JP4665451B2 - Ｌ−リジンまたはｌ−スレオニンの製造法 - Google Patents

Ｌ−リジンまたはｌ−スレオニンの製造法 Download PDF

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Publication number
JP4665451B2
JP4665451B2 JP2004222088A JP2004222088A JP4665451B2 JP 4665451 B2 JP4665451 B2 JP 4665451B2 JP 2004222088 A JP2004222088 A JP 2004222088A JP 2004222088 A JP2004222088 A JP 2004222088A JP 4665451 B2 JP4665451 B2 JP 4665451B2
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gene
lysine
threonine
seq
strain
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JP2005058227A5 (enExample
JP2005058227A (ja
Inventor
ヴァン ディエン ステファン
真太郎 岩谷
佳弘 臼田
和彦 松井
勇太 中井
智子 鈴木
美加 守屋
雄一郎 辻
拓嗣 植田
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2004222088A 2003-07-29 2004-07-29 Ｌ−リジンまたはｌ−スレオニンの製造法 Expired - Lifetime JP4665451B2 (ja)

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JP2004222088A JP4665451B2 (ja) 2003-07-29 2004-07-29 Ｌ−リジンまたはｌ−スレオニンの製造法

Applications Claiming Priority (2)

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JP2003202842 2003-07-29
JP2004222088A JP4665451B2 (ja) 2003-07-29 2004-07-29 Ｌ−リジンまたはｌ−スレオニンの製造法

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JP2005058227A JP2005058227A (ja) 2005-03-10
JP2005058227A5 JP2005058227A5 (enExample) 2007-08-09
JP4665451B2 true JP4665451B2 (ja) 2011-04-06

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Family Applications (2)

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JP2004221708A Expired - Fee Related JP4894134B2 (ja) 2003-07-29 2004-07-29 物質生産に影響する代謝フラックスの決定方法
JP2004222088A Expired - Lifetime JP4665451B2 (ja) 2003-07-29 2004-07-29 Ｌ−リジンまたはｌ−スレオニンの製造法

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US (3) US7306933B2 (enExample)
EP (2) EP1649403A2 (enExample)
JP (2) JP4894134B2 (enExample)
KR (2) KR101073370B1 (enExample)
CN (2) CN100520793C (enExample)
AT (1) ATE397059T1 (enExample)
BR (2) BRPI0413007B1 (enExample)
DE (1) DE602004014158D1 (enExample)
DK (1) DK1651758T3 (enExample)
ES (1) ES2305849T3 (enExample)
PL (1) PL1651758T3 (enExample)
RU (1) RU2337140C2 (enExample)
WO (2) WO2005010794A2 (enExample)
ZA (1) ZA200510144B (enExample)

Families Citing this family (165)

