BRPI0413030A - métodos para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, para criar uma cepa bacteriana apresentando uma capacidade de produzir substáncia, e para produzir uma substáncia, programa para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, e, meio de registro que pode ser lido por computador - Google Patents

métodos para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, para criar uma cepa bacteriana apresentando uma capacidade de produzir substáncia, e para produzir uma substáncia, programa para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, e, meio de registro que pode ser lido por computador

Info

Publication number
BRPI0413030A
BRPI0413030A BRPI0413030-8A BRPI0413030A BRPI0413030A BR PI0413030 A BRPI0413030 A BR PI0413030A BR PI0413030 A BRPI0413030 A BR PI0413030A BR PI0413030 A BRPI0413030 A BR PI0413030A
Authority
BR
Brazil
Prior art keywords
substance
cells
determining
metabolic
metabolic flow
Prior art date
Application number
BRPI0413030-8A
Other languages
English (en)
Inventor
Stephen Van Dien
Shintaro Iwatani
Yoshihiro Usuda
Kazuhiko Matsui
Takuji Ueda
Yuichiro Tsuji
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34100609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0413030(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BRPI0413030A publication Critical patent/BRPI0413030A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"MéTODOS PARA DETERMINAR PELO MENOS UMA PRODUçãO DE SUBSTáNCIA QUE AFETA FLUXO METABóLICO USANDO CéLULAS, PARA CRIAR UMA CEPA BACTERIANA APRESENTANDO UMA CAPACIDADE DE PRODUZIR SUBSTáNCIA, E PARA PRODUZIR UMA SUBSTáNCIA, PROGRAMA PARA DETERMINAR PELO MENOS UMA PRODUçãO DE SUBSTáNCIA QUE AFETA FLUXO METABóLICO USANDO CéLULAS, E, MEIO DE REGISTRO QUE PODE SER LIDO POR COMPUTADOR". Uma produção de substância que afeta fluxo metabólico empregando células é determinada por meio de 1) criação de uma matriz estequiométrica com base em fórmulas de reações bioquímicas de um substrato por meio de uma substância produzida desejada, 2) seleção do mesmo número de fluxos metabólicos independentes de todos os fluxos metabólicos que o grau de liberdade da matriz estequiométrica como fluxos livres, 3) criação de um número suficiente de combinações randómicas dos fluxos livres para uma análise estatística e cálculo de uma distribuição de fluxo metabólico de cada combinação criada com base na matriz estequiométrica, 4) obtenção de uma equação de regressão incluindo um número mínimo de fluxos livres que mostra uma correlação com produção de substância das distribuições calculadas de fluxos metabólicos por meio de uma análise estatística multivariável, e 5) determinação de pelo menos uma produção de substância que afeta fluxo metabólico com base em um coeficiente na equação de regressão obtida.
BRPI0413030-8A 2003-07-29 2004-07-29 métodos para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, para criar uma cepa bacteriana apresentando uma capacidade de produzir substáncia, e para produzir uma substáncia, programa para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, e, meio de registro que pode ser lido por computador BRPI0413030A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003202842 2003-07-29
PCT/JP2004/011212 WO2005010794A2 (en) 2003-07-29 2004-07-29 Method for determining metabolic flux affecting substance production

Publications (1)

Publication Number Publication Date
BRPI0413030A true BRPI0413030A (pt) 2006-10-03

Family

ID=34100609

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0413007A BRPI0413007B1 (pt) 2003-07-29 2004-07-29 método de produzir l-lisina ou l-treonina
BRPI0413030-8A BRPI0413030A (pt) 2003-07-29 2004-07-29 métodos para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, para criar uma cepa bacteriana apresentando uma capacidade de produzir substáncia, e para produzir uma substáncia, programa para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, e, meio de registro que pode ser lido por computador

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0413007A BRPI0413007B1 (pt) 2003-07-29 2004-07-29 método de produzir l-lisina ou l-treonina

Country Status (14)

