KR20050004161A - C-아릴 글루코시드 sglt2 억제제 및 억제 방법 - Google Patents
C-아릴 글루코시드 sglt2 억제제 및 억제 방법 Download PDFInfo
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Abstract
Description
Claims (17)
- 하기 화학식 I의 화합물 또는 그의 제약학적으로 허용가능한 염, 그의 입체이성질체 또는 그의 프로드러그 에스테르.<화학식 I>
- 제1항에 있어서, 하기 화학식을 갖는 화합물.
- 제1항에서 정의된 화합물 및 그의 제약학적으로 허용가능한 담체를 포함하는 제약 조성물.
- 제3항에서 정의된 SGLT2 억제제 화합물, 및 SGLT2 억제제 이외의 항당뇨병제, 당뇨병 합병증 치료제, 항비만제, 항고혈압제, 항혈소판제, 항아테롬성경화증제 및(또는) 지질 강하제 (lipid-lowering agent)를 포함하는 제약 조합물.
- 제4항에 있어서, 상기 SGLT2 억제제 화합물 및 항당뇨병제를 포함하는 제약 조합물.
- 제5항에 있어서, 항당뇨병제가 1종, 2종, 3종 또는 그 이상의 비구아니드, 술포닐 우레아, 글루코시다제 억제제, PPAR γ작용제, PPAR α/γ 이중 작용제, aP2 억제제, DP4 억제제, 인슐린 증감제, 글루카곤 유사 펩티드-1 (GLP-1), 인슐린, 메글리티니드, PTP1B 억제제, 글리코겐 포스포릴라제 억제제 및(또는) 글루코스-6-포스파타제 억제제인 조합물.
- 제6항에 있어서, 항당뇨병제가 1종, 2종, 3종 또는 그 이상의 메트포르민, 글리부리드, 글리메피리드, 글리피리드, 글리피지드, 클로르프로파미드, 글리클라지드, 아카르보스, 미글리톨, 피오글리타존, 트로글리타존, 로시글리타존, 인슐린, G1-262570, 이사글리타존, JTT-501, NN-2344, L895645, YM-440, R-119702, AJ9677, 레파글리니드, 나테글리니드, KAD1129, AR-HO39242, GW-409544, KRP297, AC2993, LY315902 및(또는) NVP-DPP-728A인 조합물.
- 제5항에 있어서, SGLT2 억제제 화합물이 항당뇨병제에 대해 약 0.01 내지 약 300:1의 중량비로 존재하는 조합물.
- 제4항에 있어서, 항비만제가 베타 3 아드레날린성 작용제, 리파제 억제제, 세로토닌 (및 도파민) 재흡수 억제제, 티로이드 수용체 베타 화합물 및(또는) 식욕 감퇴제인 조합물.
- 제9항에 있어서, 항비만제가 오를리스타트, ATL-962, AJ9677, L750355, CP331648, 시부트라민, 토피라메이트, 악소킨, 덱삼페타민, 펜테르민, 페닐프로판올아민 및(또는) 마진돌인 조합물.
- 제4항에 있어서, 지질 강하제가 MTP 억제제, HMG CoA 환원효소 억제제, 스쿠알렌 합성효소 억제제, 피브르산 유도체, LDL 수용체 활성의 증진조절제 (upregulator), 리폭시게나제 억제제 또는 ACAT 억제제인 조합물.
- 제11항에 있어서, 지질 강하제가 프라바스타틴, 로바스타틴, 심바스타틴, 아토르바스타틴, 세리바스타틴, 플루바스타틴, 니스바스타틴, 비사스타틴, 아타바스타틴, 로수바스타틴, 페노피브레이트, 겜피브로질, 클로피브레이트, 아바시미베, TS-962, MD-700 및(또는) LY295427인 조합물.
- 제11항에 있어서, SGLT2 억제제가 지질 강하제에 대해 약 0.01 내지 약 300:1의 중량비로 존재하는 조합물.
- 치료를 필요로 하는 포유류종에게 제1항에서 정의된 화합물을 치료적 유효량으로 투여하는 것을 포함하는, 당뇨병, 당뇨병성 망막병증, 당뇨병성 신경병증, 당뇨성 신장병증, 지연된 창상 치유, 인슐린 저항증, 과혈당증, 고인슐린혈증, 지방산 또는 글리세롤의 혈중 농도 상승, 고지혈증, 비만, 고중성지방혈증, X 증후군, 당뇨병 합병증, 아테롬성경화증 또는 고혈압의 발병 또는 진행을 치료 또는 지연시키거나, 또는 고밀도 지단백질 수준을 증가시키는 방법.
- 제14항에 있어서, SGLT2 억제제 화합물이 하기의 화학식을 갖는 것인 방법.
- 치료를 필요로 하는 포유류종에게 제1항에서 정의된 화합물을 단독으로 또는 또다른 항당뇨병제, 당뇨병 합병증 치료제, 항비만제, 항고혈압제, 항혈소판제, 항아테롬성경화증제 및(또는) 저지혈증제와 조합하여 치료적 유효량으로 투여하는 것을 포함하는 II형 당뇨병의 치료 방법.
- 하기 화학식의 화합물 또는 그의 제약학적으로 허용가능한 염, 그의 모든 입체이성질체 또는 그의 프로드러그 에스테르.
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US10/151,436 US6515117B2 (en) | 1999-10-12 | 2002-05-20 | C-aryl glucoside SGLT2 inhibitors and method |
US10/151,436 | 2002-05-20 | ||
PCT/US2003/015591 WO2003099836A1 (en) | 2002-05-20 | 2003-05-15 | C-aryl glucoside sglt2 inhibitors and method |
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KR20050004161A true KR20050004161A (ko) | 2005-01-12 |
KR101021752B1 KR101021752B1 (ko) | 2011-03-15 |
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Cited By (2)
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KR101454051B1 (ko) * | 2007-03-22 | 2014-10-27 | 아스트라제네카 아베 | 다파글리플로진 프로필렌 글리콜 수화물을 함유하는 제약 제형 |
KR102490653B1 (ko) * | 2022-08-03 | 2023-01-20 | 진양제약주식회사 | 다파글리플로진 및 글리메피리드를 포함하는 약제학적 조성물 |
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