WO1988010129A1 - Slow delivery injection device - Google Patents

Slow delivery injection device Download PDF

Info

Publication number
WO1988010129A1
WO1988010129A1 PCT/AU1988/000203 AU8800203W WO8810129A1 WO 1988010129 A1 WO1988010129 A1 WO 1988010129A1 AU 8800203 W AU8800203 W AU 8800203W WO 8810129 A1 WO8810129 A1 WO 8810129A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
damper
device
spring
means
Prior art date
Application number
PCT/AU1988/000203
Other languages
French (fr)
Inventor
Allan Kenneth Wallace
Original Assignee
Nova Medical Pty. Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AUPI2710 priority Critical
Priority to AU271087 priority
Application filed by Nova Medical Pty. Limited filed Critical Nova Medical Pty. Limited
Publication of WO1988010129A1 publication Critical patent/WO1988010129A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2086Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir

Abstract

A self-contained device (30) which holds the body (42) of a syringe generally axially aligned with an internal damper unit (37) having an enveloping tension spring (12) acting between a base part of the device (30) and a piston (35) which generally houses the damper (37) and spring (12). The damper (37) includes an externally adjustable damping control (39) for setting the damping resistance to compression of the damper (37). Extension of the damper (37) offers substantially no resistance other than that required to extend the spring (12). The device can be loaded with a filled syringe (42) and will then slowly discharge the syringe at a selectable rate according to the setting of dial (39).

Description

"SLOW DELIVERY INJECTION DEVICE"

The present invention relates to a slow injection device and more particularly to a manually operable slow injection device. BACKGROUND ART

It is reported that the vast majority of adverse drug reactions due to the bolus injection of drugs by hand via a syringe are due to the rate of injection, not to the species of drug. Ideally, the contents of a syringe need to be delivered over a number of minutes. Clinical practice is such that this rarely occurs due to time pressure on the staff who must operate the syringe manually.

Electrically operated syringe pumps are known however these machines are of considerable complexity and are designed to inject very small doses of medicine with considerable accuracy over a long period which may be up to 24 hours. Such syringe pumps do not provide the cheap, simple and manually operated device suitable for the slow injection of drugs over a period of up to, say, 15 minutes. DISCLOSURE OF THE INVENTION

The present invention consists in a slow injection device comprising holding means to hold a syringe, manually actuable energy storage means adapted to apply a force to a syringe held by the holding means to bias the syringe to a condition in which the contents thereof are expelled therefrom, and rate controlling means to control the rate of release of energy from the energy storage means. The syringe for use in the slow injection' device according to the present invention will preferably be of a conventional type except that a short length of plastic tubing will be provided between the syringe and the cannula. The cannula may be positioned in the patient or intravenous line and the syringe placed in the slow injection device located on a bedside table or other location adjacent the patient.

The holding means may be any suitable mounting capable of receiving a conventional syringe while leaving the barrel and pistons of the syringe free for relative movement between- a condition in which there is space within the syringe containing a liquid to be injected and a condition in which the contents of the syringe will have been expelled therefrom (the latter being hereinafter called a closed condition) .

The energy storage means are manually actuable to raise the energy level therein sufficiently to bias a syringe to the closed condition. The energy storage means might comprise a spring such ,as a helical tension or compression spring, a gas spring or a biphase gas/liquid equilibrium mixture, e.g., a refrigerant. In the latter case the gas/liquid mixture would provide a driving force dependent upon temperature rather than displacement as is the case with a spring. The rate controlling means are required to regulate the rate of release of energy from the energy storage device such that the syringe is moved to the closed condition over the desired time. In preferred embodiments of the invention the rate controlling means comprise a hydraulic cylinder arrangement containing an incompressible fluid which is moved through a restricted aperture or a linear or rotary viscous damper. In the former case it is required that there be a reservoir to receive the displaced fluid; in order to save space this reservoir may comprise or include the reverse side of the piston being driven. If desired the hydraulic cylinder may be replaced by bellows or a bellowphragm equivalent.

In another embodiment of the invention the energy storage device may be a spring or the like which drives a pinion through a one way clutch and an adjustable governor which acts as the rate limiting means. The pinion in turn drives a rack which acts to move the syringe to the closed condition. In this arrangement the governor could be replaced with another form of rate limiting device such as an escapement, a centrifugal governor, a magnetic damper, or a viscous damper such as an oil film damper or an air paddle damper.

