JP3788519B2 - 微小スケール流体装置の高処理能力スクリーニングアッセイシステム - Google Patents
微小スケール流体装置の高処理能力スクリーニングアッセイシステム Download PDFInfo
- Publication number
- JP3788519B2 JP3788519B2 JP50423798A JP50423798A JP3788519B2 JP 3788519 B2 JP3788519 B2 JP 3788519B2 JP 50423798 A JP50423798 A JP 50423798A JP 50423798 A JP50423798 A JP 50423798A JP 3788519 B2 JP3788519 B2 JP 3788519B2
- Authority
- JP
- Japan
- Prior art keywords
- channels
- channel
- component
- reaction
- biochemical system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 title claims description 143
- 238000012188 high-throughput screening assay Methods 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 263
- 238000012360 testing method Methods 0.000 claims description 195
- 239000000758 substrate Substances 0.000 claims description 124
- 238000006243 chemical reaction Methods 0.000 claims description 114
- 238000000034 method Methods 0.000 claims description 89
- 239000003446 ligand Substances 0.000 claims description 86
- 102000004190 Enzymes Human genes 0.000 claims description 76
- 108090000790 Enzymes Proteins 0.000 claims description 76
- 238000001514 detection method Methods 0.000 claims description 59
- 238000012216 screening Methods 0.000 claims description 42
- 230000003993 interaction Effects 0.000 claims description 41
- 239000011324 bead Substances 0.000 claims description 34
- 238000009739 binding Methods 0.000 claims description 28
- 239000011521 glass Substances 0.000 claims description 15
- 230000033001 locomotion Effects 0.000 claims description 15
- 230000006870 function Effects 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 13
- 229920000307 polymer substrate Polymers 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 8
- 230000009969 flowable effect Effects 0.000 claims description 7
- 230000014759 maintenance of location Effects 0.000 claims description 7
- 239000011159 matrix material Substances 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 5
- 239000010703 silicon Substances 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 3
- 238000001917 fluorescence detection Methods 0.000 claims description 2
- 230000003915 cell function Effects 0.000 claims 4
- 230000003833 cell viability Effects 0.000 claims 2
- 238000010030 laminating Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 67
- 238000003556 assay Methods 0.000 description 62
- 239000000463 material Substances 0.000 description 55
- 102000005962 receptors Human genes 0.000 description 49
- 108020003175 receptors Proteins 0.000 description 49
- 230000000694 effects Effects 0.000 description 47
- 125000006850 spacer group Chemical group 0.000 description 46
- 239000003112 inhibitor Substances 0.000 description 22
- 239000000126 substance Substances 0.000 description 21
- 239000013076 target substance Substances 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 16
- -1 viral epitopes Substances 0.000 description 16
- 238000010586 diagram Methods 0.000 description 15
- 239000000203 mixture Substances 0.000 description 14
- 239000000872 buffer Substances 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 13
- 230000005684 electric field Effects 0.000 description 12
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 12
- 239000000556 agonist Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 10
- 238000011534 incubation Methods 0.000 description 9
- 238000005086 pumping Methods 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 239000013626 chemical specie Substances 0.000 description 8
- 239000007850 fluorescent dye Substances 0.000 description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 230000000875 corresponding effect Effects 0.000 description 7
- 238000013461 design Methods 0.000 description 7
- 238000005370 electroosmosis Methods 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000004033 plastic Substances 0.000 description 7
