JP4381978B2 - アザインドールキナーゼインヒビター - Google Patents

アザインドールキナーゼインヒビター Download PDF

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Publication number
JP4381978B2
JP4381978B2 JP2004523591A JP2004523591A JP4381978B2 JP 4381978 B2 JP4381978 B2 JP 4381978B2 JP 2004523591 A JP2004523591 A JP 2004523591A JP 2004523591 A JP2004523591 A JP 2004523591A JP 4381978 B2 JP4381978 B2 JP 4381978B2
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JP
Japan
Prior art keywords
pyrrolo
methyl
substituted
fluoro
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2004523591A
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English (en)
Japanese (ja)
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JP2005538990A (ja
Inventor
ラジーブ・ビデ
ルジャン・リュエル
カール・ティボー
アレクサンドル・ルルー
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Child & Adolescent Psychology (AREA)
JP2004523591A 2002-07-19 2003-07-18 アザインドールキナーゼインヒビター Expired - Fee Related JP4381978B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39725602P 2002-07-19 2002-07-19
US44721303P 2003-02-13 2003-02-13
PCT/US2003/022554 WO2004009601A1 (en) 2002-07-19 2003-07-18 Azaindole kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2005538990A JP2005538990A (ja) 2005-12-22
JP4381978B2 true JP4381978B2 (ja) 2009-12-09

Family

ID=30773005

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004523591A Expired - Fee Related JP4381978B2 (ja) 2002-07-19 2003-07-18 アザインドールキナーゼインヒビター
JP2004523256A Expired - Lifetime JP4361485B2 (ja) 2002-07-19 2003-07-18 キナーゼの新規インヒビター

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004523256A Expired - Lifetime JP4361485B2 (ja) 2002-07-19 2003-07-18 キナーゼの新規インヒビター

Country Status (32)

Country Link
US (6) US6869952B2 (cg-RX-API-DMAC7.html)
EP (3) EP1539763B1 (cg-RX-API-DMAC7.html)
JP (2) JP4381978B2 (cg-RX-API-DMAC7.html)
KR (1) KR100901939B1 (cg-RX-API-DMAC7.html)
CN (3) CN1681508B (cg-RX-API-DMAC7.html)
AR (1) AR040500A1 (cg-RX-API-DMAC7.html)
AT (2) ATE505471T1 (cg-RX-API-DMAC7.html)
AU (2) AU2003254017A1 (cg-RX-API-DMAC7.html)
BR (2) BRPI0312940B1 (cg-RX-API-DMAC7.html)
CA (2) CA2492665A1 (cg-RX-API-DMAC7.html)
CO (1) CO5680407A2 (cg-RX-API-DMAC7.html)
CY (1) CY1112628T1 (cg-RX-API-DMAC7.html)
DE (1) DE60336732D1 (cg-RX-API-DMAC7.html)
DK (1) DK1534290T3 (cg-RX-API-DMAC7.html)
ES (1) ES2377963T3 (cg-RX-API-DMAC7.html)
GE (2) GEP20074124B (cg-RX-API-DMAC7.html)
HR (2) HRP20050058A2 (cg-RX-API-DMAC7.html)
IL (3) IL166129A0 (cg-RX-API-DMAC7.html)
IS (2) IS7646A (cg-RX-API-DMAC7.html)
MX (2) MXPA05000715A (cg-RX-API-DMAC7.html)
MY (1) MY134848A (cg-RX-API-DMAC7.html)
NO (2) NO330132B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ537523A (cg-RX-API-DMAC7.html)
PE (1) PE20040680A1 (cg-RX-API-DMAC7.html)
PL (2) PL375352A1 (cg-RX-API-DMAC7.html)
PT (1) PT1534290E (cg-RX-API-DMAC7.html)
RS (2) RS20050041A (cg-RX-API-DMAC7.html)
RU (2) RU2331642C2 (cg-RX-API-DMAC7.html)
SI (1) SI1534290T1 (cg-RX-API-DMAC7.html)
TW (1) TWI329112B (cg-RX-API-DMAC7.html)
UA (1) UA82846C2 (cg-RX-API-DMAC7.html)
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CA2273083C (en) * 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
DE69734871D1 (de) * 1997-05-30 2006-01-19 St Microelectronics Srl Verfahren zur Herstellung eines Germanium-implantierten bipolaren Heteroübergangtransistors
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
ATE418546T1 (de) 2002-04-23 2009-01-15 Bristol Myers Squibb Co Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen
EP2289894A3 (en) 2002-04-23 2011-07-20 Bristol-Myers Squibb Company Pyrrolo-triazine compounds useful as kinase inhibitors
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DK1767535T3 (da) * 2002-08-23 2010-04-12 Sloan Kettering Inst Cancer Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse
TW200420565A (en) 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
KR20050099525A (ko) 2003-02-05 2005-10-13 브리스톨-마이어스 스큅 컴퍼니 피롤로트리아진 키나제 억제제의 제조 방법
EP2341067A1 (en) 2003-07-18 2011-07-06 Amgen, Inc Specific binding agents to hepatocyte growth factor
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