|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
|
US6361974B1
(en)
|
1995-12-07 |
2002-03-26 |
Diversa Corporation |
Exonuclease-mediated nucleic acid reassembly in directed evolution
|
|
US5830696A
(en)
|
1996-12-05 |
1998-11-03 |
Diversa Corporation |
Directed evolution of thermophilic enzymes
|
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
|
US6562594B1
(en)
|
1999-09-29 |
2003-05-13 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
|
US6537776B1
(en)
|
1999-06-14 |
2003-03-25 |
Diversa Corporation |
Synthetic ligation reassembly in directed evolution
|
|
US6939689B2
(en)
|
1995-12-07 |
2005-09-06 |
Diversa Corporation |
Exonuclease-mediated nucleic acid reassembly in directed evolution
|
|
US6358709B1
(en)
|
1995-12-07 |
2002-03-19 |
Diversa Corporation |
End selection in directed evolution
|
|
US6352842B1
(en)
|
1995-12-07 |
2002-03-05 |
Diversa Corporation |
Exonucease-mediated gene assembly in directed evolution
|
|
US6740506B2
(en)
|
1995-12-07 |
2004-05-25 |
Diversa Corporation |
End selection in directed evolution
|
|
US6238884B1
(en)
|
1995-12-07 |
2001-05-29 |
Diversa Corporation |
End selection in directed evolution
|
|
US6713279B1
(en)
|
1995-12-07 |
2004-03-30 |
Diversa Corporation |
Non-stochastic generation of genetic vaccines and enzymes
|
|
US6171820B1
(en)
*
|
1995-12-07 |
2001-01-09 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
|
US7371376B1
(en)
|
1996-10-18 |
2008-05-13 |
Genentech, Inc. |
Anti-ErbB2 antibodies
|
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
|
US7112655B1
(en)
|
1997-02-27 |
2006-09-26 |
Japan Tobacco, Inc. |
JTT-1 protein and methods of inhibiting lymphocyte activation
|
|
JP3521382B2
(ja)
|
1997-02-27 |
2004-04-19 |
日本たばこ産業株式会社 |
細胞間接着及びシグナル伝達を媒介する細胞表面分子
|
|
SI1325932T1
(OSRAM)
|
1997-04-07 |
2005-08-31 |
Genentech Inc |
|
|
US20070059302A1
(en)
*
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US20020032315A1
(en)
*
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US6864227B1
(en)
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
|
US6887674B1
(en)
|
1998-04-13 |
2005-05-03 |
California Institute Of Technology |
Artery- and vein-specific proteins and uses therefor
|
|
JP2002530081A
(ja)
|
1998-11-18 |
2002-09-17 |
ジェネンテック・インコーポレーテッド |
親抗体より高度な結合親和性を持つ抗体変異体
|
|
EP1950300A3
(en)
|
1998-11-18 |
2011-03-23 |
Genentech, Inc. |
Antibody variants with higher binding affinity compared to parent antibodies
|
|
WO2000034337A1
(en)
*
|
1998-12-10 |
2000-06-15 |
Tsukuba Research Laboratory, Toagosei Co., Ltd. |
Humanized monoclonal antibodies against vascular endothelial cell growth factor
|
|
ATE300957T1
(de)
*
|
1998-12-22 |
2005-08-15 |
Genentech Inc |
Antagonisten von vaskular-endothelialen zellwachstumsfaktoren und ihre anwendung
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
|
WO2000064946A2
(en)
|
1999-04-28 |
2000-11-02 |
Board Of Regents, The University Of Texas System |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
|
EP1203026A4
(en)
*
|
1999-07-29 |
2005-03-16 |
Dyax Corp |
FRACTIONS BINDING FIBRIN
|
|
JP4210454B2
(ja)
|
2001-03-27 |
2009-01-21 |
日本たばこ産業株式会社 |
炎症性腸疾患治療剤
|
|
JP3871503B2
(ja)
|
1999-08-30 |
2007-01-24 |
日本たばこ産業株式会社 |
免疫性疾患治療剤
|
|
EP1757311B1
(en)
|
1999-12-24 |
2009-02-11 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
CA2921260A1
(en)
|
1999-12-24 |
2001-06-28 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
US20040002068A1
(en)
|
2000-03-01 |
2004-01-01 |
Corixa Corporation |
Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
|
|
JP3597140B2
(ja)
|
2000-05-18 |
2004-12-02 |
日本たばこ産業株式会社 |
副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
|
|
CA2648051A1
(en)
|
2000-06-23 |
2002-01-03 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
|
|
DK2042597T3
(da)
|
2000-06-23 |
2014-08-11 |
Genentech Inc |
Sammensætninger og fremgangsmåder til diagnose og behandling af sygdomme, der involverer angiogenese
|
|
US6902718B2
(en)
|
2000-10-24 |
2005-06-07 |
Diatide, Inc. |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
|
|
US6989138B2
(en)
|
2000-10-24 |
2006-01-24 |
Diatide, Inc. |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans
|
|
JP4212278B2
(ja)
|
2001-03-01 |
2009-01-21 |
日本たばこ産業株式会社 |
移植片拒絶反応抑制剤
|
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
|
US7117096B2
(en)
|
2001-04-17 |
2006-10-03 |
Abmaxis, Inc. |
Structure-based selection and affinity maturation of antibody library
|
|
TWI284539B
(en)
|
2001-07-30 |
2007-08-01 |
Epix Pharm Inc |
A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
|
|
US20050123925A1
(en)
|
2002-11-15 |
2005-06-09 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
PL213948B1
(pl)
*
|
2001-10-25 |
2013-05-31 |
Genentech Inc |
Kompozycje zawierajace glikoproteine, czasteczka kwasu nukleinowego kodujaca te glikoproteine, komórka gospodarza, sposób wytwarzania glikoproteiny, kompozycja do zastosowania do leczenia, zastosowanie kompozycji i zestaw zawierajacy kompozycje
|
|
US20030190705A1
(en)
*
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
|
EP2048154B2
(en)
|
2002-02-05 |
2015-06-03 |
Genentech, Inc. |
Protein purification
|
|
WO2003102132A2
(en)
|
2002-04-26 |
2003-12-11 |
Genetech, Inc. |
Non-affinity purification of proteins
|
|
NZ571508A
(en)
*
|
2002-05-24 |
2010-05-28 |
Schering Corp |
Neutralizing human anti-IGFR antibody
|
|
US9028822B2
(en)
|
2002-06-28 |
2015-05-12 |
Domantis Limited |
Antagonists against TNFR1 and methods of use therefor
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
NZ574146A
(en)
|
2002-07-15 |
2010-05-28 |
Univ Texas |
Peptides binding to phosphatidylethanolamine and their use in treating viral infections
|
|
PT1523496E
(pt)
|
2002-07-18 |
2011-09-29 |
Merus B V |
Produção de misturas de anticorpos de forma recombinante
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
WO2004065417A2
(en)
*
|
2003-01-23 |
2004-08-05 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
|
EP2192172B1
(en)
|
2003-02-03 |
2014-12-03 |
iBio, Inc. |
System for expression of genes in plants
|
|
WO2004080418A2
(en)
|
2003-03-12 |
2004-09-23 |
Vasgene Therapeutics, Inc. |
Nucleic acid compounds for inhibiting angiogenesis and tumor growth
|
|
US7381410B2
(en)
|
2003-03-12 |
2008-06-03 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
|
US8431396B2
(en)
|
2003-03-21 |
2013-04-30 |
The Cleveland Clinic Foundation |
Anti-angiogenic peptides
|
|
ES2427641T3
(es)
|
2003-05-22 |
2013-10-31 |
Ibio, Inc. |
Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana
|
|
US20050186208A1
(en)
|
2003-05-30 |
2005-08-25 |
Genentech, Inc. |
Treatment with anti-VEGF antibodies
|
|
EP1639009B1
(en)
|
2003-05-30 |
2013-02-27 |
Merus B.V. |
Fab library for the preparation of a mixture of antibodies
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
CA2531595C
(en)
|
2003-07-28 |
2015-12-08 |
Genentech, Inc. |
Reducing protein a leaching during protein a affinity chromatography
|
|
EP1664115A2
(en)
*
|
2003-08-01 |
2006-06-07 |
Genentech, Inc. |
Antibody cdr polypeptide sequences with restricted diversity
|
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
US7920906B2
(en)
|
2005-03-10 |
2011-04-05 |
Dexcom, Inc. |
System and methods for processing analyte sensor data for sensor calibration
|
|
NZ592039A
(en)
|
2003-08-27 |
2013-03-28 |
Ophthotech Corp |
Combination therapy for the treatment of ocular neovascular disorders
|
|
FR2859725B1
(fr)
*
|
2003-09-16 |
2006-03-10 |
Neovacs |
Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine
|
|
US9247900B2
(en)
|
2004-07-13 |
2016-02-02 |
Dexcom, Inc. |
Analyte sensor
|
|
CA2554054C
(en)
|
2004-01-20 |
2013-06-04 |
Merus B.V. |
Mixtures of binding proteins
|
|
EP3653641A1
(en)
|
2004-02-19 |
2020-05-20 |
Genentech, Inc. |
Cdr-repaired antibodies
|
|
NZ549787A
(en)
|
2004-03-12 |
2010-05-28 |
Vasgene Therapeutics Inc |
Antibodies binding to EphB4 for inhibiting angiogenesis and tumor growth
|
|
KR20070034465A
(ko)
|
2004-03-12 |
2007-03-28 |
바스진 테라퓨틱스, 인크. |
혈관형성 및 종양 성장을 억제하기 위한 폴리펩티드 화합물
|
|
JP2008500830A
(ja)
|
2004-06-01 |
2008-01-17 |
ドマンティス リミテッド |
増加した血清半減期を有する二重特異性融合抗体
|
|
US7946984B2
(en)
|
2004-07-13 |
2011-05-24 |
Dexcom, Inc. |
Transcutaneous analyte sensor
|
|
US20060270922A1
(en)
|
2004-07-13 |
2006-11-30 |
Brauker James H |
Analyte sensor
|
|
US8604185B2
(en)
|
2004-07-20 |
2013-12-10 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
|
EP1771474B1
(en)
*
|
2004-07-20 |
2010-01-27 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
|
BRPI0513601A
(pt)
|
2004-07-23 |
2008-05-13 |
Genentech Inc |
métodos de produção de cristais de anticorpo ou seu fragmento, composições, formulação, cristal de anticorpo ou seu fragmento, método de tratamento e métodos de produção de cristais e de gel de proteìna de anticorpo ou seu fragmento
|
|
US7662926B2
(en)
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
|
US7655229B2
(en)
|
2004-09-02 |
2010-02-02 |
Chan Andrew C |
Anti-FC-gamma RIIB receptor antibody and uses therefor
|
|
AU2005286662B2
(en)
|
2004-09-23 |
2011-10-06 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
|
PL1802334T3
(pl)
*
|
2004-10-21 |
2013-01-31 |
Genentech Inc |
Sposób leczenia wewnątrzgałkowych chorób neowaskularnych
|
|
EP2290087A3
(en)
|
2004-12-22 |
2011-06-15 |
Genentech, Inc. |
Methods for producing soluble multi-membrane-spanning proteins
|
|
EP1833512A1
(en)
*
|
2005-01-06 |
2007-09-19 |
GE Healthcare AS |
Optical imaging
|
|
US20070166388A1
(en)
|
2005-02-18 |
2007-07-19 |
Desai Neil P |
Combinations and modes of administration of therapeutic agents and combination therapy
|
|
US8735394B2
(en)
|
2005-02-18 |
2014-05-27 |
Abraxis Bioscience, Llc |
Combinations and modes of administration of therapeutic agents and combination therapy
|
|
US20160355591A1
(en)
|
2011-05-02 |
2016-12-08 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
|
DK2586459T3
(en)
|
2005-03-25 |
2017-09-11 |
Regeneron Pharma |
VEGF antagonist formulations
|
|
US20060233810A1
(en)
*
|
2005-04-15 |
2006-10-19 |
Yaolin Wang |
Methods and compositions for treating or preventing cancer
|
|
EP1895947A2
(en)
*
|
2005-06-17 |
2008-03-12 |
Abbott Laboratories |
Improved method of treating degenerative spinal disorders
|
|
USRE47223E1
(en)
|
2005-06-20 |
2019-02-05 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
PL2135881T3
(pl)
*
|
2005-06-20 |
2012-02-29 |
Genentech Inc |
Przeciwciała wiążące się z antygenem TAT10772 związanym z nowotworem, do diagnozowania i leczenia nowotworu
|
|
KR101446025B1
(ko)
|
2005-08-03 |
2014-10-01 |
아이바이오, 인크. |
면역글로불린의 생산을 위한 조성물 및 방법
|
|
PL3311805T3
(pl)
|
2005-08-31 |
2020-07-27 |
Abraxis Bioscience, Llc |
Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe
|
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
|
KR100877824B1
(ko)
|
2005-11-11 |
2009-01-12 |
한국생명공학연구원 |
E2epf ucp-vhl 상호작용 및 그 용도
|
|
JP5199108B2
(ja)
*
|
2005-11-14 |
2013-05-15 |
ユニヴァーシティー オブ サザン カリフォルニア |
インテグリン結合小分子
|
|
TW200804425A
(en)
*
|
2005-12-06 |
2008-01-16 |
Domantis Ltd |
Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor
|
|
PL1962895T3
(pl)
†
|
2005-12-16 |
2013-06-28 |
Regeneron Pharma |
Terapeutyczne zastosowanie antagonisty dii4 oraz inhibitora vegf do inhibicji wzrostu nowotworów
|
|
TWI596111B
(zh)
|
2006-01-05 |
2017-08-21 |
建南德克公司 |
抗ephb4抗體及使用該抗體之方法
|
|
ZA200806187B
(en)
|
2006-01-20 |
2009-10-28 |
Genentech Inc |
Anti-EphrinB2 antibodies and methods using same
|
|
CA2642054C
(en)
|
2006-02-13 |
2017-11-21 |
Fraunhofer Usa, Inc. |
Influenza antigens, vaccine compositions, and related methods
|
|
AR059851A1
(es)
|
2006-03-16 |
2008-04-30 |
Genentech Inc |
Anticuerpos de la egfl7 y metodos de uso
|
|
WO2008060645A2
(en)
|
2006-03-21 |
2008-05-22 |
Genentech, Inc. |
Combinatorial therapy involving alpha5beta1 antagonists
|
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
|
CN101405030B
(zh)
*
|
2006-03-22 |
2013-03-13 |
霍夫曼-拉罗奇有限公司 |
针对血管内皮生长因子的抗体和针对人表皮生长因子2型受体的抗体在制备治疗肿瘤的试剂盒中的应用
|
|
EP1999151A2
(en)
*
|
2006-03-29 |
2008-12-10 |
Genentech, Inc. |
Diagnostics and treatments for tumors
|
|
ES2828739T3
(es)
|
2006-04-07 |
2021-05-27 |
Aerpio Pharmaceuticals Inc |
Anticuerpos que se unen a la proteína tirosina fosfatasa beta humana (HPTP-beta) y sus usos
|
|
SG175615A1
(en)
|
2006-06-06 |
2011-11-28 |
Genentech Inc |
Anti-dll4 antibodies and methods using same
|
|
WO2007143689A2
(en)
*
|
2006-06-06 |
2007-12-13 |
Genentech, Inc. |
Compositions and methods for modulating vascular development
|
|
RU2432155C3
(ru)
|
2006-06-16 |
2017-11-17 |
Ридженерон Фармасьютикалз, Инк. |
Составы антагониста vegf, подходящие для интравитреального введения
|
|
FR2902799B1
(fr)
|
2006-06-27 |
2012-10-26 |
Millipore Corp |
Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
|
|
WO2008011513A2
(en)
|
2006-07-19 |
2008-01-24 |
The Cleveland Clinic Foundation |
Compounds and methods of modulating angiogenesis
|
|
CN100448892C
(zh)
*
|
2006-08-02 |
2009-01-07 |
中国人民解放军军事医学科学院基础医学研究所 |
抗肿瘤血管内皮生长因子受体vegf-r2抗原及其编码基因与应用
|
|
EP2441472B1
(en)
|
2006-08-21 |
2015-06-10 |
F. Hoffmann-La Roche AG |
Tumor therapy with an anti-VEGF antibody
|
|
ME02371B
(me)
|
2006-09-29 |
2016-06-20 |
Oncomed Pharm Inc |
Sastojci i postupci za dijagnstikovanje i tretman raka
|
|
ZA200901518B
(en)
|
2006-10-04 |
2010-05-26 |
Genentech Inc |
Elisa for VEGF
|
|
US20110076279A1
(en)
*
|
2006-10-20 |
2011-03-31 |
Schering Corporation |
Fully human anti-vegf antibodies and methods of using
|
|
SG10201503407WA
(en)
|
2006-12-19 |
2015-06-29 |
Genentech Inc |
Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
|
|
US8362217B2
(en)
|
2006-12-21 |
2013-01-29 |
Emd Millipore Corporation |
Purification of proteins
|
|
WO2008079280A1
(en)
|
2006-12-21 |
2008-07-03 |
Millipore Corporation |
Purification of proteins
|
|
US8569464B2
(en)
|
2006-12-21 |
2013-10-29 |
Emd Millipore Corporation |
Purification of proteins
|
|
EP2377527B1
(en)
|
2007-01-22 |
2013-07-17 |
Genentech, Inc. |
Polyelectrolyte precipitation and purification of antibodies
|
|
WO2008091222A1
(en)
*
|
2007-01-26 |
2008-07-31 |
Bioinvent International Ab |
Dll4 signaling inhibitors and uses thereof
|
|
EP2125896A2
(en)
|
2007-02-09 |
2009-12-02 |
Genetech, Inc. |
Anti-robo4 antibodies and uses therefor
|
|
CL2008001334A1
(es)
|
2007-05-08 |
2008-09-22 |
Genentech Inc |
Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer.