In yet a further embodiment of the invention the energy storage device comprises a spring, diaphragm, or an elastic dirigible reservoir connected to a hydraulic ram through an assymetric control valve. Movement of the piston into the barrel of the ram to allow mounting of the syringe in the device according to the invention serves to compress the spring or to distend the diaphragm or dirigible reservoir. The energy stored is then used to return hydraulic fluid through the control valve at a slow rate into the ram and thus slowly move the syringe to the closed condition.

BRIEF DESCRIPTION OF THE DRAWINGS The following drawings illustrate preferred exemplary embodiments of the invention to be described in detail with reference to the drawings: -

Fig. 1 is a perspective view of a device according to the present invention; Fig. 2 is a diagrammatic representation (not to scale) of the device of Fig. 1;

Fig. 3 is a sectional view through an alternative form of rate limiting means for inclusion in the device of

Fig. 1; Fig. 4 is a sectional view of an alternative embodiment of the invention; and

Fig. 5 is a detailed sectional view of a component of the device of Fig. 4.

BEST MODE OF CARRYING OUT THE INVENTION The slow injection device 10 comprises syringe clamping means 11, on energy storage spring 12, and rate limiting means 13.

The syringe clamping means 11 include a first end plate 14 having a vertically extending slot 15 opening into its upper edge and adapted to receive the apertured end of a syringe 16; and a second end plate 17 slidably mounted on device 10 and adapted to bear against the free end of the piston of syringe 16.

The energy storage spring 12 is arranged to bear, directly or indirectly, on an end plate 17 to urge it into contact with the free end of the piston of syringe 16 and in turn to urge the syringe into a closed condition.

The rate of movement of end plate 17 is controlled by the rate limiting means 13. As shown in Fig. 2 the rate limiting means 13 compresses an hydraulic ram 18 having a barrel 19 connected to the device 10 and a piston 21 connected to end plate 17. The barrel 19 is in fluid communication with a dirigible reservoir 22 through an assymetric control valve 23. In operation the end plate 17 is drawn back from end plate 15 to allow the insertion of syringe 16 into the device 10. This movement compresses spring 12 and simultaneously forces hydraulic fluid from ram 18 through the control valve 23 into the dirigible reservoir 22. The spring 12 then serves to urge the syringe 16 into a closed condition however the rate at which this is achieved is controlled by the rate at which hydraulic fluid is permitted to flow from the reservoir 22 back to the ram 18 through the control valve 23. Fig. 3 shows an alternative arrangement of rate control means 13. In this arrangement the dirigible reservoir 22 is dispensed with and the hydraulic fluid flows from ram 18 through a control valve 24 back into the ram 18 on the reverse side of piston 21. The piston 21 of hydraulic ram 18 includes one way valve 25 to allow ready installation of a syringe 16 into the device 10.

The slow injection device 30 shown in Fig. 4 includes a helical tension spring 12 attached at one end to lug 31 and at the opposite end to anchor 32. The lug 31 is rigid with base art 33 which includes a generally cylindrical housing portion 34 at one of its ends.

Held telescopically within the housing portion 34 is a piston 35 being substantially fully enclosed with the exception of a longitudinally running slot 36 which accommodates the lug 31. The anchor 32 is at an internal end of the piston 35, the anchor 32 also locating one end of a hydraulic damper unit 37. The opposite end of the damper unit 37 being a damper rod 38, is attached to the lug 31. The damper unit 37 provides an hydraulic resistance to its longitudinal movement being adjustable by way of., adjustment knob 39.

The base part 33 further includes a syringe body holding portion 40 adapted to restrain the finger plate 41 of a syringe 42. The syringe body holding portion 40 is adapted to take a range of standard syringes 42.

A thumb plate engaging portion 43 is attached to one end of the piston 35 proximate the syringe body holding portion 40. The thumb plate engaging portion 43 is adapted to hold, and push under the action of the spring 12, the thumb plate and thus piston of the syringe 42.

Fig. 5 shows the damper unit 37 in more detail. The damper unit 37 includes an internal cylindrical bore 44 and a mating piston 45 in close engagement. The piston 45 preferably includes a low friction seal such as FTFE produced cap seal. The piston 45 is connected to the damper rod 38 extending to the exterior of the body of the damper unit 37. The piston 45 includes an internal valve mechanism 46 which allows asymmetric damping characteristics, that is, there is substantialy damping only in one longitudinal direction of movement of the piston 45 relative to the bore 44. The direction of damping will be as the damper unit 37 compresses.

