MX2022006807A - Análogos de rapamicina y usos de estos. - Google Patents

Análogos de rapamicina y usos de estos.

Info

Publication number
MX2022006807A
MX2022006807A MX2022006807A MX2022006807A MX2022006807A MX 2022006807 A MX2022006807 A MX 2022006807A MX 2022006807 A MX2022006807 A MX 2022006807A MX 2022006807 A MX2022006807 A MX 2022006807A MX 2022006807 A MX2022006807 A MX 2022006807A
Authority
MX
Mexico
Prior art keywords
present
compositions
methods
compounds
rapamycin analogs
Prior art date
Application number
MX2022006807A
Other languages
English (en)
Inventor
Eddine Saiah
David John O'neill
Seong Woo Anthony Kang
Original Assignee
Anakuria Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anakuria Therapeutics Inc filed Critical Anakuria Therapeutics Inc
Publication of MX2022006807A publication Critical patent/MX2022006807A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención proporciona compuestos, composiciones de estos y métodos para usarlos. La presente invención se relaciona con compuestos y métodos útiles para modular la actividad de mTORC1. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden compuestos proporcionados de la presente invención y métodos para usar tales composiciones en el tratamiento de diversos trastornos.
MX2022006807A 2019-12-05 2020-12-04 Análogos de rapamicina y usos de estos. MX2022006807A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962944166P 2019-12-05 2019-12-05
PCT/US2020/063351 WO2021113665A1 (en) 2019-12-05 2020-12-04 Rapamycin analogs and uses thereof

Publications (1)

Publication Number Publication Date
MX2022006807A true MX2022006807A (es) 2022-09-12

Family

ID=76222025

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022006807A MX2022006807A (es) 2019-12-05 2020-12-04 Análogos de rapamicina y usos de estos.

Country Status (12)

Country Link
US (2) US11819476B2 (es)
EP (1) EP4069223A4 (es)
JP (1) JP2023506410A (es)
KR (1) KR20220128345A (es)
CN (1) CN115209897A (es)
AU (1) AU2020397938A1 (es)
BR (1) BR112022010754A2 (es)
CA (1) CA3163680A1 (es)
IL (1) IL293549A (es)
MX (1) MX2022006807A (es)
TW (1) TW202134234A (es)
WO (1) WO2021113665A1 (es)

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KR102643707B1 (ko) 2019-01-22 2024-03-04 에오비안 파마슈티컬스, 인크. Mtorc 조절제 및 이의 용도
IL296828A (en) 2020-03-27 2022-11-01 Aeovian Pharmaceuticals Inc mtorc1 modulators and their uses
EP4185590A2 (en) * 2020-07-21 2023-05-31 Aeovian Pharmaceuticals, Inc. Mtorc1 modulators and uses thereof
JP2024503898A (ja) * 2021-01-22 2024-01-29 ヤンセン ファーマシューティカ エヌ．ベー． ラパマイシン類似体及びその使用
CN114539203A (zh) * 2022-03-10 2022-05-27 李科 一种低成本碳酸亚乙烯酯的合成方法
WO2023196676A1 (en) * 2022-04-09 2023-10-12 The Brigham And Women's Hospital, Inc. Treating tuberous sclerosis complex-associated diseases
CN115097046B (zh) * 2022-07-07 2023-09-26 国药集团川抗制药有限公司 一种分离雷帕霉素及其杂质的方法

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Also Published As

Publication number Publication date
EP4069223A4 (en) 2023-12-20
CA3163680A1 (en) 2021-06-10
WO2021113665A1 (en) 2021-06-10
JP2023506410A (ja) 2023-02-16
US20240139164A1 (en) 2024-05-02
US11819476B2 (en) 2023-11-21
IL293549A (en) 2022-08-01
BR112022010754A2 (pt) 2022-08-23
EP4069223A1 (en) 2022-10-12
CN115209897A (zh) 2022-10-18
TW202134234A (zh) 2021-09-16
AU2020397938A1 (en) 2022-06-23
KR20220128345A (ko) 2022-09-20
US20210186935A1 (en) 2021-06-24

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