AR087508A1 - 3,4-dihidro-1h-[1,8]naftiridinonas antibacterianas sustituidas con ciclopenta[c]pirrol - Google Patents
3,4-dihidro-1h-[1,8]naftiridinonas antibacterianas sustituidas con ciclopenta[c]pirrolInfo
- Publication number
- AR087508A1 AR087508A1 ARP120102929A ARP120102929A AR087508A1 AR 087508 A1 AR087508 A1 AR 087508A1 AR P120102929 A ARP120102929 A AR P120102929A AR P120102929 A ARP120102929 A AR P120102929A AR 087508 A1 AR087508 A1 AR 087508A1
- Authority
- AR
- Argentina
- Prior art keywords
- benzyl
- alkyl
- halo
- heteroaryl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1), donde A representa -CºC- o un resto de fórmula (2); el enlace - - - - - representa un enlace simple o un enlace doble; Z1 representa CH o N; X representa carbono o nitrógeno, y cuando X representa nitrógeno, entonces el enlace - - - - - representa un enlace simple; R1 es hidrógeno, alquilo C1-4 o halo; R2 es hidrógeno, alquilo C1-4 o halo; R3 es hidrogeno, alquilo C1-6 hidroxi o halo; R4 es hidrógeno; halo; alquilo C1-6; alquenilo C2-6; alquinilo C2-6; alquiloxi C1-6; alquiloxicarbonilo C1-4; aminocarbonilo; mono- o di(alquilo C1-4)-aminocarbonilo; arilo; ariloxi; arilcarbonilo; arilsulfonilo; heteroarilo; alquilo C1-6 sustituido con ciano; alquilo C1-6 sustituido con arilo o ariloxi; o alquilo C1-6 sustituido con heteroarilo; arilo es fenilo; fenilo sustituido con uno, dos o tres sustituyentes cada uno seleccionado individualmente entre halo, hidroxi, alquilo C1-4, alquiloxi C1-4, polihaloalquilo C1-4, polihaloalquiloxi C1-4, ciano, nitro y amino; heteroarilo es furanilo, tiofenilo, pirrolilo, pirazolilo, imidazolilo, isoxazolilo, tiazolilo, triazolilo, tetrazolilo, isotiazolilo, tiadiazolilo, oxadiazolilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo, benzo[1,3]dioxolilo, benzofuranilo, benzotiazolilo, indolilo, 2,3-dihidro-1H-indolilo, tetrahidrotiofenilo, o quinolinilo, donde cada heteroarilo puede sustituirse con uno o dos sustituyentes seleccionados cada uno independientemente entre halo, ciano, alquilo C1-4, alquiloxi C1-4, alquilcarbonilo C1-4, o fenilo; o una de sus sales de adición de ácido farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11177119 | 2011-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR087508A1 true AR087508A1 (es) | 2014-03-26 |
Family
ID=46650549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120102929A AR087508A1 (es) | 2011-08-10 | 2012-08-10 | 3,4-dihidro-1h-[1,8]naftiridinonas antibacterianas sustituidas con ciclopenta[c]pirrol |
Country Status (24)
Country | Link |
---|---|
US (7) | US8906923B2 (es) |
EP (1) | EP2742045B1 (es) |
JP (2) | JP5921687B2 (es) |
KR (1) | KR101996862B1 (es) |
CN (2) | CN105461684B (es) |
AR (1) | AR087508A1 (es) |
AU (1) | AU2012293621B2 (es) |
BR (1) | BR112014003063B1 (es) |
CA (1) | CA2842518C (es) |
CL (1) | CL2014000289A1 (es) |
DK (1) | DK2742045T3 (es) |
EA (1) | EA201490438A1 (es) |
ES (1) | ES2721658T3 (es) |
HK (2) | HK1199243A1 (es) |
HU (1) | HUE042978T2 (es) |
IL (1) | IL230549A (es) |
JO (1) | JO3611B1 (es) |
MX (1) | MX348128B (es) |
PE (1) | PE20141410A1 (es) |
TR (1) | TR201905537T4 (es) |
TW (1) | TWI568731B (es) |
UA (1) | UA111210C2 (es) |
UY (1) | UY34253A (es) |
WO (1) | WO2013021054A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105503869A (zh) | 2011-08-10 | 2016-04-20 | 爱尔兰詹森科学公司 | 抗细菌的哌啶基取代的3,4-二氢-1h-[1,8]萘啶酮 |
JO3611B1 (ar) | 2011-08-10 | 2020-08-27 | Janssen Sciences Ireland Uc | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم |
EA201590339A1 (ru) * | 2012-08-10 | 2015-06-30 | Янссен Сайенсиз Айрлэнд Юси | Новые антибактериальные соединения |
JP6546596B2 (ja) | 2013-09-26 | 2019-07-17 | カデント セラピューティクス,インコーポレーテッド | Nr2bの選択的オクタヒドロ−シクロペンタ[c]ピロール負調節因子 |
JO3579B1 (ar) * | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول |
KR102296703B1 (ko) | 2017-03-20 | 2021-09-01 | 포르마 세라퓨틱스 인크. | 피루베이트 키나제 (pkr) 활성화제로서의 피롤로피롤 조성물 |
US11691967B2 (en) | 2018-03-12 | 2023-07-04 | The Board Of Trustees Of The University Of Illinois | Antibiotics effective for gram-negative pathogens |
US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
BR112021005188A2 (pt) | 2018-09-19 | 2021-06-08 | Forma Therapeutics, Inc. | tratamento de anemia falciforme com um composto de ativação de piruvato cinase r |
KR20210093292A (ko) * | 2018-11-12 | 2021-07-27 | 데비오팜 인터네셔날 에스 에이 | 항생제 화합물, 이의 제조 방법, 이를 포함하는 약학적 조성물 및 그 용도 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4215123A (en) * | 1979-05-07 | 1980-07-29 | American Home Products Corporation | Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives |
