JP6594570B2 - ピルビン酸キナーゼ（ｐｋｒ）活性化剤としてのピロロピロール組成物 - Google Patents

ピルビン酸キナーゼ（ｐｋｒ）活性化剤としてのピロロピロール組成物 Download PDF

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JP6594570B2
JP6594570B2 JP2018560074A JP2018560074A JP6594570B2 JP 6594570 B2 JP6594570 B2 JP 6594570B2 JP 2018560074 A JP2018560074 A JP 2018560074A JP 2018560074 A JP2018560074 A JP 2018560074A JP 6594570 B2 JP6594570 B2 JP 6594570B2
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optionally substituted
alkyl
aryl
compound
heteroaryl
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JP2019521090A (ja
Inventor
アンナ エリクソン，
ニール グリーン，
ゲイリー ガスタフソン，
ビンソン ハン，
デイビッド アール． ジュニア ランシア，
ローナ ミチェル，
デイビッド リチャード，
タチアナ シェレキン，
チェイス シー． スミス，
ジョングオ ワン，
シャオジャン ジェン，
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Forma Therapeutics Inc
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Forma Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2018560074A 2017-03-20 2018-03-20 ピルビン酸キナーゼ（ｐｋｒ）活性化剤としてのピロロピロール組成物 Active JP6594570B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762473751P 2017-03-20 2017-03-20
US62/473,751 2017-03-20
PCT/US2018/023405 WO2018175474A1 (en) 2017-03-20 2018-03-20 Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators

Related Child Applications (1)

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JP2019149316A Division JP7213775B2 (ja) 2017-03-20 2019-08-16 ピルビン酸キナーゼ（ｐｋｒ）活性化剤としてのピロロピロール組成物

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JP2019521090A JP2019521090A (ja) 2019-07-25
JP6594570B2 true JP6594570B2 (ja) 2019-10-23

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JP2019149316A Active JP7213775B2 (ja) 2017-03-20 2019-08-16 ピルビン酸キナーゼ（ｐｋｒ）活性化剤としてのピロロピロール組成物

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Country Status (32)

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US (8) US10208052B1 (https=)
EP (3) EP3680241A1 (https=)
JP (2) JP6594570B2 (https=)
KR (2) KR102007135B1 (https=)
CN (2) CN113456634A (https=)
AR (2) AR111295A1 (https=)
AU (4) AU2018240172C1 (https=)
CA (1) CA3024181C (https=)
CY (2) CY1122393T1 (https=)
DK (2) DK3483164T3 (https=)
EA (1) EA201992215A1 (https=)
ES (2) ES2747768T3 (https=)
HR (2) HRP20191665T1 (https=)
HU (2) HUE049979T2 (https=)
IL (2) IL269447B (https=)
LT (2) LT3448859T (https=)
MA (3) MA50589A (https=)
MD (2) MD3483164T2 (https=)
MX (2) MX2020013936A (https=)
NZ (2) NZ763766A (https=)
PL (2) PL3448859T3 (https=)
PT (2) PT3483164T (https=)
RS (2) RS59306B1 (https=)
RU (3) RU2707751C1 (https=)
SA (1) SA519410164B1 (https=)
SG (1) SG11201908670SA (https=)
SI (2) SI3483164T1 (https=)
SM (2) SMT201900517T1 (https=)
TN (2) TN2020000045A1 (https=)
TW (2) TWI887559B (https=)
WO (1) WO2018175474A1 (https=)
ZA (1) ZA201906278B (https=)

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CN105764905B (zh) 2013-11-26 2019-06-07 豪夫迈·罗氏有限公司 新的八氢-环丁二烯并[1，2-c；3，4-c’]二吡咯-2基
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ES3064043T3 (en) * 2019-09-29 2026-04-22 Chia Tai Tianqing Pharmaceutical Group Co Ltd Crystalline forms of a capsid protein assembly inhibitor containing a pyrrole ring, and application thereof
US20230159538A1 (en) * 2020-04-01 2023-05-25 Global Blood Therapeutics, Inc. Pyrrolidine-pyrazoles as pyruvate kinase activators
US20220087983A1 (en) * 2020-09-18 2022-03-24 Forma Therapeutics, Inc. Activating pyruvate kinase r
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KR20240124324A (ko) 2021-12-21 2024-08-16 시노허브 파마슈티컬 씨오., 엘티디 비스(아자니릴리덴)설포닐 구조를 함유하는 화합물 및 약제에서의 이의 용도
EP4622958A1 (en) 2022-11-21 2025-10-01 Novo Nordisk Health Care AG Synthesis of pyrrolo[3,4-c]pyrroles
CN115957219B (zh) * 2022-12-27 2024-04-19 北京大学 M2亚型丙酮酸激酶凝聚体的解聚剂在制备抗衰老药物中的应用
WO2024230586A1 (zh) * 2023-05-05 2024-11-14 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构的化合物作为pkm2激动剂的新用途
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