ME02222B - Amid derivati piperidin-i piperazin-1-karboksilne kiseline te povezani spojevi kao modulatori amid hidrolaze masnih kiselina (faah) za liječenje tjeskobe, boli i drugih stanja - Google Patents
Amid derivati piperidin-i piperazin-1-karboksilne kiseline te povezani spojevi kao modulatori amid hidrolaze masnih kiselina (faah) za liječenje tjeskobe, boli i drugih stanjaInfo
- Publication number
- ME02222B ME02222B MEP-2015-104A MEP10415A ME02222B ME 02222 B ME02222 B ME 02222B ME P10415 A MEP10415 A ME P10415A ME 02222 B ME02222 B ME 02222B
- Authority
- ME
- Montenegro
- Prior art keywords
- acid amide
- faah
- anxiety
- modulators
- piperazine
- Prior art date
Links
- 208000019901 Anxiety disease Diseases 0.000 title 1
- 101150042613 FA2H gene Proteins 0.000 title 1
- 101150008770 FAAH gene Proteins 0.000 title 1
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 title 1
- 230000036506 anxiety Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 title 1
- YFTCCMMHBOHKKF-UHFFFAOYSA-N piperazine-1-carboxamide;piperidine Chemical class C1CCNCC1.NC(=O)N1CCNCC1 YFTCCMMHBOHKKF-UHFFFAOYSA-N 0.000 title 1
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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EP20050855824 EP1836179B1 (en) | 2004-12-30 | 2005-12-29 | Piperidine- and piperazine-1-carboxylic acid amide derivatives and related compounds as modulators of fatty acid amide hydrolase (faah) for the treatment of anxiety, pain and other conditions |
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MEP-2015-104A ME02222B (me) | 2004-12-30 | 2005-12-29 | Amid derivati piperidin-i piperazin-1-karboksilne kiseline te povezani spojevi kao modulatori amid hidrolaze masnih kiselina (faah) za liječenje tjeskobe, boli i drugih stanja |
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TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
RS56194B1 (sr) * | 2004-12-30 | 2017-11-30 | Janssen Pharmaceutica Nv | Derivativi fenilamida 4-(benzil)-piperazin-1-karboksilne kiseline i slična jedinjenja kao modulatori hidrolaze amida masnih kiselina (faah) za lečenje anksioznosti, bola i ostalih stanja |
GB0503056D0 (en) * | 2005-02-14 | 2005-03-23 | Smithkline Beecham Corp | Chemical compounds |
WO2007005510A1 (en) * | 2005-06-30 | 2007-01-11 | Janssen Pharmaceutica N.V. | N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase |
JPWO2007020888A1 (ja) * | 2005-08-12 | 2009-02-26 | 武田薬品工業株式会社 | 脳・神経細胞保護剤および睡眠障害治療薬 |
WO2007086584A1 (ja) * | 2006-01-30 | 2007-08-02 | Meiji Seika Kaisha, Ltd. | 新規FabKおよびFabI/K阻害剤 |
ITRM20060090A1 (it) * | 2006-02-22 | 2007-08-23 | Sigma Tau Ind Farmaceuti | Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita |
JP2009538358A (ja) * | 2006-05-26 | 2009-11-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 脂肪酸アミド加水分解酵素のオキサゾリルピペリジン・モジュレーター |
JPWO2008023720A1 (ja) * | 2006-08-23 | 2010-01-14 | アステラス製薬株式会社 | ウレア化合物又はその塩 |
AP2780A (en) | 2006-10-18 | 2013-09-30 | Pfizer Prod Inc | Biaryl ether urea compounds |
MX2009012765A (es) * | 2007-05-25 | 2009-12-16 | Janssen Pharmaceutica Nv | Moduladores de urea con heteroarilo sustituido de acido graso amida hidrolasa. |
EP2254415B1 (en) * | 2008-02-19 | 2013-01-23 | Janssen Pharmaceutica, N.V. | Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase |
JP2011518143A (ja) * | 2008-04-17 | 2011-06-23 | ファイザー・インク | Faah阻害剤として有用なエーテルベンジリデンピペリジンアリールカルボキサミド化合物 |
US20110053950A1 (en) * | 2008-04-17 | 2011-03-03 | Pfizer, Inc. | 4-benzylidene-3-methylpiperidine aryl carboxamide compounds useful as faah inhibitors |
EP2276737A1 (en) * | 2008-04-17 | 2011-01-26 | Pfizer Inc. | 4- [3- (aryloxy) benzylidene]-3-methyl piperidine aryl carboxamide compounds useful as faah inhibitors |
JP2011518145A (ja) * | 2008-04-17 | 2011-06-23 | ファイザー・インク | Faah阻害剤として有用な4−[3−(アリールオキシ)ベンジリデン]−3−メチルピペリジン5員アリールカルボキサミド化合物 |
JP2011518142A (ja) * | 2008-04-17 | 2011-06-23 | ファイザー・インク | Faah阻害剤として有用なエーテルベンジリデンピペリジン5員アリールカルボキサミド化合物 |
US8080566B1 (en) | 2008-06-11 | 2011-12-20 | Kalypsys, Inc | Carbazole inhibitors of histamine receptors for the treatment of disease |
US20100113465A1 (en) * | 2008-10-30 | 2010-05-06 | Pfizer Inc. | 7-azaspiro[3.5]nonane-7-carboxamide compounds |
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