AR022383A1 - Sintasas - Google Patents

Sintasas

Info

Publication number
AR022383A1
AR022383A1 ARP990104656A ARP990104656A AR022383A1 AR 022383 A1 AR022383 A1 AR 022383A1 AR P990104656 A ARP990104656 A AR P990104656A AR P990104656 A ARP990104656 A AR P990104656A AR 022383 A1 AR022383 A1 AR 022383A1
Authority
AR
Argentina
Prior art keywords
synthases
active site
syntheses
aristoloquene
epi
Prior art date
Application number
ARP990104656A
Other languages
English (en)
Original Assignee
Univ Kentucky Res Found
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky Res Found, Salk Inst For Biological Studi filed Critical Univ Kentucky Res Found
Publication of AR022383A1 publication Critical patent/AR022383A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Se describen aquí nuevas sintasas y los correspondientes ácidos nucleicos que codifican sintasas. Dichas sintasas posee una bolsa de sitio activo queincluye los residuos amino ácidos primordiales que son modificados para generar los productos e intermediarios de reaccion terpenoides deseados. Lasmodificaciones de las sintasas están disenadas en base a por ejemplo las coordenadas tridimensionales de la 5-epi-aristoloqueno sintasa del tabaco, con o sinsustrato adherido en el sitio activo.
ARP990104656A 1998-09-18 1999-09-16 Sintasas AR022383A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10099398P 1998-09-18 1998-09-18
US13062899P 1999-04-22 1999-04-22
US15026299P 1999-08-23 1999-08-23

Publications (1)

Publication Number Publication Date
AR022383A1 true AR022383A1 (es) 2002-09-04

Family

ID=27379113

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990104656A AR022383A1 (es) 1998-09-18 1999-09-16 Sintasas

Country Status (13)

Country Link
US (6) US6468772B1 (es)
EP (3) EP2322605A3 (es)
JP (3) JP2002526066A (es)
AR (1) AR022383A1 (es)
AU (2) AU776690B2 (es)
BR (1) BR9913878A (es)
CA (1) CA2342053C (es)
EA (1) EA200100365A1 (es)
IL (1) IL141948A0 (es)
MX (1) MXPA01002805A (es)
NO (1) NO20011359L (es)
PL (1) PL347308A1 (es)
WO (1) WO2000017327A2 (es)

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WO2008150461A2 (en) * 2007-06-01 2008-12-11 Sapphire Energy High throughput screening of genetically modified photosynthetic organisms
GB2463337B (en) * 2007-09-11 2012-11-21 Sapphire Energy Inc Methods of producing organic products with photosynthetic organisms
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US9714418B2 (en) 2014-03-31 2017-07-25 Evolva, Inc. Modified santalene synthase polypeptides, encoding nucleic acid molecules and uses thereof
CN109593651A (zh) 2014-08-25 2019-04-09 蒂威诺特科技有限公司 用于大麻素化合物的同时生产的设备和方法
US10876124B2 (en) * 2015-06-26 2020-12-29 The Regents Of The University Of California Fusion constructs as protein over-expression vectors
CN110551645A (zh) * 2019-08-08 2019-12-10 中国农业科学院植物保护研究所 萜烯合酶基因GhTPS14在合成橙花叔醇方面的应用
CN111621508B (zh) * 2020-06-11 2022-07-01 云南中烟工业有限责任公司 烟草萜类合成酶NtTPS7基因及其载体与应用
CN112063608B (zh) * 2020-08-27 2022-06-17 浙江工业大学 一种脂肪酸光脱羧酶突变体及其在l-草铵膦合成中的应用
CN115677808B (zh) * 2022-10-28 2024-09-20 北京中医药大学 马兜铃酸-脱氧核苷结合物的制备方法

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Also Published As

Publication number Publication date
WO2000017327A3 (en) 2001-05-31
US20020094556A1 (en) 2002-07-18
AU6045899A (en) 2000-04-10
JP2014000082A (ja) 2014-01-09
PL347308A1 (en) 2002-03-25
EP1121422A2 (en) 2001-08-08
EP2363458A2 (en) 2011-09-07
JP2002526066A (ja) 2002-08-20
WO2000017327A9 (en) 2001-10-04
EP2363458A3 (en) 2011-12-14
CA2342053C (en) 2014-04-22
EP2322605A2 (en) 2011-05-18
NO20011359D0 (no) 2001-03-16
US6569656B2 (en) 2003-05-27
US20040053386A1 (en) 2004-03-18
US20030087406A1 (en) 2003-05-08
US20020040488A1 (en) 2002-04-04
AU776690B2 (en) 2004-09-16
US6468772B1 (en) 2002-10-22
JP2011172576A (ja) 2011-09-08
BR9913878A (pt) 2001-06-12
US6559297B2 (en) 2003-05-06
NO20011359L (no) 2001-05-15
US6890752B2 (en) 2005-05-10
EA200100365A1 (ru) 2001-10-22
AU2004242423B2 (en) 2007-08-09
WO2000017327A2 (en) 2000-03-30
US6495354B2 (en) 2002-12-17
US20020094557A1 (en) 2002-07-18
CA2342053A1 (en) 2000-03-30
EP2322605A3 (en) 2011-09-14
US6645762B2 (en) 2003-11-11
AU2004242423A1 (en) 2005-01-20
MXPA01002805A (es) 2002-06-04
IL141948A0 (en) 2002-03-10

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