DK3458460T3 - Imidazoler som histondemethylase-inhibitorer - Google Patents
Imidazoler som histondemethylase-inhibitorer Download PDFInfo
- Publication number
- DK3458460T3 DK3458460T3 DK17723710.4T DK17723710T DK3458460T3 DK 3458460 T3 DK3458460 T3 DK 3458460T3 DK 17723710 T DK17723710 T DK 17723710T DK 3458460 T3 DK3458460 T3 DK 3458460T3
- Authority
- DK
- Denmark
- Prior art keywords
- histondemethylase
- imidazoles
- inhibitors
- histondemethylase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16170238.6A EP3246330A1 (en) | 2016-05-18 | 2016-05-18 | Imidazoles as histone demethylase inhibitors |
| PCT/EP2017/062009 WO2017198780A1 (en) | 2016-05-18 | 2017-05-18 | Imidazoles as histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3458460T3 true DK3458460T3 (da) | 2021-03-01 |
Family
ID=56014931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17723710.4T DK3458460T3 (da) | 2016-05-18 | 2017-05-18 | Imidazoler som histondemethylase-inhibitorer |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10562914B2 (da) |
| EP (2) | EP3246330A1 (da) |
| JP (1) | JP6972024B2 (da) |
| CN (1) | CN109641918B (da) |
| AU (1) | AU2017266325B2 (da) |
| CA (1) | CA3063785C (da) |
| DK (1) | DK3458460T3 (da) |
| WO (1) | WO2017198780A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
| CA3071804A1 (en) | 2017-08-03 | 2019-02-07 | Oryzon Genomics, S.A. | Use of a kdm1a inhibitor in the treatment of behavior alterations |
| CN113631164A (zh) | 2019-03-20 | 2021-11-09 | 奥莱松基因组股份有限公司 | 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法 |
| HRP20260110T1 (hr) | 2019-03-20 | 2026-03-13 | Oryzon Genomics, S.A. | Vafidemstat za liječenje neagresivnih simptoma graničnog poremećaja osobnosti |
| JP2022546908A (ja) | 2019-07-05 | 2022-11-10 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法 |
| IT202000007873A1 (it) | 2020-04-14 | 2021-10-14 | St Europeo Di Oncologia S R L | Molecole per uso nel trattamento delle infezioni virali |
| WO2022058405A2 (en) | 2020-09-16 | 2022-03-24 | Ifom - Istituto Firc Di Oncologia Molecolare | Histone deacetylase inhibitors and uses thereof |
| MX2023011779A (es) | 2021-04-08 | 2023-11-22 | Oryzon Genomics Sa | Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides. |
| CN119497613A (zh) | 2022-05-09 | 2025-02-21 | 奥莱松基因组股份有限公司 | 使用lsd1抑制剂治疗nf1-突变肿瘤的方法 |
| US20250275969A1 (en) | 2022-05-09 | 2025-09-04 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
| CN120529900A (zh) | 2022-11-24 | 2025-08-22 | 奥莱松基因组股份有限公司 | 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204018A (en) | 1990-02-01 | 1993-04-20 | Hoffmann-La Roche Inc. | Liquid crystals |
| GB0321003D0 (en) * | 2003-09-09 | 2003-10-08 | Angeletti P Ist Richerche Bio | Compounds, compositions and uses |
| WO2006077412A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Thienopyrroles useful in the treatment of inflammation |
| WO2009121033A2 (en) * | 2008-03-27 | 2009-10-01 | University Of Southern California | Substituted nitrogen heterocycles and synthesis and uses thereof |
| US8389580B2 (en) | 2009-06-02 | 2013-03-05 | Duke University | Arylcyclopropylamines and methods of use |
| ES2564352T3 (es) | 2010-04-20 | 2016-03-22 | Università Degli Studi Di Roma "La Sapienza" | Derivados de tranilcipromina como inhibidores de la histona-desmetilasa LSD1 y/o LSD2 |
| WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| CA2823955A1 (en) | 2011-01-19 | 2012-07-26 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-ht6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
| CN103842332B (zh) | 2011-08-09 | 2016-08-17 | 武田药品工业株式会社 | 环丙胺化合物 |
| WO2013025805A1 (en) | 2011-08-15 | 2013-02-21 | University Of Utah Research Foundation | Substituted (e)-n'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhiitors |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| WO2014164867A1 (en) * | 2013-03-11 | 2014-10-09 | Imago Biosciences | Kdm1a inhibitors for the treatment of disease |
| US9133166B2 (en) | 2013-03-14 | 2015-09-15 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| CA2915566C (en) * | 2013-06-18 | 2021-12-21 | 4Sc Discovery Gmbh | 2,3-dihydrobenzofuran-5-yl compounds as dyrk kinase inhibitors |
| CN104278008B (zh) * | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
| TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| EP2993175A1 (en) | 2014-09-05 | 2016-03-09 | IEO - Istituto Europeo di Oncologia Srl | Thienopyrroles as histone demethylase inhibitors |
| EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
-
2016
- 2016-05-18 EP EP16170238.6A patent/EP3246330A1/en not_active Withdrawn
-
2017
- 2017-05-18 EP EP17723710.4A patent/EP3458460B1/en active Active
- 2017-05-18 AU AU2017266325A patent/AU2017266325B2/en active Active
- 2017-05-18 CN CN201780044641.9A patent/CN109641918B/zh active Active
- 2017-05-18 JP JP2018560892A patent/JP6972024B2/ja active Active
- 2017-05-18 WO PCT/EP2017/062009 patent/WO2017198780A1/en not_active Ceased
- 2017-05-18 US US16/301,875 patent/US10562914B2/en active Active
- 2017-05-18 CA CA3063785A patent/CA3063785C/en active Active
- 2017-05-18 DK DK17723710.4T patent/DK3458460T3/da active
-
2019
- 2019-12-20 US US16/722,554 patent/US10961255B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN109641918B (zh) | 2021-12-21 |
| CN109641918A (zh) | 2019-04-16 |
| AU2017266325B2 (en) | 2021-07-08 |
| EP3458460B1 (en) | 2020-12-09 |
| CA3063785A1 (en) | 2017-11-23 |
| WO2017198780A1 (en) | 2017-11-23 |
| CA3063785C (en) | 2024-10-29 |
| JP2019519520A (ja) | 2019-07-11 |
| US20190152987A1 (en) | 2019-05-23 |
| JP6972024B2 (ja) | 2021-11-24 |
| EP3458460A1 (en) | 2019-03-27 |
| US10961255B2 (en) | 2021-03-30 |
| AU2017266325A1 (en) | 2019-01-17 |
| EP3246330A1 (en) | 2017-11-22 |
| US20200299303A1 (en) | 2020-09-24 |
| US10562914B2 (en) | 2020-02-18 |
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