- 238000007423 screening assay Methods 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000021615 conjugation Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 229920000515 polycarbonate Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 239000004793 Polystyrene Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 239000012491 analyte Substances 0.000 description 4
- 239000012620 biological material Substances 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 125000005647 linker group Chemical group 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 239000004417 polycarbonate Substances 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 229920002223 polystyrene Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000010453 quartz Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 102000005936 beta-Galactosidase Human genes 0.000 description 3
- 108010005774 beta-Galactosidase Proteins 0.000 description 3
- 230000008512 biological response Effects 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000001506 fluorescence spectroscopy Methods 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 125000001165 hydrophobic group Chemical group 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 230000000737 periodic effect Effects 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- KGLPWQKSKUVKMJ-UHFFFAOYSA-N 2,3-dihydrophthalazine-1,4-dione Chemical group C1=CC=C2C(=O)NNC(=O)C2=C1 KGLPWQKSKUVKMJ-UHFFFAOYSA-N 0.000 description 2
- ZTOBILYWTYHOJB-WBCGDKOGSA-N 3',6'-bis[[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]spiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CC=C2C3(C4=CC=CC=C4C(=O)O3)C3=CC=C(O[C@H]4[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O4)O)C=C3OC2=C1 ZTOBILYWTYHOJB-WBCGDKOGSA-N 0.000 description 2
- CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 2
- 229920006353 Acrylite® Polymers 0.000 description 2
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 2
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 229920004142 LEXAN™ Polymers 0.000 description 2
- 239000004418 Lexan Substances 0.000 description 2
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000005754 cellular signaling Effects 0.000 description 2
- 239000003593 chromogenic compound Substances 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000007876 drug discovery Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000002532 enzyme inhibitor Substances 0.000 description 2
- 229940125532 enzyme inhibitor Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 238000013537 high throughput screening Methods 0.000 description 2
- QRMZSPFSDQBLIX-UHFFFAOYSA-N homovanillic acid Chemical compound COC1=CC(CC(O)=O)=CC=C1O QRMZSPFSDQBLIX-UHFFFAOYSA-N 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000000984 immunochemical effect Effects 0.000 description 2
- 239000000411 inducer Substances 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical compound [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 238000005459 micromachining Methods 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 229920002492 poly(sulfone) Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical compound C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- XORFPBHYHGEHFP-WMZOPIPTSA-N (13s,14s)-3-amino-13-methyl-12,14,15,16-tetrahydro-11h-cyclopenta[a]phenanthren-17-one Chemical compound NC1=CC=C2C(CC[C@]3([C@H]4CCC3=O)C)=C4C=CC2=C1 XORFPBHYHGEHFP-WMZOPIPTSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N 1-Heptene Chemical class CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 1
- NZDOXVCRXDAVII-UHFFFAOYSA-N 1-[4-(1h-benzimidazol-2-yl)phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=C(C=2NC3=CC=CC=C3N=2)C=C1 NZDOXVCRXDAVII-UHFFFAOYSA-N 0.000 description 1
