DE69329106T2 - Oxazolidinderivat und sein pharmazeutisch verträgliches salz - Google Patents
Oxazolidinderivat und sein pharmazeutisch verträgliches salzInfo
- Publication number
- DE69329106T2 DE69329106T2 DE69329106T DE69329106T DE69329106T2 DE 69329106 T2 DE69329106 T2 DE 69329106T2 DE 69329106 T DE69329106 T DE 69329106T DE 69329106 T DE69329106 T DE 69329106T DE 69329106 T2 DE69329106 T2 DE 69329106T2
- Authority
- DE
- Germany
- Prior art keywords
- represent
- alkyl
- alkylene
- optionally halogenated
- coor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11177392 | 1992-04-30 | ||
PCT/JP1993/000559 WO1993022298A1 (en) | 1992-04-30 | 1993-04-28 | Oxazolidine derivative and pharmaceutically acceptable salt thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69329106D1 DE69329106D1 (de) | 2000-08-31 |
DE69329106T2 true DE69329106T2 (de) | 2001-03-22 |
Family
ID=14569807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69329106T Expired - Fee Related DE69329106T2 (de) | 1992-04-30 | 1993-04-28 | Oxazolidinderivat und sein pharmazeutisch verträgliches salz |
Country Status (10)
Country | Link |
---|---|
US (1) | US5480899A (de) |
EP (1) | EP0605729B1 (de) |
KR (1) | KR0146931B1 (de) |
AT (1) | ATE194981T1 (de) |
AU (1) | AU653896B2 (de) |
CA (1) | CA2112129C (de) |
DE (1) | DE69329106T2 (de) |
FI (1) | FI935920A0 (de) |
HU (2) | HU220601B1 (de) |
WO (1) | WO1993022298A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU653896B2 (en) * | 1992-04-30 | 1994-10-13 | Taiho Pharmaceutical Co., Ltd. | Oxazolidine derivative and pharmaceutically acceptable salt thereof |
DK1251127T3 (da) * | 1992-12-23 | 2006-03-06 | Bristol Myers Squibb Co | Nye sidekædede-bærende taxaner og mellemprodukter deraf |
TW268952B (de) * | 1993-02-26 | 1996-01-21 | Takeda Pharm Industry Co Ltd | |
DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
TW286317B (de) * | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
DE4408534A1 (de) * | 1994-03-14 | 1995-09-28 | Hoechst Ag | Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden |
DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
ATE170179T1 (de) * | 1994-11-02 | 1998-09-15 | Merck Patent Gmbh | Adhäsionsrezeptor-antagonisten |
US6465650B1 (en) | 1995-03-13 | 2002-10-15 | Aventis Pharma Deutschland Gmbh | Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids |
ID30299A (id) | 1998-06-05 | 2001-11-22 | Astrazeneca Ab | Turunan oksazolidinon, proses pembuatannya dan komposisi farmasi yang mengandungnya |
GB9812019D0 (en) * | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
AU2006335108B2 (en) * | 2005-12-30 | 2011-04-07 | Merck Sharp & Dohme Corp. | CETP inhibitors |
JP5040036B2 (ja) | 2005-12-30 | 2012-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | Cetp阻害剤として有用な1,3−オキサゾリジン−2−オン誘導体 |
CA2678577A1 (en) * | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
EP2141154A4 (de) | 2007-03-30 | 2011-06-01 | Inst Med Molecular Design Inc | Oxazolidinonderivat mit hemmender wirkung auf die 11-hydroxysteroiddehydrogenase vom typ i |
ES2395081T3 (es) * | 2007-07-26 | 2013-02-08 | Vitae Pharmaceuticals, Inc. | Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 |
AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
CA2712500A1 (en) * | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP2011510083A (ja) * | 2008-01-24 | 2011-03-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 3,5−二置換−1,3−オキサゾリジン−2−オン誘導体 |
CA2714532A1 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
JP5730021B2 (ja) * | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤としてのシクロアルキルラクタム誘導体 |
JP5538356B2 (ja) * | 2008-03-18 | 2014-07-02 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の阻害剤 |
JP5538365B2 (ja) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
JP5451752B2 (ja) * | 2008-05-01 | 2014-03-26 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
RU2531272C2 (ru) | 2008-05-01 | 2014-10-20 | Вайтаи Фармасьютиклз, Инк. | Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1 |
