HRP20161074T1 - Benzoksazolski inhibitori kinaza i postupci njihove upotrebe - Google Patents
Benzoksazolski inhibitori kinaza i postupci njihove upotrebe Download PDFInfo
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- HRP20161074T1 HRP20161074T1 HRP20161074TT HRP20161074T HRP20161074T1 HR P20161074 T1 HRP20161074 T1 HR P20161074T1 HR P20161074T T HRP20161074T T HR P20161074TT HR P20161074 T HRP20161074 T HR P20161074T HR P20161074 T1 HRP20161074 T1 HR P20161074T1
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- cancer
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- pharmaceutically acceptable
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- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- 239000000825 pharmaceutical preparation Substances 0.000 claims 16
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 201000008808 Fibrosarcoma Diseases 0.000 claims 1
- 206010023774 Large cell lung cancer Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000009546 lung large cell carcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000001989 nasopharynx Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Claims (18)
1. Spoj, naznačen time što ima sljedeću strukturu:
[image]
,
ili njegova farmaceutski prihvatljiva sol.
2. Farmaceutski pripravak, naznačen time što sadrži terapijski djelotvornu količinu spoja ili farmaceutski prihvatljivu sol u skladu s patentnim zahtjevom 1, kao i farmaceutski prihvatljivu podlogu.
3. Spoj, ili farmaceutski prihvatljiva sol, u skladu s patentnim zahtjevom 1, naznačen time što je namijenjen upotrebi u liječenju raka.
4. Farmaceutski pripravak u skladu s patentnim zahtjevom 2, naznačen time što je namijenjen upotrebi u liječenju raka.
5. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je rak fibrosarkom, rak gušterače, rak bubrega, rak jetre, melanom, rak nazofarinksa, rak želuca, rak jajnika, leukemija, mijelom, rak dojke, rak prostate, kolorektalni rak, rak pluća, glioblastom, rak maternice, rak mokraćnog mjehura, mezoteliom, rak glave, rak vrata, te rak vrata maternice.
6. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak bubrega.
7. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak karcinom bubrežnih stanica.
8. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak dojke.
9. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak maternice.
10. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak mokraćnog mjehura.
11. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak kolorektalni rak.
12. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak pluća.
13. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak velikih stanica pluća.
14. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak malih stanica pluća.
15. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak glioblastom.
16. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak ginekološki rak.
17. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak vrata maternice.
18. Spoj, ili farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 3, ili farmaceutski pripravak, namijenjen upotrebi u skladu s patentnim zahtjevom 4, naznačeni time što je navedeni rak rak želuca.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19820008P | 2008-11-03 | 2008-11-03 | |
| US20192308P | 2008-12-16 | 2008-12-16 | |
| US21426109P | 2009-04-20 | 2009-04-20 | |
| US23065509P | 2009-07-31 | 2009-07-31 | |
| US12/586,309 US8476282B2 (en) | 2008-11-03 | 2009-09-17 | Benzoxazole kinase inhibitors and methods of use |
| US12/586,241 US8476431B2 (en) | 2008-11-03 | 2009-09-17 | Benzoxazole kinase inhibitors and methods of use |
| EP09823947.8A EP2365750B1 (en) | 2008-11-03 | 2009-11-02 | Benzoxazole kinase inhibitors and methods of use |
| PCT/US2009/005959 WO2010051043A1 (en) | 2008-11-03 | 2009-11-02 | Benzoxazole kinase inhibitors and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161074T1 true HRP20161074T1 (hr) | 2016-10-21 |
Family
ID=42337454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161074TT HRP20161074T1 (hr) | 2008-11-03 | 2016-08-24 | Benzoksazolski inhibitori kinaza i postupci njihove upotrebe |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US8476282B2 (hr) |
| EP (2) | EP2365750B1 (hr) |
| JP (8) | JP5897333B2 (hr) |
| KR (2) | KR101737192B1 (hr) |
| CN (2) | CN102271513B (hr) |
| AU (1) | AU2009310364B2 (hr) |
| BR (1) | BRPI0920500B1 (hr) |
| CA (1) | CA2741898C (hr) |
| CY (1) | CY1117913T1 (hr) |
| DK (1) | DK2365750T3 (hr) |
| ES (1) | ES2588197T3 (hr) |
| HK (1) | HK1162855A1 (hr) |
| HR (1) | HRP20161074T1 (hr) |
| HU (1) | HUE029906T2 (hr) |
| IL (3) | IL212586A (hr) |
| LT (1) | LT2365750T (hr) |
| MX (3) | MX361811B (hr) |
| MY (2) | MY182533A (hr) |
| NZ (2) | NZ592608A (hr) |
| PL (1) | PL2365750T3 (hr) |
| PT (1) | PT2365750T (hr) |
| SG (2) | SG10201501702WA (hr) |
| SI (1) | SI2365750T1 (hr) |
| SM (1) | SMT201600278B (hr) |
| WO (2) | WO2010051042A1 (hr) |
| ZA (1) | ZA201103270B (hr) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
| DK2004654T3 (da) | 2006-04-04 | 2013-07-22 | Univ California | Pyrazolopyrimidin derivater til anvendelse som kinase antagonister |
| WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| US8703777B2 (en) | 2008-01-04 | 2014-04-22 | Intellikine Llc | Certain chemical entities, compositions and methods |
| JP5547099B2 (ja) | 2008-03-14 | 2014-07-09 | インテリカイン， エルエルシー | キナーゼ阻害剤および使用方法 |
| WO2009114874A2 (en) * | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
| AU2009268611B2 (en) | 2008-07-08 | 2015-04-09 | Intellikine, Llc | Kinase inhibitors and methods of use |
| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
| JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン， エルエルシー | 複素環キナーゼ阻害剤 |
| ES2570429T3 (es) | 2008-10-16 | 2016-05-18 | Univ California | Inhibidores de heteroaril quinasa de anillo condensado |
| US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
| JP5789252B2 (ja) | 2009-05-07 | 2015-10-07 | インテリカイン， エルエルシー | 複素環式化合物およびその使用 |
| SG178454A1 (en) | 2009-08-17 | 2012-03-29 | Intellikine Inc | Heterocyclic compounds and uses thereof |
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