- ADEORFBTPGKHRP-UHFFFAOYSA-N 1-[7-(dimethylamino)-4-methyl-2-oxochromen-3-yl]pyrrole-2,5-dione Chemical compound O=C1OC2=CC(N(C)C)=CC=C2C(C)=C1N1C(=O)C=CC1=O ADEORFBTPGKHRP-UHFFFAOYSA-N 0.000 description 1
- TUISHUGHCOJZCP-UHFFFAOYSA-N 1-fluoranthen-3-ylpyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=C2C3=C1C=CC=C3C1=CC=CC=C12 TUISHUGHCOJZCP-UHFFFAOYSA-N 0.000 description 1
- RUFPHBVGCFYCNW-UHFFFAOYSA-N 1-naphthylamine Chemical compound C1=CC=C2C(N)=CC=CC2=C1 RUFPHBVGCFYCNW-UHFFFAOYSA-N 0.000 description 1
- TZMSYXZUNZXBOL-UHFFFAOYSA-N 10H-phenoxazine Chemical compound C1=CC=C2NC3=CC=CC=C3OC2=C1 TZMSYXZUNZXBOL-UHFFFAOYSA-N 0.000 description 1
- RNIPJYFZGXJSDD-UHFFFAOYSA-N 2,4,5-triphenyl-1h-imidazole Chemical compound C1=CC=CC=C1C1=NC(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)N1 RNIPJYFZGXJSDD-UHFFFAOYSA-N 0.000 description 1
- SCSMTGPIQWEYHG-UHFFFAOYSA-N 2,4-diphenylfuran-3-one Chemical compound O=C1C(C=2C=CC=CC=2)OC=C1C1=CC=CC=C1 SCSMTGPIQWEYHG-UHFFFAOYSA-N 0.000 description 1
- PAYROHWFGZADBR-UHFFFAOYSA-N 2-[[4-amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propane-1,3-diol Chemical compound C1=C(I)C(OC)=CC(C(C)C)=C1OC1=CN=C(NC(CO)CO)N=C1N PAYROHWFGZADBR-UHFFFAOYSA-N 0.000 description 1
- FXOFHRIXQOZXNZ-UHFFFAOYSA-N 2-aminoethyl 2,3-dihydroxypropyl hydrogen phosphate;5-(dimethylamino)naphthalene-1-sulfonic acid Chemical compound NCCOP(O)(=O)OCC(O)CO.C1=CC=C2C(N(C)C)=CC=CC2=C1S(O)(=O)=O FXOFHRIXQOZXNZ-UHFFFAOYSA-N 0.000 description 1
- JBIJLHTVPXGSAM-UHFFFAOYSA-N 2-naphthylamine Chemical compound C1=CC=CC2=CC(N)=CC=C21 JBIJLHTVPXGSAM-UHFFFAOYSA-N 0.000 description 1
- IGHBXJSNZCFXNK-UHFFFAOYSA-N 4-chloro-7-nitrobenzofurazan Chemical compound [O-][N+](=O)C1=CC=C(Cl)C2=NON=C12 IGHBXJSNZCFXNK-UHFFFAOYSA-N 0.000 description 1
- IMBZIEUTNYFSHV-UHFFFAOYSA-N 4-methyl-2,5-diphenyl-1,3-oxazole Chemical compound CC=1N=C(C=2C=CC=CC=2)OC=1C1=CC=CC=C1 IMBZIEUTNYFSHV-UHFFFAOYSA-N 0.000 description 1
- NWQCTCKWUOEREG-UHFFFAOYSA-N 5-(2-methylanilino)naphthalene-2-sulfonic acid Chemical compound CC1=CC=CC=C1NC1=CC=CC2=CC(S(O)(=O)=O)=CC=C12 NWQCTCKWUOEREG-UHFFFAOYSA-N 0.000 description 1
- MMODPNWQZVBPDI-UHFFFAOYSA-N 5-acetamido-5-isothiocyanato-2-[2-(2-sulfophenyl)ethenyl]cyclohexa-1,3-diene-1-sulfonic acid Chemical compound C1=CC(NC(=O)C)(N=C=S)CC(S(O)(=O)=O)=C1C=CC1=CC=CC=C1S(O)(=O)=O MMODPNWQZVBPDI-UHFFFAOYSA-N 0.000 description 1
- MGKOJZBNNSRXRO-UHFFFAOYSA-N 6-(n-methylanilino)naphthalene-2-sulfonic acid Chemical compound C=1C=C2C=C(S(O)(=O)=O)C=CC2=CC=1N(C)C1=CC=CC=C1 MGKOJZBNNSRXRO-UHFFFAOYSA-N 0.000 description 1
- DTFZXNJFEIZTJR-UHFFFAOYSA-N 6-anilinonaphthalene-2-sulfonic acid Chemical compound C1=CC2=CC(S(=O)(=O)O)=CC=C2C=C1NC1=CC=CC=C1 DTFZXNJFEIZTJR-UHFFFAOYSA-N 0.000 description 1
- FWEOQOXTVHGIFQ-UHFFFAOYSA-N 8-anilinonaphthalene-1-sulfonic acid Chemical compound C=12C(S(=O)(=O)O)=CC=CC2=CC=CC=1NC1=CC=CC=C1 FWEOQOXTVHGIFQ-UHFFFAOYSA-N 0.000 description 1
- IRBAWVGZNJIROV-SFHVURJKSA-N 9-(2-cyclopropylethynyl)-2-[[(2s)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one Chemical compound C1=C2C3=CC=C(C#CC4CC4)C=C3CCN2C(=O)N=C1OC[C@@H]1COCCO1 IRBAWVGZNJIROV-SFHVURJKSA-N 0.000 description 1
- XJGFWWJLMVZSIG-UHFFFAOYSA-N 9-aminoacridine Chemical group C1=CC=C2C(N)=C(C=CC=C3)C3=NC2=C1 XJGFWWJLMVZSIG-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 244000105975 Antidesma platyphyllum Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 102000000905 Cadherin Human genes 0.000 description 1
- 108050007957 Cadherin Proteins 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000009410 Chemokine receptor Human genes 0.000 description 1
- 108050000299 Chemokine receptor Proteins 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- BVTJGGGYKAMDBN-UHFFFAOYSA-N Dioxetane Chemical compound C1COO1 BVTJGGGYKAMDBN-UHFFFAOYSA-N 0.000 description 1
