NO338446B1 - Injeksjonsanordning - Google Patents

Injeksjonsanordning Download PDF

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Publication number
NO338446B1
NO338446B1 NO20065973A NO20065973A NO338446B1 NO 338446 B1 NO338446 B1 NO 338446B1 NO 20065973 A NO20065973 A NO 20065973A NO 20065973 A NO20065973 A NO 20065973A NO 338446 B1 NO338446 B1 NO 338446B1
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housing
injection device
syringe
cuff
housing closure
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NO20065973A
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English (en)
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NO20065973L (no
Inventor
Rosie Habeshaw
Tim Barrow-Williams
Matthew Brady
Nigel Harrison
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Cilag Gmbh Int
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Application filed by Cilag Gmbh Int filed Critical Cilag Gmbh Int
Publication of NO20065973L publication Critical patent/NO20065973L/no
Publication of NO338446B1 publication Critical patent/NO338446B1/no

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321Means for protection against accidental injuries by used needles
    • A61M5/3213Caps placed axially onto the needle, e.g. equipped with finger protection guards
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206With automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3103Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3107Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
    • A61M2005/3109Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • A61M5/3204Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices

Description

Den foreliggende oppfinnelse vedrører en injeksjonsanordning av typen som opptar en sprøyte, strekker den, tømmer dens innhold og så trekker den inn automatisk. Anordninger av denne generelle type er vist i WO 95/35126 og EP-A-0 516 473, og benytter en drivfjær og en form for utløsningsmekanisme som frigjør sprøyten fra påvirkning fra drivfjæren etter at dens innhold antas å ha blitt tømt, for å tillate den å bli trukket tilbake av en returfjær.
Ofte kreves det at slike injeksjonsanordninger arbeider med å forsegle det hypoderme sprøyter som typisk har en hermetisk forseglet deksel eller "mansjett" som dekker den hypoderme nålen og bibeholder steriliteten til sprøyteinnholdet. Naturligvis er det nødvendig å bibeholde steriliteten til sprøyteinnholdet inntil administrasjonstidspunktet, som innebærer at for anordninger som er konstruert for å være adbruk- og kasttypen må mansjetten bli fjernet med sprøyten inne i injeksjonsanordningen.
Typisk medfører handlingen som kreves for å fjerne mansjetten fra sprøyten enten at mansjetten trekkes vekk fra sprøyten eller at den vris og trekkes vekk fra sprøyten. Hvis en fylt sprøyte har ligget en stund før den blir benyttet, er det ofte vanskelig å fjerne mansjetten fra sprøyten, og det kreves ofte en vesentlig kraft på mer enn 20N.
Hvis injeksjonsanordningene blir benyttet av pasienter med reumatisk artritt eller eldre eller svake pasienter, er det vanskelig for pasienten å fjerne mansjetten fra sprøyten før bruk. I tillegg er støvlene små og vanskelige å gripe for alle brukere, men spesielt for brukere som har dårlig bøyelighet i leddene, eller begrenset manuell fingerferdighet. Siden mansjetten til sprøyten kan være plassert inne i huset, kan det også være begrenset atkomst til mansjetten.
US 6575939 A vedrører en engangsinnretning for å injisere en dose av et legemiddel, omfattende en sprøyte og en stempelstang som er forsynt med en krave plassert i et hus dannet av to deler, en fremre del og en bakre del, montert inne i hverandre og i stand til å gli i forhold til hverandre.
Injeksjonsanordningene i henhold til den foreliggende oppfinnelse er konstruert for å håndtere disse problemene.
Den injeksjonsanordning i henhold til den foreliggende oppfinnelse innbefatter:
et hus avpasset for å oppta en sprøyte med en tømmedyse og en mansjett som dekker dens tømmedyse, i hvilket hus definerer en første akse og med første og andre ender, hvor tømmedysen er i stand til å strekke seg fra den første enden av huset gjennom en utgangsåpning, og hvor huset videre har en kamoverflate i sin første ende; og et huslukkeelement med en kamoverflate for kommunikasjon med kamoverflaten på huset slik at rotasjonen av huslukkeelementet om aksen får huslukkeelementet til å beveges aksialt vekk fra huset;
i det huslukkeelementet videre innbefatter midler for tilkopling til mansjetten til sprøyten slik at fjerning av huslukkeelementet fra huset forårsaker fjerning av mansjetten fra sprøyten;
hvor kamoverflatene på huset og huslukkemidlet innbefatter korresponderende krumme overflater; og
hvor midlene for tilkopling innbefatter en presset gripeskive med en profilert indre diameter.
Huslukkelementet kan videre innbefatte et utvendig gripetrekk med hvilket en bruker kan gripe huslukkeelementet.
Et av huslukkeelementene og huset kan videre innbefatte en rigg med hvilken korresponderende innsnitt på den andre av huslukkeelementet og huset kan kommunisere for å bibeholde huslukkelementet på huset.
I bruk ville mansjetten bli innsatt i sentret av gripeskiven, og den profilerte indre diameteren vil deformeres litt for å omkranse mansjetten. Spesielt ville gripskiven bli bøyd til en kjeglestubbeform. Imidlertid, når hetten blir fjernet, ville gripskiven grave inn i mansjetten og forhindre den fra å bli fjernet fra hetten.
Den indre diameteren til gripeskiven kan være forsynt med torner (castellated). Alternativt kan gripeskiven innbefatte en innvendig tannet stjerneskive (star washer) eller ristesikker skive
Midlene for tilkopling kan være dannet av metall.
Midlene for tilkopling kan bli holdt i et innsnitt støpt i huslukkeelementet.
