BRPI0712516A2 - compostos, composições farmacêuticas, antagonista receptor de a2b, método para uso terapêutico e/ou tratamento profilático e uso de antagonista receptor de a2b - Google Patents
compostos, composições farmacêuticas, antagonista receptor de a2b, método para uso terapêutico e/ou tratamento profilático e uso de antagonista receptor de a2bInfo
- Publication number
- BRPI0712516A2 BRPI0712516A2 BRPI0712516A BRPI0712516A BRPI0712516A2 BR PI0712516 A2 BRPI0712516 A2 BR PI0712516A2 BR PI0712516 A BRPI0712516 A BR PI0712516A BR PI0712516 A BRPI0712516 A BR PI0712516A BR PI0712516 A2 BRPI0712516 A2 BR PI0712516A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonist
- therapeutic
- compounds
- pharmaceutical compositions
- prophylactic treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80148106P | 2006-05-18 | 2006-05-18 | |
PCT/EP2007/054416 WO2007134958A1 (en) | 2006-05-18 | 2007-05-08 | Thiazolo-pyramidine / pyridine urea derivatives as adenosine a2b receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0712516A2 true BRPI0712516A2 (pt) | 2016-08-23 |
Family
ID=38308768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0712516A BRPI0712516A2 (pt) | 2006-05-18 | 2007-05-08 | compostos, composições farmacêuticas, antagonista receptor de a2b, método para uso terapêutico e/ou tratamento profilático e uso de antagonista receptor de a2b |
Country Status (17)
Country | Link |
---|---|
US (1) | US7947692B2 (pt) |
EP (1) | EP2027132B1 (pt) |
JP (1) | JP5026511B2 (pt) |
KR (1) | KR101077295B1 (pt) |
CN (1) | CN101448844B (pt) |
AR (1) | AR060957A1 (pt) |
AT (1) | ATE481409T1 (pt) |
AU (1) | AU2007253485B2 (pt) |
BR (1) | BRPI0712516A2 (pt) |
CA (1) | CA2651769C (pt) |
CL (1) | CL2007001380A1 (pt) |
DE (1) | DE602007009221D1 (pt) |
ES (1) | ES2350013T3 (pt) |
IL (1) | IL195006A0 (pt) |
MX (1) | MX2008014690A (pt) |
TW (1) | TW200813073A (pt) |
WO (1) | WO2007134958A1 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ME02222B (me) | 2004-12-30 | 2016-02-20 | Janssen Pharmaceutica Nv | Amid derivati piperidin-i piperazin-1-karboksilne kiseline te povezani spojevi kao modulatori amid hidrolaze masnih kiselina (faah) za liječenje tjeskobe, boli i drugih stanja |
MX2009012765A (es) * | 2007-05-25 | 2009-12-16 | Janssen Pharmaceutica Nv | Moduladores de urea con heteroarilo sustituido de acido graso amida hidrolasa. |
WO2009011872A1 (en) * | 2007-07-17 | 2009-01-22 | Merck & Co., Inc. | Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2009078999A1 (en) * | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
EP2242745A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8598356B2 (en) | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
CA2754890C (en) * | 2009-03-13 | 2018-01-16 | Piet Herdewijn | Bicyclic heterocycles |
US8901111B2 (en) | 2009-06-05 | 2014-12-02 | Janssen Pharmaceutica Nv | Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase |
WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
MX2012001064A (es) * | 2009-07-24 | 2012-07-17 | Univ Vanderbilt | Inhibidores de la fosfolipasa d selectivos de isoforma. |
CA2785284A1 (en) * | 2009-12-25 | 2011-06-30 | Tomoyuki Kamino | Novel aryl urea derivative |
UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
EP2640704A1 (en) * | 2010-11-15 | 2013-09-25 | Abbvie Inc. | Nampt inhibitors |
UY33726A (es) | 2010-11-15 | 2012-06-29 | Abbott Lab | Inhibidores de nampt y rock |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
DE102011083283A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen |
CA2850597A1 (en) | 2011-09-30 | 2013-04-04 | Vanderbilt University | Antiviral therapies with phospholipase d inhibitors |
RU2475481C1 (ru) * | 2012-03-01 | 2013-02-20 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение |
RU2504541C1 (ru) * | 2012-12-26 | 2014-01-20 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция для местного применения |
WO2013129973A1 (ru) * | 2012-03-01 | 2013-09-06 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение |
US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
