A1 (en) * 2022-11-30 2025-10-08 Velozbio Company Compositions and methods for protein production
EP4627098A1 (en) 2022-12-02 2025-10-08 Amyris Bio Products Portugal, Unipessoal, LDA Compositions and methods for using previously cultured cells
CN118755690B (zh) * 2024-09-06 2024-11-19 四川盈嘉合生科技有限公司 一种蔗糖合成酶及其在生物合成甜菊糖苷中的应用
CN119265154B (zh) * 2024-12-10 2025-05-13 诸城市浩天药业有限公司 一种糖基转移酶ugt76g4突变体及其应用

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) * 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−１，３グリコシルステビオシドの製造方法
JPS59101408A (ja) 1982-12-02 1984-06-12 Junichi Iwamura 植物生長調整剤
US5198360A (en) 1990-01-19 1993-03-30 Eli Lilly And Company Dna sequence conferring a plaque inhibition phenotype
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
FI960173L (fi) 1993-07-15 1996-03-15 Neose Pharm Inc Menetelmä sakkaridikoostumusten syntetisoimiseksi
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
AU9455398A (en) * 1997-10-06 1999-04-27 Centre National De La Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
KR100657388B1 (ko) 1998-04-14 2006-12-13 교와 학꼬 고교 가부시키가이샤 미생물에 의한 이소프레노이드 화합물의 제조 방법
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP2100963B1 (en) 1998-07-06 2011-12-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
JP3277275B2 (ja) 1998-07-28 2002-04-22 有限会社シャトウバッグ バッグ等に用いる模様付き表地材及びその製造方法
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
JP2002533090A (ja) 1998-12-23 2002-10-08 ザ、サミュアル、ラバツ、ノゥブル、ファウンデイシャン、インク 植物形質転換法
MXPA01010486A (es) 1999-04-15 2002-03-27 Calgene Llc Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol.
AU4365200A (en) 1999-04-21 2000-11-02 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
WO2001011055A1 (en) 1999-08-04 2001-02-15 Adelbert Bacher Isoprenoid biosynthesis
AU6780700A (en) 1999-08-18 2001-03-13 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
WO2001083769A2 (en) 2000-05-03 2001-11-08 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
CA2420555C (en) 2000-08-24 2012-10-23 Jeffrey F. Harper Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
WO2002024865A2 (en) 2000-09-19 2002-03-28 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
ATE384119T1 (de) 2000-09-29 2008-02-15 Cargill Inc Isoprenoidproduktion
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
WO2002059297A2 (en) 2001-01-25 2002-08-01 Evolva Biotech A/S A library of a collection of cells
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
AU2002316966B2 (en) 2001-06-06 2007-05-17 Dsm Ip Assets B.V. Improved isoprenoid production
EP1402042A2 (en) 2001-06-22 2004-03-31 Syngenta Participations AG Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
JP2005185101A (ja) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
US7514597B2 (en) 2002-08-20 2009-04-07 Suntory Limited Glycosyltransferase gene
EP1543115B1 (en) * 2002-09-27 2008-05-07 DSM IP Assets B.V. Squalene synthase (sqs) gene
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
KR101190897B1 (ko) 2003-06-12 2012-10-12 디에스엠 아이피 어셋츠 비.브이. 피드백 내성 메발로네이트 키나아제
US20060150283A1 (en) 2004-02-13 2006-07-06 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
ES2379368T3 (es) 2004-05-21 2012-04-25 The Regents Of The University Of California Método para aumentar la producción de compuestos isoprenoides
CA2559760A1 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
WO2006016395A1 (ja) 2004-08-09 2006-02-16 National University Corporation Tohoku University Ｕｄｐ−グルクロニル基転移酵素およびその遺伝子
JP5074185B2 (ja) 2004-08-19 2012-11-14 ディーエスエム アイピー アセッツ ビー．ブイ． イソプレノイドの生成
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
WO2006063752A1 (en) 2004-12-14 2006-06-22 Dsm Ip Assets B.V. Improved mevalonate kinase
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
JP4284562B2 (ja) 2005-03-04 2009-06-24 独立行政法人産業技術総合研究所 Ｕｄｐ−キシロースの製造方法
WO2007022318A2 (en) 2005-08-17 2007-02-22 Cornell Research Foundation Nucleic acids and proteins associated with sucrose accumulation in coffee
EP1916888A4 (en) 2005-08-22 2011-05-18 Co2 Boost Llc DEVICE AND PROCESS FOR GENERATING CO2 USED FOR HARVEST PRODUCTION AND SUBMARINE GARDENING
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
EP1971228A1 (en) 2005-11-23 2008-09-24 The Coca-Cola Company Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
US7927851B2 (en) * 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
EP2090662A3 (en) 2006-04-05 2012-10-31 Metanomics GmbH Process for the production of a fine chemical
US8114645B2 (en) 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2007147275A1 (en) 2006-06-19 2007-12-27 Givaudan Sa Nucleic acid, polypeptide and its use
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
DK2066778T3 (en) 2006-09-26 2016-04-18 Amyris Biotechnologies Inc PREPARATION OF ISOPRENOIDS AND ISOPRENOID PRECURSORS
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) * 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−ｎ−ビオースｉ及びガラクト−ｎ−ビオースの製造方法