* Cited by examiner, † Cited by third party
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ATE411378T1 (de) 2000-01-21 2008-10-15 Ajinomoto Kk Verfahren zur herstellung von l-lysin
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
ES2331956T3 (es) * 2004-01-30 2010-01-21 Ajinomoto Co., Inc. Microorganismo que produce l-aminoacidos y procedimiento para producir l-aminoacidos.
US8510054B2 (en) * 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
JP4802507B2 (ja) * 2004-02-05 2011-10-26 味の素株式会社 同位体で標識された基質を用いた細胞内代謝フラックスの解析方法
JP4654592B2 (ja) * 2004-04-02 2011-03-23 味の素株式会社 代謝フラックスの決定方法
BRPI0516261A (pt) 2004-10-07 2008-08-26 Ajinomoto Kk método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
US7915018B2 (en) * 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
WO2007013639A1 (en) 2005-07-25 2007-02-01 Ajinomoto Co., Inc. A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE cpxR GENE
WO2007017710A1 (en) 2005-08-11 2007-02-15 Metabolic Explorer Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression
US8977530B2 (en) 2005-09-15 2015-03-10 Korea Advanced Institute Of Science And Technology Method for identifying genes for enhancing the production of useful substances
EP1929028A1 (en) 2005-09-27 2008-06-11 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids
WO2007037460A1 (en) 2005-09-27 2007-04-05 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007185184A (ja) * 2005-12-16 2007-07-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
EP1979486B1 (en) 2006-01-30 2013-04-17 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009095237A (ja) 2006-02-02 2009-05-07 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2009118740A (ja) 2006-03-03 2009-06-04 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2186881B1 (en) * 2006-03-23 2014-04-23 Ajinomoto Co., Inc. A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA
RU2338784C2 (ru) * 2006-03-24 2008-11-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты)
JP2009060791A (ja) * 2006-03-30 2009-03-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2009165355A (ja) 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
KR100727053B1 (ko) * 2006-05-04 2007-06-12 한국과학기술원 대사산물들의 플럭스 섬 프로파일링을 이용한 생물개량방법
JP5407858B2 (ja) * 2006-07-19 2014-02-05 味の素株式会社 腸内細菌科の細菌を用いたｌ−アミノ酸の製造方法
JP2010017081A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010017082A (ja) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2008072761A2 (en) * 2006-12-11 2008-06-19 Ajinomoto Co., Inc. Method for producing an l-amino acid
RU2006143864A (ru) 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
KR100818202B1 (ko) * 2006-12-22 2008-03-31 한국과학기술원 미생물의 성장에 필수적인 대사산물의 스크리닝 방법
RU2006145712A (ru) * 2006-12-22 2008-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной способностью к утилизации глицерина
BRPI0703692B1 (pt) 2006-12-25 2016-12-27 Ajinomoto Kk método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores
KR101730837B1 (ko) 2007-01-22 2017-04-27 아지노모토 가부시키가이샤 Ｌ-아미노산을 생산하는 미생물 및 ｌ-아미노산의 제조법
JP2010088301A (ja) * 2007-02-01 2010-04-22 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010110216A (ja) * 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
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WO2008133131A1 (ja) 2007-04-16 2008-11-06 Ajinomoto Co., Inc. 有機酸の製造方法
BRPI0810011B1 (pt) 2007-04-17 2021-11-30 Ajinomoto Co., Inc Método para produzir uma substância ácida tendo um grupo carboxila
JP2010226956A (ja) * 2007-07-23 2010-10-14 Ajinomoto Co Inc Ｌ−リジンの製造法
WO2009031565A1 (ja) 2007-09-04 2009-03-12 Ajinomoto Co., Inc. アミノ酸生産微生物及びアミノ酸の製造法
RU2395579C2 (ru) * 2007-12-21 2010-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
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JP2011167071A (ja) * 2008-05-22 2011-09-01 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2343371B1 (en) 2008-09-05 2015-10-21 Ajinomoto Co., Inc. Method for producing l-amino acid
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JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
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JP2013074795A (ja) 2010-02-08 2013-04-25 Ajinomoto Co Inc 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法
RU2012133186A (ru) 2010-02-11 2014-03-20 Метаболикс, Инк. Способ получения гамма-бутиролактона
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KR20060026436A (ko) 2006-03-23
WO2005010794A3 (en) 2005-12-01
US7809511B2 (en) 2010-10-05
ZA200510144B (en) 2007-03-28
CN1829792A (zh) 2006-09-06
PL1651758T3 (pl) 2009-04-30
DK1651758T3 (da) 2008-09-01
JP2005058227A (ja) 2005-03-10
BRPI0413030A (pt) 2006-10-03
EP1651758A1 (en) 2006-05-03
US8030036B2 (en) 2011-10-04
US20060154344A1 (en) 2006-07-13
ES2305849T3 (es) 2008-11-01
CN1856792A (zh) 2006-11-01
WO2005010175A1 (en) 2005-02-03
WO2005010794A2 (en) 2005-02-03
JP4894134B2 (ja) 2012-03-14
KR20060056970A (ko) 2006-05-25
BRPI0413007B1 (pt) 2019-09-03
KR101208480B1 (ko) 2012-12-05
US20060154289A1 (en) 2006-07-13
ATE397059T1 (de) 2008-06-15
CN100520793C (zh) 2009-07-29
RU2337140C2 (ru) 2008-10-27
EP1649403A2 (en) 2006-04-26
US20090148915A1 (en) 2009-06-11
KR101073370B1 (ko) 2011-10-17
EP1651758B1 (en) 2008-05-28
RU2006101328A (ru) 2006-06-27
CN100577799C (zh) 2010-01-06
JP2005058226A (ja) 2005-03-10
BRPI0413007A (pt) 2006-10-17
US7306933B2 (en) 2007-12-11

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