|
|
KR101520115B1
(ko)
|
2007-05-17 |
2015-05-13 |
제넨테크, 인크. |
항-뉴로필린 2 항체에 의한 종양 전이의 억제
|
|
PE20090321A1
(es)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
|
CA3113365A1
(en)
|
2007-07-09 |
2009-01-15 |
Genentech, Inc. |
Prevention of disulfide bond reduction during recombinant production of polypeptides
|
|
WO2009009759A2
(en)
|
2007-07-11 |
2009-01-15 |
Fraunhofer Usa, Inc. |
Yersinia pestis antigens, vaccine compositions, and related methods
|
|
JP5749009B2
(ja)
|
2007-08-13 |
2015-07-15 |
バスジーン セラピューティクス, インコーポレイテッドVasgenetherapeutics, Inc. |
EphB4に結合するヒト化抗体を利用する癌治療剤
|
|
EP2190861A4
(en)
|
2007-08-22 |
2011-03-30 |
Univ California |
ACTIVE BINDING POLYPEPTIDES AND METHOD FOR THEIR IDENTIFICATION AND USE
|
|
RU2498991C2
(ru)
|
2007-10-30 |
2013-11-20 |
Дженентек, Инк. |
Очистка антител с помощью катионообменной хроматографии
|
|
AR070032A1
(es)
|
2007-11-09 |
2010-03-10 |
Genentech Inc |
Composiciones y metodos de uso de antagonistas quinasa-1 similar al receptor de la activina (alk-1)
|
|
EP2614837A1
(en)
|
2007-11-09 |
2013-07-17 |
Affitech Research AS |
Anti-VEGF antibody compositions and methods
|
|
AR069501A1
(es)
|
2007-11-30 |
2010-01-27 |
Genentech Inc |
Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
KR20160125535A
(ko)
|
2008-03-18 |
2016-10-31 |
제넨테크, 인크. |
항-her2 항체-약물 접합체와 화학요법제의 병용물, 및 사용 방법
|
|
EP2604279A1
(en)
*
|
2008-03-27 |
2013-06-19 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting PDGFRBETA and VEGF-A
|
|
EP2280997A2
(en)
*
|
2008-04-18 |
2011-02-09 |
Xencor, Inc. |
Human equivalent monoclonal antibodies engineered from nonhuman variable regions
|
|
SG190572A1
(en)
|
2008-04-29 |
2013-06-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
SG191639A1
(en)
|
2008-06-03 |
2013-07-31 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
PE20100054A1
(es)
|
2008-06-03 |
2010-03-03 |
Abbott Lab |
Inmunoglobulina con dominio variable dual
|
|
WO2009151514A1
(en)
|
2008-06-11 |
2009-12-17 |
Millipore Corporation |
Stirred tank bioreactor
|
|
LT3216803T
(lt)
|
2008-06-25 |
2020-06-10 |
Novartis Ag |
Stabilūs ir tirpūs antikūnai, slopinantys vegf
|
|
MX2010014574A
(es)
*
|
2008-07-08 |
2011-04-27 |
Abbott Lab |
Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
|
|
US20100029491A1
(en)
*
|
2008-07-11 |
2010-02-04 |
Maike Schmidt |
Methods and compositions for diagnostic use for tumor treatment
|
|
WO2010010153A1
(en)
|
2008-07-23 |
2010-01-28 |
F. Hoffmann-La Roche Ag |
Identification of subjects being susceptible to anti-angiogenesis therapy
|
|
HUE047316T2
(hu)
|
2008-08-14 |
2020-04-28 |
Genentech Inc |
Eljárások szennyezés eltávolítására indigén fehérjekiszorításos ioncserés membrán kromatográfia alkalmazásával
|
|
EP2321433A2
(en)
*
|
2008-08-29 |
2011-05-18 |
F. Hoffmann-La Roche AG |
Diagnostics and treatments for vegf-independent tumors
|
|
US20110318360A1
(en)
|
2008-09-05 |
2011-12-29 |
Duke University |
Anti-lipid antibodies
|
|
EP2334323A2
(en)
|
2008-09-10 |
2011-06-22 |
F. Hoffmann-La Roche AG |
Compositions and methods for the prevention of oxidative degradation of proteins
|
|
WO2010037046A1
(en)
|
2008-09-28 |
2010-04-01 |
Fraunhofer Usa, Inc. |
Humanized neuraminidase antibody and methods of use thereof
|
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
|
PL2352521T3
(pl)
|
2008-10-14 |
2021-03-08 |
Genentech, Inc. |
Warianty immunoglobuliny i ich zastosowania
|
|
WO2010060748A1
(en)
|
2008-11-03 |
2010-06-03 |
Molecular Partners Ag |
Binding proteins inhibiting the vegf-a receptor interaction
|
|
EP2540843B1
(en)
|
2008-11-05 |
2014-07-02 |
Genentech, Inc. |
Genetic polymorphisms in age-related macular degeneration
|
|
KR101807319B1
(ko)
|
2008-11-22 |
2017-12-11 |
제넨테크, 인크. |
유방암의 치료를 위한, 화학요법과 조합된 항-vegf 항체의 용도
|
|
CN105037535A
(zh)
|
2008-12-16 |
2015-11-11 |
Emd密理博公司 |
搅拌槽反应器及方法
|
|
US20110020327A1
(en)
|
2008-12-16 |
2011-01-27 |
Millipore Corporation |
Purification of proteins
|
|
SG10201604988YA
(en)
|
2008-12-23 |
2016-07-28 |
Genentech Inc |
Methods and compositions for diagnostic use in cancer patients
|
|
BRPI1006141B8
(pt)
|
2009-01-12 |
2021-05-25 |
Cytomx Therapeutics Llc |
composições de anticorpo modificado, métodos para preparar e usar as mesmas
|
|
WO2010081838A2
(en)
|
2009-01-14 |
2010-07-22 |
Novartis Ag |
Sterile prefilled container
|
|
JP2012517434A
(ja)
|
2009-02-06 |
2012-08-02 |
ザ ジェネラル ホスピタル コーポレイション |
血管病変を治療する方法
|
|
CN102481341B
(zh)
|
2009-02-23 |
2017-05-17 |
希托马克斯医疗有限公司 |
蛋白原及其使用方法
|
|
EP2400992B1
(en)
|
2009-02-27 |
2015-07-22 |
Genentech, Inc. |
Methods and compositions for protein labelling
|
|
KR101739598B1
(ko)
|
2009-03-13 |
2017-06-08 |
아브락시스 바이오사이언스, 엘엘씨 |
티오콜키신 유도체와의 조합 요법
|
|
AR075925A1
(es)
|
2009-03-25 |
2011-05-04 |
Genentech Inc |
Anticuerpos anti-alfa5beta1 (alfa5beta1: glicoproteina integrina) y sus usos
|
|
CN102369215B
(zh)
|
2009-04-02 |
2015-01-21 |
罗切格利卡特公司 |
包含全长抗体和单链Fab片段的多特异性抗体
|
|
ES2537100T3
(es)
|
2009-04-07 |
2015-06-02 |
Roche Glycart Ag |
Anticuerpos biespecíficos trivalentes
|
|
JP5795759B2
(ja)
*
|
2009-04-16 |
2015-10-14 |
アッヴィ・バイオセラピューティクス・インコーポレイテッド |
抗TNF−α抗体およびその用途
|
|
BRPI1006438A2
(pt)
*
|
2009-04-20 |
2016-09-27 |
Genentech Inc |
terapia adjuvante de cancer
|
|
CA2759233C
(en)
|
2009-04-27 |
2019-07-16 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
US9309325B2
(en)
|
2009-05-07 |
2016-04-12 |
The Regents Of The University Of California |
Antibodies and methods of use thereof
|
|
CA2665956A1
(en)
*
|
2009-05-07 |
2010-11-07 |
Samir Patel |
Combination treatment for ocular diseases
|
|
CA2760246A1
(en)
|
2009-05-08 |
2010-11-11 |
Weilan Ye |
Humanized anti-egfl7 antibodies and methods using same
|
|
MX353352B
(es)
|
2009-05-08 |
2018-01-10 |
Vaccinex Inc |
Anticuerpos anti-cd100 y metodos para su uso.
|
|
AU2010262087B9
(en)
|
2009-06-15 |
2015-07-30 |
Icon Genetics Gmbh |
Nicotiana benthamiana plants deficient in xylosyltransferase activity
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
WO2011008696A2
(en)
|
2009-07-13 |
2011-01-20 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
|
AR078060A1
(es)
|
2009-07-14 |
2011-10-12 |
Novartis Ag |
Descontaminacion de superficie de contenedores previamente llenados en empaque secundario
|
|
AR077595A1
(es)
|
2009-07-27 |
2011-09-07 |
Genentech Inc |
Tratamientos de combinacion
|
|
NZ597531A
(en)
*
|
2009-07-31 |
2014-05-30 |
Genentech Inc |
Inhibition of tumor metastasis using bv8- or g-csf-antagonists
|
|
IL264336B2
(en)
|
2009-08-11 |
2024-02-01 |
Genentech Inc |
Production of proteins in cell culture medium without glutamine
|
|
MX2012001716A
(es)
|
2009-08-14 |
2012-04-02 |
Genentech Inc |
Marcadores biologicos para monitorizar la respuesta del paciente a los antagonistas vegf.
|
|
CA2771086A1
(en)
|
2009-08-15 |
2011-02-24 |
Genentech, Inc. |
Anti-angiogenesis therapy for the treatment of previously treated breast cancer
|
|
CN102686738A
(zh)
|
2009-09-01 |
2012-09-19 |
弗·哈夫曼-拉罗切有限公司 |
通过改进的a蛋白洗脱增强的蛋白质纯化
|
|
WO2011028642A1
(en)
|
2009-09-04 |
2011-03-10 |
University Of Louisville Research Foundation, Inc. |
Genetic determinants of prostate cancer risk
|
|
AU2010292060A1
(en)
|
2009-09-11 |
2012-04-12 |
Genentech, Inc. |
Method to identify a patient with an increased likelihood of responding to an anti-cancer agent
|
|
JP6091894B2
(ja)
|
2009-09-16 |
2017-03-15 |
ジェネンテック, インコーポレイテッド |
コイルドコイルおよび/またはテザー含有タンパク質複合体およびその使用
|
|
KR101557545B1
(ko)
|
2009-09-17 |
2015-10-06 |
에프. 호프만-라 로슈 아게 |
암 환자에서 진단 용도를 위한 방법 및 조성물
|
|
US8784819B2
(en)
|
2009-09-29 |
2014-07-22 |
Ibio Inc. |
Influenza hemagglutinin antibodies, compositions and related methods
|
|
US8883145B2
(en)
|
2009-10-16 |
2014-11-11 |
Oncomed Pharmaceuticals, Inc. |
Methods of treatment with DLL4 antagonists and an anti-hypertensive agent
|
|
MX2012004306A
(es)
|
2009-10-21 |
2012-04-30 |
Genentech Inc |
Polimorfismos geneticos en degeneracion macular relacionada con la edad.
