DK3222277T3 - Biphenylsulfonamidendothelin- og angiotensin II-receptorantagonist til behandling af glomerulosklerose og IgA-induceret nefropati - Google Patents

Biphenylsulfonamidendothelin- og angiotensin II-receptorantagonist til behandling af glomerulosklerose og IgA-induceret nefropati Download PDF

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Publication number
DK3222277T3
DK3222277T3 DK17157697.8T DK17157697T DK3222277T3 DK 3222277 T3 DK3222277 T3 DK 3222277T3 DK 17157697 T DK17157697 T DK 17157697T DK 3222277 T3 DK3222277 T3 DK 3222277T3
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biphenylsulfonamide
glomerulosclerosis
endothelin
angiotensin
iga
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DK17157697.8T
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English (en)
Inventor
Jinkun Zhang
Zofia E Dziewanowska
Rene Belder
Ian Henderson
Joseph B Bogardus
Zhaoying Zhang
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Ligand Pharm Inc
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
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DK17157697.8T 2009-03-31 2010-03-29 Biphenylsulfonamidendothelin- og angiotensin II-receptorantagonist til behandling af glomerulosklerose og IgA-induceret nefropati DK3222277T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16544709P 2009-03-31 2009-03-31
US16541909P 2009-03-31 2009-03-31
EP14155459.2A EP2732818B1 (en) 2009-03-31 2010-03-29 A biphenylsulfonamide endothelin and angiotensin ii receptor antagonist to treat glomerulosclerosis

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DK3222277T3 true DK3222277T3 (da) 2020-05-11

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DK17157697.8T DK3222277T3 (da) 2009-03-31 2010-03-29 Biphenylsulfonamidendothelin- og angiotensin II-receptorantagonist til behandling af glomerulosklerose og IgA-induceret nefropati
DK14155459.2T DK2732818T3 (da) 2009-03-31 2010-03-29 Biphenylsulfonamidendothelin- og angiotension II-receptorantagonist til behandling af glomerulosklerose

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DK14155459.2T DK2732818T3 (da) 2009-03-31 2010-03-29 Biphenylsulfonamidendothelin- og angiotension II-receptorantagonist til behandling af glomerulosklerose

