ATE537843T1 - Neue kinase-hemmer - Google Patents

Neue kinase-hemmer

Info

Publication number
ATE537843T1
ATE537843T1 AT03765881T AT03765881T ATE537843T1 AT E537843 T1 ATE537843 T1 AT E537843T1 AT 03765881 T AT03765881 T AT 03765881T AT 03765881 T AT03765881 T AT 03765881T AT E537843 T1 ATE537843 T1 AT E537843T1
Authority
AT
Austria
Prior art keywords
kinase inhibitors
new kinase
new
inhibitors
kinase
Prior art date
Application number
AT03765881T
Other languages
German (de)
English (en)
Inventor
Rajeev Bhide
Zhen-Wei Cai
Ligang Qian
Stephanie Barbosa
Louis Lombardo
Jeffrey Robl
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE537843T1 publication Critical patent/ATE537843T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
AT03765881T 2002-07-19 2003-07-18 Neue kinase-hemmer ATE537843T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39725602P 2002-07-19 2002-07-19
US44721303P 2003-02-13 2003-02-13
PCT/US2003/022826 WO2004009784A2 (en) 2002-07-19 2003-07-18 Novel inhibitors of kinases

Publications (1)

Publication Number Publication Date
ATE537843T1 true ATE537843T1 (de) 2012-01-15

Family

ID=30773005

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03765881T ATE537843T1 (de) 2002-07-19 2003-07-18 Neue kinase-hemmer
AT03765754T ATE505471T1 (de) 2002-07-19 2003-07-18 Azaindol-kinaseinhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03765754T ATE505471T1 (de) 2002-07-19 2003-07-18 Azaindol-kinaseinhibitoren

Country Status (32)

Country Link
US (6) US6869952B2 (cg-RX-API-DMAC7.html)
EP (3) EP1539763B1 (cg-RX-API-DMAC7.html)
JP (2) JP4361485B2 (cg-RX-API-DMAC7.html)
KR (1) KR100901939B1 (cg-RX-API-DMAC7.html)
CN (3) CN1681508B (cg-RX-API-DMAC7.html)
AR (1) AR040500A1 (cg-RX-API-DMAC7.html)
AT (2) ATE537843T1 (cg-RX-API-DMAC7.html)
AU (2) AU2003254017A1 (cg-RX-API-DMAC7.html)
BR (2) BRPI0312940B1 (cg-RX-API-DMAC7.html)
CA (2) CA2492665A1 (cg-RX-API-DMAC7.html)
CO (1) CO5680407A2 (cg-RX-API-DMAC7.html)
CY (1) CY1112628T1 (cg-RX-API-DMAC7.html)
DE (1) DE60336732D1 (cg-RX-API-DMAC7.html)
DK (1) DK1534290T3 (cg-RX-API-DMAC7.html)
ES (1) ES2377963T3 (cg-RX-API-DMAC7.html)
GE (2) GEP20074124B (cg-RX-API-DMAC7.html)
HR (2) HRP20050059B8 (cg-RX-API-DMAC7.html)
IL (3) IL166129A0 (cg-RX-API-DMAC7.html)
IS (2) IS7646A (cg-RX-API-DMAC7.html)
MX (2) MXPA05000716A (cg-RX-API-DMAC7.html)
MY (1) MY134848A (cg-RX-API-DMAC7.html)
NO (2) NO330132B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ537523A (cg-RX-API-DMAC7.html)
PE (1) PE20040680A1 (cg-RX-API-DMAC7.html)
PL (2) PL216663B1 (cg-RX-API-DMAC7.html)
PT (1) PT1534290E (cg-RX-API-DMAC7.html)
RS (2) RS20050041A (cg-RX-API-DMAC7.html)
RU (2) RU2331642C2 (cg-RX-API-DMAC7.html)
SI (1) SI1534290T1 (cg-RX-API-DMAC7.html)
TW (1) TWI329112B (cg-RX-API-DMAC7.html)
UA (1) UA82846C2 (cg-RX-API-DMAC7.html)
WO (2) WO2004009601A1 (cg-RX-API-DMAC7.html)

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US6242469B1 (en) * 1996-12-03 2001-06-05 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
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US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6867300B2 (en) * 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
CA2483164C (en) 2002-04-23 2011-06-07 Bristol-Myers Squibb Company Pyrrolo-triazine aniline compounds useful as kinase inhibitors
AU2003221753A1 (en) 2002-04-23 2003-11-10 Bristol-Myers Squibb Company Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
KR101173510B1 (ko) * 2002-08-23 2012-08-21 슬로안-케테링인스티튜트퍼캔서리서치 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
TW200420565A (en) 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
AU2004212435A1 (en) 2003-02-05 2004-08-26 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine kinase inhibitors
CN103880955A (zh) 2003-07-18 2014-06-25 安姆根有限公司 肝细胞生长因子的特异性结合物
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
US7102001B2 (en) 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
US7064203B2 (en) 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
MY145634A (en) 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7102002B2 (en) * 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
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