The adjustment knob 39 is connected to an adjacent needle valve 47 which is moved relative to its seat by rotation of the adjustment knob 39 so as to provide a variable diameter fluid flow aperture from the internal volume of the bore 44 and an external fluid flow line 48. The fluid flow line 48 extends along one edge of the body of the damper unit 37 and returns into the internal volume of the bore 44 at the end of the body opposite the needle valve 47. A closed cell foam annular block 49 is included so as to make up the long change of displaced fluid equating to the volume of the piston rod 38 within the internals of the damper unit 37 at different positions of extension of the unit as a whole. Thus no air volume is required within.

In operation the device 30 forms substantially the same task as the previously described device 10. It will be recognised by persons skilled in the art that numerous variations and modifications may be made to the invention as described above without departing from the spirit or scope of the invention as broadly described.

Claims

CLAIMS:
1. A slow injection device comprising holding means to hold a syringe, manually actuable energy storage means adapted to apply a force to a syringe held by the holding means so as to bias the syringe to a condition in which the contents thereof are expelled therefrom, and rate controlling means controlling the rate of release of energy from the energy storage means.
2. A device as in claim 1 wherein the energy storage means is a steel spring.
3. A device as in claim 1 wherein the energy storage means is compressed gas.
4. A device as in claim 1 wherein the rate controlling means is a fluid damper.
5. A device as in claim 1 wherein the rate controlling means and energy storage means are respectively a elongate fluid damper and an elongate helical steel spring concentric of the damper, the fluid damper having a damper rod extending telescopically from one end and a first spring attachment device attaching one end of the spring to an end of the damper rod and a second spring attachment means attaching an opposite end of the spring to a distal end of a body of the fluid damper.
6. A device as in claim 5 wherein the fluid damper includes a damping force adjustment means adjustable externally of the damper and the damper having substantially no damping resistance in one direction of telescopic movement of the damper rod and adjustable damping resistant in the other telescopic direction of movement of the damping rod.
7. A device as in claim 6 wherein the holding means is adapted to hold the body of a syringe and is rigidly connected to the damper rod so as to hold the syringe approximately parallel to and concentric with the damper rod and the device further comprises a syringe thumb plate engaging portion approximately concentric of the damper rod and rigidly connected to the body of the damper and wherein the spring is a tension spring such that the thumb plate engaging portion can be withdrawn away from the syringe holding means thereby extending the spring and moving the damper rod in the telescopic direction of substantially no damping resistance so as to allow placement of a standard syringe in the device and thence ; control operation of the syringe to discharge liquid within the syringe at a controlled rate proportional to the selected damping adjustment.
8. A device as in claim 6 further including a syringe held by the holding means generally aligned with the damper rod so as to provide controlled forced egress of liquid within the syringe at a rate dependent upon the selected damping force adjustment.
PCT/AU1988/000203 1987-06-25 1988-06-24 Slow delivery injection device WO1988010129A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AUPI2710 1987-06-25
AU271087 1987-06-25

Publications (1)

Publication Number Publication Date
WO1988010129A1 true WO1988010129A1 (en) 1988-12-29

Family

ID=3693202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1988/000203 WO1988010129A1 (en) 1987-06-25 1988-06-24 Slow delivery injection device

Country Status (1)

Country Link
WO (1) WO1988010129A1 (en)

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960626A3 (en) * 1998-05-29 2000-01-19 Fresenius AG Implantable solution application device and actuator for a syringe for filling the device
EP0956875A3 (en) * 1998-05-15 2000-07-19 Disetronic Licensing AG Device for the dosed application of an injectable product
US6270479B1 (en) 1998-10-26 2001-08-07 Pharmacia Ab Autoinjector
EP1596896A2 (en) * 2002-12-23 2005-11-23 Farhad Kazemzadeh Drug delivery apparatus
US7785292B2 (en) 2004-05-28 2010-08-31 Ethicon Endo-Surgery, Inc. Injection device
US7901377B1 (en) 2004-05-28 2011-03-08 Cilag Gmbh International Injection device
US8070726B2 (en) 2003-04-23 2011-12-06 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
AU2009326323B2 (en) * 2008-12-12 2013-01-17 Shl Group Ab Medicament delivery device
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
US8845594B2 (en) 2008-06-19 2014-09-30 Cilag Gmbh International Auto-injector with filling means
US8939958B2 (en) 2008-06-19 2015-01-27 Cilag Gmbh International Fluid transfer assembly for a syringe
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
EP2314259B1 (en) 2003-03-14 2015-07-29 Depuy Spine, Inc. Hydraulic device for injection of bone cement in percutaneous vertebroplasty
US9234729B2 (en) 2014-06-05 2016-01-12 Pneu-Dart, Inc. Injection dart
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9504508B2 (en) 2003-06-17 2016-11-29 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
WO2017053261A1 (en) * 2015-09-24 2017-03-30 Vidacare LLC Infusing devices, systems, and methods
US9642932B2 (en) 2006-09-14 2017-05-09 DePuy Synthes Products, Inc. Bone cement and methods of use thereof
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9750840B2 (en) 2004-03-21 2017-09-05 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
US9839460B2 (en) 2003-03-31 2017-12-12 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US10111697B2 (en) 2003-09-26 2018-10-30 DePuy Synthes Products, Inc. Device for delivering viscous material