US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
ES2432150T3 (es) | 2008-07-25 | 2013-12-02 | Boehringer Ingelheim International Gmbh | Inhibidores cíclicos de la 11 beta-hidroxiesteroide deshidrogenasa 1 |
IES20090900A2 (en) * | 2008-11-28 | 2010-07-07 | Corden Pharma Ip Ltd | Manufacture of beta blockers |
EP2393807B1 (de) | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Zyklische 11beta-hydroxysteroid-dehydrogenase-1-hemmer |
KR20120061771A (ko) * | 2009-04-30 | 2012-06-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 1,3−オキサジナン−2−オン構造に基づく11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
US8883778B2 (en) | 2009-07-01 | 2014-11-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
JP5860042B2 (ja) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 置換5、6及び7員複素環、そのような化合物を含有する医薬及びそれらの使用 |
EP2585444B1 (de) | 2010-06-25 | 2014-10-22 | Boehringer Ingelheim International GmbH | Azaspirohexanone als 11-beta-hsd1-hemmer zur behandlung von stoffwechselerkrankungen |
EP2635268A1 (de) | 2010-11-02 | 2013-09-11 | Boehringer Ingelheim International GmbH | Pharmazeutische kombinationen zur behandlung von stoffwechselerkrankungen |
EP3445753A1 (de) * | 2016-04-22 | 2019-02-27 | Kat2Biz AB | Difunktionelles pfropfmittel auf der basis von phenolischem rückgrat aus lignin |
ES2747768T3 (es) | 2017-03-20 | 2020-03-11 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
WO2022075645A1 (ko) * | 2020-10-08 | 2022-04-14 | 재단법인 대구경북첨단의료산업진흥재단 | Pcsk9 억제제로서 아미노알콜 유도체 및 이를 함유하는 고콜레스테롤 혈증의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3020262A (en) * | 1957-12-19 | 1962-02-06 | Jefferson Chem Co Inc | Method for producing 2-oxazolidones from epoxides and isocyanates |
DE3205457A1 (de) * | 1982-02-16 | 1983-08-25 | Merck Patent Gmbh, 6100 Darmstadt | Oxazolidin-2-one |
US4602093A (en) * | 1984-02-08 | 1986-07-22 | Merck & Co., Inc. | Novel substituted imidazoles, their preparation and use |
EP0394440B1 (de) * | 1987-10-20 | 1994-05-11 | Otsuka Pharmaceutical Co., Ltd. | Phenylcarbonsäure-abkömmlinge |
CA1330079C (en) * | 1988-10-13 | 1994-06-07 | Michihiko Tsujitani | Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same |
EP0393607B1 (de) * | 1989-04-19 | 1996-02-21 | Otsuka Pharmaceutical Co., Ltd. | Phenylcarbonsäurederivate mit einem Heterocyclus |
AU653896B2 (en) * | 1992-04-30 | 1994-10-13 | Taiho Pharmaceutical Co., Ltd. | Oxazolidine derivative and pharmaceutically acceptable salt thereof |
-
1993
- 1993-04-28 AU AU42710/93A patent/AU653896B2/en not_active Ceased
- 1993-04-28 CA CA002112129A patent/CA2112129C/en not_active Expired - Fee Related
- 1993-04-28 KR KR1019930704109A patent/KR0146931B1/ko not_active IP Right Cessation
- 1993-04-28 AT AT93911946T patent/ATE194981T1/de not_active IP Right Cessation
- 1993-04-28 US US08/167,798 patent/US5480899A/en not_active Expired - Fee Related
- 1993-04-28 DE DE69329106T patent/DE69329106T2/de not_active Expired - Fee Related
- 1993-04-28 HU HU9303787A patent/HU220601B1/hu not_active IP Right Cessation
- 1993-04-28 WO PCT/JP1993/000559 patent/WO1993022298A1/ja active IP Right Grant
- 1993-04-28 EP EP93911946A patent/EP0605729B1/de not_active Expired - Lifetime
- 1993-12-29 FI FI935920A patent/FI935920A0/fi not_active IP Right Cessation
-
1995
- 1995-06-30 HU HU95P/P00726P patent/HU211901A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
ATE194981T1 (de) | 2000-08-15 |
EP0605729B1 (de) | 2000-07-26 |
AU4271093A (en) | 1993-11-29 |
HU211901A9 (en) | 1996-01-29 |
KR940701389A (ko) | 1994-05-28 |
WO1993022298A1 (en) | 1993-11-11 |
HU220601B1 (hu) | 2002-03-28 |
US5480899A (en) | 1996-01-02 |
EP0605729A4 (en) | 1994-08-24 |
KR0146931B1 (ko) | 1998-08-17 |
AU653896B2 (en) | 1994-10-13 |
HUT70423A (en) | 1995-10-30 |
FI935920A (fi) | 1993-12-29 |
DE69329106D1 (de) | 2000-08-31 |
FI935920A0 (fi) | 1993-12-29 |
EP0605729A1 (de) | 1994-07-13 |
CA2112129A1 (en) | 1993-11-11 |
CA2112129C (en) | 1997-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |