NI200700166A - Ureas de piperazinil y piperidinil como moduladores de la hidrolasa de amidas de ácidos grasos - Google Patents

Ureas de piperazinil y piperidinil como moduladores de la hidrolasa de amidas de ácidos grasos

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Publication number
NI200700166A
NI200700166A NI200700166A NI200700166A NI200700166A NI 200700166 A NI200700166 A NI 200700166A NI 200700166 A NI200700166 A NI 200700166A NI 200700166 A NI200700166 A NI 200700166A NI 200700166 A NI200700166 A NI 200700166A
Authority
NI
Nicaragua
Prior art keywords
4alkyl
pyrimidinyl
pyridyl
disorders
compounds
Prior art date
Application number
NI200700166A
Other languages
English (en)
Inventor
Richard Apodaca
J Guy R Breitenbucher
Kanaka Pattabiraman
Mark Seierstad
Wei Xiao
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NI200700166A publication Critical patent/NI200700166A/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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Abstract

Los compuestos de la fórmula (I) en donde, Z es -N o >CH; R1 es -H o -C1-4alquilo; Ar1 es 2-thiazolil, 2-piridil, 3-piridil, 4-piridil 2-pirimidinil, 4-pirimidinil, 5-pirimidinil, o fenil, cada uno sustituido o sin sustituir en un miembro del anillo de carbono con una o dos mitades Ra; en donde cada mitad Ra es seleccionada independientemente del grupo que consiste en -C1-4alquilo, -C2-4alquenilo, -OH, -OC1-4alquilo, halo, -CF3, -OCF3, -SCF3, -SH, -SH, -S(O)0-2C1-4alquilo, -OSO2C1-4alquilo, -CO2C1-4alquilo, -CO2H, -COC1-4alquilo, -N(Rb)Rc, -SO2NRbRc, -NRbSO2Rc, -C(=O)NRbRc, -NO2 y -CN, en donde Rb y Rc son independientemente cada uno -H o -C1-4alquilo; y Ar2 se define en las reivindicaciones que son útiles como inhibidores de FAAH. Tales compuestos pueden ser usados en composiciones farmacéuticas y métodos para el tratamiento de estados de enfermedad, trastornos, y condiciones mediadas por la actividad de la hidrolasa de amida de ácidos grasos (FAAH). De modo que, los compuestos se pueden administrar para tratar por ej. la ansiedad, el dolor, la inflamación, trastornos del sueño, trastornos alimenticios, o trastornos de movimiento (como la esclerosis múltiple).
NI200700166A 2004-12-30 2007-06-29 Ureas de piperazinil y piperidinil como moduladores de la hidrolasa de amidas de ácidos grasos NI200700166A (es)

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