Country Link
US (3) US7306933B2 (pt)
EP (2) EP1649403A2 (pt)
JP (2) JP4894134B2 (pt)
KR (2) KR101073370B1 (pt)
CN (2) CN100577799C (pt)
AT (1) ATE397059T1 (pt)
BR (2) BRPI0413007B1 (pt)
DE (1) DE602004014158D1 (pt)
DK (1) DK1651758T3 (pt)
ES (1) ES2305849T3 (pt)
PL (1) PL1651758T3 (pt)
RU (1) RU2337140C2 (pt)
WO (2) WO2005010175A1 (pt)
ZA (1) ZA200510144B (pt)

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723081B1 (en) 2000-01-21 2010-05-25 Ajinomoto Co., Inc. Bacteria containing aspartate-semialdehyde dehydrogenase, phosphoenolpyruvate carboxylase, and transhydrogenase to produce L-lysine in escherichia, and methods of using same
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
ATE443757T1 (de) * 2004-01-30 2009-10-15 Ajinomoto Kk L-aminosäure produzierender mikroorganismus und verfahren zur l-aminosäureproduktion
JP4802507B2 (ja) * 2004-02-05 2011-10-26 味の素株式会社 同位体で標識された基質を用いた細胞内代謝フラックスの解析方法
US8510054B2 (en) * 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
JP4654592B2 (ja) * 2004-04-02 2011-03-23 味の素株式会社 代謝フラックスの決定方法
EP2818556B1 (en) 2004-10-07 2023-05-10 Ajinomoto Co., Inc. Method for producing a basic substance
US7915018B2 (en) 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
WO2007013639A1 (en) 2005-07-25 2007-02-01 Ajinomoto Co., Inc. A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE cpxR GENE
WO2007017710A1 (en) 2005-08-11 2007-02-15 Metabolic Explorer Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression
DE112005003358T5 (de) * 2005-09-15 2008-03-13 Korea Advanced Institute Of Science & Technology Verfahren zur Verbesserung von Organismen unter Verwendung von Flussabtastung, basierend auf verstärktem objektiven Fluss
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
EP1929028A1 (en) 2005-09-27 2008-06-11 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids
EP1929029A1 (en) 2005-09-27 2008-06-11 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids
JP2007185184A (ja) * 2005-12-16 2007-07-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
EP1979486B1 (en) 2006-01-30 2013-04-17 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009095237A (ja) * 2006-02-02 2009-05-07 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2009118740A (ja) 2006-03-03 2009-06-04 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2351830B1 (en) 2006-03-23 2014-04-23 Ajinomoto Co., Inc. A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA
RU2338784C2 (ru) * 2006-03-24 2008-11-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты)
JP2009060791A (ja) * 2006-03-30 2009-03-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2009165355A (ja) 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
KR100727053B1 (ko) * 2006-05-04 2007-06-12 한국과학기술원 대사산물들의 플럭스 섬 프로파일링을 이용한 생물개량방법
CN103215319A (zh) * 2006-07-19 2013-07-24 味之素株式会社 使用肠杆菌科细菌产生l-氨基酸的方法
JP2010017082A (ja) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010017081A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2094858B1 (en) * 2006-12-11 2015-02-18 Ajinomoto Co., Inc. Method for producing an l-amino acid
