CR9277A - Piperacinil y piperadinil ureas como moduladores de la amida hidrolasa de acido graso - Google Patents

Piperacinil y piperadinil ureas como moduladores de la amida hidrolasa de acido graso

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Publication number
CR9277A
CR9277A CR9277A CR9277A CR9277A CR 9277 A CR9277 A CR 9277A CR 9277 A CR9277 A CR 9277A CR 9277 A CR9277 A CR 9277A CR 9277 A CR9277 A CR 9277A
Authority
CR
Costa Rica
Prior art keywords
4alkyl
alkyl
pyrimidinyl
disorders
compounds
Prior art date
Application number
CR9277A
Other languages
English (en)
Inventor
Richard Apocada
J Guy Breitennucher
Kanaka Pattabiraman
Mark Seierstad
Wei Xiao
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR9277A publication Critical patent/CR9277A/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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Abstract

Los compuestos de formula (I): en donde Z es -N o >CH; R1 es -H o alquilo de c1-4; Ar1 es 2-tiazolilo, 2-p6iridilo, 3-piridilo, 4-piridilo, 2-pirimidinilo, 4-pirimidinilo, 5-pirimidinilo o fenilo, cada uno no sustituido o sustituido en un miembro del anillo del carbono con uno o dos porciones de Ra, en donde cada porcion de Ra se selecciona de manera independiente del grupo que consiste de alquilo de C1-4, alquenilo de c2-4, -OH, -Oalquilo de C1-4, halo, -CF3, -OCF3, -SCF3, -SH, -S(O)0-2alquilo de C1-4, -OSO2alquilo de C1-4, -CO2alquilo de C1-4, -CO2H, -COalquilo de C1-4, -N(Rb)Rc, -SO2NRbRc, -NRbSO2Rc, -C(=O)NRbRc, -NO2, y -CN, en donde Rb y Rc son cada uno de manera independiente -H o alquilo de C1-4; y Ar2 se define en las reivindicaciones, son utiles como inhibidores de la FAAH; tales compuestos pueden utilizarse en composiciones farmaceuticas y metodos para el tratamiento de estados de enfermedad, trastornos y condiciones mediadas por la actividad de la amida hidrolasa del acido graso (FAAH); asi, los compuestos pueden administrarse para tratar, por ejemplo, ansiedad, dolor, inflamacion, trastornos del sueno. trastornos de la alimentacion o trastornos del movimiento (tales como esclerosis multiple).
CR9277A 2004-12-30 2007-07-27 Piperacinil y piperadinil ureas como moduladores de la amida hidrolasa de acido graso CR9277A (es)

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