JPH07505882A - 表面抗原に関連したc‐erbB‐2(HER‐2/neu)に対する免疫毒素 - Google Patents
表面抗原に関連したc‐erbB‐2(HER‐2/neu)に対する免疫毒素Info
- Publication number
- JPH07505882A JPH07505882A JP5518465A JP51846593A JPH07505882A JP H07505882 A JPH07505882 A JP H07505882A JP 5518465 A JP5518465 A JP 5518465A JP 51846593 A JP51846593 A JP 51846593A JP H07505882 A JPH07505882 A JP H07505882A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- cells
- composition
- erbb
- tumor cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
Abstract
Description
Claims (27)
- 1.c−erbB−2蛋白質に対する抗原ドメインに対して結合特性を示す蛋白 質と植物由来の毒素の接合体により構成され、上記毒素がゲロニン、全長組み替 えゲロニン、ゲロニンフラグメントおよびゲロニン誘導体により構成される組成 物。
- 2.上記結合特性が。−erbB−2の細胞外エピトープに対するものである請 求項1の組成物。
- 3.上記蛋白質がVHセグメントで構成される請求項1の組成物。
- 4.上記蛋白質が完全な免疫グロブリン重鎖で構成されている請求項1の組成物 。
- 5.上記蛋白質がVLセグメントで構成されている請求項1の組成物。
- 6.上記蛋白質がさらにVHセグメントを含んでいる請求項5の組成物。
- 7.上記蛋白質が完全な免疫グロブリン軽鎖を含んでいる請求項1の組成物。
- 8.上記蛋白質がさらに完全な免疫グロブリン重鎖を含んでいる請求項7の組成 物。
- 9.上記蛋白質が単鎖抗体からのものである請求項1の組成物。
- 10.上記蛋白質がTAb250またはBACh−250からのものである請求 項1の組成物。
- 11.上記植物由来毒素が、上記標的部分に接合されない場合、ずっと低い細胞 影響を有する請求項1の組成物。
- 12.上記毒素が天然の毒素および組み替え毒素により構成される群から選択さ れる請求項1の組成物。
- 13.上記接合体が上記標的部分と上記成長調節子との間の融合蛋白質である請 求項1の組成物。
- 14.請求項1の医薬品組成物。
- 15.さらに、薬学的に許容可能なベヒクルを含んでいる請求項1の組成物。
- 16.請求項15の単一投与(singledose)組成物。
- 17.有効な量の請求項1による組成物を細胞に投与するステップで構成される 腫瘍細胞を措置するための方法。
- 18.上記腫瘍細胞がc−erbB−2蛋白質の過剰表現によって特徴づけられ る請求項17の方法。
- 19.上記細胞が哺乳動物悪性腫瘍細胞、卵巣,悪性腫瘍、肺悪性腫瘍細胞、唾 液腺悪性腫瘍細胞、胃癌細胞、唾液腺悪性腫瘍細胞、そして骨髄腫白血病細胞で 構成される群がら選択される請求項17の方法。
- 20.上記組成物が上記細胞の成長速度を遅らせる請求項17の措置法。
- 21.上記腫瘍細胞がヒトまたは動物のものである請求項17の措置法。
- 22.上記組成物が腫瘍状態の再発を防ぐ請求項21の措置法。
- 23.上記組成物が上記腫瘍細胞のホストの生き残り時間の措置法。
- 24.上記腫瘍細胞がイン・ビトロである請求項17の措置法。
- 25.上記腫瘍細胞が骨髄腫瘍細胞である請求項17の方法。
- 26.腫瘍性疾患を有する個人から骨髄腫瘍細胞を取り出すステップと、その骨 髄腫瘍細胞を細胞毒性的に有効な量だけ請求項1の組成物と接触させるステップ と、そして上記接触させられた骨髄腫傷を上記個人の体内に戻すステップとで構 成される、骨髄腫瘍の腫瘍細胞を殺す方法。
- 27.上記腫癌細胞がc−erbB−2蛋白質の過剰表現で特徴づけられる請求 項26の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86772892A | 1992-04-10 | 1992-04-10 | |
US867,728 | 1992-04-10 | ||
PCT/US1993/003292 WO1993021232A1 (en) | 1992-04-10 | 1993-04-08 | IMMUNOTOXINS DIRECTED AGAINST c-erbB-2 (HER-2/neu) RELATED SURFACE ANTIGENS |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07505882A true JPH07505882A (ja) | 1995-06-29 |
JP3633613B2 JP3633613B2 (ja) | 2005-03-30 |
Family
ID=25350363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51846593A Expired - Fee Related JP3633613B2 (ja) | 1992-04-10 | 1993-04-08 | 表面抗原に関連したc‐erbB‐2(HER‐2/neu)に対する免疫毒素 |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0635030B1 (ja) |
JP (1) | JP3633613B2 (ja) |
KR (1) | KR100333011B1 (ja) |
AT (1) | ATE271564T1 (ja) |
AU (1) | AU671642B2 (ja) |
CA (1) | CA2133739A1 (ja) |
DE (1) | DE69333574T2 (ja) |
DK (1) | DK0635030T3 (ja) |
ES (1) | ES2224099T3 (ja) |
FI (1) | FI113243B (ja) |
IL (1) | IL105345A (ja) |
NO (1) | NO318173B1 (ja) |
NZ (1) | NZ252800A (ja) |
PT (1) | PT635030E (ja) |
RU (1) | RU2130780C1 (ja) |
SA (1) | SA93140304B1 (ja) |
WO (1) | WO1993021232A1 (ja) |
ZA (1) | ZA932522B (ja) |
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US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5514554A (en) * | 1991-08-22 | 1996-05-07 | Becton Dickinson And Company | Methods and compositions for cancer therapy and for prognosticating responses to cancer therapy |
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PT635030E (pt) | 2004-11-30 |
KR950700939A (ko) | 1995-02-20 |
DE69333574D1 (de) | 2004-08-26 |
ZA932522B (en) | 1993-12-20 |
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IL105345A (en) | 2000-09-28 |
NZ252800A (en) | 1996-05-28 |
JP3633613B2 (ja) | 2005-03-30 |
AU671642B2 (en) | 1996-09-05 |
FI113243B (fi) | 2004-03-31 |
NO943777D0 (no) | 1994-10-07 |
SA93140304B1 (ar) | 2006-04-04 |
KR100333011B1 (ko) | 2002-11-29 |
NO943777L (no) | 1994-11-29 |
EP0635030B1 (en) | 2004-07-21 |
DK0635030T3 (da) | 2004-11-15 |
EP0635030A1 (en) | 1995-01-25 |
FI944731A (fi) | 1994-12-02 |
DE69333574T2 (de) | 2005-08-25 |
AU4280493A (en) | 1993-11-18 |
CA2133739A1 (en) | 1993-10-28 |
EP0635030A4 (en) | 1998-07-08 |
NO318173B1 (no) | 2005-02-14 |
IL105345A0 (en) | 1993-08-18 |
FI944731A0 (fi) | 1994-10-07 |
WO1993021232A1 (en) | 1993-10-28 |
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