RU2006143864A (ru) 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2006145712A (ru) * 2006-12-22 2008-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной способностью к утилизации глицерина
KR100818202B1 (ko) 2006-12-22 2008-03-31 한국과학기술원 미생물의 성장에 필수적인 대사산물의 스크리닝 방법
BRPI0703692B1 (pt) 2006-12-25 2016-12-27 Ajinomoto Kk método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores
BRPI0806790B1 (pt) 2007-01-22 2017-02-14 Ajinomoto Kk microorganismo, e, método para produzir um l-aminoácido
JP2010088301A (ja) * 2007-02-01 2010-04-22 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010110216A (ja) * 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
JP2010110217A (ja) 2007-02-22 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
EP2149608A4 (en) * 2007-04-16 2013-02-20 Ajinomoto Kk PROCESS FOR PRODUCING AN ORGANIC ACID
EP2147970B1 (en) 2007-04-17 2014-12-31 Ajinomoto Co., Inc. A method for producing an acidic substance having a carboxyl group
JP2010226956A (ja) * 2007-07-23 2010-10-14 Ajinomoto Co Inc Ｌ−リジンの製造法
BRPI0816429A2 (pt) 2007-09-04 2019-09-24 Ajinomoto Kk microorganismo, e, método para a produção de um l-aminoácido.
RU2395579C2 (ru) * 2007-12-21 2010-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
JP2010263790A (ja) * 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
RU2396336C2 (ru) 2007-09-27 2010-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
JP2010226957A (ja) * 2007-10-17 2010-10-14 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2241630B1 (en) 2007-12-06 2016-06-01 Ajinomoto Co., Inc. A method for producing an organic acid
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
BRPI0906795A2 (pt) * 2008-01-23 2015-08-18 Ajinomoto Kk Método para produzir um l-aminoácido
RU2008105793A (ru) 2008-02-19 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ конструирования оперонов, содержащих трансляционно сопряженные гены, бактерия, содержащая такой оперон, способ продукции полезного метаболита и способ мониторинга экспрессии гена
EP2246420B1 (en) 2008-02-21 2014-12-31 Ajinomoto Co., Inc. L-cysteine-producing bacterium, and method for production of l-cysteine
JP5440489B2 (ja) 2008-02-25 2014-03-12 味の素株式会社 ５’−グアニル酸の製造法
JP2011512823A (ja) 2008-03-03 2011-04-28 グローバル バイオ−ケム テクノロジー グループ カンパニー リミテッド Ｌ−リシン製造のためのリコンビナント微生物および方法
JP5332237B2 (ja) 2008-03-06 2013-11-06 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
JP2011167071A (ja) * 2008-05-22 2011-09-01 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2343371B1 (en) 2008-09-05 2015-10-21 Ajinomoto Co., Inc. Method for producing l-amino acid
ES2624913T3 (es) 2008-09-08 2017-07-18 Ajinomoto Co., Inc. Microorganismo que produce un L-aminoácido y procedimiento para producir un L-aminoácido
JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010142200A (ja) 2008-12-22 2010-07-01 Ajinomoto Co Inc Ｌ−リジンの製造法
BRPI1007069A2 (pt) 2009-01-23 2015-08-25 Ajinomoto Kk Método para produzir um l-aminoácido.
JP5521347B2 (ja) 2009-02-16 2014-06-11 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP5359409B2 (ja) 2009-03-12 2013-12-04 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