EP2124633B1 (en) 2007-01-22 2012-03-07 Cargill, Incorporated Method of producing purified rebaudioside a compositions using solvent/antisolvent crystallization
JP2008237110A (ja) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
WO2008144060A2 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (ja) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc 新規糖転移酵素、及びそれを利用した配糖体の製造
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
CN101939435A (zh) 2007-09-21 2011-01-05 巴斯夫植物科学有限公司 具有增加的产量的植物
EP2214681B1 (en) 2007-12-03 2021-10-20 DSM IP Assets B.V. Novel nutraceutical compositions containing steviol and uses thereof
AU2008343039B2 (en) 2007-12-27 2014-04-24 Heartland Consumer Products, Llc Synergistic sweetening compositions
EP2250268A4 (en) 2008-02-20 2011-08-24 Ceres Inc IMPROVED NITROGEN USE OF EFFICIENCY PROPERTIES IN PLANT NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES
TWI475963B (zh) 2008-02-25 2015-03-11 Coca Cola Co 甜菊糖苷ａ衍生性產物以及製造彼的方法
CN102015995B (zh) 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
CN101314776B (zh) * 2008-07-11 2010-11-03 南京农业大学 二磷酸尿核甘葡萄糖基转移酶基因及其所编码的蛋白质
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
PL2350110T3 (pl) 2008-10-03 2016-12-30 Nowe glikozydy stewiolowe
CN101720910B (zh) * 2008-10-23 2012-07-25 大闽食品（漳州）有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) * 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
ES2660698T3 (es) 2009-06-08 2018-03-23 Jennewein Biotechnologie Gmbh Síntesis de HMO
AU2010261471A1 (en) 2009-06-16 2011-12-15 Epc (Beijing) Natural Products Co., Ltd. Composition comprising rebaudioside D for reducing or eliminating aftertaste and preparation method thereof
SG178376A1 (en) 2009-09-04 2012-03-29 Redpoint Bio Corp Sweetness enhancers including rebaudioside a or d
CA2773917A1 (en) 2009-09-22 2011-03-31 Redpoint Bio Corporation Novel polymorphs of rebaudioside c and methods for making and using the same
ES2661539T3 (es) * 2009-10-15 2018-04-02 Purecircle Sdn Bhd Rebaudiósido D de pureza elevada y aplicaciones
US8299224B2 (en) † 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
US8993840B2 (en) 2009-11-23 2015-03-31 E I du Pont de Nemours and Compay Sucrose transporter genes for increasing plant seed lipids
CA2783351C (en) 2009-12-10 2021-09-07 Regents Of The University Of Minnesota Tal effector-mediated dna modification
MX2012007607A (es) 2009-12-28 2012-07-20 Coca Cola Co Intensificadores de dulzor, composiciones de los mismos y metodos para su uso.
KR101244315B1 (ko) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 에탄올―저항성 효모 유전자 및 이의 용도
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
EP2571991A1 (en) 2010-05-20 2013-03-27 Evolva SA Method of producing isoprenoid compounds in yeast
EP2575499A2 (en) 2010-05-31 2013-04-10 Vib Vzw The use of transporters to modulate flavor production by yeast
BR122021005297B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
US9284570B2 (en) * 2010-11-30 2016-03-15 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
JP6262653B2 (ja) * 2011-08-08 2018-01-17 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． ステビオール配糖体の組換え生産
AU2012342114B2 (en) 2011-11-23 2017-12-21 Danstar Ferment Ag Methods and materials for enzymatic synthesis of mogroside compounds
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
EP3735841A1 (en) 2011-12-19 2020-11-11 PureCircle SDN BHD Methods for purifying steviol glycosides and uses of the same
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
CN102559528B (zh) * 2012-02-09 2013-08-21 南京工业大学 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用
WO2013137487A1 (ja) 2012-03-16 2013-09-19 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
EP2852296B1 (en) 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
CN103710318B (zh) 2012-09-29 2017-01-18 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
WO2014086890A1 (en) 2012-12-05 2014-06-12 Evolva Sa Steviol glycoside compositions sensory properties
KR20150115002A (ko) 2013-02-06 2015-10-13 에볼바 에스아 레바우디오시드 ｄ 및 레바우디오시드 ｍ의 개선된 생산 방법
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
AU2014273054A1 (en) 2013-05-31 2015-12-03 Dsm Ip Assets B.V. Extracellular diterpene production
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
WO2015011209A1 (en) 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
CN105658081A (zh) 2013-07-31 2016-06-08 帝斯曼知识产权资产管理有限公司 甜菊糖苷
EP3536697A1 (en) 2013-07-31 2019-09-11 DSM IP Assets B.V. Recovery of steviol glycosides
WO2015016393A1 (ja) 2013-08-02 2015-02-05 サントリーホールディングス株式会社 ヘキセノール配糖体化酵素の利用方法
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
WO2015028324A2 (en) 2013-08-30 2015-03-05 Evolva Sa A method for producing modified resveratrol
WO2015132411A2 (en) 2014-03-07 2015-09-11 Evolva Sa Methods for recombinant production of saffron compounds
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
EP4148137A1 (en) 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
BR112018002564A2 (pt) 2015-08-07 2018-09-25 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产

