ATE481409T1 - Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor - Google Patents

Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor

Info

Publication number
ATE481409T1
ATE481409T1 AT07728869T AT07728869T ATE481409T1 AT E481409 T1 ATE481409 T1 AT E481409T1 AT 07728869 T AT07728869 T AT 07728869T AT 07728869 T AT07728869 T AT 07728869T AT E481409 T1 ATE481409 T1 AT E481409T1
Authority
AT
Austria
Prior art keywords
thiazolopyramidine
adenosine
antagonists
receptor
urea derivatives
Prior art date
Application number
AT07728869T
Other languages
English (en)
Inventor
John A Brinkman
Adrian Wai-Hing Cheung
Fariborz Firooznia
Kevin Richard Guertin
Nicholas Marcopulos
Lida Qi
Jagdish Kumar Racha
Ramakanth Sarabu
Jenny Tan
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE481409T1 publication Critical patent/ATE481409T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings
AT07728869T 2006-05-18 2007-05-08 Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor ATE481409T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80148106P 2006-05-18 2006-05-18
PCT/EP2007/054416 WO2007134958A1 (en) 2006-05-18 2007-05-08 Thiazolo-pyramidine / pyridine urea derivatives as adenosine a2b receptor antagonists

Publications (1)

Publication Number Publication Date
ATE481409T1 true ATE481409T1 (de) 2010-10-15

Family

ID=38308768

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07728869T ATE481409T1 (de) 2006-05-18 2007-05-08 Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor

Country Status (17)

Country Link
US (1) US7947692B2 (de)
EP (1) EP2027132B1 (de)
JP (1) JP5026511B2 (de)
KR (1) KR101077295B1 (de)
CN (1) CN101448844B (de)
AR (1) AR060957A1 (de)
AT (1) ATE481409T1 (de)
AU (1) AU2007253485B2 (de)
BR (1) BRPI0712516A2 (de)
CA (1) CA2651769C (de)
CL (1) CL2007001380A1 (de)
DE (1) DE602007009221D1 (de)
ES (1) ES2350013T3 (de)
IL (1) IL195006A0 (de)
MX (1) MX2008014690A (de)
TW (1) TW200813073A (de)
WO (1) WO2007134958A1 (de)

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US8598356B2 (en) 2008-11-25 2013-12-03 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
US8461159B2 (en) 2008-11-25 2013-06-11 Jannsen Pharmaceutica BV Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
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WO2010141817A1 (en) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
MX2012001064A (es) * 2009-07-24 2012-07-17 Univ Vanderbilt Inhibidores de la fosfolipasa d selectivos de isoforma.
CA2785284A1 (en) * 2009-12-25 2011-06-30 Tomoyuki Kamino Novel aryl urea derivative
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2640704A1 (de) * 2010-11-15 2013-09-25 Abbvie Inc. Nampt-inhibitoren
UY33726A (es) 2010-11-15 2012-06-29 Abbott Lab Inhibidores de nampt y rock
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
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DE102011083283A1 (de) * 2011-09-23 2013-03-28 Beiersdorf Ag Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen
CA2850597A1 (en) 2011-09-30 2013-04-04 Vanderbilt University Antiviral therapies with phospholipase d inhibitors
RU2475481C1 (ru) * 2012-03-01 2013-02-20 Общество с ограниченной ответственностью "Метаген" 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение
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WO2013129973A1 (ru) * 2012-03-01 2013-09-06 Общество с ограниченной ответственностью "Метаген" 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение
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US10273243B2 (en) 2013-03-14 2019-04-30 The Trustees Of Columbia University In The City Of New York 4-phenylpiperidines, their preparation and use
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Also Published As

Publication number Publication date
AU2007253485B2 (en) 2010-07-08
EP2027132A1 (de) 2009-02-25
CL2007001380A1 (es) 2008-01-04
BRPI0712516A2 (pt) 2016-08-23
KR101077295B1 (ko) 2011-10-26
IL195006A0 (en) 2009-08-03
MX2008014690A (es) 2008-11-27
EP2027132B1 (de) 2010-09-15
KR20080111141A (ko) 2008-12-22
CA2651769A1 (en) 2007-11-29
CN101448844A (zh) 2009-06-03
US20070270433A1 (en) 2007-11-22
JP5026511B2 (ja) 2012-09-12
JP2009537473A (ja) 2009-10-29
AU2007253485A1 (en) 2007-11-29
US7947692B2 (en) 2011-05-24
CN101448844B (zh) 2012-07-25
ES2350013T3 (es) 2011-01-14
WO2007134958A1 (en) 2007-11-29
DE602007009221D1 (de) 2010-10-28
TW200813073A (en) 2008-03-16
AR060957A1 (es) 2008-07-23
CA2651769C (en) 2013-12-17

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