EP2460883A4 (en) 2009-07-29 2013-01-16 Ajinomoto Kk PROCESS FOR THE PREPARATION OF L-AMINO ACID
JP2012196144A (ja) 2009-08-03 2012-10-18 Ajinomoto Co Inc ビブリオ属細菌を用いたｌ−リジンの製造法
JP5636648B2 (ja) 2009-08-10 2014-12-10 味の素株式会社 ５’−グアニル酸の製造法
WO2011021717A2 (en) 2009-08-21 2011-02-24 Ajinomoto Co.,Inc. Method for producing hydroxylated amino acids
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2011034263A1 (ko) * 2009-09-18 2011-03-24 한국과학기술원 필수 대사산물을 이용한 병원성 미생물의 약물 표적 예측 방법
RU2009136544A (ru) 2009-10-05 2011-04-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-цистеина с использованием бактерии семейства enterobacteriaceae
JP2013013329A (ja) 2009-11-06 2013-01-24 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2011065469A1 (ja) 2009-11-30 2011-06-03 味の素株式会社 Ｌ－システイン生産菌及びｌ－システインの製造法
RU2010101135A (ru) 2010-01-15 2011-07-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) Бактерия семейства enterobacteriaceae - продуцент l-аспартата или метаболитов, производных l-аспартата, и способ получения l-аспартата или метаболитов, производных l-аспартата
RU2460793C2 (ru) 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae
JP2013074795A (ja) 2010-02-08 2013-04-25 Ajinomoto Co Inc 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法
CA2788596A1 (en) 2010-02-11 2011-08-18 Metabolix, Inc. Process for producing a monomer component from a genetically modified polyhydroxyalkanoate biomass
RU2471868C2 (ru) 2010-02-18 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Мутантная аденилатциклаза, днк, кодирующая ее, бактерия семейства enterobacteriaceae, содержащая указанную днк, и способ получения l-аминокислот
RU2471870C2 (ru) 2010-06-03 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА И L-ЦИТРУЛЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА pepA
RU2010122646A (ru) 2010-06-03 2011-12-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, в которой ослаблена экспрессия генов, кодирующих транспортер лизина/аргинина/орнитина
RU2482188C2 (ru) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ РОДА Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН astCADBE
RU2501858C2 (ru) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae
CN103119154B (zh) 2010-09-14 2015-11-25 味之素株式会社 含硫氨基酸生产菌以及含硫氨基酸的制造方法
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2014087259A (ja) 2011-02-22 2014-05-15 Ajinomoto Co Inc Ｌ−システイン生産菌及びｌ−システインの製造法
BR112013023465B1 (pt) 2011-04-01 2020-10-27 Ajinomoto Co., Inc método para produzir l-cisteína
JP2014131487A (ja) 2011-04-18 2014-07-17 Ajinomoto Co Inc Ｌ−システインの製造法
US20140114082A1 (en) 2011-06-08 2014-04-24 Metabolix, Inc. Biorefinery Process For THF Production
BR112014002859A2 (pt) 2011-08-10 2017-06-13 Metabolix Inc purificação pós-processamento para produção de gama-butiro lactona
RU2011134436A (ru) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности
EP2765190B1 (en) 2011-10-07 2018-05-23 Ajinomoto Co., Inc. Mutant y-glutamyltransferase, and method for producing y-glutamylvalylglycine or salt thereof
JP2015013812A (ja) 2011-11-01 2015-01-22 味の素株式会社 植物ウイルスの感染抑制剤およびそれを用いた植物ウイルス感染抑制方法
AU2012333515B2 (en) 2011-11-02 2015-07-16 Ajinomoto Co., Inc. Method for secreting and producing proteins