Also Published As

Publication number Publication date
SG10201606569VA (en) 2016-09-29
AU2020200157A1 (en) 2020-01-30
EP2742142B1 (en) 2016-06-01
AU2017258907A1 (en) 2017-11-30
WO2013022989A2 (en) 2013-02-14
US12416034B2 (en) 2025-09-16
CA2843606C (en) 2021-10-05
US20170321238A1 (en) 2017-11-09
KR20140057322A (ko) 2014-05-12
AU2022203048A1 (en) 2022-05-26
EP2742142B2 (en) 2020-03-25
US20230407360A1 (en) 2023-12-21
KR20200057799A (ko) 2020-05-26
AU2020200157B2 (en) 2022-02-10
SG10201606563PA (en) 2016-10-28
BR122020019161B1 (pt) 2022-04-05
JP2014524247A (ja) 2014-09-22
US20220228185A1 (en) 2022-07-21
AU2012294452A1 (en) 2014-02-06
AU2022203048B2 (en) 2024-03-28
CA3128532A1 (en) 2013-02-14
AU2012294452B2 (en) 2017-08-10
EP2742142A2 (en) 2014-06-18
EP3009508A1 (en) 2016-04-20
US20140329281A1 (en) 2014-11-06
KR102114493B1 (ko) 2020-05-26
BR112014003037A2 (pt) 2018-09-04
BR122021015508B1 (pt) 2022-03-29
JP2022101592A (ja) 2022-07-06
JP2018019715A (ja) 2018-02-08
CN103732753A (zh) 2014-04-16
US20200123583A1 (en) 2020-04-23
JP7057765B2 (ja) 2022-04-20
AU2012294452C1 (en) 2017-11-30
SG10201606565XA (en) 2016-10-28
AU2012294452A8 (en) 2014-03-06
EP3792350A1 (en) 2021-03-17
EP3009508B1 (en) 2020-11-25
BR112014003037B1 (pt) 2022-04-05
JP6554518B2 (ja) 2019-07-31
WO2013022989A3 (en) 2013-07-04
AU2024204171A1 (en) 2024-07-11
BR122021015509B1 (pt) 2022-03-29
SG10201606567TA (en) 2016-10-28
JP2024112815A (ja) 2024-08-21
CA2843606A1 (en) 2013-02-14
CN108396044A (zh) 2018-08-14
JP6262653B2 (ja) 2018-01-17
US10435730B2 (en) 2019-10-08
JP2019205445A (ja) 2019-12-05
US9631215B2 (en) 2017-04-25
CN103732753B (zh) 2018-03-30

Similar Documents

Publication Publication Date Title
MY173212A (en) Recombinant production of steviol glycosides
MY167872A (en) Recombinant production of steviol glycosides
MY207631A (en) Microbial production of steviol glycosides
MX355785B (es) Composicions y metodos para la biosintesis de vainillina o de beta-d-glucosido de vainillina.
MX2020005268A (es) Variedades de stevia autocompatibles, metodos de crianza a partir de las mismas y metodos para preparar nuevas composiciones usando las variedades.
MX2019004596A (es) Composicion de estevia.
MX2012003686A (es) Rebaudiosido d de alta pureza y aplicaciones.
MX2019004598A (es) Composicion de estevia.
MX341095B (es) Composicion de estevia.
MX362676B (es) Composición de estevia.
IN2015DN01103A (enExample)
WO2013021261A3 (en) Methods and materials for recombinant production of saffron compounds
MY162232A (en) Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
MX2019006162A (es) Ingredientes de comida de stevia rebaudiana.
MY185012A (en) Metabolically engineered organisms for the production of added value bio-products
PH12013502685A1 (en) Algal lipid compositions and methods of preparing and utilizing the same
IN2012DN01454A (enExample)
MX2012013024A (es) Composiciones edulcorantes con resabio amargo reducido y metodos de preparacion.
MY182946A (en) Production of organic acids by fermentation at low ph
UA108602C2 (uk) Бактерія, що виробляє сіалову кислоту
WO2013088246A3 (en) Process for the purification of rebaudioside a and compositions thereof
MX2021003887A (es) Composicion de estevia.
HK1183764A (en) Recombinant production of steviol glycosides
GEU20121747Y (en) Cocktail preparation
UA46746U (ru) Способ приготовления очищенного экстракта стевии медовой (stevia rebaudiana bertoni)