ATE537269T1 - Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen - Google Patents
Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungenInfo
- Publication number
- ATE537269T1 ATE537269T1 AT05857432T AT05857432T ATE537269T1 AT E537269 T1 ATE537269 T1 AT E537269T1 AT 05857432 T AT05857432 T AT 05857432T AT 05857432 T AT05857432 T AT 05857432T AT E537269 T1 ATE537269 T1 AT E537269T1
- Authority
- AT
- Austria
- Prior art keywords
- coa
- isoprenoid
- hmg
- present
- invention further
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57349204P | 2004-05-21 | 2004-05-21 | |
PCT/US2005/017874 WO2006085899A2 (en) | 2004-05-21 | 2005-05-20 | Method for enhancing production of isoprenoid compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE537269T1 true ATE537269T1 (de) | 2011-12-15 |
Family
ID=36793476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05857432T ATE537269T1 (de) | 2004-05-21 | 2005-05-20 | Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen |
Country Status (11)
Country | Link |
---|---|
US (2) | US7183089B2 (de) |
EP (2) | EP1765418B1 (de) |
JP (1) | JP4926061B2 (de) |
CN (1) | CN101023181A (de) |
AT (1) | ATE537269T1 (de) |
AU (1) | AU2005327292B2 (de) |
BR (1) | BRPI0510115B1 (de) |
CA (1) | CA2567547C (de) |
ES (1) | ES2379368T3 (de) |
MX (1) | MXPA06013502A (de) |
WO (1) | WO2006085899A2 (de) |
Families Citing this family (63)
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AU2462497A (en) * | 1996-04-17 | 1997-11-19 | Hubert Koster | A combinatorial protecting group strategy for multifunctional molecules |
US20050287596A9 (en) * | 1998-06-26 | 2005-12-29 | Braisted Andrew C | Novel ligands and libraries of ligands |
US20030033626A1 (en) | 2000-07-31 | 2003-02-13 | Hahn Frederick M. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
ES2319634T3 (es) * | 2002-03-11 | 2009-05-11 | Caprotec Bioanalytics Gmbh | Compuestos y metodos para analizar el proteoma. |
SG153699A1 (en) * | 2003-01-16 | 2009-07-29 | Caprotec Bioanalytics Gmbh | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
ES2626018T3 (es) | 2005-06-07 | 2017-07-21 | Dsm Nutritional Products Ag | Microorganismos eucariotas para la producción de lípidos y antioxidantes |
EP1931770A4 (de) * | 2005-10-07 | 2009-11-25 | Univ California | Für modifizierte cytochrom-p450-enzyme codierende nukleinsäuren und verfahren zur verwendung davon |
WO2007136847A2 (en) * | 2006-05-19 | 2007-11-29 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
US9765363B1 (en) * | 2006-05-26 | 2017-09-19 | Amyris, Inc. | Apparatus for making bio-organic compounds |
AU2007351658B2 (en) * | 2006-08-01 | 2013-05-30 | Dsm Nutritional Products Ag | Oil producing microbes and methods of modification thereof |
US8257957B2 (en) | 2006-09-26 | 2012-09-04 | The Regents Of The University Of California | Production of isoprenoids and isoprenoid precursors |
US8234641B2 (en) * | 2006-10-17 | 2012-07-31 | Managelq, Inc. | Compliance-based adaptations in managed virtual systems |
WO2008094546A2 (en) * | 2007-01-31 | 2008-08-07 | The Regents Of The University Of California | Genetically modified host cells for increased p450 activity levels and methods of use thereof |
WO2009006386A2 (en) | 2007-06-29 | 2009-01-08 | The Regents Of The University Of California | Host cells and methods for producing isoprenyl alkanoates |
US8067632B2 (en) * | 2007-07-26 | 2011-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Process to produce prostratin and structural or functional analogs thereof |
US8309323B2 (en) * | 2007-11-13 | 2012-11-13 | Synthetic Genomics, Inc. | Dimethyloctane as an advanced biofuel |
SG191671A1 (en) * | 2007-12-13 | 2013-07-31 | Danisco Us Inc | Cultured cells that produce isoprene and methods for producing isoprene |
WO2009097339A1 (en) * | 2008-01-31 | 2009-08-06 | Amyris Biotechnologies, Inc. | Methods of monitoring metabolic pathways |
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CA2719923A1 (en) * | 2008-04-08 | 2009-10-15 | Amyris Biotechnologies, Inc. | Expression of heterologous sequences |
