DK3448859T3 - Pyrrolopyrrolsammensætninger som pyruvatkinase- (pkr) aktivatorer - Google Patents

Pyrrolopyrrolsammensætninger som pyruvatkinase- (pkr) aktivatorer Download PDF

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Publication number
DK3448859T3
DK3448859T3 DK18716455.3T DK18716455T DK3448859T3 DK 3448859 T3 DK3448859 T3 DK 3448859T3 DK 18716455 T DK18716455 T DK 18716455T DK 3448859 T3 DK3448859 T3 DK 3448859T3
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Prior art keywords
pyrrolopyrrol
pkr
activators
compositions
pyruvat
Prior art date
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DK18716455.3T
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English (en)
Inventor
Anna Ericsson
Neal Green
Gary Gustafson
Bingsong Han
Jr David R Lancia
Lorna Mitchell
David Richard
Tatiana Shelekhin
Chase C Smith
Zhongguo Wang
Xiaozhang Zheng
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Forma Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
DK18716455.3T 2017-03-20 2018-03-20 Pyrrolopyrrolsammensætninger som pyruvatkinase- (pkr) aktivatorer DK3448859T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762473751P 2017-03-20 2017-03-20
PCT/US2018/023405 WO2018175474A1 (en) 2017-03-20 2018-03-20 Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators

Publications (1)

Publication Number Publication Date
DK3448859T3 true DK3448859T3 (da) 2019-09-23

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK18716455.3T DK3448859T3 (da) 2017-03-20 2018-03-20 Pyrrolopyrrolsammensætninger som pyruvatkinase- (pkr) aktivatorer
DK18209919.2T DK3483164T3 (da) 2017-03-20 2018-03-20 Pyrrolopyrrolsammensætninger som pyruvatkinase (pkr) aktivatorer

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Country Status (32)

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US (7) US11014927B2 (da)
EP (3) EP3483164B1 (da)
JP (2) JP6594570B2 (da)
KR (2) KR102007135B1 (da)
CN (2) CN109311897B (da)
AR (2) AR111295A1 (da)
AU (4) AU2018240172C1 (da)
BR (1) BR112018075312A2 (da)
CA (1) CA3024181C (da)
CY (2) CY1122393T1 (da)
DK (2) DK3448859T3 (da)
EA (1) EA201992215A1 (da)
ES (2) ES2788856T3 (da)
HR (2) HRP20191665T1 (da)
HU (2) HUE049979T2 (da)
IL (2) IL269447B (da)
LT (2) LT3483164T (da)
MA (3) MA44795B1 (da)
MD (2) MD3448859T2 (da)
MX (2) MX2020013936A (da)
NZ (2) NZ763766A (da)
PL (2) PL3483164T3 (da)
PT (2) PT3483164T (da)
RS (2) RS60209B1 (da)
RU (3) RU2736217C2 (da)
SA (1) SA519410164B1 (da)
SG (1) SG11201908670SA (da)
SI (2) SI3483164T1 (da)
TN (2) TN2020000045A1 (da)
TW (2) TWI772389B (da)
WO (1) WO2018175474A1 (da)
ZA (1) ZA201906278B (da)

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MY187449A (en) 2013-11-26 2021-09-22 Hoffmann La Roche New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl
HUE046820T2 (hu) 2014-03-26 2020-03-30 Hoffmann La Roche Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként
JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CR20180058A (es) 2015-09-04 2018-02-26 Hoffmann La Roche Nuevos derivados de fenoximetilo
KR20180054830A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 오토탁신(atx) 억제제로서의 이환형 화합물
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MX2018001890A (es) 2015-09-24 2018-06-20 Hoffmann La Roche Compuestos biciclicos como inhibidores de autotaxina (atx).
CN107922415B (zh) * 2015-09-24 2022-04-15 豪夫迈·罗氏有限公司 新的作为双重atx/ca抑制剂的二环化合物
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EP3852791A4 (en) * 2018-09-19 2022-06-15 Forma Therapeutics, Inc. ACTIVATION OF PYRUVATE KINASE R
US20220031671A1 (en) * 2018-09-19 2022-02-03 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
BR112021004599A2 (pt) * 2018-09-19 2021-05-25 Forma Therapeutics, Inc. inibição de peptidase 9x específica de ubiquitina
US20210346356A1 (en) * 2018-09-19 2021-11-11 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
WO2020191022A1 (en) * 2019-03-18 2020-09-24 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
WO2021055863A1 (en) * 2019-09-19 2021-03-25 Forma Therapeutics, Inc. Pyruvate kinase r (pkr) activating compositions
WO2021055807A1 (en) * 2019-09-19 2021-03-25 Forma Therapeutics, Inc. Activating pyruvate kinase r
WO2021202796A1 (en) * 2020-04-01 2021-10-07 Global Blood Therapeutics, Inc. Pyrrolidine-pyrazoles as pyruvate kinase activators
US20220087983A1 (en) * 2020-09-18 2022-03-24 Forma Therapeutics, Inc. Activating pyruvate kinase r
WO2023116774A1 (zh) * 2021-12-21 2023-06-29 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构的化合物及其在医药上的用途
CN115957219B (zh) * 2022-12-27 2024-04-19 北京大学 M2亚型丙酮酸激酶凝聚体的解聚剂在制备抗衰老药物中的应用

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