MX2022000150A - Enzima de glicosiltransferasa dependiente de difosfato de uridina. - Google Patents
Enzima de glicosiltransferasa dependiente de difosfato de uridina.Info
- Publication number
- MX2022000150A MX2022000150A MX2022000150A MX2022000150A MX2022000150A MX 2022000150 A MX2022000150 A MX 2022000150A MX 2022000150 A MX2022000150 A MX 2022000150A MX 2022000150 A MX2022000150 A MX 2022000150A MX 2022000150 A MX2022000150 A MX 2022000150A
- Authority
- MX
- Mexico
- Prior art keywords
- ugt
- uridine diphosphate
- aspects
- dependent glycosyltransferase
- host cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01262—Soyasapogenol glucuronosyltransferase (2.4.1.262)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
En varios aspectos, la presente invención proporciona enzimas de glicosiltransferasa dependientes de uridina difosfato (UGT) capaces de catalizar la transferencia de un resto de monosacárido desde un azúcar NDP al carbono 3' de un resto de azúcar de un sustrato, tal como un glicano terpenoide, que funciona como una "1-3 UGT". En otros aspectos, la invención proporciona polinucleótidos que codifican la 1-3 UGT, y células huésped que los comprenden. En aún otros aspectos, la invención proporciona métodos para preparar sustratos glucosilados, que incluyen glucósidos de esteviol, usando la enzima y las células huésped de la descripción.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962866148P | 2019-06-25 | 2019-06-25 | |
PCT/US2020/039648 WO2020264179A1 (en) | 2019-06-25 | 2020-06-25 | Uridine diphosphate-dependent glycosyltransferase enzyme |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022000150A true MX2022000150A (es) | 2022-05-20 |
Family
ID=74062053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022000150A MX2022000150A (es) | 2019-06-25 | 2020-06-25 | Enzima de glicosiltransferasa dependiente de difosfato de uridina. |
Country Status (11)
Country | Link |
---|---|
US (2) | US11168309B2 (es) |
EP (1) | EP3990628A4 (es) |
JP (1) | JP2022530706A (es) |
KR (1) | KR20220034793A (es) |
CN (1) | CN114174501A (es) |
AU (1) | AU2020302789A1 (es) |
BR (1) | BR112021026306A2 (es) |
CA (1) | CA3144658A1 (es) |
IL (1) | IL289202A (es) |
MX (1) | MX2022000150A (es) |
WO (1) | WO2020264179A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11091743B2 (en) | 2016-08-12 | 2021-08-17 | Amyris, Inc. | UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides |
EP3765627A4 (en) * | 2018-03-12 | 2021-10-13 | Conagen Inc. | BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N |
EP3824093A4 (en) * | 2018-07-16 | 2022-06-01 | Manus Bio, Inc. | PRODUCTION OF STEVIOL GLYCOSIDES BY WHOLE-CELL BIOTRANSFORMATION |
US11168309B2 (en) * | 2019-06-25 | 2021-11-09 | Manus Bio Inc. | Uridine diphosphate-dependent glycosyltransferase enzyme |
EP4286515A1 (en) * | 2021-01-27 | 2023-12-06 | Korea Advanced Institute of Science and Technology | C-glycosyltransferase variants and use thereof |
CN115725528B (zh) * | 2021-08-30 | 2024-01-12 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
KR20230098495A (ko) * | 2021-12-24 | 2023-07-04 | 주식회사 삼양사 | 당전이 효소 변이체 및 이를 이용한 스테비올 배당체의 제조방법 |
CN115094074B (zh) * | 2022-06-28 | 2024-02-27 | 诸城市浩天药业有限公司 | 双功能udp-糖基转移酶及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY180803A (en) | 2010-06-02 | 2020-12-09 | Evolva Inc | Recombinant production of steviol glycosides |
WO2013022989A2 (en) * | 2011-08-08 | 2013-02-14 | Evolva Sa | Recombinant production of steviol glycosides |
AU2014214004B2 (en) | 2013-02-06 | 2018-05-24 | Evolva Sa | Methods for improved production of Rebaudioside D and Rebaudioside M |
US10273519B2 (en) * | 2013-07-23 | 2019-04-30 | Dsm Ip Assets B.V. | Diterpene production in Yarrowia |
BR112017005656A2 (pt) | 2014-09-19 | 2018-07-31 | Purecircle Sdn Bhd | glicosídeos de esteviol de alta pureza |
CN107109453A (zh) * | 2014-11-05 | 2017-08-29 | 马努斯生物合成股份有限公司 | 甜菊醇糖苷的微生物产生 |
CA3175100A1 (en) * | 2017-02-03 | 2018-08-09 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
EP3824093A4 (en) * | 2018-07-16 | 2022-06-01 | Manus Bio, Inc. | PRODUCTION OF STEVIOL GLYCOSIDES BY WHOLE-CELL BIOTRANSFORMATION |
US11168309B2 (en) * | 2019-06-25 | 2021-11-09 | Manus Bio Inc. | Uridine diphosphate-dependent glycosyltransferase enzyme |
-
2020
- 2020-06-25 US US16/912,374 patent/US11168309B2/en active Active
- 2020-06-25 CN CN202080051996.2A patent/CN114174501A/zh active Pending
- 2020-06-25 CA CA3144658A patent/CA3144658A1/en active Pending
- 2020-06-25 WO PCT/US2020/039648 patent/WO2020264179A1/en unknown
- 2020-06-25 BR BR112021026306A patent/BR112021026306A2/pt active Search and Examination
- 2020-06-25 MX MX2022000150A patent/MX2022000150A/es unknown
- 2020-06-25 KR KR1020227002106A patent/KR20220034793A/ko not_active Application Discontinuation
- 2020-06-25 AU AU2020302789A patent/AU2020302789A1/en active Pending
- 2020-06-25 EP EP20832927.6A patent/EP3990628A4/en active Pending
- 2020-06-25 JP JP2021576711A patent/JP2022530706A/ja active Pending
-
2021
- 2021-10-06 US US17/495,139 patent/US11788070B2/en active Active
- 2021-12-21 IL IL289202A patent/IL289202A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020302789A1 (en) | 2022-01-27 |
US20210009968A1 (en) | 2021-01-14 |
US11168309B2 (en) | 2021-11-09 |
US11788070B2 (en) | 2023-10-17 |
CA3144658A1 (en) | 2020-12-30 |
JP2022530706A (ja) | 2022-06-30 |
IL289202A (en) | 2022-02-01 |
BR112021026306A2 (pt) | 2022-09-06 |
CN114174501A (zh) | 2022-03-11 |
WO2020264179A1 (en) | 2020-12-30 |
US20220090031A1 (en) | 2022-03-24 |
KR20220034793A (ko) | 2022-03-18 |
EP3990628A4 (en) | 2023-08-02 |
EP3990628A1 (en) | 2022-05-04 |
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