AU2009240505B2 (en) | 2008-04-23 | 2013-09-05 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
MX343063B (es) | 2008-05-16 | 2016-10-21 | Reg Life Sciences Llc | Metodos y composiciones para producir hidrocarburos. |
JP2011520471A (ja) * | 2008-05-23 | 2011-07-21 | サイバス オイルズ,エルエルシー | 酵母を使用したスクアレンの生成 |
AU2009269147B2 (en) * | 2008-06-30 | 2013-08-22 | Danisco Us Inc. | Polymers of isoprene from renewable resources |
RU2563513C2 (ru) | 2008-07-02 | 2015-09-20 | ДАНИСКО ЮЭс ИНК. | Композиции и способы получения изопрена, не содержащего с5-углеводородов в условиях нарушения взаимосвязи между продуцированием изопрена и ростом клеток и/или в условиях продуцирования изопрена на безопасных рабочих уровнях |
MY169163A (en) | 2008-09-15 | 2019-02-19 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
WO2010031077A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
CN102264910B (zh) | 2008-10-28 | 2015-08-26 | Reg生命科学有限责任公司 | 用于产生脂肪醇的方法和组合物 |
CA2759700A1 (en) | 2009-04-23 | 2010-10-28 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
ES2625154T3 (es) * | 2009-11-23 | 2017-07-18 | Nucelis Llc | Métodos y composiciones para producir escualeno empleando levaduras |
BR112012030836B8 (pt) | 2010-06-02 | 2024-02-06 | Evolva Nutrition Inc | Hospedeiro recombinante que compreende genes recombinantes para produção de esteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol |
EP2633043A2 (de) | 2010-10-27 | 2013-09-04 | Danisco US Inc. | Isoprensynthasevarianten zur verbesserten herstellung von isopren |
JP6126597B2 (ja) | 2011-08-08 | 2017-05-10 | エヴォルヴァ エスアー.Evolva Sa. | サフラン化合物の組換え生成のための方法および材料 |
BR122021015509B1 (pt) | 2011-08-08 | 2022-03-29 | Evolva Sa | Método para produzir um glicosídeo de esteviol alvo |
MX346459B (es) * | 2011-11-09 | 2017-03-22 | Amyris Inc | Produccion de isoprenoides derivados de acetil - coenzima a. |
US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
JP5827601B2 (ja) * | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
CN103087972B (zh) | 2013-02-01 | 2014-11-05 | 中国科学院天津工业生物技术研究所 | 生产萜类化合物的重组微生物及构建方法 |
CA2899276C (en) | 2013-02-06 | 2022-11-01 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
SG10201705993YA (en) | 2013-02-11 | 2017-08-30 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
DK2970926T3 (en) | 2013-03-13 | 2018-04-16 | Dsm Nutritional Products Ag | GENMANIPULATION OF MICROorganisms |
JP6282813B2 (ja) | 2013-07-16 | 2018-02-21 | 住友ゴム工業株式会社 | ヒドロキシメチルグルタリルCoAレダクターゼの発現をbZIP型転写因子により調整する方法、bZIP型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
CN103602626B (zh) * | 2013-10-12 | 2016-02-10 | 中国科学院青岛生物能源与过程研究所 | 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌 |
BR112017002783A2 (pt) | 2014-08-11 | 2017-12-19 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
MX2017003130A (es) | 2014-09-09 | 2017-10-24 | Evolva Sa | Produccion de glucosidos de esteviol en hospederos recombinantes. |
CA2973674A1 (en) | 2015-01-30 | 2016-08-04 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
CN115851470A (zh) | 2015-03-16 | 2023-03-28 | 帝斯曼知识产权资产管理有限公司 | Udp-糖基转移酶 |
AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
CN109312378A (zh) | 2016-05-16 | 2019-02-05 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
CN106367508B (zh) * | 2016-09-13 | 2019-10-29 | 东北农业大学 | 一种用于鉴定杂合型类异戊二烯化合物产生菌的简并引物与应用 |
US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US11365417B2 (en) * | 2017-09-12 | 2022-06-21 | Bio Capital Holdings, LLC | Biological devices and methods of use thereof to produce steviol glycosides |
WO2019090286A2 (en) * | 2017-11-06 | 2019-05-09 | The Regents Of The University Of California | Production of valerenic acid in fungal cells |
KR20200095534A (ko) | 2017-12-07 | 2020-08-10 | 지머젠 인코포레이티드 | 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로 |
CA3086490A1 (en) | 2017-12-21 | 2019-06-27 | Zymergen Inc. | Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone |
CN109777815B (zh) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA合成酶基因RKHMGCS及其应用 |