|
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
|
JP5818805B2
(ja)
|
2009-12-11 |
2015-11-18 |
ジェネンテック, インコーポレイテッド |
抗vegf−c抗体及びその使用方法
|
|
US8765432B2
(en)
|
2009-12-18 |
2014-07-01 |
Oligasis, Llc |
Targeted drug phosphorylcholine polymer conjugates
|
|
SG181834A1
(en)
|
2009-12-21 |
2012-07-30 |
Genentech Inc |
Antibody formulation
|
|
HUE027713T2
(en)
|
2009-12-23 |
2016-10-28 |
Hoffmann La Roche |
Anti-BV8 antibodies and their use
|
|
US20130178608A1
(en)
|
2009-12-29 |
2013-07-11 |
Samir Kulkarni |
Protein purification by ion exchange
|
|
US20120309056A1
(en)
|
2010-02-04 |
2012-12-06 |
Leon Arnaud |
Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
|
|
AR080244A1
(es)
|
2010-02-23 |
2012-03-21 |
Genentech Inc |
Terapia anti-angiogenesis para el tratamiento del cancer ovarico
|
|
CN103124564B
(zh)
|
2010-03-22 |
2016-11-09 |
弗·哈夫曼-拉罗切有限公司 |
对于稳定含有蛋白质的制剂有用的组合物和方法
|
|
AR080793A1
(es)
|
2010-03-26 |
2012-05-09 |
Roche Glycart Ag |
Anticuerpos biespecificos
|
|
TWI426920B
(zh)
|
2010-03-26 |
2014-02-21 |
Hoffmann La Roche |
雙專一性、雙價抗-vegf/抗-ang-2抗體
|
|
CN105147613A
(zh)
|
2010-03-29 |
2015-12-16 |
阿布拉科斯生物科学有限公司 |
增强药物递送和治疗剂有效性的方法
|
|
RU2016119999A
(ru)
|
2010-03-29 |
2018-11-08 |
АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи |
Способы лечения онкологических заболеваний
|
|
EP2560641A2
(en)
|
2010-04-19 |
2013-02-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor
|
|
AR081361A1
(es)
|
2010-04-30 |
2012-08-29 |
Molecular Partners Ag |
Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
|
|
WO2011139718A1
(en)
|
2010-05-03 |
2011-11-10 |
Genentech, Inc. |
Compositions and methods useful for reducing the viscosity of protein-containing formulations
|
|
DK2571903T3
(da)
|
2010-05-17 |
2019-11-04 |
Emd Millipore Corp |
Polymerer, der reagerer på stimuli, til oprensning af biomolekyler
|
|
BR112012030197A2
(pt)
|
2010-05-28 |
2015-09-29 |
Genentech Inc |
diminuição do nível de lactato e aumento da produção de poliptídeo por subregulação da expressão de lactato desidrogenase e piruvato desidrogenase cinase.
|
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
|
WO2011153243A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Anti-angiogenesis therapy for treating gastric cancer
|
|
EP2575804A4
(en)
|
2010-06-04 |
2013-10-23 |
Abraxis Bioscience Llc |
METHOD FOR THE TREATMENT OF PANCREASCRE
|
|
ES2751381T3
(es)
|
2010-06-24 |
2020-03-31 |
Hoffmann La Roche |
Composiciones y procedimientos que contienen alquilglucósidos para estabilizar formulaciones que contienen proteínas
|
|
CA2799472A1
(en)
|
2010-07-02 |
2012-01-05 |
Genentech, Inc. |
Treatment of vascularized pigment epithelial detachment with anti-vegf therapy
|
|
NZ605449A
(en)
|
2010-07-09 |
2015-03-27 |
Genentech Inc |
Anti-neuropilin antibodies and methods of use
|
|
AU2011281702A1
(en)
|
2010-07-19 |
2013-01-31 |
F. Hoffmann-La Roche Ag |
Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
|
|
EP2596362A1
(en)
|
2010-07-19 |
2013-05-29 |
F. Hoffmann-La Roche AG |
Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
|
|
CA2807014A1
(en)
|
2010-08-03 |
2012-02-09 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
MX2013001267A
(es)
|
2010-08-13 |
2013-04-10 |
Genentech Inc |
ANTICUERPOS A IL-1ß E EIL-18 PARA TRATAMIENTO DE ENFERMEDAD.
|
|
TW201208703A
(en)
|
2010-08-17 |
2012-03-01 |
Roche Glycart Ag |
Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
|
|
WO2012025530A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
|
CA2809433A1
(en)
|
2010-08-26 |
2012-03-01 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
|
US8551479B2
(en)
|
2010-09-10 |
2013-10-08 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating melanoma
|
|
CN103347514B
(zh)
|
2010-11-15 |
2017-02-08 |
戊瑞治疗有限公司 |
Fgfr1胞外域组合疗法
|
|
EP2655413B1
(en)
|
2010-12-23 |
2019-01-16 |
F.Hoffmann-La Roche Ag |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
JOP20210044A1
(ar)
*
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
|
WO2012092539A2
(en)
|
2010-12-31 |
2012-07-05 |
Takeda Pharmaceutical Company Limited |
Antibodies to dll4 and uses thereof
|
|
WO2012095514A1
(en)
|
2011-01-14 |
2012-07-19 |
Vivalis |
Recombinant protein production system
|
|
WO2012116927A1
(en)
|
2011-02-28 |
2012-09-07 |
F. Hoffmann-La Roche Ag |
Monovalent antigen binding proteins
|
|
MX341921B
(es)
|
2011-02-28 |
2016-09-07 |
Hoffmann La Roche |
Proteinas de union a antigeno.
|
|
CN103561771B
(zh)
|
2011-03-17 |
2019-01-04 |
伯明翰大学 |
重新定向的免疫治疗
|
|
EP3590965A1
(en)
|
2011-03-29 |
2020-01-08 |
Roche Glycart AG |
Antibody fc variants
|
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
|
WO2012135759A1
(en)
|
2011-04-01 |
2012-10-04 |
Genentech, Inc. |
Combinations of akt inhibitor compounds and abiraterone, and methods of use
|
|
AU2012245439B2
(en)
|
2011-04-20 |
2017-04-06 |
Acceleron Pharma, Inc. |
Endoglin polypeptides and uses thereof
|
|
CA2834776A1
(en)
|
2011-05-03 |
2012-11-08 |
Genentech, Inc. |
Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies
|
|
WO2012172054A1
(en)
|
2011-06-16 |
2012-12-20 |
Scil Proteins Gmbh |
Modified multimeric ubiquitin proteins binding vegf-a
|
|
WO2013003680A1
(en)
|
2011-06-30 |
2013-01-03 |
Genentech, Inc. |
Anti-c-met antibody formulations
|
|
EP2732269B1
(en)
|
2011-07-12 |
2017-10-18 |
Epitomics, Inc. |
Facs-based method for obtaining an antibody sequence
|
|
US9181532B2
(en)
|
2011-07-29 |
2015-11-10 |
Icon Genetics Gmbh |
Production of galactosylated N-glycans in plants
|
|
WO2013025944A1
(en)
|
2011-08-17 |
2013-02-21 |
Genentech, Inc. |
Inhibition of angiogenesis in refractory tumors
|
|
CN107722122B
(zh)
|
2011-09-23 |
2022-05-27 |
昂考梅德药品有限公司 |
Vegf/dll4结合剂及其应用
|
|
US10196664B2
(en)
|
2011-10-04 |
2019-02-05 |
Icon Genetics Gmbh |
Nicotiana benthamiana plants deficient in fucosyltransferase activity
|
|
PT2766093T
(pt)
|
2011-10-11 |
2018-05-18 |
Vaccinex Inc |
Utilização de moléculas de ligação a semaforina-4d para modulação da permeabilidade da barreira hematoencefálica
|
|
BR112014008759A8
(pt)
*
|
2011-10-13 |
2017-09-12 |
Aerpio Therapeutics Inc |
Tratamento de doença ocular
|
|
US20130095065A1
(en)
|
2011-10-13 |
2013-04-18 |
Aerpio Therapeutics, Inc. |
Methods for Treating Vascular Leak Syndrome and Cancer
|
|
WO2013082511A1
(en)
|
2011-12-02 |
2013-06-06 |
Genentech, Inc. |
Methods for overcoming tumor resistance to vegf antagonists
|
|
CA2858347C
(en)
|
2011-12-05 |
2020-07-07 |
Duke University |
V1v2 immunogens
|
|
US8790652B2
(en)
|
2011-12-06 |
2014-07-29 |
Vaccinex, Inc. |
Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis
|
|
RU2648999C2
(ru)
|
2011-12-22 |
2018-03-29 |
Дженентек, Инк. |
Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии
|
|
WO2013091903A1
(en)
|
2011-12-22 |
2013-06-27 |
Novo Nordisk A/S |
Anti-crac channel antibodies
|
|
BR112014015851A2
(pt)
|
2011-12-30 |
2019-09-24 |
Abbvie Inc |
proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17
|
|
BR112014017320A2
(pt)
|
2012-01-13 |
2018-05-29 |
Genentech Inc |
método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico
|
|
RU2644341C2
(ru)
|
2012-02-10 |
2018-02-08 |
Дженентек, Инк. |
Одноцепочечные антитела и другие гетеромультимеры
|
|
WO2013127829A1
(en)
|
2012-02-27 |
2013-09-06 |
Universitat De Barcelona |
Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs
|
|
JP6563197B2
(ja)
|
2012-03-13 |
2019-08-21 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
卵巣癌の治療のための併用療法
|
|
MY171729A
(en)
|
2012-03-27 |
2019-10-25 |
Genentech Inc |
Improved harvest operations for recombinant proteins
|
|
HK1200739A1
(en)
|
2012-03-30 |
2015-08-14 |
霍夫曼-拉罗奇有限公司 |
Diagnostic methods and compositions for treatment of cancer
|
|
ES2740749T3
(es)
|
2012-04-20 |
2020-02-06 |
Merus Nv |
Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
|
|
US10494440B2
(en)
|
2012-05-11 |
2019-12-03 |
Vaccinex, Inc. |
Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
|
|
WO2013170182A1
(en)
|
2012-05-11 |
2013-11-14 |
Synta Pharmaceuticals Corp. |
Treating cancer with an hsp90 inhibitory compound
|
|
EP2855528B1
(en)
|
2012-05-31 |
2019-06-19 |
Genentech, Inc. |
Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists
|
|
AU2013269594C1
(en)
|
2012-06-01 |
2020-12-17 |
Novartis Ag |
Syringe
|
|
HK1202265A1
(en)
|
2012-06-08 |
2015-09-25 |
霍夫曼-拉罗奇有限公司 |
Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
|
|
CA2871880A1
(en)
|
2012-06-27 |
2014-01-03 |
F. Hoffmann-La Roche Ag |
Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
|
|
RU2015100656A
(ru)
|
2012-06-27 |
2016-08-20 |
Ф. Хоффманн-Ля Рош Аг |
Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения
|
|
JOP20200175A1
(ar)
|
2012-07-03 |
2017-06-16 |
Novartis Ag |
حقنة
|
|
US9695233B2
(en)
|
2012-07-13 |
2017-07-04 |
Roche Glycart Ag |
Bispecific anti-VEGF/anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases
|
|
BR112015002681A2
(pt)
|
2012-08-07 |
2018-08-28 |
Genentech Inc |
método para tratar um paciente e kit
|
|
HRP20190060T1
(hr)
|
2012-09-19 |
2019-02-22 |
F. Hoffmann - La Roche Ag |
Postupci i sastavi za sprečavanje pogrešne ugradnje norleukina u proteine
|
|
AU2013337811A1
(en)
|
2012-10-31 |
2015-05-14 |
Oncomed Pharmaceuticals, Inc. |
Methods and monitoring of treatment with a DLL4 antagonist
|
|
BR112015009961B1
(pt)
|
2012-11-01 |
2020-10-20 |
Abbvie Inc. |
proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende
|
|
JP2016500058A
(ja)
|
2012-11-12 |
2016-01-07 |
レッドウッド バイオサイエンス, インコーポレイテッド |
化合物および抱合体を生成するための方法
|
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
|
EP2920148B1
(en)
|
2012-11-16 |
2019-06-12 |
The Regents of the University of California |
Pictet-spengler ligation for protein chemical modification
|
|
MX2015007931A
(es)
|
2012-12-18 |
2015-10-05 |
Novartis Ag |
Composiciones y metodos que utilizan una etiqueta de peptido que se une a hialuronano.
|
|
EP2934602B1
(en)
|
2012-12-19 |
2019-02-27 |
Genentech, Inc. |
Methods and compositions for radiohalogen protein labeling
|
|
WO2014110261A1
(en)
|
2013-01-11 |
2014-07-17 |
Massachusetts Eye And Ear Infirmary |
Cyp450 lipid metabolites reduce inflammation and angiogenesis
|
|
ES2774964T3
(es)
|
2013-02-04 |
2020-07-23 |
Vascular Biogenics Ltd |
Métodos para inducir la capacidad de respuesta a un agente antiangiogénico
|
|
CA2901226C
(en)
|
2013-02-18 |
2020-11-17 |
Vegenics Pty Limited |
Vascular endothelial growth factor binding proteins
|
|
SG11201507475UA
(en)
|
2013-03-13 |
2015-10-29 |
Genentech Inc |
Antibody formulations
|
|
JP2016513478A
(ja)
|
2013-03-15 |
2016-05-16 |
ジェネンテック, インコーポレイテッド |
細胞培養培地及び抗体を産生する方法
|
|
MX2015013166A
(es)
|
2013-03-15 |
2015-12-11 |
Abbvie Inc |
Proteinas de union especificas duales dirigidas contra il-1 beta y/o il-17.
|
|
US9707154B2
(en)
|
2013-04-24 |
2017-07-18 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
CN105164157B
(zh)
|
2013-04-29 |
2024-05-28 |
豪夫迈·罗氏有限公司 |
Fc-受体结合的修饰的非对称抗体及使用方法
|
|
UA118029C2
(uk)
|
2013-04-29 |
2018-11-12 |
Ф. Хоффманн-Ля Рош Аг |
Модифіковане антитіло, що зв'язується з людським fcrn, й способи його застосування
|
|
AU2014268519A1
(en)
|
2013-05-23 |
2015-11-05 |
Five Prime Therapeutics, Inc. |
Methods of treating cancer
|
|
KR101541478B1
(ko)
*
|
2013-05-31 |
2015-08-05 |
동아쏘시오홀딩스 주식회사 |
항-vegf 항체 및 이를 포함하는 암 또는 신생혈관형성관련 질환의 예방, 진단 또는 치료용 약학 조성물
|
|
ES2782834T3
(es)
|
2013-06-25 |
2020-09-16 |
Vaccinex Inc |
Uso de moléculas inhibidoras de semaforina-4D en combinación con una terapia inmunomoduladora para inhibir el crecimiento tumoral y la metástasis
|
|
SG11201510315TA
(en)
|
2013-07-12 |
2016-01-28 |
Ophthotech Corp |
Methods for treating or preventing ophthalmological conditions
|
|
KR20180021234A
(ko)
|
2013-08-12 |
2018-02-28 |
제넨테크, 인크. |
보체-연관 상태의 치료를 위한 조성물 및 방법
|
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
|
US10456470B2
(en)
|
2013-08-30 |
2019-10-29 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of glioblastoma
|
|
WO2015035342A2
(en)
|
2013-09-08 |
2015-03-12 |
Oligasis Llc |
Factor viii zwitterionic polymer conjugates
|
|
NZ630881A
(en)
|
2013-10-10 |
2016-03-31 |
Vaccinex Inc |
Use of semaphorin-4d binding molecules for treatment of atherosclerosis
|
|
KR20160044060A
(ko)
|
2013-10-11 |
2016-04-22 |
에프. 호프만-라 로슈 아게 |
다중특이적 도메인 교환된 통상의 가변 경쇄 항체
|
|
NZ630892A
(en)
|
2013-10-21 |
2016-03-31 |
Vaccinex Inc |
Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
|
|
CN105899225A
(zh)
|
2013-10-25 |
2016-08-24 |
阿塞勒隆制药公司 |
用于治疗纤维化疾病的内皮联蛋白肽
|
|
ES2875878T3
(es)
|
2013-11-18 |
2021-11-11 |
Formycon Ag |
Composición farmacéutica de un anticuerpo anti-VEGF
|
|
US9493413B2
(en)
|
2013-11-27 |
2016-11-15 |
Redwood Bioscience, Inc. |
Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
|
|
CN105263959A
(zh)
*
|
2013-12-31 |
2016-01-20 |
财团法人生物技术开发中心 |
抗vegf抗体及其用途
|
|
CN110981957B
(zh)
|
2014-01-15 |
2024-12-24 |
豪夫迈·罗氏有限公司 |
具有改善的蛋白A结合作用的Fc区变体
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
AU2015217278B2
(en)
|
2014-02-14 |
2020-03-19 |
Macrogenics, Inc. |
Improved methods for the treatment of vascularizing cancers
|
|
EP3108255B1
(en)
|
2014-02-18 |
2020-08-12 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway
|
|
WO2015128795A1
(en)
|
2014-02-25 |
2015-09-03 |
Dr. Reddy's Laboratories Limited |
Process for modifying galactosylation and g0f content of a glycoprotein composition by glutamine supplementation
|
|
CN106103465B
(zh)
|
2014-03-10 |
2021-01-08 |
吉瑞工厂 |
使用预清洗步骤的免疫球蛋白纯化
|
|
KR102442436B1
(ko)
|
2014-03-14 |
2022-09-15 |
노파르티스 아게 |
Lag-3에 대한 항체 분자 및 그의 용도
|
|
CA2943329A1
(en)
|
2014-03-24 |
2015-10-01 |
Genentech, Inc. |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
MX2016012779A
(es)
|
2014-03-31 |
2017-04-27 |
Genentech Inc |
Terapia de combinacion con agentes antiangiogénesis y agonistas de unión a ox40.
