IL306100A - Amino-substituted heterocycles for the treatment of cancer with EGFR mutations - Google Patents

Amino-substituted heterocycles for the treatment of cancer with EGFR mutations

Info

Publication number
IL306100A
IL306100A IL306100A IL30610023A IL306100A IL 306100 A IL306100 A IL 306100A IL 306100 A IL306100 A IL 306100A IL 30610023 A IL30610023 A IL 30610023A IL 306100 A IL306100 A IL 306100A
Authority
IL
Israel
Prior art keywords
amino
treating cancers
egfr mutations
substituted heterocycles
heterocycles
Prior art date
Application number
IL306100A
Other languages
English (en)
Hebrew (he)
Inventor
Kristin Lynne Andrews
Baudouin Gerard
Joshua Courtney Horan
Scot Richard Mente
Henry Efrem Pelish
Matthew D Shair
Yuting Sun
Anupong Tangpeerachaikul
Original Assignee
Nuvalent Inc
Kristin Lynne Andrews
Baudouin Gerard
Joshua Courtney Horan
Scot Richard Mente
Henry Efrem Pelish
Matthew D Shair
Yuting Sun
Anupong Tangpeerachaikul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvalent Inc, Kristin Lynne Andrews, Baudouin Gerard, Joshua Courtney Horan, Scot Richard Mente, Henry Efrem Pelish, Matthew D Shair, Yuting Sun, Anupong Tangpeerachaikul filed Critical Nuvalent Inc
Publication of IL306100A publication Critical patent/IL306100A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL306100A 2021-04-13 2022-04-12 Amino-substituted heterocycles for the treatment of cancer with EGFR mutations IL306100A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163174177P 2021-04-13 2021-04-13
US202163239089P 2021-08-31 2021-08-31
US202163242837P 2021-09-10 2021-09-10
US202163292605P 2021-12-22 2021-12-22
PCT/US2022/024334 WO2022221227A1 (en) 2021-04-13 2022-04-12 Amino-substituted heterocycles for treating cancers with egfr mutations

Publications (1)

Publication Number Publication Date
IL306100A true IL306100A (en) 2023-11-01

Family

ID=81392726

Family Applications (1)

Application Number Title Priority Date Filing Date
IL306100A IL306100A (en) 2021-04-13 2022-04-12 Amino-substituted heterocycles for the treatment of cancer with EGFR mutations

Country Status (13)

Country Link
US (2) US12037346B2 (https=)
EP (1) EP4323356A1 (https=)
JP (2) JP7696443B2 (https=)
KR (2) KR20250151577A (https=)
AU (1) AU2022257621A1 (https=)
BR (1) BR112023021111A2 (https=)
CA (1) CA3213079A1 (https=)
CL (1) CL2023003020A1 (https=)
IL (1) IL306100A (https=)
MX (1) MX2023012060A (https=)
PE (1) PE20240327A1 (https=)
TW (1) TW202309022A (https=)
WO (1) WO2022221227A1 (https=)

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TW202214641A (zh) 2020-06-30 2022-04-16 美商艾瑞生藥股份有限公司 Ｈｅｒ２突變抑制劑
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CN116789609A (zh) * 2023-03-03 2023-09-22 南京优氟医药科技有限公司 一种(r)-2-(哌嗪-2-基)乙腈盐酸盐的制备方法
WO2024215809A2 (en) * 2023-04-11 2024-10-17 Cogent Biosciences, Inc. Erbb2 inhibitors
WO2025051148A1 (zh) * 2023-09-05 2025-03-13 北京鞍石生物科技股份有限公司 含氮杂芳基化合物及其制备方法和应用
AU2024345242A1 (en) * 2023-09-22 2026-04-09 Hanmi Pharm. Co. Ltd. Novel skeletal derivative effective for her2 mutation, and pharmaceutical composition comprising same
WO2025195327A1 (zh) * 2024-03-19 2025-09-25 北京鞍石生物科技股份有限公司 螺环/桥环化合物及其制备方法和应用
WO2026081108A1 (en) * 2024-10-16 2026-04-23 The Regents Of The University Of California Compositions and methods for inhibiting egfr

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