- QTANTQQOYSUMLC-UHFFFAOYSA-O Ethidium cation Chemical compound C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 QTANTQQOYSUMLC-UHFFFAOYSA-O 0.000 description 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 description 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- 239000004425 Makrolon Substances 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 108010049175 N-substituted Glycines Proteins 0.000 description 1
- UCIRZXAGRBPGJM-UHFFFAOYSA-N NC1=CC=CN=C1.NC1=CC=CN=C1.ICCCCCCCCCCI Chemical compound NC1=CC=CN=C1.NC1=CC=CN=C1.ICCCCCCCCCCI UCIRZXAGRBPGJM-UHFFFAOYSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 108700020962 Peroxidase Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 244000208734 Pisonia aculeata Species 0.000 description 1
- 229920005438 Plexiglas® VS-UVT Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920002396 Polyurea Polymers 0.000 description 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 102000003800 Selectins Human genes 0.000 description 1
- 108090000184 Selectins Proteins 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- ODJLBQGVINUMMR-UHFFFAOYSA-N Strophanthidin Natural products CC12CCC(C3(CCC(O)CC3(O)CC3)C=O)C3C1(O)CCC2C1=CC(=O)OC1 ODJLBQGVINUMMR-UHFFFAOYSA-N 0.000 description 1
- 229940127321 Structural Macromolecules Drugs 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 108070000030 Viral receptors Proteins 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- YGPZYYDTPXVBRA-RTDBHSBRSA-N [(2r,3s,4r,5r,6s)-2-[[(2r,3r,4r,5s,6r)-3-[[(3r)-3-dodecanoyloxytetradecanoyl]amino]-6-(hydroxymethyl)-5-phosphonooxy-4-[(3r)-3-tetradecanoyloxytetradecanoyl]oxyoxan-2-yl]oxymethyl]-3,6-dihydroxy-5-[[(3r)-3-hydroxytetradecanoyl]amino]oxan-4-yl] (3r)-3-hydr Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](O)O1 YGPZYYDTPXVBRA-RTDBHSBRSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920006397 acrylic thermoplastic Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960001441 aminoacridine Drugs 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000011840 criminal investigation Methods 0.000 description 1
- 102000003675 cytokine receptors Human genes 0.000 description 1
- 108010057085 cytokine receptors Proteins 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000005081 epithelial layer Anatomy 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 230000010429 evolutionary process Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000003269 fluorescent indicator Substances 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000004374 forensic analysis Methods 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 235000009424 haa Nutrition 0.000 description 1
- 229920000140 heteropolymer Polymers 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 102000002467 interleukin receptors Human genes 0.000 description 1
- 108010093036 interleukin receptors Proteins 0.000 description 1
- 102000027411 intracellular receptors Human genes 0.000 description 1
- 108091008582 intracellular receptors Proteins 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 1
- 238000000670 ligand binding assay Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- KNJDBYZZKAZQNG-UHFFFAOYSA-N lucigenin Chemical compound [O-][N+]([O-])=O.[O-][N+]([O-])=O.C12=CC=CC=C2[N+](C)=C(C=CC=C2)C2=C1C1=C(C=CC=C2)C2=[N+](C)C2=CC=CC=C12 KNJDBYZZKAZQNG-UHFFFAOYSA-N 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- VRBDBUHDIOJNGW-UHFFFAOYSA-N n,n-dimethylnaphtho[2,3-h]cinnolin-6-amine Chemical compound C1=CC=C2C=C3C(N(C)C)=CC4=CC=NN=C4C3=CC2=C1 VRBDBUHDIOJNGW-UHFFFAOYSA-N 0.000 description 1
- OUAAURDVPDKVAK-UHFFFAOYSA-N n-phenyl-1h-benzimidazol-2-amine Chemical compound N=1C2=CC=CC=C2NC=1NC1=CC=CC=C1 OUAAURDVPDKVAK-UHFFFAOYSA-N 0.000 description 1
- IHRUNHAGYIHWNV-UHFFFAOYSA-N naphtho[2,3-h]cinnoline Chemical compound C1=NN=C2C3=CC4=CC=CC=C4C=C3C=CC2=C1 IHRUNHAGYIHWNV-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 description 1