WO2013069634A1 (ja) 2011-11-11 2013-05-16 味の素株式会社 発酵法による目的物質の製造法
JP6187779B2 (ja) 2012-08-10 2017-08-30 味の素株式会社 γ−グルタミルバリルグリシン結晶の製造方法
RU2550269C2 (ru) 2012-08-17 2015-05-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, СОДЕРЖАЩЕЙ N-АЦЕТИЛОРНИТИНДЕАЦЕТИЛАЗУ С НАРУШЕННОЙ АКТИВНОСТЬЮ
RU2013118637A (ru) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ РАЗРЕГУЛИРОВАН ГЕН yjjK
KR101773755B1 (ko) 2013-05-13 2017-09-01 아지노모토 가부시키가이샤 Ｌ-아미노산의 제조법
JP2016165225A (ja) 2013-07-09 2016-09-15 味の素株式会社 有用物質の製造方法
RU2013140115A (ru) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ НАРУШЕНА ЭКСПРЕССИЯ КЛАСТЕРА ГЕНОВ znuACB
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのｌ−アミノ酸の製造方法
RU2013144250A (ru) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА, КОДИРУЮЩЕГО ФОСФАТНЫЙ ТРАНСПОРТЕР
WO2015050234A1 (ja) 2013-10-02 2015-04-09 味の素株式会社 アンモニア制御装置およびアンモニア制御方法
EP3054005B1 (en) 2013-10-02 2019-11-20 Ajinomoto Co., Inc. Heparosan-producing bacterium and heparosan manufacturing method
CN104736707B (zh) 2013-10-21 2017-08-25 味之素株式会社 生产l‑氨基酸的方法
BR112016008830B1 (pt) 2013-10-23 2023-02-23 Ajinomoto Co., Inc Método para produzir uma substância alvo
WO2015115612A1 (ja) 2014-01-31 2015-08-06 味の素株式会社 変異型グルタミン酸－システインリガーゼ、及び、γ－グルタミルバリルグリシンの製造法
RU2014105547A (ru) 2014-02-14 2015-08-20 Адзиномото Ко., Инк. СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, ИМЕЮЩЕЙ СВЕРХЭКСПРЕССИРУЕМЫЙ ГЕН yajL
JP2017216881A (ja) 2014-12-26 2017-12-14 味の素株式会社 ジカルボン酸の製造方法
CN104878034B (zh) * 2015-04-17 2018-04-27 上海工业生物技术研发中心 L-赖氨酸基因工程生产菌
AU2016265751A1 (en) 2015-05-19 2017-12-14 Lucite International Uk Limited Process for the biological production of methacrylic acid and derivatives thereof
RU2015120052A (ru) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. Способ получения L-аминокислоты с использованием бактерии семейства Enterobacteriaceae, в которой ослаблена экспрессия гена gshA
KR101694811B1 (ko) * 2015-07-15 2017-01-13 대상 주식회사 말산 효소 또는 젖산 탈수소효소의 불활성화에 의한 아미노산 고생산능 변이 균주
CN105018413B (zh) * 2015-08-28 2018-04-03 中国科学院重庆绿色智能技术研究院 一种浮游植物细胞模型及其构建和应用
JP6881448B2 (ja) 2015-10-27 2021-06-02 味の素株式会社 アルデヒドの製造方法
JP6623690B2 (ja) 2015-10-30 2019-12-25 味の素株式会社 グルタミン酸系ｌ−アミノ酸の製造法
EP3402891A1 (en) 2016-01-12 2018-11-21 Ajinomoto Co., Inc. Method for producing benzaldehyde
EP3420096A1 (en) 2016-02-25 2019-01-02 Ajinomoto Co., Inc. A method for producing l-amino acids using a bacterium of the family enterobacteriaceae overexpressing a gene encoding an iron exporter
CN109937258B (zh) 2016-10-21 2023-06-23 味之素株式会社 蛋白质的分泌产生方法
EP3530748B1 (en) 2016-10-21 2021-06-02 Ajinomoto Co., Inc. Method for the secretory production proteins
EP3532631A1 (en) 2016-10-26 2019-09-04 Ajinomoto Co., Inc. Method for producing l-methionine or metabolites requiring s-adenosylmethionine for synthesis
WO2018079685A1 (en) 2016-10-26 2018-05-03 Ajinomoto Co., Inc. Method for producing objective substance
JP2019536449A (ja) 2016-10-26 2019-12-19 味の素株式会社 目的物質の製造方法
CN109952380B (zh) 2016-10-26 2023-07-14 味之素株式会社 用于生产目标物质的方法
WO2018079683A1 (en) 2016-10-26 2018-05-03 Ajinomoto Co., Inc. Method for producing objective substance