Midlene for tilkopling kan bli rommet i et sentralt boss støpt inn i innsiden av huslukkemidlene. Midlene for tilkopling kan bli holdt på plass i huslukkemidlene av et innsnitt støpt i det sentrale bosset.
Huslukkemidlene kan videre innbefatte en støtteunderflate for understøttelse av en ende av en mansjett hos en sprøyte.
Oppfinnelsen vil nå bli beskrevet som eksempel med henvisning til de medfølgende tegninger, der: Fig. 1 viser et perspektivriss av en injeksjonsanordning i henhold til den foreliggende oppfinnelse med huslukkelementet fjernet og nålen i en utstrakt posisjon; Fig. 2 viser et planriss av en injeksjonsanordning i fig. 1; Fig. 3 viser et sideriss av injeksjonsanordning i fig. 1; Fig. 4 viser et perspektivriss fra injeksjonsanordningen i figurene 1 til 3, med huslukkelementet på plass; Fig. 5 viser et planriss av injeksjonsanordningen i fig. 4; Fig. 6 viser et perspektivriss av en torneutstyrt (castellated) gripeskive for bruk i en injeksjonsanordning i henhold til en utførelsesform av den foreliggende oppfinnelse; Fig. 7 viser et huslukkelement for bruk i en injeksjonsanordning i henhold til en utførelsesform av den foreliggende oppfinnelse; Fig. 8 viser hetten i fig. 7 tilkoplet en sprøytemansjett for en sprøyte benyttet sammen med en injeksjonsanordning i henhold til en utførelselsform av den foreliggende oppfinnelse; og Fig. 9 viser et tverrsnittriss av en del av en injeksjonsanordning i henhold til en utførelsesform av den foreliggende oppfinnelse. Figurene 1 til 5 og 9 viser en injeksjonsanordning 110 i henhold til en første utførelsesform av den foreliggende oppfinnelse. Injeksjonsanordningen har et injeksjonsanordningshus 112.
Huset 112 inneholder en hypoderm sprøyte 114 av konvensjonell type, inkludert et sprøytelegeme 116 som definerer et reservoar og som i en ende ender i hypoderm nål 118. Sprøyten 114 har en hermetisk forseglet deksel eller "mansjett" som dekker den hypoderme nålen 118 og bibeholder steriliteten til sprøyteinnholdet. Mansjetten er generelt utformet av en myk gummi av plastmaterialet. Selv om den viste sprøyten er av hypoderm type, trenger dette ikke nødvendigvis å være slik. Transkutane eller ballistisk dermale og subkutane sprøyter kan også bli benyttet sammen med en injeksjonsanordning i henhold til den foreliggende oppfinnelse.
Injeksjonsanordningen er videre tilveiebrakt med en hette 130. Som det best fremgår av figurene 1 til 3 og 7, blir hetten bibeholdt på huset 112 av en rygg 113 på huset 112, og et tilsvarende innsnitt 131 på innsiden av hetten 130.
Nær enden av huset 112 fra hvilken den hypoderme nålen kan strekke seg, er det tilveiebrakt en krum kamoverflate 150 som korresponderer med en annen krum kamoverflate 152 på hetten 130.
Slik det kan sees av figurene 7 og 8, er innsiden av hetten 130 tilveiebrakt med en torneutstyrt gripeskive 160. Denne gripeskiven 160 er vist i fig. 6. Gripeskiven 160 blir holdt på plass i hetten 130 av et tilsvarende innsnitt 162 som er støpt inn i innsiden av hetten 130. Utsiden av hetten 130 er tilveiebrakt med et par gripeoverflater 170. Disse gripeoverflatene 170 tilveiebringer en overflate gjennom hvilken bruker kan gripe hetten 130.
Slik det kan sees fra fig. 9, kan innsiden av hetten 130 være tilveiebrakt med en støtteoverflate 180 som understøtter enden av mansjetten 120.
Under tilvirkning av injeksjonsanordningen 110 blir sprøyten 114 og mansjetten 120 innsatt i huset som en enkel del. Hetten blir plassert på huset slik at mansjetten 120 blir tvunget inn i senter av den tornutstyrte skiven 160 og ryggen 113 på huset går i inngrep med innsnittet 131 i hetten 130.1 tillegg blir de to kamoverflaten 150 innrettet. Ved å tvinge mansjetten 120 inn i den torneutstyrte skiven 160 deformeres tornene slik at skiven antar en lett kjeglestubbform. Metallet fra hvilket skiven 160 er utformet skjærer inn i den mykere plast, eller gummimaterialet fra hvilket mansjetten 120 er utformet. Følgelig tilveiebringes et svært fast grep på mansjetten 120.
Når injeksjonsanordningen 110 skal benyttes, holder brukeren huset med en hånd, og griper hetten 130 med den andre hånden ved bruk av gripeoverflaten 170. Brukeren roterer så hetten 130. Ved rotering av hetten 130 beveger de to kamoverflaten 150,152 seg over hverandre, og hetten 130 blir beveget aksialt vekk fra huset 112. Denne rotasjonsbindende- og aksialbevegelsen vrir og trekker også mansjetten 120 av sprøyten 114. Mansjetten 120 blir holdt stasjonær i hetten 130 av den torneutstyrte skiven 160 fordi kraften som kreves for å vri mansjetten 120 å fjerne den fra sprøyten 114 er vesentlig mindre enn den som kreves for å trekke mansjetten 120 ut av senter av den torneutstyrte skiven 160. Støtteoverflaten 180 hjelper til å forhindre mansjetten 120 fra å bli trukket vekk fra sprøyten 114 i en vinkel, ved å bibeholde den aksiale innretningen av mansjetten 120 med hetten 130.
Den foreliggende oppfinnelsen tilveiebringer en enkel og effektiv måte å løse problemene for de tidligere kjente anordninger på. Siden ingen modifikasjoner må gjøres med sprøyten eller mansjetten, kan en standard sprøyte benyttes og tilvirkningskostnadene kan bli redusert. Videre er toleransene som sprøyten og mansjetten er plassert i huset med ikke kritiske, siden mansjetten ikke kan bli fjernet etter at den har blitt innsatt i den torneutstyrte skiven. Det har ingen betydning hvor mye mansjetten strekker seg gjennom skiven, gitt at skiven griper mansjetten tilstrekkelig. Siden innsetningsdybden og den nøyaktige størrelsen til sprøyten og mansjetten kan bli utsatt for variasjon, er dette en vesentlig fordel.
I tillegg er antallet operasjonelle trinn som kreves for å benytte anordningen minimalisert, siden det ikke er nødvendig å utføre to separate trinn for å fjerne hetten og mansjetten.