CN117165502A (zh) * | 2022-05-26 | 2023-12-05 | 牛津大学(苏州)科技有限公司 | 一种合成萜类化合物的共培养系统和方法 |
NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
WO2024107105A1 (en) * | 2022-11-14 | 2024-05-23 | Agency For Science, Technology And Research | Biosynthesis of isoprenoid |
CN116925991A (zh) * | 2023-07-28 | 2023-10-24 | 天津大学 | 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用 |
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US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
DK0889120T3 (da) | 1994-12-09 | 2002-07-22 | Imp College Innovations Ltd | Virulensgener i VGC2-regionen af Salmonella |
US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
JP2002515738A (ja) | 1996-01-23 | 2002-05-28 | アフィメトリックス,インコーポレイティド | 核酸分析法 |
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US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
JP2002519416A (ja) * | 1998-07-06 | 2002-07-02 | イーストマン ケミカル カンパニー | トコフェロールの製造 |
DK2305825T3 (en) | 1998-07-06 | 2015-03-02 | Dcv Inc | A process for the production of vitamins |
AR022383A1 (es) | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
US6645747B1 (en) | 1999-09-21 | 2003-11-11 | E. I. Du Pont De Nemours And Company | Cis-prenyltransferases from plants |
GB9925453D0 (en) * | 1999-10-27 | 1999-12-29 | Univ Bristol | Increasing isoprenoid biosynthesis |
US20030033626A1 (en) | 2000-07-31 | 2003-02-13 | Hahn Frederick M. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
CA2422730A1 (en) | 2000-09-19 | 2002-03-28 | Microbia, Inc. | Modulation of secondary metabolite production by zinc binuclear cluster proteins |
US20040063182A1 (en) | 2000-12-28 | 2004-04-01 | Chikara Ohto | Process for producing prenyl alcohol |
JP3838033B2 (ja) | 2000-12-28 | 2006-10-25 | トヨタ自動車株式会社 | プレニルアルコールの製造方法 |
US7238514B2 (en) | 2001-01-05 | 2007-07-03 | William Marsh Rice University | Diterpene-producing unicellular organism |
GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
EP1392824B1 (de) | 2001-06-06 | 2008-08-20 | DSM IP Assets B.V. | Verbesserte isoprenoid herstellung |
US20040110259A1 (en) | 2001-08-03 | 2004-06-10 | Baugh Mariah R | Drug metabolizing enzymes |
US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
US7927794B2 (en) * | 2003-09-29 | 2011-04-19 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
-
2005
- 2005-05-20 US US11/134,705 patent/US7183089B2/en active Active
- 2005-05-20 BR BRPI0510115-8A patent/BRPI0510115B1/pt active IP Right Grant
- 2005-05-20 MX MXPA06013502A patent/MXPA06013502A/es active IP Right Grant
- 2005-05-20 AU AU2005327292A patent/AU2005327292B2/en active Active
- 2005-05-20 WO PCT/US2005/017874 patent/WO2006085899A2/en active Application Filing
- 2005-05-20 ES ES05857432T patent/ES2379368T3/es active Active
- 2005-05-20 CN CNA2005800243430A patent/CN101023181A/zh active Pending
- 2005-05-20 CA CA2567547A patent/CA2567547C/en active Active
- 2005-05-20 AT AT05857432T patent/ATE537269T1/de active
- 2005-05-20 JP JP2007527501A patent/JP4926061B2/ja active Active
- 2005-05-20 EP EP05857432A patent/EP1765418B1/de active Active
- 2005-05-20 EP EP10177421A patent/EP2365090A1/de not_active Withdrawn
-
2007
- 2007-01-17 US US11/624,094 patent/US7670825B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2005327292A1 (en) | 2006-08-17 |
CA2567547C (en) | 2012-10-23 |
EP1765418A2 (de) | 2007-03-28 |
US7183089B2 (en) | 2007-02-27 |
EP2365090A1 (de) | 2011-09-14 |
BRPI0510115B1 (pt) | 2022-09-27 |
BRPI0510115A (pt) | 2007-09-25 |
EP1765418A4 (de) | 2008-07-02 |
ES2379368T3 (es) | 2012-04-25 |
JP4926061B2 (ja) | 2012-05-09 |
MXPA06013502A (es) | 2007-03-01 |
WO2006085899A3 (en) | 2007-05-18 |
WO2006085899A2 (en) | 2006-08-17 |
US20090004724A1 (en) | 2009-01-01 |
CA2567547A1 (en) | 2006-08-17 |
EP1765418B1 (de) | 2011-12-14 |
CN101023181A (zh) | 2007-08-22 |
US7670825B2 (en) | 2010-03-02 |
US20060079476A1 (en) | 2006-04-13 |
AU2005327292B2 (en) | 2010-11-04 |
JP2008500063A (ja) | 2008-01-10 |
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