|
|
JP2017515811A
(ja)
|
2014-05-01 |
2017-06-15 |
ジェネンテック, インコーポレイテッド |
抗d因子抗体変異体及びその使用法
|
|
RU2702748C2
(ru)
|
2014-05-12 |
2019-10-11 |
Формикон Аг |
Предварительно заполненный пластиковый шприц, содержащий антагонист vegf
|
|
CA2949121A1
(en)
|
2014-05-15 |
2015-11-19 |
Bristol-Myers Squibb Company |
Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
|
|
KR102557615B1
(ko)
|
2014-06-06 |
2023-07-20 |
레드우드 바이오사이언스 인코포레이티드 |
항-her2 항체-메이탄신 컨쥬게이트 및 이것의 사용 방법
|
|
WO2015198243A2
(en)
|
2014-06-25 |
2015-12-30 |
Novartis Ag |
Compositions and methods for long acting proteins
|
|
US20170327553A1
(en)
|
2014-06-25 |
2017-11-16 |
Novartis Ag |
Compositions and methods for long acting proteins
|
|
US9840553B2
(en)
|
2014-06-28 |
2017-12-12 |
Kodiak Sciences Inc. |
Dual PDGF/VEGF antagonists
|
|
SI3166401T1
(sl)
|
2014-07-09 |
2020-11-30 |
F. Hoffmann-La Roche Ag |
Prilagoditev pH-vrednosti za okrevanje celičnih bank po odtajanju
|
|
CN106460067A
(zh)
|
2014-07-14 |
2017-02-22 |
豪夫迈·罗氏有限公司 |
诊断方法和用于治疗成胶质细胞瘤的组合物
|
|
CN105330739B
(zh)
*
|
2014-08-12 |
2020-12-25 |
中美华世通生物医药科技(武汉)有限公司 |
与人血管内皮生长因子特异性结合的抗体或其抗原结合片段及其用途
|
|
EP3180018B1
(en)
|
2014-08-12 |
2019-07-24 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein
|
|
US20170224777A1
(en)
|
2014-08-12 |
2017-08-10 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine
|
|
JP6681905B2
(ja)
|
2014-09-13 |
2020-04-15 |
ノバルティス アーゲー |
Alk阻害剤の併用療法
|
|
RU2704611C2
(ru)
|
2014-09-15 |
2019-10-30 |
Дженентек, Инк. |
Составы на основе антител
|
|
KR20170066546A
(ko)
|
2014-10-03 |
2017-06-14 |
노파르티스 아게 |
조합 요법
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
EA201790834A1
(ru)
|
2014-10-14 |
2018-01-31 |
Новартис Аг |
Молекулы антител к pd-l1 и их применение
|
|
WO2016061562A2
(en)
|
2014-10-17 |
2016-04-21 |
Kodiak Sciences Inc. |
Butyrylcholinesterase zwitterionic polymer conjugates
|
|
US10316094B2
(en)
|
2014-10-24 |
2019-06-11 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for inducing phagocytosis of MHC class I positive cells and countering anti-CD47/SIRPA resistance
|
|
PT3212233T
(pt)
|
2014-10-31 |
2020-07-16 |
Oncomed Pharm Inc |
Terapia combinada para o tratamento de doenças
|
|
EP3218403B1
(en)
|
2014-11-10 |
2020-05-13 |
F.Hoffmann-La Roche Ag |
Anti-interleukin-33 antibodies and uses thereof
|
|
EP3227332B1
(en)
|
2014-12-03 |
2019-11-06 |
F.Hoffmann-La Roche Ag |
Multispecific antibodies
|
|
CN112826934A
(zh)
|
2014-12-11 |
2021-05-25 |
拜耳医药保健有限责任公司 |
具有小的活动性脉络膜新生血管病变的年龄相关性黄斑变性的治疗
|
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
|
AR103173A1
(es)
|
2014-12-22 |
2017-04-19 |
Novarits Ag |
Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
|
|
HK1243141A1
(zh)
|
2014-12-23 |
2018-07-06 |
豪夫迈.罗氏有限公司 |
用於治疗和诊断化学疗法抗性癌症的组合物和方法
|
|
EP3250596A1
(en)
*
|
2015-01-28 |
2017-12-06 |
Pfizer Inc |
Stable aqueous anti- vascular endothelial growth factor (vegf) antibody formulation
|
|
KR20220070057A
(ko)
|
2015-03-09 |
2022-05-27 |
인테크린 테라퓨틱스, 아이엔씨. |
비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법
|
|
CN115932273A
(zh)
|
2015-04-24 |
2023-04-07 |
豪夫迈·罗氏有限公司 |
鉴定包含结合多肽的细菌的方法
|
|
US20180155429A1
(en)
|
2015-05-28 |
2018-06-07 |
Bristol-Myers Squibb Company |
Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
|
|
US11078278B2
(en)
|
2015-05-29 |
2021-08-03 |
Bristol-Myers Squibb Company |
Treatment of renal cell carcinoma
|
|
US20170000885A1
(en)
|
2015-06-08 |
2017-01-05 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
|
RS61532B1
(sr)
|
2015-07-14 |
2021-04-29 |
Bristol Myers Squibb Co |
Postupak lečenja kancera primenom inhibitora imunološke kontrolne tačke; antitelo koje se vezuje za receptor programirane smrti-1 (pd-1) ili ligand programirane smrti-1 (pd-l1)
|
|
JP6916776B2
(ja)
|
2015-07-29 |
2021-08-11 |
アラーガン、インコーポレイテッドAllergan,Incorporated |
Ang−2に対する重鎖のみ抗体
|
|
US20180222982A1
(en)
|
2015-07-29 |
2018-08-09 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
|
ES2878188T3
(es)
|
2015-07-29 |
2021-11-18 |
Novartis Ag |
Terapias de combinación que comprenden moléculas de anticuerpos contra LAG-3
|
|
EP3316902A1
(en)
|
2015-07-29 |
2018-05-09 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
HU231463B1
(hu)
|
2015-08-04 |
2024-01-28 |
Richter Gedeon Nyrt. |
Módszer rekombináns proteinek galaktóz tartalmának növelésére
|
|
EP3334762A1
(en)
|
2015-08-14 |
2018-06-20 |
Allergan, Inc. |
Heavy chain only antibodies to pdgf
|
|
WO2017034906A1
(en)
*
|
2015-08-21 |
2017-03-02 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
|
IL257531B2
(en)
|
2015-09-17 |
2023-04-01 |
Immunogen Inc |
Medicinal compositions containing anti-folr1 immunoconjugates
|
|
WO2017046140A1
(en)
|
2015-09-18 |
2017-03-23 |
Bayer Pharma Aktiengesellschaft |
Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
|
|
US10647752B2
(en)
|
2015-09-22 |
2020-05-12 |
Inserm (Institut National De La Santé Et De La Recherche Medicale) |
Polypeptides capable of inhibiting the binding between leptin and Neuropilin-1
|
|
RU2763916C2
(ru)
|
2015-09-23 |
2022-01-11 |
Дженентек, Инк. |
Оптимизированные варианты анти-vegf антител
|
|
ES2968074T3
(es)
|
2015-09-23 |
2024-05-07 |
Mereo Biopharma 5 Inc |
Anticuerpo bi-específico anti-VEGF/DLL4 para su uso en el tratamiento del cáncer de ovario resistente al platino
|
|
WO2017055325A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of nk cells in a tissue sample
|
|
WO2017055326A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of myeloid dendritic cells in a tissue sample
|
|
WO2017055324A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of cells of monocytic origin in a tissue sample
|
|
WO2017055319A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of b cells in a tissue sample
|
|
WO2017055322A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of neutrophils in a tissue sample
|
|
WO2017055321A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of fibroblasts in a tissue sample
|
|
WO2017055320A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample
|
|
WO2017055327A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of endothelial cells in a tissue sample
|
|
WO2017064121A1
(en)
|
2015-10-13 |
2017-04-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
|
|
CN108289951A
(zh)
|
2015-10-30 |
2018-07-17 |
豪夫迈·罗氏有限公司 |
抗-因子d抗体和缀合物
|
|
EP3368578B1
(en)
|
2015-10-30 |
2021-03-17 |
H. Hoffnabb-La Roche Ag |
Anti-htra1 antibodies and methods of use thereof
|
|
CN108472382A
(zh)
|
2015-10-30 |
2018-08-31 |
豪夫迈·罗氏有限公司 |
抗-因子d抗体变体缀合物及其用途
|
|
AU2016344133A1
(en)
|
2015-10-30 |
2018-05-17 |
Genentech, Inc. |
Anti-Factor D antibody formulations
|
|
MA43186B1
(fr)
|
2015-11-03 |
2022-03-31 |
Janssen Biotech Inc |
Anticorps se liant spécifiquement à pd-1 et leurs utilisations
|
|
EP3370764A4
(en)
|
2015-11-05 |
2019-07-17 |
The Regents of The University of California |
Cells labeled with lipid conjugates and method of use thereof
|
|
JP6855496B2
(ja)
|
2015-11-09 |
2021-04-07 |
アール.ピー.シェーラー テクノロジーズ エルエルシー |
抗cd22抗体−メイタンシンコンジュゲートおよびその使用方法
|
|
EP3377151A1
(en)
|
2015-11-18 |
2018-09-26 |
Formycon AG |
Pre-filled plastic syringe containing a vegf antagonist
|
|
RU2734958C2
(ru)
|
2015-11-18 |
2020-10-26 |
Формикон Аг |
Предварительно заполненная фармацевтическая упаковка, содержащая жидкий состав на основе антагониста vegf
|
|
MX382662B
(es)
|
2015-11-18 |
2025-03-11 |
Sio2 Medical Products Inc |
Envase farmacéutico para formulaciones oftálmicas.