Claims (11)

1. Injeksjonsanordning (110), innbefatter: - et hus (112) avpasset for å oppta en sprøyte (114) med en tømmedyse (118) og en mansjett (120) som dekker dens tømmedyse, i hvilket hus definerer en første akse og med første og andre ender, hvor tømmedysen er i stand til å strekke seg fra den første enden av huset gjennom en utgangsåpning, og hvor huset videre har en kamoverflate (150) i sin første ende; ogkarakterisert ved: et huslukkeelement (130) med en kamoverflate (152) for kommunikasjon med kamoverflaten på huset slik at rotasjonen av huslukkeelementet om aksen får huslukkeelementet til å beveges aksialt vekk fra huset; - i det huslukkeelementet videre innbefatter midler (160) for tilkopling til mansjetten til sprøyten slik at fjerning av huslukkeelementet fra huset forårsaker fjerning av mansjetten fra sprøyten; - hvor kamoverflatene på huset og huslukkemidlet innbefatter korresponderende krumme overflater; og hvor midlene for tilkopling innbefatter en presset gripeskive (160) med en profilert indre diameter.
2. Injeksjonsanordning i henhold til krav 1,karakterisertved å innbefatte et ytre gripetrekk (170) ved hjelp av hvilke en bruker kan gripe huslukkeelementet.
3. Injeksjonsanordning i henhold til et hvilket som helst av de foregående krav,karakterisert vedat huslukkeelementet og huset innbefatter en rygg (113) med hvilken en korresponderende innsnitt (131) på den andre av huslukkeelementet og huset kan kommunisere for å bibeholde huslukkeelementet på huset.
4. Injeksjonsanordning i henhold til krav 1,karakterisertv e d at den indre diameteren til gripeskiven er tornutstyrt (castellated).
5. Injeksjonsanordning i henhold til krav 1,karakterisertv e d at gripeskiven innbefatter en innvendig tannet stjerneskive eller en ristesikker skive.
6. Injeksjonsanordning i henhold til et hvilket som helst av kravene 1, 4 eller 5,karakterisert vedat ved tilkopling av mansjetten til sprøyten til huslukkeelementet blir gripeskiven bøyd til en kjeglestubbeform.
7. Injeksjonsanordning i henhold til et hvilket som helst av de foregående krav,karakterisert vedat midlet for tilkopling er utformet av metall.
8. Injeksjonsanordning i henhold til et hvilket som helst av de foregående krav,karakterisert vedat midlet for tilkopling blir holdt i et innsnitt støpt inn i huslukkemidlene.
9. Injeksjonsanordning i henhold til et hvilke som helst av de foregående krav,karakterisert vedat midlet for tilkopling rommes i et sentralt boss støpt inn i innsiden av huslukkemidlene.
10. Injeksjonsanordning i henhold til krav 9,karakterisertv e d at midlet for tilkobling blir holdt på plass i huslukkemidlene ved hjelp av et innsnitt (162) støpt inn i det sentrale bosset.
11. Injeksjonsanordning i henhold til et hvilke som helst av de foregående krav,karakterisert vedå innbefatte en støtteoverflate (180) for understøttelse av en ende av en mansjett for en sprøyte.
NO20065973A 2004-05-28 2006-12-22 Injeksjonsanordning NO338446B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0412051A GB2414400B (en) 2004-05-28 2004-05-28 Injection device
PCT/GB2005/002116 WO2005115508A1 (en) 2004-05-28 2005-05-27 Injection device