- CSHWQDPOILHKBI-UHFFFAOYSA-N peryrene Natural products C1=CC(C2=CC=CC=3C2=C2C=CC=3)=C3C2=CC=CC3=C1 CSHWQDPOILHKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- RDOWQLZANAYVLL-UHFFFAOYSA-N phenanthridine Chemical group C1=CC=C2C3=CC=CC=C3C=NC2=C1 RDOWQLZANAYVLL-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 238000001020 plasma etching Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000412 polyarylene Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
- DLOBKMWCBFOUHP-UHFFFAOYSA-N pyrene-1-sulfonic acid Chemical compound C1=C2C(S(=O)(=O)O)=CC=C(C=C3)C2=C2C3=CC=CC2=C1 DLOBKMWCBFOUHP-UHFFFAOYSA-N 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 102000027240 receptors by ligand Human genes 0.000 description 1
- 108091008562 receptors by ligand Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- HSSLDCABUXLXKM-UHFFFAOYSA-N resorufin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3N=C21 HSSLDCABUXLXKM-UHFFFAOYSA-N 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229930187593 rose bengal Natural products 0.000 description 1
- 229940081623 rose bengal Drugs 0.000 description 1
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 description 1
- VDNLFJGJEQUWRB-UHFFFAOYSA-N rose bengal free acid Chemical compound OC(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C(O)=C(I)C=C21 VDNLFJGJEQUWRB-UHFFFAOYSA-N 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- OSQUFVVXNRMSHL-LTHRDKTGSA-M sodium;3-[(2z)-2-[(e)-4-(1,3-dibutyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)but-2-enylidene]-1,3-benzoxazol-3-yl]propane-1-sulfonate Chemical compound [Na+].O=C1N(CCCC)C(=S)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 OSQUFVVXNRMSHL-LTHRDKTGSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- ODJLBQGVINUMMR-HZXDTFASSA-N strophanthidin Chemical compound C1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@@]5(O)CC4)C=O)CC[C@@]32C)=CC(=O)OC1 ODJLBQGVINUMMR-HZXDTFASSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000003631 wet chemical etching Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5064—Endothelial cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5097—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving plant cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00824—Ceramic
- B01J2219/00828—Silicon wafers or plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00831—Glass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00833—Plastic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00853—Employing electrode arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
- B01J2219/00954—Measured properties
- B01J2219/00961—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
- B01J2219/00968—Type of sensors
- B01J2219/0097—Optical sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S366/00—Agitating
- Y10S366/02—Micromixers: segmented laminar flow with boundary mixing orthogonal to the direction of fluid propagation with or without geometry influences from the pathway
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/110833—Utilizing a moving indicator strip or tape
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Clinical Laboratory Science (AREA)
- Fluid Mechanics (AREA)
- Botany (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Physiology (AREA)
- Electrochemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/671,987 US5942443A (en) | 1996-06-28 | 1996-06-28 | High throughput screening assay systems in microscale fluidic devices |
| US08/671,987 | 1996-06-28 | ||
| US08/761,575 | 1996-12-06 | ||
| US08/761,575 US6046056A (en) | 1996-06-28 | 1996-12-06 | High throughput screening assay systems in microscale fluidic devices |
