BR112013000867A2 - composto de purina seletivos para delta p110 de pi3k e métodos de uso. - Google Patents
composto de purina seletivos para delta p110 de pi3k e métodos de uso.Info
- Publication number
- BR112013000867A2 BR112013000867A2 BR112013000867A BR112013000867A BR112013000867A2 BR 112013000867 A2 BR112013000867 A2 BR 112013000867A2 BR 112013000867 A BR112013000867 A BR 112013000867A BR 112013000867 A BR112013000867 A BR 112013000867A BR 112013000867 A2 BR112013000867 A2 BR 112013000867A2
- Authority
- BR
- Brazil
- Prior art keywords
- delta
- pi3k
- methods
- purine compound
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
composto de purina seletivos para delta p110 de pi3k e métodos de uso. a invenção provê compostos que tem a fórmula geral: e estereoisômeros, tautômeros ou sai aceitos farmaceuticamente desses, em que r^1^,r^2^,r^3^,r^4^ e n são definidos aqui, composições incluindo os compostos e método de utilizar os compostos para tratar uma doença ou distúrbio mediado pelo isoforma delta de p110 de quinase pi3 selecionado de distúrbios imunológicos, câncer, doenças cardiovasculares, infecção viral, inflamação,distúrbios de funções de metabolismo/endócrinas e distúrbios neurológicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36432410P | 2010-07-14 | 2010-07-14 | |
PCT/EP2011/061930 WO2012007493A1 (en) | 2010-07-14 | 2011-07-13 | Purine compounds selective for ρi3κ p110 delta, and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013000867A2 true BR112013000867A2 (pt) | 2016-05-17 |
Family
ID=44532789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013000867A BR112013000867A2 (pt) | 2010-07-14 | 2011-07-13 | composto de purina seletivos para delta p110 de pi3k e métodos de uso. |
Country Status (11)
Country | Link |
---|---|
US (1) | US8293736B2 (pt) |
EP (1) | EP2593455B1 (pt) |
JP (1) | JP5555378B2 (pt) |
KR (1) | KR101531117B1 (pt) |
CN (1) | CN103003279B (pt) |
BR (1) | BR112013000867A2 (pt) |
CA (1) | CA2802808A1 (pt) |
ES (1) | ES2536780T3 (pt) |
MX (1) | MX2013000389A (pt) |
RU (1) | RU2013104038A (pt) |
WO (1) | WO2012007493A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009146406A1 (en) * | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
CN102711766B (zh) * | 2009-11-12 | 2014-06-04 | 霍夫曼-拉罗奇有限公司 | N-9-取代的嘌呤化合物、组合物和使用方法 |
SG190890A1 (en) | 2010-12-16 | 2013-07-31 | Hoffmann La Roche | Tricyclic pi3k inhibitor compounds and methods of use |
EP2790705B1 (en) | 2011-12-15 | 2017-12-06 | Novartis AG | Use of inhibitors of the activity or function of pi3k |
EA035391B1 (ru) | 2012-11-08 | 2020-06-05 | Ризен Фармасьютикалз Са | Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназы |
CN104513254B (zh) | 2013-09-30 | 2019-07-26 | 上海璎黎药业有限公司 | 稠合嘧啶类化合物、中间体、其制备方法、组合物和应用 |
MX2016004964A (es) | 2013-10-16 | 2016-07-11 | Shanghai Yingli Pharm Co Ltd | Compuesto heterociclico fusionado, metodo de preparacion del mismo, composicion farmaceutica, y usos del mismo. |
WO2015188369A1 (en) | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
EP3209664B1 (en) | 2014-10-22 | 2020-06-03 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds as pi3k inhibitors |
ES2749679T3 (es) | 2014-10-22 | 2020-03-23 | Bristol Myers Squibb Co | Compuestos de pirrolotriazina amina sustituidos como inhibidores de PI3k |
MX2017012390A (es) | 2015-03-30 | 2018-01-26 | Daiichi Sankyo Co Ltd | Derivados de 6-morfolinil-2-pirazolil-9h-purina y su uso como inhibidores de fosfoinositol-3-cinasa (pi3k). |
GB201514751D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
WO2018062382A1 (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | [2-(1-メチル-1h-ピラゾール-4-イル)-6-(モルホリン-4-イル)-9h-プリン-8-イル][4-(モルホリン-4-イル)ピペリジン-1-イル]メタノン及びその製薬上許容される塩の結晶 |
ES2911522T3 (es) | 2016-12-02 | 2022-05-19 | Daiichi Sankyo Co Ltd | Novedosa endo-ß-n-acetilglucosaminidasa |
JP7358890B2 (ja) | 2019-10-01 | 2023-10-11 | 富士フイルムビジネスイノベーション株式会社 | 物体質感計測装置 |
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US3016378A (en) | 1959-07-01 | 1962-01-09 | Thomae Gmbh Dr K | Amino-substituted purine derivatives |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
JPS60260579A (ja) | 1984-01-13 | 1985-12-23 | Yoshitomi Pharmaceut Ind Ltd | プリン誘導体 |