CN109890960B (zh) 2016-10-27 2023-02-17 味之素株式会社 用于生产醛的方法
GB201619827D0 (en) 2016-11-23 2017-01-04 Lucite Int Uk Ltd Process for the production of methyl methacrylate
CN110494567B (zh) 2017-03-28 2024-07-12 味之素株式会社 生产rna的方法
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
US10858676B2 (en) 2017-05-22 2020-12-08 Ajinomoto Co., Inc. Method for producing objective substance
CN112292450A (zh) 2017-09-25 2021-01-29 味之素株式会社 蛋白质的制造方法和二糖的制造方法
US11680279B2 (en) 2017-11-29 2023-06-20 Ajinomoto Co., Inc. Method for producing objective substance
KR101947945B1 (ko) 2018-01-25 2019-02-13 씨제이제일제당 (주) L-아미노산을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아미노산의 생산방법
EP3756466A4 (en) 2018-02-20 2021-11-24 Ajinomoto Co., Inc. RNA SILENCING INDUCTION PROCESS
JP7124338B2 (ja) 2018-02-27 2022-08-24 味の素株式会社 変異型グルタチオン合成酵素、及び、γ－グルタミルバリルグリシンの製造法
SG11202001730TA (en) 2018-03-27 2020-03-30 Cj Cheiljedang Corp A novel promoter and a method for producing l-amino acid using the same
KR20210002575A (ko) 2018-04-20 2021-01-08 아지노모토 가부시키가이샤 단백질의 분비 생산법
JP2021521897A (ja) 2018-05-04 2021-08-30 味の素株式会社 パントエア属細菌を用いたｌ−メチオニンの製造方法
JP7447810B2 (ja) 2018-05-23 2024-03-12 味の素株式会社 腸内細菌科を用いたトリペプチドγ－ＧＬＵ－ＶＡＬ－ＧＬＹの製造方法
WO2020027251A1 (en) 2018-08-03 2020-02-06 Ajinomoto Co., Inc. Method for producing objective substance
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
JP7375767B2 (ja) 2018-10-25 2023-11-08 味の素株式会社 タンパク質の分泌生産法
JP7491312B2 (ja) 2018-12-27 2024-05-28 味の素株式会社 腸内細菌科の細菌の発酵による塩基性ｌ－アミノ酸またはその塩の製造方法
KR102276219B1 (ko) 2019-02-15 2021-07-12 씨제이제일제당 (주) 생물반응기의 운전 조건을 결정하는 장치 및 방법
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
JP7533448B2 (ja) 2019-03-29 2024-08-14 味の素株式会社 アロラクトースの製造法
BR112021017870A2 (pt) 2019-04-05 2021-12-07 Ajinomoto Kk Método para produzir um l-aminoácido
CN113811524A (zh) 2019-05-08 2021-12-17 味之素株式会社 香兰素的制造方法
KR102221040B1 (ko) 2019-05-09 2021-03-03 씨제이제일제당 주식회사 L-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산을 생산하는 방법
KR102153534B1 (ko) 2019-09-02 2020-09-09 씨제이제일제당 주식회사 신규한 프로모터 및 이를 이용한 아미노산 생산 방법
JP2022550084A (ja) 2019-09-25 2022-11-30 味の素株式会社 細菌の発酵によるｌ－アミノ酸の製造方法
JPWO2021085405A1 (pt) 2019-10-28 2021-05-06
CA3191344A1 (en) 2020-09-09 2022-03-17 Nara Kwon A recombinant microorganism for producing l-glutamic acid and a method for producing l-glutamic acid using the same
JPWO2022092018A1 (pt) 2020-10-28 2022-05-05
KR102527096B1 (ko) 2021-02-01 2023-04-28 씨제이제일제당 주식회사 프리페네이트 탈수 효소 (Prephenate dehydratase) 변이체 및 이를 이용한 분지쇄 아미노산 생산 방법
KR102649245B1 (ko) 2021-03-08 2024-03-21 씨제이제일제당 주식회사 L-아미노산을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아미노산의 생산방법
KR102339271B1 (ko) 2021-05-07 2021-12-14 씨제이제일제당 주식회사 신규 프로모터 및 이의 용도
KR102339264B1 (ko) 2021-05-07 2021-12-14 씨제이제일제당 주식회사 신규 프로모터 및 이의 용도
KR20240032941A (ko) 2021-07-07 2024-03-12 아지노모토 가부시키가이샤 비천연 아미노산 함유 단백질의 분비 생산법
GB2621337A (en) 2022-08-08 2024-02-14 Mitsubishi Chemical Uk Ltd Process for the biological production of methacrylic acid and derivatives thereof
US20240117393A1 (en) 2022-09-30 2024-04-11 Ajinomoto Co., Inc. Method for producing l-amino acid

