HRP20171197T1 - Bifenilsulfonamidni antagonist receptora endotelina i angiotensina ii, namijenjen liječenju glomeruloskleroze - Google Patents
Bifenilsulfonamidni antagonist receptora endotelina i angiotensina ii, namijenjen liječenju glomeruloskleroze Download PDFInfo
- Publication number
- HRP20171197T1 HRP20171197T1 HRP20171197TT HRP20171197T HRP20171197T1 HR P20171197 T1 HRP20171197 T1 HR P20171197T1 HR P20171197T T HRP20171197T T HR P20171197TT HR P20171197 T HRP20171197 T HR P20171197T HR P20171197 T1 HRP20171197 T1 HR P20171197T1
- Authority
- HR
- Croatia
- Prior art keywords
- biphenylsulfonamide
- endothelin
- angiotensin
- receptor antagonist
- glomerulosclerosis
- Prior art date
Links
- 206010061989 glomerulosclerosis Diseases 0.000 title claims 3
- SBXDENYROQKXBE-UHFFFAOYSA-N 2-phenylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 SBXDENYROQKXBE-UHFFFAOYSA-N 0.000 title 1
- 102000002045 Endothelin Human genes 0.000 title 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Claims (2)
1. Spoj Formule I:
[image]
,
ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju glomeruloskleroze.
2. Upotreba spoja Formule I:
[image]
,
ili njegove farmaceutski prihvatljive soli, naznačena time što je spoj namijenjen proizvodnji medikamenta za liječenje glomeruloskleroze.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16544709P | 2009-03-31 | 2009-03-31 | |
| US16541909P | 2009-03-31 | 2009-03-31 | |
| EP14155459.2A EP2732818B1 (en) | 2009-03-31 | 2010-03-29 | A biphenylsulfonamide endothelin and angiotensin ii receptor antagonist to treat glomerulosclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171197T1 true HRP20171197T1 (hr) | 2017-10-20 |
Family
ID=42828649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171197TT HRP20171197T1 (hr) | 2009-03-31 | 2017-08-03 | Bifenilsulfonamidni antagonist receptora endotelina i angiotensina ii, namijenjen liječenju glomeruloskleroze |
| HRP20200665TT HRP20200665T1 (hr) | 2009-03-31 | 2020-04-24 | Bifenilsulfonamidni antagonist receptora za endotelin i angiotenzin ii za liječenje glomeruloskleroze i iga-inducirane nefropatije |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200665TT HRP20200665T1 (hr) | 2009-03-31 | 2020-04-24 | Bifenilsulfonamidni antagonist receptora za endotelin i angiotenzin ii za liječenje glomeruloskleroze i iga-inducirane nefropatije |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20140142149A1 (hr) |
| EP (4) | EP3708163A1 (hr) |
| JP (3) | JP2012522058A (hr) |
| CN (2) | CN102421434A (hr) |
| CY (2) | CY1119232T1 (hr) |
| DK (2) | DK3222277T3 (hr) |
| ES (2) | ES2811342T3 (hr) |
| HK (1) | HK1244687A1 (hr) |
| HR (2) | HRP20171197T1 (hr) |
| HU (2) | HUE033494T2 (hr) |
| LT (2) | LT2732818T (hr) |
| PL (2) | PL3222277T3 (hr) |
| PT (2) | PT3222277T (hr) |
| SI (2) | SI2732818T1 (hr) |
| WO (1) | WO2010114801A1 (hr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2806921C (en) | 2010-07-23 | 2019-11-26 | Trustees Of Boston University | Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery |
| AR083417A1 (es) * | 2010-10-14 | 2013-02-21 | Novartis Ag | Composiciones farmaceuticas que contienen un dgat1 inhibidor |
| US20130022551A1 (en) * | 2011-07-22 | 2013-01-24 | Trustees Of Boston University | DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS |
| RU2661402C2 (ru) * | 2011-10-17 | 2018-07-16 | Лексикон Фармасьютикалз, Инк. | Твердые дозированные формы (s)-этил 2-амино-3-(4-(2-амино-6((r)-1-(4-хлор-2-(3-метил-1н-пиразол-1-ил)фенил)-2,2,2-трифторэтокси)пиримидин-4-ил)фенил)пропаноата |
| PT2797416T (pt) | 2011-12-28 | 2017-10-23 | Global Blood Therapeutics Inc | Compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos |
| ES2790358T3 (es) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular |
| EP2875359A4 (en) | 2012-03-30 | 2015-08-19 | Charles R Drew University Of Medicine And Science | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLISM SYNDROME DISEASES |
| US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| MY180206A (en) | 2013-03-15 | 2020-11-25 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| AP2015008718A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| CA3151685A1 (en) | 2013-06-13 | 2014-12-18 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| AU2015214502B2 (en) | 2014-02-05 | 2019-06-06 | Merck Sharp & Dohme Llc | Tablet formulation for CGRP-active compounds |
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| CN104367576A (zh) * | 2014-10-24 | 2015-02-25 | 南方医科大学南方医院 | 化合物icg-001在制备治疗高血压的药物中的用途 |
| US10202457B2 (en) | 2015-08-24 | 2019-02-12 | Trustees Of Boston University | Anti-DEspR monoclonal antibody targeted therapy and imaging for cancer and stroke |
| MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
| AR108435A1 (es) | 2016-05-12 | 2018-08-22 | Global Blood Therapeutics Inc | Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído |
| TWI778983B (zh) * | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
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| US793898A (en) | 1905-03-01 | 1905-07-04 | William Mcintosh | Locomotive-tender frame. |
| US1395298A (en) | 1919-11-20 | 1921-11-01 | Walter H Richman | Container |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
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| US6638937B2 (en) * | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
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| US7390824B1 (en) | 1999-09-07 | 2008-06-24 | Bristol-Myers Squibb Company | Method for treating diabetes employing an aP2 inhibitor and combination |
| US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| AU2092601A (en) * | 1999-12-15 | 2001-06-25 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
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