PT1309726E - Mediadores de interferência por rna específicos de sequência de rna - Google Patents

Mediadores de interferência por rna específicos de sequência de rna Download PDF

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Publication number
PT1309726E
PT1309726E PT01922870T PT01922870T PT1309726E PT 1309726 E PT1309726 E PT 1309726E PT 01922870 T PT01922870 T PT 01922870T PT 01922870 T PT01922870 T PT 01922870T PT 1309726 E PT1309726 E PT 1309726E
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Portugal
Prior art keywords
rna
mrna
gene
dsrna
cell
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PT01922870T
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English (en)
Portuguese (pt)
Inventor
Thomas Tuschl
Phillip A Sharp
Phillip D Zamore
David P Bartel
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Whitehead Biomedical Inst
Max Planck Ges Zur Forderung W
Massachusetts Inst Technology
Univ Massachusetts
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38068195&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1309726(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Whitehead Biomedical Inst, Max Planck Ges Zur Forderung W, Massachusetts Inst Technology, Univ Massachusetts filed Critical Whitehead Biomedical Inst
Publication of PT1309726E publication Critical patent/PT1309726E/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
    • A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/70—Invertebrates
    • A01K2227/703—Worms, e.g. Caenorhabdities elegans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/53—Physical structure partially self-complementary or closed
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PT01922870T 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna PT1309726E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19359400P 2000-03-30 2000-03-30
EP00126325 2000-12-01
US26523201P 2001-01-31 2001-01-31

Publications (1)

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PT1309726E true PT1309726E (pt) 2010-03-08

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ID=38068195

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PT01922870T PT1309726E (pt) 2000-03-30 2001-03-30 Mediadores de interferência por rna específicos de sequência de rna
PT14164227T PT2796553T (pt) 2000-03-30 2001-03-30 Mediadores de interferência de arn específicos de sequência de arn

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Country Status (16)

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US (19) US20020086356A1 (enExample)
EP (3) EP2028278B1 (enExample)
JP (6) JP5500750B2 (enExample)
KR (3) KR101215789B1 (enExample)
AT (1) ATE450621T2 (enExample)
AU (4) AU2001249622B2 (enExample)
BR (1) BR0107536A (enExample)
CA (1) CA2404890C (enExample)
CY (2) CY1109864T1 (enExample)
DE (1) DE60140676D1 (enExample)
DK (2) DK1309726T4 (enExample)
ES (2) ES2336887T5 (enExample)
IL (4) IL151928A0 (enExample)
NZ (2) NZ522045A (enExample)
PT (2) PT1309726E (enExample)
WO (1) WO2001075164A2 (enExample)

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