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US3279653A (en) * 1964-12-17 1966-10-18 Frederick W Pfleger Escapement controlled dispensing apparatus
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US3605745A (en) * 1969-12-15 1971-09-20 Milton Hodosh Dental injection apparatus
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Cited By (49)

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Publication number Priority date Publication date Assignee Title
US7931625B2 (en) 1998-05-15 2011-04-26 Tecpharma Licensing Ag Device for administering an injectable product
EP0956875A3 (en) * 1998-05-15 2000-07-19 Disetronic Licensing AG Device for the dosed application of an injectable product
US7357791B2 (en) 1998-05-15 2008-04-15 Tecpharma Licensing Ag Device for administering an injectable product
US7931626B2 (en) 1998-05-15 2011-04-26 Tecpharma Licensing Ag Device for administering an injectable product
US6730060B1 (en) 1998-05-29 2004-05-04 Fresenius Medical Care Deutschland Gmbh Implantable device for administering a treatment solution and operating device for a syringe for filling the device
EP0960626A3 (en) * 1998-05-29 2000-01-19 Fresenius AG Implantable solution application device and actuator for a syringe for filling the device
US6371939B2 (en) 1998-10-26 2002-04-16 Pharmacia Ab Autoinjector
US6270479B1 (en) 1998-10-26 2001-08-07 Pharmacia Ab Autoinjector
EP1596896A4 (en) * 2002-12-23 2006-09-20 Farhad Kazemzadeh Drug delivery apparatus
US7270648B2 (en) 2002-12-23 2007-09-18 Farhad Kazemzadeh Drug delivery apparatus
US8394061B2 (en) 2002-12-23 2013-03-12 Farhad Kazemzadeh Drug delivery apparatus
EP1596896A2 (en) * 2002-12-23 2005-11-23 Farhad Kazemzadeh Drug delivery apparatus
JP2006514850A (en) * 2002-12-23 2006-05-18 カゼムザデー、ファラッド Dispensing device
EP2314259B1 (en) 2003-03-14 2015-07-29 Depuy Spine, Inc. Hydraulic device for injection of bone cement in percutaneous vertebroplasty
US9839460B2 (en) 2003-03-31 2017-12-12 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US8070726B2 (en) 2003-04-23 2011-12-06 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
US9072828B2 (en) 2003-04-23 2015-07-07 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
US9504508B2 (en) 2003-06-17 2016-11-29 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US10039585B2 (en) 2003-06-17 2018-08-07 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US10111697B2 (en) 2003-09-26 2018-10-30 DePuy Synthes Products, Inc. Device for delivering viscous material
US9750840B2 (en) 2004-03-21 2017-09-05 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US7901377B1 (en) 2004-05-28 2011-03-08 Cilag Gmbh International Injection device
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US7785292B2 (en) 2004-05-28 2010-08-31 Ethicon Endo-Surgery, Inc. Injection device
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9642932B2 (en) 2006-09-14 2017-05-09 DePuy Synthes Products, Inc. Bone cement and methods of use thereof
US10272174B2 (en) 2006-09-14 2019-04-30 DePuy Synthes Products, Inc. Bone cement and methods of use thereof
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US8939958B2 (en) 2008-06-19 2015-01-27 Cilag Gmbh International Fluid transfer assembly for a syringe
US8845594B2 (en) 2008-06-19 2014-09-30 Cilag Gmbh International Auto-injector with filling means
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
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