JO3611B1 - سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم - Google Patents

سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم

Info

Publication number
JO3611B1
JO3611B1 JOP/2012/0223A JOP20120223A JO3611B1 JO 3611 B1 JO3611 B1 JO 3611B1 JO P20120223 A JOP20120223 A JO P20120223A JO 3611 B1 JO3611 B1 JO 3611B1
Authority
JO
Jordan
Prior art keywords
naphthyridinones
dihydro
pyrrole substituted
cyclopenta
antibacterial
Prior art date
Application number
JOP/2012/0223A
Other languages
English (en)
Inventor
David Francis Alain Lancois
Magali Madeleine Simone Motte
Jerôme Emile Georges Guillemont
Wendy Mia Albert Balemans
Anil Koul
Eric Pierre Alexandre Arnoult
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46650549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3611(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Application granted granted Critical
Publication of JO3611B1 publication Critical patent/JO3611B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

<strong>يتعلق الاختراع الحالي بمركبات مبتكرة لها الصيغ</strong><span dir="LTR"> (I) </span><strong>والتي تمنع نشاط انزيم فاب 1 وهي مفيدة بالتالي بمعالجة الاصابات الجرثومية. كما ايضا بتركيبات صيدلانية تشتمل على تلك المركبات وعمليات كيميائية لتحضير تلك المركبات</strong><span dir="LTR">.</span>
JOP/2012/0223A 2011-08-10 2012-08-07 سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم JO3611B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11177119 2011-08-10

Publications (1)

Publication Number Publication Date
JO3611B1 true JO3611B1 (ar) 2020-08-27

Family

ID=46650549

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2012/0223A JO3611B1 (ar) 2011-08-10 2012-08-07 سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم

Country Status (24)

Country Link
US (7) US8906923B2 (ar)
EP (1) EP2742045B1 (ar)
JP (2) JP5921687B2 (ar)
KR (1) KR101996862B1 (ar)
CN (2) CN105461684B (ar)
AR (1) AR087508A1 (ar)
AU (1) AU2012293621B2 (ar)
BR (1) BR112014003063B1 (ar)
CA (1) CA2842518C (ar)
CL (1) CL2014000289A1 (ar)
DK (1) DK2742045T3 (ar)
EA (1) EA201490438A1 (ar)
ES (1) ES2721658T3 (ar)
HK (2) HK1199243A1 (ar)
HU (1) HUE042978T2 (ar)
IL (1) IL230549A (ar)
JO (1) JO3611B1 (ar)
MX (1) MX348128B (ar)
PE (1) PE20141410A1 (ar)
TR (1) TR201905537T4 (ar)
TW (1) TWI568731B (ar)
UA (1) UA111210C2 (ar)
UY (1) UY34253A (ar)
WO (1) WO2013021054A1 (ar)

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JO3611B1 (ar) 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
ES2881681T3 (es) 2011-08-10 2021-11-30 Janssen Sciences Ireland Unlimited Co 3,4-Dihidro-1H-[1,8]naftiridinonas sustituidas con piperidinilo antibacterianas
JP6250667B2 (ja) * 2012-08-10 2017-12-20 ヤンセン・サイエンシズ・アイルランド・ユーシー 新しい抗菌化合物
US9540324B2 (en) 2013-09-26 2017-01-10 Luc Therapeutics, Inc. Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
ES2747768T3 (es) 2017-03-20 2020-03-11 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR)
WO2019177975A1 (en) 2018-03-12 2019-09-19 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens
CN113226356A (zh) 2018-09-19 2021-08-06 福马治疗股份有限公司 活化丙酮酸激酶r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
WO2020099341A1 (en) * 2018-11-12 2020-05-22 Debiopharm International S.A. Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof

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JP4961084B2 (ja) 1999-10-08 2012-06-27 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
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DE60230934D1 (de) * 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
PL1828167T3 (pl) * 2004-06-04 2015-02-27 Debiopharm Int Sa Pochodne akryloamidu jako środki antybiotykowe
US7732612B2 (en) 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
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EP2687533B1 (en) * 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
KR20130010456A (ko) * 2009-11-18 2013-01-28 에프에이비 파마 에스에이에스 신규의 헤테로사이클릭 아크릴아미드 및 약제로서 이의 용도
US8766017B2 (en) 2011-07-29 2014-07-01 Eastman Chemical Company Integrated process for the preparation of 1,4-cyclohexanedimethanol from terephthalic acid
WO2013019710A1 (en) 2011-07-29 2013-02-07 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hiv
US9394295B2 (en) 2011-08-10 2016-07-19 Janssen Sciences Ireland Uc Antibacterial homopiperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones
ES2881681T3 (es) 2011-08-10 2021-11-30 Janssen Sciences Ireland Unlimited Co 3,4-Dihidro-1H-[1,8]naftiridinonas sustituidas con piperidinilo antibacterianas
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم

Also Published As

Publication number Publication date
US20160194324A1 (en) 2016-07-07
US8906923B2 (en) 2014-12-09
IL230549A0 (en) 2014-03-31
EA201490438A1 (ru) 2014-06-30
CN103874698B (zh) 2016-03-23
MX2014001600A (es) 2014-04-25
UA111210C2 (uk) 2016-04-11
US10501463B2 (en) 2019-12-10
JP5921687B2 (ja) 2016-05-24
US20190194194A1 (en) 2019-06-27
BR112014003063B1 (pt) 2020-11-17
US9617262B2 (en) 2017-04-11
HK1199243A1 (zh) 2015-06-26
CA2842518A1 (en) 2013-02-14
IL230549A (en) 2017-07-31
US20170174683A1 (en) 2017-06-22
BR112014003063A2 (pt) 2017-02-21
NZ620212A (en) 2015-10-30
ES2721658T3 (es) 2019-08-02
JP2014531404A (ja) 2014-11-27
CA2842518C (en) 2019-07-23
PE20141410A1 (es) 2014-10-13
KR20140072034A (ko) 2014-06-12
TW201313714A (zh) 2013-04-01
CN105461684B (zh) 2018-09-25
US20140171451A1 (en) 2014-06-19
AU2012293621B2 (en) 2016-07-21
US10526331B2 (en) 2020-01-07
US9290493B2 (en) 2016-03-22
EP2742045B1 (en) 2019-01-23
EP2742045A1 (en) 2014-06-18
US9884864B2 (en) 2018-02-06
TWI568731B (zh) 2017-02-01
CN105461684A (zh) 2016-04-06
JP2016190843A (ja) 2016-11-10
MX348128B (es) 2017-05-26
CL2014000289A1 (es) 2014-07-11
KR101996862B1 (ko) 2019-07-05
HK1223352A1 (zh) 2017-07-28
TR201905537T4 (tr) 2019-05-21
HUE042978T2 (hu) 2019-07-29
AU2012293621A1 (en) 2014-02-13
US10155759B2 (en) 2018-12-18
US20180105525A1 (en) 2018-04-19
US20150080413A1 (en) 2015-03-19
US20190084982A1 (en) 2019-03-21
UY34253A (es) 2013-02-28
WO2013021054A1 (en) 2013-02-14
CN103874698A (zh) 2014-06-18
AR087508A1 (es) 2014-03-26
DK2742045T3 (en) 2019-04-23

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