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
US4782137A (en) | 1984-01-24 | 1988-11-01 | Immunex Corporation | Synthesis of protein with an identification peptide, and hybrid polypeptide incorporating same |
DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
US5332744A (en) | 1989-05-30 | 1994-07-26 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
US5866702A (en) | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
ES2360933T3 (es) | 2000-04-27 | 2011-06-10 | Astellas Pharma Inc. | Derivados de heteroarilo condensados. |
EP1427413A2 (en) | 2001-09-13 | 2004-06-16 | Synta Pharmaceuticals Corporation | 2-aroylimidazole compounds for treating cancer |
JP2005512972A (ja) | 2001-10-12 | 2005-05-12 | アイアールエム エルエルシー | キナーゼ阻害剤足場およびそれらの調製方法 |
US6949644B2 (en) | 2001-10-12 | 2005-09-27 | Irm Llc | Methods for the synthesis of substituted purines |
US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
US20050288503A1 (en) | 2002-09-06 | 2005-12-29 | Adams Jerry L | Novel compounds |
AU2003284142A1 (en) | 2002-10-15 | 2004-05-04 | Synta Pharmaceuticals Corp | Aromatic bicyclic heterocyles to modulate 1L-12 production |
EP1626725A4 (en) | 2003-05-29 | 2006-06-14 | Synta Pharmaceuticals Corp | Heterocyclic compounds for the prevention and treatment of disorders associated with excessive bone formation |
HUE030950T2 (en) | 2004-05-13 | 2017-06-28 | Icos Corp | Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol |
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WO2008116909A1 (en) | 2007-03-28 | 2008-10-02 | Neurosearch A/S | Purinyl derivatives and their use as potassium channel modulators |
US7893060B2 (en) * | 2007-06-12 | 2011-02-22 | F. Hoffmann-La Roche Ag | Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase |
EP2207781B1 (en) | 2007-09-24 | 2012-11-28 | Genentech, Inc. | Thiazolopyrimidine p13k inhibitor compounds and methods of use |
US20110009403A1 (en) * | 2007-10-05 | 2011-01-13 | S*Bio Pte Ltd. | 2-morpholinylpurines as inhibitors of pi3k |
JP5638955B2 (ja) | 2007-10-26 | 2014-12-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Pi3キナーゼ阻害剤として有用なプリン誘導体 |
JP5608099B2 (ja) * | 2008-01-30 | 2014-10-15 | ジェネンテック, インコーポレイテッド | ピラゾロピリミジンpi3k阻害剤化合物および使用方法 |
WO2009146406A1 (en) | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
CA2730271A1 (en) * | 2008-07-07 | 2010-01-14 | Xcovery Holding Company Llc | Pi3k isoform selective inhibitors |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
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CN102459272B (zh) * | 2009-05-27 | 2014-08-06 | 健泰科生物技术公司 | 对P110δ具有选择性的为PI3K抑制剂的二环嘧啶化合物和使用方法 |
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-
2011
- 2011-07-13 JP JP2013519085A patent/JP5555378B2/ja not_active Expired - Fee Related
- 2011-07-13 BR BR112013000867A patent/BR112013000867A2/pt not_active IP Right Cessation
- 2011-07-13 CN CN201180034691.1A patent/CN103003279B/zh not_active Expired - Fee Related
- 2011-07-13 MX MX2013000389A patent/MX2013000389A/es active IP Right Grant
- 2011-07-13 KR KR1020137003606A patent/KR101531117B1/ko not_active IP Right Cessation
- 2011-07-13 WO PCT/EP2011/061930 patent/WO2012007493A1/en active Application Filing
- 2011-07-13 ES ES11736322.6T patent/ES2536780T3/es active Active
- 2011-07-13 RU RU2013104038/04A patent/RU2013104038A/ru not_active Application Discontinuation
- 2011-07-13 US US13/181,647 patent/US8293736B2/en not_active Expired - Fee Related
- 2011-07-13 EP EP11736322.6A patent/EP2593455B1/en not_active Not-in-force
- 2011-07-13 CA CA2802808A patent/CA2802808A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2013531022A (ja) | 2013-08-01 |
MX2013000389A (es) | 2013-03-08 |
KR20130038921A (ko) | 2013-04-18 |
WO2012007493A1 (en) | 2012-01-19 |
ES2536780T3 (es) | 2015-05-28 |
RU2013104038A (ru) | 2014-08-20 |
CA2802808A1 (en) | 2012-01-19 |
JP5555378B2 (ja) | 2014-07-23 |
EP2593455A1 (en) | 2013-05-22 |
CN103003279B (zh) | 2015-09-23 |
CN103003279A (zh) | 2013-03-27 |
EP2593455B1 (en) | 2015-03-18 |
US20120015931A1 (en) | 2012-01-19 |
US8293736B2 (en) | 2012-10-23 |
KR101531117B1 (ko) | 2015-06-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |