RU2707751C1 - Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr) - Google Patents

Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr) Download PDF

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RU2707751C1
RU2707751C1 RU2018139648A RU2018139648A RU2707751C1 RU 2707751 C1 RU2707751 C1 RU 2707751C1 RU 2018139648 A RU2018139648 A RU 2018139648A RU 2018139648 A RU2018139648 A RU 2018139648A RU 2707751 C1 RU2707751 C1 RU 2707751C1
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compound
alkyl
aryl
atoms
heteroaryl
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RU2018139648A
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English (en)
Russian (ru)
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Анна Эрикссон
Нил ГРИН
Гари Густафсон
Бинсун Хан
Мл.. Дэвид Р. ЛАНЧИА
Лорна МИТЧЕЛЛ
Дэвид РИЧАРД
Татьяна Шелехин
Чейз К. СМИТ
Чжунго Ван
Сяочжан Чжэн
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Форма Терапьютикс, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2018139648A 2017-03-20 2018-03-20 Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr) RU2707751C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762473751P 2017-03-20 2017-03-20
US62/473,751 2017-03-20
PCT/US2018/023405 WO2018175474A1 (en) 2017-03-20 2018-03-20 Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators

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RU2019137023A Division RU2736217C2 (ru) 2017-03-20 2018-03-20 Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr)

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RU2707751C1 true RU2707751C1 (ru) 2019-11-29

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RU2018139648A RU2707751C1 (ru) 2017-03-20 2018-03-20 Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr)
RU2019137023A RU2736217C2 (ru) 2017-03-20 2018-03-20 Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr)
RU2020136402A RU2020136402A (ru) 2017-03-20 2020-11-06 Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr)

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RU2020136402A RU2020136402A (ru) 2017-03-20 2020-11-06 Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr)

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US (8) US10208052B1 (https=)
EP (3) EP3680241A1 (https=)
JP (2) JP6594570B2 (https=)
KR (2) KR102007135B1 (https=)
CN (2) CN113456634A (https=)
AR (2) AR111295A1 (https=)
AU (4) AU2018240172C1 (https=)
CA (1) CA3024181C (https=)
CY (2) CY1122393T1 (https=)
DK (2) DK3483164T3 (https=)
EA (1) EA201992215A1 (https=)
ES (2) ES2747768T3 (https=)
HR (2) HRP20191665T1 (https=)
HU (2) HUE049979T2 (https=)
IL (2) IL269447B (https=)
LT (2) LT3448859T (https=)
MA (3) MA50589A (https=)
MD (2) MD3483164T2 (https=)
MX (2) MX2020013936A (https=)
NZ (2) NZ763766A (https=)
PL (2) PL3448859T3 (https=)
PT (2) PT3483164T (https=)
RS (2) RS59306B1 (https=)
RU (3) RU2707751C1 (https=)
SA (1) SA519410164B1 (https=)
SG (1) SG11201908670SA (https=)
SI (2) SI3483164T1 (https=)
SM (2) SMT201900517T1 (https=)
TN (2) TN2020000045A1 (https=)
TW (2) TWI887559B (https=)
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