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976843A (en) * 1992-04-22 1999-11-02 Ajinomoto Co., Inc. Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
WO1990004636A1 (en) 1988-10-25 1990-05-03 Vsesojuzny Nauchno-Issledovatelsky Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov (Vniigenetika) Strain of bacteria escherichia coli, producer of l-threonine
US6132999A (en) 1992-09-21 2000-10-17 Ajinomoto Co., Inc. L-threonine-producing microbacteria and a method for the production of L-threonine
AU687458B2 (en) * 1993-10-28 1998-02-26 Ajinomoto Co., Inc. Process for producing substance
AU3482200A (en) 1999-02-02 2000-08-25 Bernhard Palsson Methods for identifying drug targets based on genomic sequence data
FR2796080B1 (fr) * 1999-06-18 2003-08-08 Orsan Procede de production de la l-lysine par surexpression de l'enzyme malique
US6830903B1 (en) 1999-07-23 2004-12-14 Archer-Daniels-Midland Company Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene
JP4306169B2 (ja) 1999-12-24 2009-07-29 味の素株式会社 Ｌ−アミノ酸の製造法及び新規遺伝子
JP4380029B2 (ja) 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
BR0106255A (pt) * 2000-12-22 2002-08-20 Método papa produzir uma substância alvo pela utilização de um microorganismo
WO2002055995A2 (en) 2001-01-10 2002-07-18 Penn State Res Found Method and system for modeling cellular metabolism
JP2002209596A (ja) 2001-01-19 2002-07-30 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
WO2002070730A2 (en) * 2001-03-01 2002-09-12 The Regents Of The University Of California Models and methods for determining systemic properties of regulated reaction networks
JP2002330763A (ja) * 2001-05-02 2002-11-19 Ajinomoto Co Inc 発酵法による目的物質の製造法
IL160151A0 (en) * 2001-08-10 2004-07-25 Nat Public Health Inst Identification of a dna variant associated with adult type hypolactasia
WO2003029425A2 (en) * 2001-10-01 2003-04-10 Diversa Corporation Whole cell engineering using real-time metabolic flux analysis
JP2003250544A (ja) 2002-03-04 2003-09-09 National Institute Of Technology & Evaluation タンパク質の性質を改変する方法
DE10224088A1 (de) 2002-05-31 2003-12-11 Degussa Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien die ein abgeschwächtes mez-Gen enthalten
US6911332B2 (en) 2002-06-12 2005-06-28 Ajinomoto Co., Inc. Isolated polynucleotides encoding d-arabino-3-hexulose-6-phosphate synthases from Methylophilus methylotrophus
AU2003205041A1 (en) 2002-07-12 2004-01-29 Ajinomoto Co., Inc. Method for producing target substance by fermentation
BR0304860A (pt) 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
US7026149B2 (en) 2003-02-28 2006-04-11 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in the stress response to environmental changes in Methylophilus methylotrophus
US20060019356A1 (en) 2003-02-28 2006-01-26 Yoshihiro Usuda Polynucleotides encoding polypeptides involved in intermediates metabolism of the central metabolic pathway in Methylophilus methylotrophus
US7060475B2 (en) 2003-02-28 2006-06-13 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in intermediates metabolism of central metabolic pathway in methylophilus methylotrophus
US7029893B2 (en) 2003-02-28 2006-04-18 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus
US7468262B2 (en) * 2003-05-16 2008-12-23 Ajinomoto Co., Inc. Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum
JP4380305B2 (ja) * 2003-11-21 2009-12-09 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
ATE443757T1 (de) 2004-01-30 2009-10-15 Ajinomoto Kk L-aminosäure produzierender mikroorganismus und verfahren zur l-aminosäureproduktion
US7915018B2 (en) * 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
WO2006078039A1 (en) * 2005-01-18 2006-07-27 Ajinomoto Co., Inc. L-amino acid producing microorganism and a method for producing l-amino acid
US20070004014A1 (en) * 2005-06-29 2007-01-04 Yuichiro Tsuji Method for producing l-threonine

