JP7696443B2 - Ｅｇｆｒ変異を有するがんを処置するためのアミノ置換ヘテロ環類 - Google Patents

Ｅｇｆｒ変異を有するがんを処置するためのアミノ置換ヘテロ環類 Download PDF

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JP7696443B2
JP7696443B2 JP2023562688A JP2023562688A JP7696443B2 JP 7696443 B2 JP7696443 B2 JP 7696443B2 JP 2023562688 A JP2023562688 A JP 2023562688A JP 2023562688 A JP2023562688 A JP 2023562688A JP 7696443 B2 JP7696443 B2 JP 7696443B2
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JP2024516371A (ja
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リン アンドルーズ クリスティン
ジェラード ボードワン
コートニー ホラン ジョシュア
リチャード メンテ スコット
エフレム ペリッシュ ヘンリー
ディー． シャイアー マシュー
サン ユーティン
タンペーラチャイクル アヌポン
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ヌバレント， インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023562688A 2021-04-13 2022-04-12 Ｅｇｆｒ変異を有するがんを処置するためのアミノ置換ヘテロ環類 Active JP7696443B2 (ja)

Priority Applications (1)

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JP2025096800A JP2025134754A (ja) 2021-04-13 2025-06-10 Ｅｇｆｒ変異を有するがんを処置するためのアミノ置換ヘテロ環類

Applications Claiming Priority (9)

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US202163174177P 2021-04-13 2021-04-13
US63/174,177 2021-04-13
US202163239089P 2021-08-31 2021-08-31
US63/239,089 2021-08-31
US202163242837P 2021-09-10 2021-09-10
US63/242,837 2021-09-10
US202163292605P 2021-12-22 2021-12-22
US63/292,605 2021-12-22
PCT/US2022/024334 WO2022221227A1 (en) 2021-04-13 2022-04-12 Amino-substituted heterocycles for treating cancers with egfr mutations

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JP2024516371A5 JP2024516371A5 (https=) 2025-05-01
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JP2025096800A Pending JP2025134754A (ja) 2021-04-13 2025-06-10 Ｅｇｆｒ変異を有するがんを処置するためのアミノ置換ヘテロ環類

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US (2) US12037346B2 (https=)
EP (1) EP4323356A1 (https=)
JP (2) JP7696443B2 (https=)
KR (2) KR20250151577A (https=)
AU (1) AU2022257621A1 (https=)
BR (1) BR112023021111A2 (https=)
CA (1) CA3213079A1 (https=)
CL (1) CL2023003020A1 (https=)
IL (1) IL306100A (https=)
MX (1) MX2023012060A (https=)
PE (1) PE20240327A1 (https=)
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TW202214641A (zh) 2020-06-30 2022-04-16 美商艾瑞生藥股份有限公司 Ｈｅｒ２突變抑制劑
EP4304586A4 (en) 2021-03-10 2025-04-02 Jnana Therapeutics Inc. SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION
TW202309022A (zh) * 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
CR20230604A (es) * 2021-06-26 2024-02-19 Array Biopharma Inc Inhibidores de mutación de her2
WO2023081637A1 (en) 2021-11-02 2023-05-11 Enliven Therapeutics, Inc. Fused tetracyclic quinazoline derivatives as inhibitors of erbb2
CN117384162A (zh) * 2022-05-17 2024-01-12 浙江文达医药科技有限公司 选择性her2抑制剂
WO2024027695A1 (zh) * 2022-08-04 2024-02-08 微境生物医药科技(上海)有限公司 作为her2抑制剂的化合物
CN116082335B (zh) * 2023-01-16 2026-02-24 上海凌凯科技股份有限公司 一种二芳基醚化合物的制备方法
CN116789609A (zh) * 2023-03-03 2023-09-22 南京优氟医药科技有限公司 一种(r)-2-(哌嗪-2-基)乙腈盐酸盐的制备方法
WO2024215809A2 (en) * 2023-04-11 2024-10-17 Cogent Biosciences, Inc. Erbb2 inhibitors
WO2025051148A1 (zh) * 2023-09-05 2025-03-13 北京鞍石生物科技股份有限公司 含氮杂芳基化合物及其制备方法和应用
AU2024345242A1 (en) * 2023-09-22 2026-04-09 Hanmi Pharm. Co. Ltd. Novel skeletal derivative effective for her2 mutation, and pharmaceutical composition comprising same
WO2025195327A1 (zh) * 2024-03-19 2025-09-25 北京鞍石生物科技股份有限公司 螺环/桥环化合物及其制备方法和应用
WO2026081108A1 (en) * 2024-10-16 2026-04-23 The Regents Of The University Of California Compositions and methods for inhibiting egfr

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