| PCT/US1997/010894 WO1998000231A1 (en) | 1996-06-28 | 1997-06-24 | High-throughput screening assay systems in microscale fluidic devices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001502790A JP2001502790A (ja) | 2001-02-27 |
| JP2001502790A5 JP2001502790A5 (enExample) | 2004-12-09 |
| JP3788519B2 true JP3788519B2 (ja) | 2006-06-21 |
Family
ID=27100659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50423798A Expired - Lifetime JP3788519B2 (ja) | 1996-06-28 | 1997-06-24 | 微小スケール流体装置の高処理能力スクリーニングアッセイシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (13) | US6429025B1 (enExample) |
| EP (1) | EP0907412B1 (enExample) |
| JP (1) | JP3788519B2 (enExample) |
| CN (1) | CN1173776C (enExample) |
| BR (1) | BR9710054A (enExample) |
| CA (1) | CA2258489C (enExample) |
| NZ (1) | NZ333346A (enExample) |
| WO (1) | WO1998000231A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007524851A (ja) * | 2004-01-26 | 2007-08-30 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体送達のシステムおよび方法 |
| DE102024106741A1 (de) * | 2024-03-08 | 2025-09-11 | Schott Ag | Mikroarrays mit Nitrozellulosebeschichtung und Herstellungsverfahren |
Families Citing this family (695)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US5885470A (en) * | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| CA2255599C (en) | 1996-04-25 | 2006-09-05 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
| JP3361530B2 (ja) * | 1996-06-28 | 2003-01-07 | カリパー・テクノロジーズ・コープ. | 電子ピペッタおよび電気泳動バイアスのための補償手段 |
| CN1173776C (zh) | 1996-06-28 | 2004-11-03 | 卡钳技术有限公司 | 在微规模流体性设备里的高通过量的筛选分析系统 |
| US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| US6391622B1 (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| AU760310B2 (en) * | 1997-04-14 | 2003-05-15 | Caliper Life Sciences, Inc. | Controlled fluid transport in microfabricated polymeric substrates |
| ATE484541T1 (de) * | 1997-04-21 | 2010-10-15 | California Inst Of Techn | Multifunctionelle polymer-beschichtung |
| US5976336A (en) | 1997-04-25 | 1999-11-02 | Caliper Technologies Corp. | Microfluidic devices incorporating improved channel geometries |
| US7033474B1 (en) | 1997-04-25 | 2006-04-25 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
| CN1105914C (zh) * | 1997-04-25 | 2003-04-16 | 卡钳技术有限公司 | 改进了通道几何结构的微型流体装置 |
| WO1998056956A1 (en) | 1997-06-09 | 1998-12-17 | Caliper Technologies Corporation | Apparatus and methods for correcting for variable velocity in microfluidic systems |
| US6001231A (en) * | 1997-07-15 | 1999-12-14 | Caliper Technologies Corp. | Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems |
| US6514412B1 (en) | 1998-06-18 | 2003-02-04 | 3M Innovative Properties Company | Microstructured separation device |
| US6431695B1 (en) | 1998-06-18 | 2002-08-13 | 3M Innovative Properties Company | Microstructure liquid dispenser |
| US6375871B1 (en) * | 1998-06-18 | 2002-04-23 | 3M Innovative Properties Company | Methods of manufacturing microfluidic articles |
| US6907921B2 (en) | 1998-06-18 | 2005-06-21 | 3M Innovative Properties Company | Microchanneled active fluid heat exchanger |
| US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
| US6893877B2 (en) | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
| US6251343B1 (en) | 1998-02-24 | 2001-06-26 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
| US7497994B2 (en) | 1998-02-24 | 2009-03-03 | Khushroo Gandhi | Microfluidic devices and systems incorporating cover layers |
| US6756019B1 (en) | 1998-02-24 | 2004-06-29 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
| DE19815882A1 (de) * | 1998-04-08 | 1999-10-14 | Fuhr Guenther | Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen |
| US6123798A (en) | 1998-05-06 | 2000-09-26 | Caliper Technologies Corp. | Methods of fabricating polymeric structures incorporating microscale fluidic elements |
| JP2002528699A (ja) * | 1998-05-22 | 2002-09-03 | カリフォルニア インスティチュート オブ テクノロジー | 微細製作細胞分類器 |