CZ302015B6 (cs) | 1999-10-08 | 2010-09-08 | Affinium Pharmaceuticals, Inc. | Inhibitory Fab I |
JP4831907B2 (ja) | 1999-10-08 | 2011-12-07 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | FabI阻害剤 |
CO5251401A1 (es) | 1999-10-08 | 2003-02-28 | Smithkline Beecham Corp | Inhibidores de fab i |
ATE420640T1 (de) | 2001-04-06 | 2009-01-15 | Affinium Pharm Inc | Fab-i-inhibitoren |
SI1828167T1 (sl) | 2004-06-04 | 2014-12-31 | Debiopharm International Sa Forum "Apres-Demain" | Akrilamidni derivati kot anitibiotična sredstva |
US7732612B2 (en) | 2004-09-09 | 2010-06-08 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
US7973060B2 (en) | 2005-10-13 | 2011-07-05 | Crystalgenomics, Inc. | Fab I inhibitor and process for preparing same |
EP2054422B1 (en) * | 2006-07-20 | 2017-06-14 | Debiopharm International SA | Acrylamide derivatives as fab i inhibitors |
WO2008098374A1 (en) * | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
AU2010320963B2 (en) | 2009-11-18 | 2015-07-09 | Fab Pharma Sas | Novel heterocyclic acrylamides and their use as pharmaceuticals |
JP2014524409A (ja) | 2011-07-29 | 2014-09-22 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | Hivの治療のための組成物および方法 |
US8766017B2 (en) | 2011-07-29 | 2014-07-01 | Eastman Chemical Company | Integrated process for the preparation of 1,4-cyclohexanedimethanol from terephthalic acid |
CN105503869A (zh) | 2011-08-10 | 2016-04-20 | 爱尔兰詹森科学公司 | 抗细菌的哌啶基取代的3,4-二氢-1h-[1,8]萘啶酮 |
JP6521631B2 (ja) | 2011-08-10 | 2019-05-29 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | 抗菌性ホモピペリジニル置換3,4−ジヒドロ−1h−[1,8]−ナフチリジノン類 |
JO3611B1 (ar) * | 2011-08-10 | 2020-08-27 | Janssen Sciences Ireland Uc | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم |
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2012
- 2012-08-07 JO JOP/2012/0223A patent/JO3611B1/ar active
- 2012-08-10 EA EA201490438A patent/EA201490438A1/ru unknown
- 2012-08-10 PE PE2014000186A patent/PE20141410A1/es active IP Right Grant
- 2012-08-10 ES ES12746093T patent/ES2721658T3/es active Active
- 2012-08-10 TW TW101128885A patent/TWI568731B/zh active
- 2012-08-10 AR ARP120102929A patent/AR087508A1/es active IP Right Grant
- 2012-08-10 US US14/237,862 patent/US8906923B2/en active Active
- 2012-08-10 CN CN201511000870.XA patent/CN105461684B/zh active Active
- 2012-08-10 MX MX2014001600A patent/MX348128B/es active IP Right Grant
- 2012-08-10 AU AU2012293621A patent/AU2012293621B2/en active Active
- 2012-08-10 TR TR2019/05537T patent/TR201905537T4/tr unknown
- 2012-08-10 EP EP12746093.9A patent/EP2742045B1/en active Active
- 2012-08-10 CA CA2842518A patent/CA2842518C/en active Active
- 2012-08-10 CN CN201280038643.4A patent/CN103874698B/zh active Active
- 2012-08-10 KR KR1020147005329A patent/KR101996862B1/ko active IP Right Grant
- 2012-08-10 DK DK12746093.9T patent/DK2742045T3/en active
- 2012-08-10 UY UY0001034253A patent/UY34253A/es active IP Right Grant
- 2012-08-10 HU HUE12746093A patent/HUE042978T2/hu unknown
- 2012-08-10 WO PCT/EP2012/065733 patent/WO2013021054A1/en active Application Filing
- 2012-08-10 JP JP2014524410A patent/JP5921687B2/ja active Active
- 2012-08-10 BR BR112014003063-4A patent/BR112014003063B1/pt active IP Right Grant
- 2012-10-08 UA UAA201400628A patent/UA111210C2/uk unknown
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2014
- 2014-01-20 IL IL230549A patent/IL230549A/en active IP Right Grant
- 2014-02-05 CL CL2014000289A patent/CL2014000289A1/es unknown
- 2014-11-24 US US14/552,108 patent/US9290493B2/en active Active
- 2014-12-18 HK HK14112687.7A patent/HK1199243A1/zh unknown
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2016
- 2016-03-16 US US15/071,612 patent/US9617262B2/en active Active
- 2016-04-12 JP JP2016079689A patent/JP2016190843A/ja not_active Withdrawn
- 2016-10-03 HK HK16111498.6A patent/HK1223352A1/zh unknown
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2017
- 2017-03-09 US US15/454,703 patent/US9884864B2/en active Active
- 2017-12-18 US US15/845,854 patent/US10155759B2/en active Active
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2018
- 2018-11-16 US US16/194,052 patent/US10501463B2/en active Active
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2019
- 2019-02-26 US US16/286,383 patent/US10526331B2/en active Active
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