DK3458460T3 - Imidazoler som histondemethylase-inhibitorer - Google Patents
Imidazoler som histondemethylase-inhibitorer Download PDFInfo
- Publication number
- DK3458460T3 DK3458460T3 DK17723710.4T DK17723710T DK3458460T3 DK 3458460 T3 DK3458460 T3 DK 3458460T3 DK 17723710 T DK17723710 T DK 17723710T DK 3458460 T3 DK3458460 T3 DK 3458460T3
- Authority
- DK
- Denmark
- Prior art keywords
- histondemethylase
- imidazoles
- inhibitors
- histondemethylase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16170238.6A EP3246330A1 (en) | 2016-05-18 | 2016-05-18 | Imidazoles as histone demethylase inhibitors |
| PCT/EP2017/062009 WO2017198780A1 (en) | 2016-05-18 | 2017-05-18 | Imidazoles as histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3458460T3 true DK3458460T3 (da) | 2021-03-01 |
Family
ID=56014931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17723710.4T DK3458460T3 (da) | 2016-05-18 | 2017-05-18 | Imidazoler som histondemethylase-inhibitorer |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10562914B2 (da) |
| EP (2) | EP3246330A1 (da) |
| JP (1) | JP6972024B2 (da) |
| CN (1) | CN109641918B (da) |
| AU (1) | AU2017266325B2 (da) |
| CA (1) | CA3063785A1 (da) |
| DK (1) | DK3458460T3 (da) |
| WO (1) | WO2017198780A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
| BR112020000827A2 (pt) | 2017-08-03 | 2020-07-21 | Oryzon Genomics, S.A. | métodos de tratamento de alterações de comportamento |
| US20220151998A1 (en) | 2019-03-20 | 2022-05-19 | Oryzon Genomics, S.A. | Methods of treating borderline personality disorder |
| JP2022526755A (ja) | 2019-03-20 | 2022-05-26 | オリソン ヘノミクス，ソシエダ アノニマ | 化合物バフィデムスタット（ｖａｆｉｄｅｍｓｔａｔ）などｋｄｍ１ａ阻害剤を使用した注意欠陥多動性障害の処置方法 |
| JP2022546908A (ja) | 2019-07-05 | 2022-11-10 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法 |
| IT202000007873A1 (it) | 2020-04-14 | 2021-10-14 | St Europeo Di Oncologia S R L | Molecole per uso nel trattamento delle infezioni virali |
| WO2022058405A2 (en) | 2020-09-16 | 2022-03-24 | Ifom - Istituto Firc Di Oncologia Molecolare | Histone deacetylase inhibitors and uses thereof |
| WO2022214303A1 (en) | 2021-04-08 | 2022-10-13 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors for treating myeloid cancers |
| WO2023217784A1 (en) | 2022-05-09 | 2023-11-16 | Oryzon Genomics, S.A. | Methods of treating nf1-mutant tumors using lsd1 inhibitors |
| WO2023217758A1 (en) | 2022-05-09 | 2023-11-16 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204018A (en) | 1990-02-01 | 1993-04-20 | Hoffmann-La Roche Inc. | Liquid crystals |
| GB0321003D0 (en) * | 2003-09-09 | 2003-10-08 | Angeletti P Ist Richerche Bio | Compounds, compositions and uses |
| JP2008527032A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なチエノピロール |
| US20110098483A1 (en) * | 2008-03-27 | 2011-04-28 | University Of Southern California | Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof |
| US8389580B2 (en) | 2009-06-02 | 2013-03-05 | Duke University | Arylcyclopropylamines and methods of use |
| EP2560949B1 (en) | 2010-04-20 | 2015-12-02 | Università degli Studi di Roma "La Sapienza" | Tranylcypromine derivatives as inhibitors of histone demethylase lsd1 and/or lsd2 |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| EP2668191A4 (en) | 2011-01-19 | 2014-08-20 | Albany Molecular Res Inc | BENZOFURO- [3,2-C-] PYRIDINES AND RELATED ANALOGS AS SEROTONIN-SUBTYPE-6 (5-HT6) MODULATORS FOR THE TREATMENT OF ADIPOSITAS, METABOLISM SYNDROME, COGNITION AND SCHIZOPHRENIA |
| AP2014007488A0 (en) | 2011-08-09 | 2014-03-31 | Takeda Pharmaceutical | Cyclopropaneamine compound |
| US8987335B2 (en) | 2011-08-15 | 2015-03-24 | University Of Utah Research Foundation | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| WO2014164867A1 (en) * | 2013-03-11 | 2014-10-09 | Imago Biosciences | Kdm1a inhibitors for the treatment of disease |
| JP6276378B2 (ja) | 2013-03-14 | 2018-02-07 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| WO2014202638A1 (en) * | 2013-06-18 | 2014-12-24 | 4Sc Discovery Gmbh | 2,3-dihydrobenzofuran-5-yl compounds as dyrk kinase inhibitors |
| CN104278008B (zh) * | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
| US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
| EP2993175A1 (en) * | 2014-09-05 | 2016-03-09 | IEO - Istituto Europeo di Oncologia Srl | Thienopyrroles as histone demethylase inhibitors |
| EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
-
2016
- 2016-05-18 EP EP16170238.6A patent/EP3246330A1/en not_active Withdrawn
-
2017
- 2017-05-18 US US16/301,875 patent/US10562914B2/en active Active
- 2017-05-18 CA CA3063785A patent/CA3063785A1/en active Pending
- 2017-05-18 JP JP2018560892A patent/JP6972024B2/ja active Active
- 2017-05-18 AU AU2017266325A patent/AU2017266325B2/en active Active
- 2017-05-18 EP EP17723710.4A patent/EP3458460B1/en active Active
- 2017-05-18 WO PCT/EP2017/062009 patent/WO2017198780A1/en unknown
- 2017-05-18 DK DK17723710.4T patent/DK3458460T3/da active
- 2017-05-18 CN CN201780044641.9A patent/CN109641918B/zh active Active
-
2019
- 2019-12-20 US US16/722,554 patent/US10961255B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3458460A1 (en) | 2019-03-27 |
| US20200299303A1 (en) | 2020-09-24 |
| US10961255B2 (en) | 2021-03-30 |
| JP6972024B2 (ja) | 2021-11-24 |
| EP3246330A1 (en) | 2017-11-22 |
| US10562914B2 (en) | 2020-02-18 |
| EP3458460B1 (en) | 2020-12-09 |
| JP2019519520A (ja) | 2019-07-11 |
| WO2017198780A1 (en) | 2017-11-23 |
| CN109641918B (zh) | 2021-12-21 |
| AU2017266325A1 (en) | 2019-01-17 |
| CA3063785A1 (en) | 2017-11-23 |
| CN109641918A (zh) | 2019-04-16 |
| US20190152987A1 (en) | 2019-05-23 |
| AU2017266325B2 (en) | 2021-07-08 |
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