ME02688B - Hinazolinoni kao inhibitori humane fosfatidilinozitol 3 - kinaze delta - Google Patents

Hinazolinoni kao inhibitori humane fosfatidilinozitol 3 - kinaze delta

Info

Publication number
ME02688B
ME02688B MEP-2016-297A MEP29716A ME02688B ME 02688 B ME02688 B ME 02688B ME P29716 A MEP29716 A ME P29716A ME 02688 B ME02688 B ME 02688B
Authority
ME
Montenegro
Prior art keywords
quinazolinones
inhibitors
kinase delta
human phosphatidylinositol
phosphatidylinositol
Prior art date
Application number
MEP-2016-297A
Other languages
English (en)
Unknown language (me)
Inventor
Kerry W Fowler
Danwen Huang
Edward A Kesicki
Hua Chee Ooi
Amy R Oliver
Fuqiang Ruan
Jennifer Treiberg
Kamal Deep Puri
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02688(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of ME02688B publication Critical patent/ME02688B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P11/02Nasal agents, e.g. decongestants
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    • A61P11/06Antiasthmatics
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    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • A61P37/02Immunomodulators
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    • A61P39/06Free radical scavengers or antioxidants
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
MEP-2016-297A 2004-05-13 2005-05-12 Hinazolinoni kao inhibitori humane fosfatidilinozitol 3 - kinaze delta ME02688B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57078404P 2004-05-13 2004-05-13
PCT/US2005/016778 WO2005113556A1 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
EP05752122.1A EP1761540B1 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Publications (1)

Publication Number Publication Date
ME02688B true ME02688B (me) 2017-10-20

Family

ID=34969603

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2016-284A ME02695B (me) 2004-05-13 2005-05-12 Hinazolinoni kao inhibitori humane fosfatidilonozitol 3- delta kinaze
MEP-2016-297A ME02688B (me) 2004-05-13 2005-05-12 Hinazolinoni kao inhibitori humane fosfatidilinozitol 3 - kinaze delta

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-2016-284A ME02695B (me) 2004-05-13 2005-05-12 Hinazolinoni kao inhibitori humane fosfatidilonozitol 3- delta kinaze

Country Status (23)

Country Link
US (14) USRE44638E1 (h)
EP (4) EP1761540B1 (h)
JP (1) JP2007537291A (h)
CN (2) CN101031569B (h)
AU (2) AU2005245875C1 (h)
BE (1) BE2017C002I2 (h)
CA (1) CA2566609C (h)
CY (3) CY2016046I1 (h)
DK (2) DK1761540T3 (h)
ES (3) ES2607804T3 (h)
FR (1) FR17C1007I2 (h)
HR (2) HRP20161751T1 (h)
HU (3) HUE030839T2 (h)
IL (4) IL179176A (h)
LT (3) LT2612862T (h)
LU (1) LUC00005I2 (h)
ME (2) ME02695B (h)
NL (1) NL300867I2 (h)
PL (3) PL1761540T3 (h)
PT (3) PT3153514T (h)
RS (2) RS55546B1 (h)
SI (2) SI3153514T1 (h)
WO (2) WO2005113556A1 (h)

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EP2004654B1 (en) 2006-04-04 2013-05-22 The Regents of the University of California Pyrazolopyrimidine derivatives for use as kinase antagonists
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US20130231356A1 (en) 2013-09-05
FR17C1007I1 (fr) 2017-04-21
US8207153B2 (en) 2012-06-26
PL2612862T3 (pl) 2017-08-31
FR17C1007I2 (fr) 2018-03-23
US9149477B2 (en) 2015-10-06
US20140378479A1 (en) 2014-12-25
CA2566609A1 (en) 2005-12-01
PL3153514T3 (pl) 2022-01-10
US20140121224A1 (en) 2014-05-01
DK2612862T3 (en) 2016-12-05
PL1761540T3 (pl) 2017-06-30
AU2005245875C1 (en) 2017-08-31
SI2612862T1 (sl) 2017-04-26
CY1118493T1 (el) 2017-07-12
RS55551B1 (sr) 2017-05-31
HRP20161751T1 (hr) 2017-04-07
PT2612862T (pt) 2016-12-15
US20080275067A1 (en) 2008-11-06
IL241732A0 (en) 2015-11-30
PT3153514T (pt) 2021-06-25
US20160075705A1 (en) 2016-03-17
ME02695B (me) 2017-10-20
AU2009230739A1 (en) 2009-11-12
PT1761540T (pt) 2016-12-07
CN101031569B (zh) 2011-06-22
AU2005245875A1 (en) 2005-12-01
BE2017C002I2 (h) 2024-08-08
EP1761540B1 (en) 2016-09-28
IL179176A (en) 2015-10-29
EP2612862A2 (en) 2013-07-10
US20210332047A1 (en) 2021-10-28
HUS1700006I1 (hu) 2017-03-28
IL241732B (en) 2019-10-31
EP3153514B1 (en) 2021-04-21
IL179176A0 (en) 2007-03-08
AU2005245875B2 (en) 2009-07-30
DK1761540T3 (en) 2016-11-21
CY2016046I2 (el) 2017-11-14
ES2607804T3 (es) 2017-04-04
JP2007537291A (ja) 2007-12-20
CY1118516T1 (el) 2017-07-12
CN101031569A (zh) 2007-09-05
HUE030839T2 (en) 2017-06-28
LT1761540T (lt) 2017-02-27
CY2016046I1 (el) 2017-11-14
LT2612862T (lt) 2017-01-25
WO2005113554A2 (en) 2005-12-01
NL300867I2 (h) 2017-05-09
LTC1761540I2 (lt) 2019-04-10
LTPA2017004I1 (lt) 2017-03-10
US8779131B2 (en) 2014-07-15
US20130116266A1 (en) 2013-05-09
US20140121223A1 (en) 2014-05-01
USRE44638E1 (en) 2013-12-10
US10336756B2 (en) 2019-07-02
CN102229609A (zh) 2011-11-02
US20100256167A1 (en) 2010-10-07
HRP20161657T1 (hr) 2017-02-10
US8993583B2 (en) 2015-03-31
US20100256168A1 (en) 2010-10-07
USRE44599E1 (en) 2013-11-12
HUE030950T2 (en) 2017-06-28
WO2005113554A3 (en) 2006-04-06
IL269976B (en) 2021-04-29
EP2612862A3 (en) 2014-01-08
WO2005113556A1 (en) 2005-12-01
RS55546B1 (sr) 2017-05-31
US8980901B2 (en) 2015-03-17
CA2566609C (en) 2012-06-26

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