ES2700541T3 (es) | 2013-03-14 | 2019-02-18 | Univ Columbia | Octahidrociclopentapirroles, su preparación y uso |
US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
AU2014334040A1 (en) * | 2013-10-07 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | Cyclic thienouracil-carboxamides and use thereof |
WO2015168286A1 (en) | 2014-04-30 | 2015-11-05 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparaiton and use |
CN109311897B (zh) | 2017-03-20 | 2021-07-20 | 福马治疗股份有限公司 | 作为丙酮酸激酶(pkr)活化剂的吡咯并吡咯组合物 |
HRP20230251T1 (hr) * | 2017-08-01 | 2023-04-14 | Merck Patent Gmbh | Derivati tiazolopridina kao antagonisti adenozinskih receptora |
US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
WO2022258622A1 (en) * | 2021-06-07 | 2022-12-15 | Ares Trading S.A. | Combination treatment of cancer |
CN114591327B (zh) * | 2022-03-25 | 2023-02-07 | 河南大学 | 吲哚啉哌啶脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用 |
WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060481A (en) * | 1998-05-28 | 2000-05-09 | The Penn State Research Foundation | Method for improving insulin sensitivity using an adenosine receptor antagonist |
MXPA02012596A (es) * | 2000-06-21 | 2003-04-10 | Hoffmann La Roche | Derivados de benzotiazol. |
US6713499B2 (en) * | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
EP1388341A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
WO2005028484A1 (en) * | 2003-09-19 | 2005-03-31 | F. Hoffmann-La Roche Ag | Thiazolopyridine derivatives as adenosine receptor ligands |
GB0401336D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
ES2241496B1 (es) * | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
MX2007001271A (es) * | 2004-08-05 | 2007-03-21 | Hoffmann La Roche | N-acil-2-aminotiazoles sustituidos. |
-
2007
- 2007-05-08 BR BRPI0712516A patent/BRPI0712516A2/pt not_active IP Right Cessation
- 2007-05-08 CN CN2007800180233A patent/CN101448844B/zh not_active Expired - Fee Related
- 2007-05-08 ES ES07728869T patent/ES2350013T3/es active Active
- 2007-05-08 WO PCT/EP2007/054416 patent/WO2007134958A1/en active Application Filing
- 2007-05-08 AT AT07728869T patent/ATE481409T1/de active
- 2007-05-08 JP JP2009510407A patent/JP5026511B2/ja not_active Expired - Fee Related
- 2007-05-08 CA CA2651769A patent/CA2651769C/en not_active Expired - Fee Related
- 2007-05-08 KR KR1020087028022A patent/KR101077295B1/ko not_active IP Right Cessation
- 2007-05-08 AU AU2007253485A patent/AU2007253485B2/en not_active Ceased
- 2007-05-08 MX MX2008014690A patent/MX2008014690A/es active IP Right Grant
- 2007-05-08 DE DE602007009221T patent/DE602007009221D1/de active Active
- 2007-05-08 EP EP07728869A patent/EP2027132B1/en not_active Not-in-force
- 2007-05-11 US US11/801,972 patent/US7947692B2/en not_active Expired - Fee Related
- 2007-05-15 TW TW096117228A patent/TW200813073A/zh unknown
- 2007-05-15 CL CL2007001380A patent/CL2007001380A1/es unknown
- 2007-05-16 AR ARP070102114A patent/AR060957A1/es not_active Application Discontinuation
-
2008
- 2008-10-30 IL IL195006A patent/IL195006A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2007253485B2 (en) | 2010-07-08 |
EP2027132A1 (en) | 2009-02-25 |
CL2007001380A1 (es) | 2008-01-04 |
KR101077295B1 (ko) | 2011-10-26 |
IL195006A0 (en) | 2009-08-03 |
ATE481409T1 (de) | 2010-10-15 |
MX2008014690A (es) | 2008-11-27 |
EP2027132B1 (en) | 2010-09-15 |
KR20080111141A (ko) | 2008-12-22 |
CA2651769A1 (en) | 2007-11-29 |
CN101448844A (zh) | 2009-06-03 |
US20070270433A1 (en) | 2007-11-22 |
JP5026511B2 (ja) | 2012-09-12 |
JP2009537473A (ja) | 2009-10-29 |
AU2007253485A1 (en) | 2007-11-29 |
US7947692B2 (en) | 2011-05-24 |
CN101448844B (zh) | 2012-07-25 |
ES2350013T3 (es) | 2011-01-14 |
WO2007134958A1 (en) | 2007-11-29 |
DE602007009221D1 (de) | 2010-10-28 |
TW200813073A (en) | 2008-03-16 |
AR060957A1 (es) | 2008-07-23 |
CA2651769C (en) | 2013-12-17 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
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B350 | Update of information on the portal [chapter 15.35 patent gazette] |