JP5897333B2 - ベンゾオキサゾールキナーゼ阻害剤および使用方法 - Google Patents

ベンゾオキサゾールキナーゼ阻害剤および使用方法 Download PDF

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JP5897333B2
JP5897333B2 JP2011534529A JP2011534529A JP5897333B2 JP 5897333 B2 JP5897333 B2 JP 5897333B2 JP 2011534529 A JP2011534529 A JP 2011534529A JP 2011534529 A JP2011534529 A JP 2011534529A JP 5897333 B2 JP5897333 B2 JP 5897333B2
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alkyl
aryl
alkenyl
alkynyl
heteroaryl
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JP2012507522A (ja
JP2012507522A5 (enExample
Inventor
ピンダ レン，
ピンダ レン，
イー リュー，
イー リュー，
リアンシェン リー，
リアンシェン リー，
カトリーナ チャン，
カトリーナ チャン，
トロイ エドワード ウィルソン，
トロイ エドワード ウィルソン，
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インテリカイン， エルエルシー
インテリカイン， エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2011534529A 2008-11-03 2009-11-02 ベンゾオキサゾールキナーゼ阻害剤および使用方法 Active JP5897333B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US19820008P 2008-11-03 2008-11-03
US61/198,200 2008-11-03
US20192308P 2008-12-16 2008-12-16
US61/201,923 2008-12-16
US21426109P 2009-04-20 2009-04-20
US61/214,261 2009-04-20
US23065509P 2009-07-31 2009-07-31
US61/230,655 2009-07-31
US12/586,241 US8476431B2 (en) 2008-11-03 2009-09-17 Benzoxazole kinase inhibitors and methods of use
US12/586,309 2009-09-17
US12/586,241 2009-09-17
US12/586,309 US8476282B2 (en) 2008-11-03 2009-09-17 Benzoxazole kinase inhibitors and methods of use
PCT/US2009/005959 WO2010051043A1 (en) 2008-11-03 2009-11-02 Benzoxazole kinase inhibitors and methods of use

Related Child Applications (2)

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JP2014179810A Division JP5897667B2 (ja) 2008-11-03 2014-09-04 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2016039988A Division JP6235058B2 (ja) 2008-11-03 2016-03-02 ベンゾオキサゾールキナーゼ阻害剤および使用方法

Publications (3)

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JP2012507522A JP2012507522A (ja) 2012-03-29
JP2012507522A5 JP2012507522A5 (enExample) 2012-12-20
JP5897333B2 true JP5897333B2 (ja) 2016-03-30

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JP2011534529A Active JP5897333B2 (ja) 2008-11-03 2009-11-02 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2014179810A Active JP5897667B2 (ja) 2008-11-03 2014-09-04 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2016039988A Active JP6235058B2 (ja) 2008-11-03 2016-03-02 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2017205797A Withdrawn JP2018021073A (ja) 2008-11-03 2017-10-25 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2019109399A Withdrawn JP2019178151A (ja) 2008-11-03 2019-06-12 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2020173377A Withdrawn JP2021008514A (ja) 2008-11-03 2020-10-14 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2022139129A Withdrawn JP2022169786A (ja) 2008-11-03 2022-09-01 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2023127917A Pending JP2023139324A (ja) 2008-11-03 2023-08-04 ベンゾオキサゾールキナーゼ阻害剤および使用方法

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JP2014179810A Active JP5897667B2 (ja) 2008-11-03 2014-09-04 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2016039988A Active JP6235058B2 (ja) 2008-11-03 2016-03-02 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2017205797A Withdrawn JP2018021073A (ja) 2008-11-03 2017-10-25 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2019109399A Withdrawn JP2019178151A (ja) 2008-11-03 2019-06-12 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2020173377A Withdrawn JP2021008514A (ja) 2008-11-03 2020-10-14 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2022139129A Withdrawn JP2022169786A (ja) 2008-11-03 2022-09-01 ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2023127917A Pending JP2023139324A (ja) 2008-11-03 2023-08-04 ベンゾオキサゾールキナーゼ阻害剤および使用方法

Country Status (25)

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US (6) US8476431B2 (enExample)
EP (2) EP2365750B1 (enExample)
JP (8) JP5897333B2 (enExample)
KR (2) KR101737192B1 (enExample)
CN (2) CN104710428B (enExample)
AU (1) AU2009310364B2 (enExample)
BR (1) BRPI0920500B1 (enExample)
CA (1) CA2741898C (enExample)
CY (1) CY1117913T1 (enExample)
DK (1) DK2365750T3 (enExample)
ES (1) ES2588197T3 (enExample)
HR (1) HRP20161074T1 (enExample)
HU (1) HUE029906T2 (enExample)
IL (3) IL212586A (enExample)
LT (1) LT2365750T (enExample)
MX (3) MX361811B (enExample)
MY (2) MY166032A (enExample)
NZ (2) NZ592608A (enExample)
PL (1) PL2365750T3 (enExample)
PT (1) PT2365750T (enExample)
SG (2) SG10201501703TA (enExample)
SI (1) SI2365750T1 (enExample)
SM (1) SMT201600278B (enExample)
WO (2) WO2010051043A1 (enExample)
ZA (1) ZA201103270B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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