Publications (2)

Publication Number Publication Date
NO20065973L NO20065973L (no) 2007-02-27
NO338446B1 true NO338446B1 (no) 2016-08-15

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US (1) US9895493B2 (no)
EP (1) EP1755706B2 (no)
JP (1) JP4795338B2 (no)
KR (1) KR101175604B1 (no)
CN (1) CN101018579B (no)
AT (1) ATE460954T1 (no)
AU (1) AU2005247146B2 (no)
BR (1) BRPI0510480B8 (no)
CA (1) CA2568660C (no)
DE (1) DE602005020000D1 (no)
DK (1) DK1755706T4 (no)
EA (1) EA010196B1 (no)
ES (1) ES2341659T5 (no)
GB (1) GB2414400B (no)
IL (1) IL179657A (no)
MX (1) MXPA06013895A (no)
NO (1) NO338446B1 (no)
NZ (1) NZ552330A (no)
PL (1) PL1755706T5 (no)
PT (1) PT1755706E (no)
UA (1) UA91978C2 (no)
WO (1) WO2005115508A1 (no)
ZA (2) ZA200610840B (no)

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GB2414409B (en) 2004-05-28 2009-11-18 Cilag Ag Int Injection device
GB2414406B (en) 2004-05-28 2009-03-18 Cilag Ag Int Injection device
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
GB2414401B (en) 2004-05-28 2009-06-17 Cilag Ag Int Injection device
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
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GB2414400B (en) 2009-01-14
CN101018579B (zh) 2010-09-29
EP1755706B1 (en) 2010-03-17
EA200602248A1 (ru) 2007-04-27
BRPI0510480A (pt) 2007-11-06
EA010196B1 (ru) 2008-06-30
US20090054849A1 (en) 2009-02-26
NO20065973L (no) 2007-02-27
AU2005247146A1 (en) 2005-12-08
IL179657A (en) 2010-06-16
JP4795338B2 (ja) 2011-10-19
WO2005115508A1 (en) 2005-12-08
MXPA06013895A (es) 2007-03-07
ES2341659T5 (es) 2015-03-23
GB0412051D0 (en) 2004-06-30
CN101018579A (zh) 2007-08-15
DK1755706T4 (en) 2015-03-30
PL1755706T3 (pl) 2010-08-31
ATE460954T1 (de) 2010-04-15
ZA200610837B (en) 2008-09-25
ZA200610840B (en) 2008-06-25
JP2008500855A (ja) 2008-01-17
PL1755706T5 (pl) 2015-06-30
DK1755706T3 (da) 2010-06-21
BRPI0510480B1 (pt) 2017-05-02
CA2568660A1 (en) 2005-12-08
PT1755706E (pt) 2010-04-23
KR101175604B1 (ko) 2012-08-22
KR20070050409A (ko) 2007-05-15
BRPI0510480B8 (pt) 2021-06-22
ES2341659T3 (es) 2010-06-24
AU2005247146B2 (en) 2010-05-27
UA91978C2 (en) 2010-09-27
IL179657A0 (en) 2007-05-15
NZ552330A (en) 2009-05-31
EP1755706B2 (en) 2014-12-17
CA2568660C (en) 2014-11-18
GB2414400A (en) 2005-11-30
US9895493B2 (en) 2018-02-20
EP1755706A1 (en) 2007-02-28

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