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US (4) US20140142149A1 (da)
EP (4) EP3708163A1 (da)
JP (3) JP2012522058A (da)
CN (2) CN102421434A (da)
CY (2) CY1119232T1 (da)
DK (2) DK3222277T3 (da)
ES (2) ES2811342T3 (da)
HK (1) HK1244687A1 (da)
HR (2) HRP20171197T1 (da)
HU (2) HUE033494T2 (da)
LT (2) LT2732818T (da)
PL (2) PL3222277T3 (da)
PT (2) PT3222277T (da)
SI (2) SI2732818T1 (da)
WO (1) WO2010114801A1 (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2806921C (en) 2010-07-23 2019-11-26 Trustees Of Boston University Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
AR083417A1 (es) * 2010-10-14 2013-02-21 Novartis Ag Composiciones farmaceuticas que contienen un dgat1 inhibidor
US20130022551A1 (en) * 2011-07-22 2013-01-24 Trustees Of Boston University DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS
RU2661402C2 (ru) * 2011-10-17 2018-07-16 Лексикон Фармасьютикалз, Инк. Твердые дозированные формы (s)-этил 2-амино-3-(4-(2-амино-6((r)-1-(4-хлор-2-(3-метил-1н-пиразол-1-ил)фенил)-2,2,2-трифторэтокси)пиримидин-4-ил)фенил)пропаноата
PT2797416T (pt) 2011-12-28 2017-10-23 Global Blood Therapeutics Inc Compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
EP2875359A4 (en) 2012-03-30 2015-08-19 Charles R Drew University Of Medicine And Science COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLISM SYNDROME DISEASES
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MY180206A (en) 2013-03-15 2020-11-25 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
CA3151685A1 (en) 2013-06-13 2014-12-18 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AU2015214502B2 (en) 2014-02-05 2019-06-06 Merck Sharp & Dohme Llc Tablet formulation for CGRP-active compounds
DK3102208T3 (da) 2014-02-07 2021-03-08 Global Blood Therapeutics Inc Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
CN104367576A (zh) * 2014-10-24 2015-02-25 南方医科大学南方医院 化合物icg-001在制备治疗高血压的药物中的用途
US10202457B2 (en) 2015-08-24 2019-02-12 Trustees Of Boston University Anti-DEspR monoclonal antibody targeted therapy and imaging for cancer and stroke
MA43373A (fr) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) * 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
CN110049764A (zh) 2016-10-13 2019-07-23 雷特罗芬公司 用于治疗肾脏疾病或病症的联苯磺酰胺化合物
US11166939B2 (en) * 2017-04-25 2021-11-09 Otsuka Pharmaceutical Co. Ltd Lisinopril compositions with an ingestible event marker
EP3684400A4 (en) 2017-09-18 2021-06-16 Trustees of Boston University METHOD OF TREATMENT OF NETOSE AND NEUTROPHILER ACTIVATION
WO2019241609A1 (en) 2018-06-15 2019-12-19 Trustees Of Boston University Polypeptide compositions and methods for site-specific targeting of therapeutic agents
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
EP3860594A1 (en) 2018-10-04 2021-08-11 Travere Therapeutics, Inc. Biphenyl sulfonamide compounds for the treatment of type iv collagen diseases
WO2020132594A1 (en) * 2018-12-21 2020-06-25 Retrophin, Inc. Amorphous sparsentan compositions
WO2020136441A1 (en) * 2018-12-28 2020-07-02 Gnt Pharma Co., Ltd. Compositions and methods for treating neurodegenerative disorders
WO2020166710A1 (ja) 2019-02-15 2020-08-20 国立大学法人東北大学 1,3-ジオキソラン誘導体
US11584792B2 (en) 2020-10-15 2023-02-21 Trustees Of Boston University Antibody therapies and methods for treating coronavirus infection
WO2022140537A1 (en) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Treatment of migraine
WO2022246200A1 (en) 2021-05-21 2022-11-24 Travere Therapeutics, Inc. Methods of treating kidney diseases or disorders
JP7458085B2 (ja) 2021-07-28 2024-03-29 株式会社三協 錠剤用崩壊剤及びこれを利用した錠剤
KR20240051999A (ko) 2021-08-26 2024-04-22 상하이 한서 바이오메디컬 컴퍼니 리미티드 방향족 고리 함유 생물학적 길항제, 이의 제조 방법 및 용도
AU2022428746A1 (en) * 2021-12-28 2024-04-04 Alchemedicine, Inc. Compound, angiotensin II type 1 receptor antagonist and pharmaceutical composition
WO2024073672A1 (en) 2022-09-30 2024-04-04 Travere Therapeutics, Inc. Combination therapy with sparsentan and a sglt2 inhibitor for treating kidney diseases or disorders
CN115636799A (zh) * 2022-11-04 2023-01-24 苏州莱安医药化学技术有限公司 一种双效内皮素-血管紧张素受体拮抗剂的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US793898A (en) 1905-03-01 1905-07-04 William Mcintosh Locomotive-tender frame.
US1395298A (en) 1919-11-20 1921-11-01 Walter H Richman Container
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
AU767456B2 (en) * 1998-07-06 2003-11-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
US6638937B2 (en) * 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
US6380184B1 (en) 1998-10-28 2002-04-30 Bristol-Myers Squibb Co. Benzoazepines and analogs thereof useful as growth hormone secretagogues
EP1156803A4 (en) 1999-02-09 2004-03-17 Bristol Myers Squibb Co FXA LACTAM INHIBITORS AND METHOD
US6518292B1 (en) 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
US7390824B1 (en) 1999-09-07 2008-06-24 Bristol-Myers Squibb Company Method for treating diabetes employing an aP2 inhibitor and combination
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
AU2092601A (en) * 1999-12-15 2001-06-25 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

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US20150164865A1 (en) 2015-06-18
DK2732818T3 (da) 2017-08-14
SI2732818T1 (sl) 2017-12-29
EP3708163A1 (en) 2020-09-16
US9662312B2 (en) 2017-05-30
EP2413930A1 (en) 2012-02-08
PT3222277T (pt) 2020-07-08
ES2811342T3 (es) 2021-03-11
LT2732818T (lt) 2017-09-25
EP2732818A1 (en) 2014-05-21
US20180344705A1 (en) 2018-12-06
PL3222277T3 (pl) 2020-08-24
CN104107176A (zh) 2014-10-22
ES2636087T3 (es) 2017-10-05
SI3222277T1 (sl) 2021-02-26
LT3222277T (lt) 2020-05-11
HUE033494T2 (en) 2017-12-28
HRP20171197T1 (hr) 2017-10-20
WO2010114801A1 (en) 2010-10-07
HK1244687A1 (zh) 2018-08-17
HRP20200665T1 (hr) 2020-08-21
US20170354646A1 (en) 2017-12-14
CN102421434A (zh) 2012-04-18
JP2012522058A (ja) 2012-09-20
PT2732818T (pt) 2017-08-07
EP2413930A4 (en) 2012-09-26
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EP2732818B1 (en) 2017-05-03
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EP3222277B1 (en) 2020-02-26
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