Also Published As

Publication number Publication date
BRPI0413007A (pt) 2006-10-17
US20060154344A1 (en) 2006-07-13
CN1829792A (zh) 2006-09-06
KR101208480B1 (ko) 2012-12-05
KR20060026436A (ko) 2006-03-23
US20060154289A1 (en) 2006-07-13
JP4665451B2 (ja) 2011-04-06
WO2005010794A3 (en) 2005-12-01
RU2337140C2 (ru) 2008-10-27
US7809511B2 (en) 2010-10-05
KR20060056970A (ko) 2006-05-25
DE602004014158D1 (de) 2008-07-10
KR101073370B1 (ko) 2011-10-17
WO2005010794A2 (en) 2005-02-03
EP1651758B1 (en) 2008-05-28
ES2305849T3 (es) 2008-11-01
ZA200510144B (en) 2007-03-28
EP1649403A2 (en) 2006-04-26
EP1651758A1 (en) 2006-05-03
US20090148915A1 (en) 2009-06-11
RU2006101328A (ru) 2006-06-27
CN100520793C (zh) 2009-07-29
JP4894134B2 (ja) 2012-03-14
CN100577799C (zh) 2010-01-06
JP2005058227A (ja) 2005-03-10
CN1856792A (zh) 2006-11-01
PL1651758T3 (pl) 2009-04-30
US7306933B2 (en) 2007-12-11
JP2005058226A (ja) 2005-03-10
DK1651758T3 (da) 2008-09-01
WO2005010175A1 (en) 2005-02-03
BRPI0413007B1 (pt) 2019-09-03
US8030036B2 (en) 2011-10-04
ATE397059T1 (de) 2008-06-15

Similar Documents

Publication Publication Date Title
BRPI0413030A (pt) métodos para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, para criar uma cepa bacteriana apresentando uma capacidade de produzir substáncia, e para produzir uma substáncia, programa para determinar pelo menos uma produção de substáncia que afeta fluxo metabólico usando células, e, meio de registro que pode ser lido por computador
Kirk et al. Science and social work: A critical appraisal
Jayasinghe Social determinants of health inequalities: towards a theoretical perspective using systems science
Lawlor et al. Is housework good for health? Levels of physical activity and factors associated with activity in elderly women. Results from the British Women's Heart and Health Study
Owen et al. Trajectories of change in psychotherapy
Minami et al. Preliminary evidence on the effectiveness of psychological treatments delivered at a university counseling center.
Rosnow et al. Effect sizes: Why, when, and how to use them
Amasuomo et al. Perceived thermal discomfort and stress behaviours affecting students’ learning in lecture theatres in the humid tropics
Zeb et al. Transformational and Transactional Leadership Styles and its Impact on the Performance of the Public Sector Organizations in Pakistan.
Percevic et al. What is the predictive value of responses to psychotherapy for its future course? Empirical explorations and consequences for outcome monitoring
Nikolaos An examination of a burnout model in basketball coaches.
HRP20100382T8 (en) Assay and kit for predicting implantation success in assisted fertilisation
Wheeler et al. All-human microphysical model of metastasis therapy
Valančius et al. Influence of indoor air temperature variation on office work performance
Jern et al. A high-powered replication study finds no effect of starting or stopping hormonal contraceptive use on relationship quality
Gordois et al. Cost–utility analysis of imatinib mesilate for the treatment of advanced stage chronic myeloid leukaemia
Zhao et al. Developing a new heat strain evaluation index to classify and predict human thermal risk in hot and humid environments
Obembe Determinants of scientific productivity among Nigerian University academics
Unni et al. Quality of life of pharmacy students in the United States
Kokko et al. Trajectories based on postcomprehensive and higher education: Their correlates and antecedents
Henderson et al. Predictors of academic productivity in emergency medicine
Gaines, Jr Classifying dating couples: Gender as reflected in traits, roles, and resulting behavior
Wojciechowski The future of physical therapist education
Deepa et al. A Study on The Cognitive Development of Young Adults of Working And Non-Working Mothers In Kerala, India
Véliz et al. The development of the research capabilities of Chilean faculty

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2317 DE 02-06-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.