KR100606871B1 - 당뇨병의 치료 또는 예방을 위한 디펩티딜 펩티다제 억제제로서 베타-아미노 테트라하이드로이미다조 (1, 2-a) 피라진 및 테트라하이드로트리아졸로 (4, 3-a) 피라진 - Google Patents
당뇨병의 치료 또는 예방을 위한 디펩티딜 펩티다제 억제제로서 베타-아미노 테트라하이드로이미다조 (1, 2-a) 피라진 및 테트라하이드로트리아졸로 (4, 3-a) 피라진 Download PDFInfo
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- KR100606871B1 KR100606871B1 KR1020047000166A KR20047000166A KR100606871B1 KR 100606871 B1 KR100606871 B1 KR 100606871B1 KR 1020047000166 A KR1020047000166 A KR 1020047000166A KR 20047000166 A KR20047000166 A KR 20047000166A KR 100606871 B1 KR100606871 B1 KR 100606871B1
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- 0 *CC(*)CC(*1CC2=**=C(*)*2CC1)=O Chemical compound *CC(*)CC(*1CC2=**=C(*)*2CC1)=O 0.000 description 1
- BUBSBWRFTWMLPQ-GFCCVEGCSA-N N[C@@H](CC(N1Cc2nc(C(F)(F)F)c[n]2CC1)=O)Cc(cc(cc1)F)c1F Chemical compound N[C@@H](CC(N1Cc2nc(C(F)(F)F)c[n]2CC1)=O)Cc(cc(cc1)F)c1F BUBSBWRFTWMLPQ-GFCCVEGCSA-N 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30347401P | 2001-07-06 | 2001-07-06 | |
US60/303,474 | 2001-07-06 | ||
PCT/US2002/021349 WO2003004498A1 (en) | 2001-07-06 | 2002-07-05 | Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040010842A KR20040010842A (ko) | 2004-01-31 |
KR100606871B1 true KR100606871B1 (ko) | 2006-08-01 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047000166A KR100606871B1 (ko) | 2001-07-06 | 2002-07-05 | 당뇨병의 치료 또는 예방을 위한 디펩티딜 펩티다제 억제제로서 베타-아미노 테트라하이드로이미다조 (1, 2-a) 피라진 및 테트라하이드로트리아졸로 (4, 3-a) 피라진 |
Country Status (46)
Families Citing this family (427)
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JP4504924B2 (ja) * | 2002-12-20 | 2010-07-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての3−アミノ−4−フェニルブタン酸誘導体 |
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KR20060056944A (ko) | 2003-07-14 | 2006-05-25 | 아레나 파마슈티칼스, 인크. | 대사 조절제로서 융합된 아릴 및 헤테로아릴 유도체 및이에 관련된 장애의 예방 또는 치료 |
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