IT1274018B - Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica - Google Patents

Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Info

Publication number
IT1274018B
IT1274018B ITMI940326A ITMI940326A IT1274018B IT 1274018 B IT1274018 B IT 1274018B IT MI940326 A ITMI940326 A IT MI940326A IT MI940326 A ITMI940326 A IT MI940326A IT 1274018 B IT1274018 B IT 1274018B
Authority
IT
Italy
Prior art keywords
octano
analgesic activity
diazabicycle
derivatives
diazabicycle derivatives
Prior art date
Application number
ITMI940326A
Other languages
English (en)
Inventor
Giorgio Cignarella
Original Assignee
Riace Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riace Ets filed Critical Riace Ets
Priority to ITMI940326A priority Critical patent/IT1274018B/it
Publication of ITMI940326A0 publication Critical patent/ITMI940326A0/it
Priority to EP95909700A priority patent/EP0746560A1/en
Priority to US08/696,948 priority patent/US5672601A/en
Priority to PCT/EP1995/000476 priority patent/WO1995023152A1/en
Priority to AU18085/95A priority patent/AU1808595A/en
Publication of ITMI940326A1 publication Critical patent/ITMI940326A1/it
Application granted granted Critical
Publication of IT1274018B publication Critical patent/IT1274018B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

Si descrivono composti di formula generale (I): (FORMULA I) dove R e R1, diversi fra loro, sono un gruppo acile o un gruppo -CH2-(A)-B, dove A e B sono come definiti di seguito. I composti di formula (I) sono analgesici ad attività centrale.
ITMI940326A 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica IT1274018B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica
EP95909700A EP0746560A1 (en) 1994-02-23 1995-02-10 3,8-diazabicyclo 3.2.1]octane derivatives having analgesic activity
US08/696,948 US5672601A (en) 1994-02-23 1995-02-10 3-8-diazabicyclo 3.2.1! octane derivatives having analgesic activity
PCT/EP1995/000476 WO1995023152A1 (en) 1994-02-23 1995-02-10 3,8-diazabicyclo[3.2.1]octane derivatives having analgesic activity
AU18085/95A AU1808595A (en) 1994-02-23 1995-02-10 3,8-diazabicyclo{3.2.1}octane derivatives having analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Publications (3)

Publication Number Publication Date
ITMI940326A0 ITMI940326A0 (it) 1994-02-23
ITMI940326A1 ITMI940326A1 (it) 1995-08-23
IT1274018B true IT1274018B (it) 1997-07-14

Family

ID=11367953

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI940326A IT1274018B (it) 1994-02-23 1994-02-23 Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica

Country Status (5)

Country Link
US (1) US5672601A (it)
EP (1) EP0746560A1 (it)
AU (1) AU1808595A (it)
IT (1) IT1274018B (it)
WO (1) WO1995023152A1 (it)

Families Citing this family (36)

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IT1291632B1 (it) * 1997-04-22 1999-01-11 Univ Degli Studi Milano Derivati di 9,10-diazatriciclo (4.2.1.1 alla 2,5)decano e di 9,10- diazatriciclo (3.3.1.1 alla 2,6) decano ad attivita' analgesica
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
US7265115B2 (en) 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
IT1317841B1 (it) * 2000-02-18 2003-07-15 Univ Degli Studi Milano Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica.
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
KR101052287B1 (ko) * 2002-07-05 2011-07-27 타가셉트 인코포레이티드 Ｎ-아릴 디아자스피로시클릭 화합물, 그 제조방법, 및 그용도
WO2004009775A2 (en) 2002-07-19 2004-01-29 Targacept, Inc. Methods and compositions relating to chimeric nicotinic receptor subunits
CN100340561C (zh) * 2002-07-26 2007-10-03 神经研究公司 二氮杂双环壬烷和－癸烷衍生物以及它们用作阿片样物质受体配基的用途
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
US7402592B2 (en) * 2003-10-15 2008-07-22 Targacept, Inc. Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders
US7816356B2 (en) 2003-11-14 2010-10-19 Daniel Yohannes Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands
ITMI20040954A1 (it) * 2004-05-12 2004-08-12 Univ Degli Studi Milano Derivati del 3,6-diazabiciclo 3.1.i.eptano ad attivita' analgesica
US7384929B2 (en) * 2004-09-20 2008-06-10 Targacept, Inc. N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
UA88792C2 (ru) 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
EP1819709B1 (en) * 2004-11-30 2009-02-11 Neurosearch A/S Novel diazabicyclic aryl derivatives as cholinergy ligands
JP2009506037A (ja) * 2005-08-22 2009-02-12 ターガセプト，インコーポレイテッド ヘテロアリール置換ジアザトリシクロアルカン、その調製方法およびその使用方法
EP2133337A1 (en) * 2006-05-09 2009-12-16 AstraZeneca AB Salt forms of (2S)-(4E)-N-Methyl-5-[(5-Isopropoxy)pyridin-3-yl]-4-penten-2-amine
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
TW200829244A (en) * 2006-09-15 2008-07-16 Astrazeneca Ab Therapeutic combinations 482
EP2112923A1 (en) * 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
CA2695214A1 (en) * 2007-07-31 2009-02-05 Targacept, Inc. Transdermal administration of (2s)-(4e)-n-methyl-5-(3-(5-is0pr0p0xypyridin)yl)-4-penten-2-amine
CN104193741B (zh) * 2007-10-01 2016-08-24 阿尔法梅根有限责任公司 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物
IT1390848B1 (it) 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Composti farmaceutici
IT1395452B1 (it) * 2009-02-25 2012-09-21 Neuroscienze Pharmaness S C A Rl Microemulsioni
EP2149370A1 (en) 2008-07-31 2010-02-03 Neuroscienze Pharmaness S.C. A R.L. Diazabicyclic compounds and microemulsions thereof
IT1390850B1 (it) * 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Microemulsioni
SG181109A1 (en) 2009-12-07 2012-07-30 Targacept Inc 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands
IT1396951B1 (it) 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
WO2011146009A1 (en) 2010-05-20 2011-11-24 Targacept Inc. New process for the preparation of aryl substituted olefinic amines
US9434724B2 (en) 2014-07-11 2016-09-06 Alpharmagen, Llc Quinuclidines for modulating alpha 7 activity
JP6651546B2 (ja) 2015-05-11 2020-02-19 カディラ・ヘルスケア・リミテッド カッパ（κ）オピオイド受容体（ＫＯＲ）アゴニストとしての新規の短鎖ペプチド
LT3448859T (lt) 2017-03-20 2019-10-25 Forma Therapeutics Inc Pirolpirolo kompozicijos, kaip piruvato kinazės (pkr) aktyvatoriai
US11001588B2 (en) 2018-09-19 2021-05-11 Forma Therapeutics, Inc. Activating pyruvate kinase R and mutants thereof
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB949088A (en) * 1961-06-26 1964-02-12 Lepetit Spa Diazabicyclo-octane derivatives
IT1271350B (it) * 1993-01-29 1997-05-27 Riace Establischment Derivati di 3,8 diazabiciclo (3,2,1) - ottani quali medicamenti ad attivita' analgesica centrale

Also Published As

Publication number Publication date
EP0746560A1 (en) 1996-12-11
ITMI940326A1 (it) 1995-08-23
WO1995023152A1 (en) 1995-08-31
AU1808595A (en) 1995-09-11
ITMI940326A0 (it) 1994-02-23
US5672601A (en) 1997-09-30

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Effective date: 19970226