|
|
DK3384049T3
(da)
|
2015-12-03 |
2023-10-02 |
Regeneron Pharma |
Fremgangsmåder til associering af genetiske varianter med et klinisk resultat hos patienter, der lider af aldersrelateret makuladegeneration behandlet med anti-VEGF
|
|
WO2017106656A1
(en)
|
2015-12-17 |
2017-06-22 |
Novartis Ag |
Antibody molecules to pd-1 and uses thereof
|
|
JP7088454B2
(ja)
|
2015-12-30 |
2022-06-21 |
コディアック サイエンシーズ インコーポレイテッド |
抗体および抗体複合体
|
|
EP3407868A1
(en)
|
2016-01-26 |
2018-12-05 |
Formycon AG |
Liquid formulation of a vegf antagonist
|
|
CN109069638B
(zh)
|
2016-03-24 |
2022-03-29 |
璟尚生物制药公司 |
用于癌症治疗的三特异性抑制剂
|
|
US10941406B2
(en)
|
2016-03-29 |
2021-03-09 |
Geltor, Inc. |
Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1
|
|
KR20190003957A
(ko)
|
2016-04-15 |
2019-01-10 |
제넨테크, 인크. |
암 모니터링 및 치료 방법
|
|
WO2017181111A2
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Methods for monitoring and treating cancer
|
|
JP7169195B2
(ja)
|
2016-05-20 |
2022-11-10 |
バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド |
癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用
|
|
JP7050702B2
(ja)
|
2016-07-08 |
2022-04-08 |
ジェネンテック, インコーポレイテッド |
Nrf2及びその遺伝子の下流標的遺伝子の発現状態及び変異状態によるがんの診断及び治療方法
|
|
TWI823836B
(zh)
|
2016-07-08 |
2023-12-01 |
美商建南德克公司 |
人類副睪蛋白4(he4)用於評定癌症治療反應性之用途
|
|
WO2018011166A2
(en)
|
2016-07-12 |
2018-01-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of myeloid dendritic cells in a tissue sample
|
|
US11613586B2
(en)
|
2016-07-15 |
2023-03-28 |
Takeda Pharmaceutical Company Limited |
Methods and materials for assessing response to plasmablast- and plasma cell-depleting therapies
|
|
SG11201900464TA
(en)
|
2016-07-20 |
2019-02-27 |
Aerpio Therapeutics Inc |
HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß)
|
|
CN106222129A
(zh)
*
|
2016-07-29 |
2016-12-14 |
广东东阳光药业有限公司 |
一种提高抗体纯度的细胞培养基和培养方法
|
|
WO2018018613A1
(zh)
|
2016-07-29 |
2018-02-01 |
广东东阳光药业有限公司 |
一种提高抗体纯度的细胞培养基和培养方法
|
|
MX2019001635A
(es)
|
2016-08-12 |
2019-06-10 |
Genentech Inc |
Terapia de combinacion con un inhibidor de mek, un inhibidor del eje de pd-1, y un inhibidor de vegf.
|
|
ES2836286T3
(es)
*
|
2016-08-23 |
2021-06-24 |
Medimmune Ltd |
Anticuerpos anti-VEGF-A y usos de los mismos
|
|
JPWO2018070390A1
(ja)
|
2016-10-12 |
2019-08-22 |
第一三共株式会社 |
抗robo4抗体と他剤を含む組成物
|
|
CA3040179A1
(en)
|
2016-10-19 |
2018-04-26 |
Adverum Biotechnologies, Inc. |
Modified aav capsids and uses thereof
|
|
US10537637B2
(en)
|
2017-01-05 |
2020-01-21 |
Gensun Biopharma Inc. |
Checkpoint regulator antagonists
|
|
US10350266B2
(en)
|
2017-01-10 |
2019-07-16 |
Nodus Therapeutics, Inc. |
Method of treating cancer with a multiple integrin binding Fc fusion protein
|
|
WO2018132516A1
(en)
|
2017-01-10 |
2018-07-19 |
Nodus Therapeutics |
Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator
|
|
AU2018228873A1
(en)
|
2017-03-01 |
2019-08-29 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
EP3601332A1
(en)
*
|
2017-03-24 |
2020-02-05 |
Council of Scientific and Industrial Research |
A process for the purification of recombinant antibody fragments
|
|
SG11201909046XA
(en)
|
2017-04-03 |
2019-10-30 |
Coherus Biosciences Inc |
PPARγ AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY
|
|
JOP20190245A1
(ar)
|
2017-04-20 |
2019-10-15 |
Novartis Ag |
أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
|
|
KR102607655B1
(ko)
|
2017-05-19 |
2023-11-28 |
카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 |
리폴딩된 재조합 인간화 라니비주맙의 제조 방법
|
|
WO2018215580A1
(en)
|
2017-05-24 |
2018-11-29 |
Formycon Ag |
Method for sterilizing prefilled plastic syringes containing a vegf antagonist
|
|
US20200171244A1
(en)
|
2017-05-24 |
2020-06-04 |
Sio2 Medical Products, Inc. |
Sterilizable pharmaceutical package for ophthalmic formulations
|
|
US20200237997A1
(en)
|
2017-05-24 |
2020-07-30 |
Formycon Ag |
Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
|
|
TW201904610A
(zh)
|
2017-06-14 |
2019-02-01 |
德商拜耳製藥公司 |
用於治療新生血管型青光眼之非抗體vegf拮抗劑
|
|
CN110785187B
(zh)
|
2017-06-22 |
2024-04-05 |
诺华股份有限公司 |
针对cd73的抗体分子及其用途
|
|
US20200172628A1
(en)
|
2017-06-22 |
2020-06-04 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
EP3650045B1
(en)
|
2017-07-04 |
2024-11-13 |
Daiichi Sankyo Company, Limited |
Drug for retinal degenerative disease associated with photoreceptor degeneration
|
|
WO2019020777A1
(en)
|
2017-07-26 |
2019-01-31 |
Formycon Ag |
LIQUID FORMULATION OF A VEGF ANTAGONIST
|
|
WO2019057946A1
(en)
|
2017-09-25 |
2019-03-28 |
F. Hoffmann-La Roche Ag |
MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS
|
|
US11180541B2
(en)
|
2017-09-28 |
2021-11-23 |
Geltor, Inc. |
Recombinant collagen and elastin molecules and uses thereof
|
|
CN111356480A
(zh)
|
2017-10-20 |
2020-06-30 |
脉管生物生长有限公司 |
用于抗血管生成剂疗法的诊断方法
|
|
MY207644A
(en)
|
2017-12-19 |
2025-03-07 |
Akouos Inc |
Aav-mediated delivery of therapeutic antibodies to the inner ear
|
|
CN111511400B
(zh)
|
2017-12-29 |
2025-08-29 |
豪夫迈·罗氏有限公司 |
抗vegf抗体及其使用方法
|
|
CN110003328B
(zh)
*
|
2018-01-05 |
2022-04-19 |
百奥泰生物制药股份有限公司 |
一种长效低毒的重组抗vegf人源化单克隆抗体及其生产方法
|
|
WO2019140410A1
(en)
|
2018-01-12 |
2019-07-18 |
Takeda Pharmaceutical Company Limited |
Subcutaneous dosing of anti-cd38 antibodies
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
CN111699004A
(zh)
|
2018-02-06 |
2020-09-22 |
豪夫迈·罗氏有限公司 |
眼科疾病的治疗
|
|
CN112203679A
(zh)
|
2018-03-02 |
2021-01-08 |
科达制药股份有限公司 |
Il-6抗体及其融合构建体和缀合物
|
|
CA3093468A1
(en)
|
2018-03-09 |
2019-09-12 |
Agenus Inc. |
Anti-cd73 antibodies and methods of use thereof
|
|
WO2019201195A1
(zh)
|
2018-04-16 |
2019-10-24 |
上海岸阔医药科技有限公司 |
预防或治疗肿瘤疗法副作用的方法
|
|
JP7235770B2
(ja)
|
2018-05-10 |
2023-03-08 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
高濃度vegf受容体融合タンパク質を含む製剤
|
|
AU2019274657A1
(en)
|
2018-05-24 |
2020-12-10 |
Janssen Biotech, Inc. |
PSMA binding agents and uses thereof
|
|
US11519020B2
(en)
|
2018-05-25 |
2022-12-06 |
Regeneron Pharmaceuticals, Inc. |
Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
|
|
AR126019A1
(es)
|
2018-05-30 |
2023-09-06 |
Novartis Ag |
Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
|
|
WO2019229116A1
(en)
|
2018-05-31 |
2019-12-05 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Intravitreal delivery of a decorin polypeptide for the treatment of choroidal neovascularisation
|
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
WO2020006516A1
(en)
|
2018-06-29 |
2020-01-02 |
Gensun Biopharma, Inc. |
Antitumor immune checkpoint regulator antagonists
|
|
MX2020013633A
(es)
|
2018-07-03 |
2021-03-25 |
Bristol Myers Squibb Co |
Metodos para producir proteinas recombinantes.
|
|
GB201811410D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
OX40 Binding molecules
|
|
CN109053895B
(zh)
|
2018-08-30 |
2020-06-09 |
中山康方生物医药有限公司 |
抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
|
|
EP3856245A4
(en)
|
2018-09-24 |
2022-10-26 |
EyePoint Pharmaceuticals, Inc. |
MULTISPECIFIC ANTIBODIES THAT TARGET HPTP - ß (VE-PTP) AND VEGF
|
|
US12415980B2
(en)
|
2018-10-10 |
2025-09-16 |
Boehringer Ingelheim International Gmbh |
Method for membrane gas transfer in high density bioreactor culture
|
|
WO2020081767A1
(en)
|
2018-10-18 |
2020-04-23 |
Genentech, Inc. |
Diagnostic and therapeutic methods for sarcomatoid kidney cancer
|
|
HU231514B1
(hu)
|
2018-11-07 |
2024-07-28 |
Richter Gedeon Nyrt. |
Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
|
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
|
CN109134651B
(zh)
*
|
2018-12-03 |
2019-02-22 |
上海复宏汉霖生物技术股份有限公司 |
一种抗vegf的单克隆抗体及其制备方法和应用
|
|
US20200207812A1
(en)
|
2018-12-07 |
2020-07-02 |
Coherus Biosciences, Inc. |
Methods for producing recombinant proteins
|
|
AU2019402097A1
(en)
|
2018-12-17 |
2021-06-10 |
Revitope Limited |
Twin immune cell engager
|
|
CA3131936A1
(en)
|
2019-03-13 |
2020-09-17 |
Vascular Biogenics Ltd. |
Methods of anti-tumor therapy
|
|
AU2020254582B2
(en)
|
2019-04-01 |
2025-12-18 |
Genentech, Inc. |
Compositions and methods for stabilizing protein-containing formulations
|
|
HU231498B1
(hu)
|
2019-04-04 |
2024-05-28 |
Richter Gedeon Nyrt |
Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával
|
|
CN113993885B
(zh)
|
2019-04-12 |
2025-04-25 |
格尔托公司 |
重组弹性蛋白及其生产
|
|
US11591395B2
(en)
|
2019-04-19 |
2023-02-28 |
Janssen Biotech, Inc. |
Methods of treating prostate cancer with an anti-PSMA/CD3 antibody
|
|
TWI862583B
(zh)
|
2019-04-26 |
2024-11-21 |
美商愛德維仁生物科技公司 |
用於玻璃體內遞送之變異體aav蛋白殼
|
|
AU2020270376A1
(en)
|
2019-05-03 |
2021-10-07 |
Genentech, Inc. |
Methods of treating cancer with an anti-PD-L1 antibody
|
|
EP3965816A1
(en)
|
2019-05-06 |
2022-03-16 |
MedImmune Limited |
Combination of monalizumab, durvalumab, chemotherapy and bevacizumab or cetuximab for the treatment of colorectal cancer
|
|
US10851157B2
(en)
|
2019-07-01 |
2020-12-01 |
Gensun Biopharma, Inc. |
Antagonists targeting the TGF-β pathway
|
|
KR20220039777A
(ko)
|
2019-08-01 |
2022-03-29 |
브리스톨-마이어스 스큅 컴퍼니 |
유가식 세포 배양에서 단백질 생산성을 개선시키는 방법
|
|
JP2022548881A
(ja)
|
2019-09-18 |
2022-11-22 |
ノバルティス アーゲー |
Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
|
|
WO2021072265A1
(en)
|
2019-10-10 |
2021-04-15 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
|
WO2021072182A1
(en)
|
2019-10-11 |
2021-04-15 |
Coherus Biosciences, Inc. |
Methods for producing ranibizumab
|
|
WO2021072210A1
(en)
|
2019-10-11 |
2021-04-15 |
Coherus Biosciences, Inc. |
Methods of purifying ranibizumab or a ranibizumab variant
|
|
JP7558272B2
(ja)
|
2019-11-19 |
2024-09-30 |
プロタリクス リミテッド |
形質転換細胞からの構築物の除去
|
|
KR20220104033A
(ko)
|
2019-11-25 |
2022-07-25 |
아케소 바이오파마, 인크. |
항-pd-1-항-vegfa 이중특이항체, 약학 조성물 및 이의 용도
|
|
WO2021180818A1
(en)
|
2020-03-11 |
2021-09-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy
|
|
TW202144410A
(zh)
|
2020-03-13 |
2021-12-01 |
美商建南德克公司 |
抗介白素-33抗體及其用途
|
|
US12091681B2
(en)
|
2020-03-27 |
2024-09-17 |
Mendus B.V. |
Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
|
|
EP4127724A1
(en)
|
2020-04-03 |
2023-02-08 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
WO2022003568A1
(en)
|
2020-06-30 |
2022-01-06 |
Dcprime B.V. |
Use of leukemia-derived cells in ovarian cancer vaccines
|
|
MX2023000547A
(es)
|
2020-07-16 |
2023-02-13 |
Novartis Ag |
Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas.
|
|
CN114106190B
(zh)
*
|
2020-08-31 |
2025-04-08 |
普米斯生物技术(珠海)有限公司 |
一种抗vegf/pd-l1双特异性抗体及其用途
|
|
JP2023542924A
(ja)
|
2020-09-22 |
2023-10-12 |
ブリストル-マイヤーズ スクイブ カンパニー |
治療タンパク質を生産するための方法
|
|
KR20230113283A
(ko)
|
2020-10-05 |
2023-07-28 |
프로탈릭스 리미티드 |
다이서-유사 넉아웃 식물 세포
|
|
EP4228706A1
(en)
|
2020-10-15 |
2023-08-23 |
Genentech, Inc. |
Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics
|
|
IL301293A
(en)
|
2020-11-13 |
2023-05-01 |
Genentech Inc |
Methods and compositions comprising a krasg12c inhibitor and a vegf inhibitor for treating solid tumors
|
|
CA3201005A1
(en)
|
2020-11-20 |
2022-05-27 |
R.P. Scherer Technologies, Llc |
Glycoside dual-cleavage linkers for antibody-drug conjugates
|
|
MX2023006451A
(es)
|
2020-12-01 |
2023-06-15 |
Akouos Inc |
Construcciones de anticuerpos anti-vegf y metodos relacionados para el tratamiento de los sintomas asociados al schwannoma vestibular.
|
|
WO2022157715A1
(en)
|
2021-01-22 |
2022-07-28 |
Dcprime B.V. |
Methods of tumor vaccination
|
|
PE20240761A1
(es)
|
2021-01-28 |
2024-04-17 |
Janssen Biotech Inc |
Proteinas de union a psma y usos de estas
|
|
EP4304633A1
(en)
|
2021-03-12 |
2024-01-17 |
Mendus B.V. |
Methods of vaccination and use of cd47 blockade
|
|
KR20230156910A
(ko)
|
2021-03-12 |
2023-11-15 |
아케소 바이오파마, 인크. |
항-pd-1-항-vegfa 이중특이적 항체를 함유하는 약학적 조합 및 이의 용도
|
|
EP4329734A4
(en)
|
2021-04-26 |
2025-04-02 |
Celanese EVA Performance Polymers LLC |
Implantable device for the delayed release of a macromolecular drug compound
|
|
WO2022232503A1
(en)
|
2021-04-30 |
2022-11-03 |
Genentech, Inc. |
Therapeutic and diagnostic methods and compositions for cancer
|
|
JP2024519888A
(ja)
|
2021-05-28 |
2024-05-21 |
上海瑞宏迪医薬有限公司 |
カプシド変異を有する組換えアデノ随伴ウイルス及びその応用
|
|
WO2022256820A1
(en)
|
2021-06-03 |
2022-12-08 |
Gensun Biopharma Inc. |
Multispecific antagonists
|
|
TW202309078A
(zh)
|
2021-07-02 |
2023-03-01 |
美商建南德克公司 |
治療癌症之方法及組成物
|
|
CN117715936A
(zh)
|
2021-07-28 |
2024-03-15 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的方法和组合物
|
|
US20250115666A1
(en)
|
2021-08-05 |
2025-04-10 |
Bristol-Myers Squibb Company |
Cell culture methods for producing therapeutic proteins
|
|
CN118043350A
(zh)
|
2021-08-13 |
2024-05-14 |
信达生物制药(苏州)有限公司 |
抗vegf a和vegf c双特异性抗体及其用途
|
|
EP4145456A1
(en)
|
2021-09-06 |
2023-03-08 |
Bayer AG |
Prediction of a change related to a macular fluid
|
|
US20240390869A1
(en)
|
2021-09-21 |
2024-11-28 |
Bristol-Myers Squibb Company |
Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container
|
|
WO2023080900A1
(en)
|
2021-11-05 |
2023-05-11 |
Genentech, Inc. |
Methods and compositions for classifying and treating kidney cancer
|
|
JPWO2023144973A1
(OSRAM)
|
2022-01-27 |
2023-08-03 |
|
|
|
KR20240144944A
(ko)
|
2022-01-28 |
2024-10-04 |
온퀄리티 파마슈티컬스 차이나 리미티드 |
항종양제와 관련된 질병 또는 증상을 예방하거나 치료하는 방법
|
|
WO2023150142A1
(en)
|
2022-02-02 |
2023-08-10 |
Akouos, Inc. |
Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms
|
|
KR20240150493A
(ko)
|
2022-02-21 |
2024-10-15 |
온퀄리티 파마슈티컬스 차이나 리미티드 |
화합물 및 그 용도
|
|
WO2024040175A1
(en)
|
2022-08-18 |
2024-02-22 |
Pulmatrix Operating Company, Inc. |
Methods for treating cancer using inhaled angiogenesis inhibitor
|
|
WO2024051223A1
(zh)
|
2022-09-09 |
2024-03-14 |
中山康方生物医药有限公司 |
药物组合及用途
|
|
WO2024186635A2
(en)
|
2023-03-03 |
2024-09-12 |
Celldex Therapeutics, Inc. |
Anti-stem cell factor (scf) and anti-thymic stromal lymphopoietin (tslp) antibodies and bispecific constructs
|
|
WO2024263904A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
WO2024263195A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
WO2025157267A1
(zh)
*
|
2024-01-25 |
2025-07-31 |
中山康方生物医药有限公司 |
抗pd-1-抗vegfa的双特异性抗体的医药用途
|