| US6306590B1 (en) | 1998-06-08 | 2001-10-23 | Caliper Technologies Corp. | Microfluidic matrix localization apparatus and methods |
| US6274089B1 (en) | 1998-06-08 | 2001-08-14 | Caliper Technologies Corp. | Microfluidic devices, systems and methods for performing integrated reactions and separations |
| EP1084391A4 (en) * | 1998-06-08 | 2006-06-14 | Caliper Life Sciences Inc | MICROFLUIDIC DEVICES, SYSTEMS AND METHODS FOR REALIZING INTEGRATED REACTIONS AND SEPARATIONS |
| US6149882A (en) | 1998-06-09 | 2000-11-21 | Symyx Technologies, Inc. | Parallel fixed bed reactor and fluid contacting apparatus |
| WO1999067639A1 (en) * | 1998-06-25 | 1999-12-29 | Caliper Technologies Corporation | High throughput methods, systems and apparatus for performing cell based screening assays |
| US7155344B1 (en) | 1998-07-27 | 2006-12-26 | Caliper Life Sciences, Inc. | Distributed database for analytical instruments |
| US6540896B1 (en) | 1998-08-05 | 2003-04-01 | Caliper Technologies Corp. | Open-Field serial to parallel converter |
| US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
| US6716394B2 (en) | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
| US6447724B1 (en) | 1998-08-11 | 2002-09-10 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
| US20010041964A1 (en) | 1998-09-14 | 2001-11-15 | George M. Grass | Pharmacokinetic-based drug design tool and method |
| EP1124939B1 (en) | 1998-10-08 | 2003-04-23 | AstraZeneca AB | Microfabricated cell injector |
| JP3884911B2 (ja) * | 1998-10-09 | 2007-02-21 | 株式会社日立製作所 | キャピラリ電気泳動装置及び試料分析装置並びに電気泳動分離用液体試料カセット |
| GB9822185D0 (en) * | 1998-10-13 | 1998-12-02 | Zeneca Ltd | Device |
| US6149787A (en) | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
| US6498497B1 (en) * | 1998-10-14 | 2002-12-24 | Caliper Technologies Corp. | Microfluidic controller and detector system with self-calibration |
| AU2003204460B2 (en) * | 1998-10-14 | 2005-11-10 | Caliper Life Sciences, Inc. | Microfluidic controller and detector system with self-calibration |
| HK1039805A1 (zh) * | 1998-11-05 | 2002-05-10 | Chemometec A/S | 颗粒评价方法以及用於该方法的系统和装置 |
| US6150119A (en) * | 1999-01-19 | 2000-11-21 | Caliper Technologies Corp. | Optimized high-throughput analytical system |
| US6416642B1 (en) | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
| JP3441993B2 (ja) * | 1999-01-27 | 2003-09-02 | 松下電器産業株式会社 | コレステロールセンサ |
| US20020019059A1 (en) | 1999-01-28 | 2002-02-14 | Calvin Y.H. Chow | Devices, systems and methods for time domain multiplexing of reagents |
| ATE556149T1 (de) * | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
| US7150994B2 (en) | 1999-03-03 | 2006-12-19 | Symyx Technologies, Inc. | Parallel flow process optimization reactor |
| DE19910392B4 (de) * | 1999-03-05 | 2005-03-17 | Clondiag Chip Technologies Gmbh | Mikrosäulenreaktor |
| US6326083B1 (en) | 1999-03-08 | 2001-12-04 | Calipher Technologies Corp. | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety |
| US6303343B1 (en) | 1999-04-06 | 2001-10-16 | Caliper Technologies Corp. | Inefficient fast PCR |
| WO2000062050A1 (en) * | 1999-04-09 | 2000-10-19 | The University Of Manchester Institute Of Science & Technology | Electrophoresis method and apparatus with time- or space-modulated sample injection |
| US6322683B1 (en) * | 1999-04-14 | 2001-11-27 | Caliper Technologies Corp. | Alignment of multicomponent microfabricated structures |
| ATE419528T1 (de) * | 1999-04-28 | 2009-01-15 | Eidgenoess Tech Hochschule | Polyionische beschichtungen für analytische und sensor-vorrichtungen |
| US6458259B1 (en) | 1999-05-11 | 2002-10-01 | Caliper Technologies Corp. | Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow |
| EP1180244A2 (en) * | 1999-05-13 | 2002-02-20 | Caliper Technologies Corporation | High troughput assay systems and methods |
| US6592821B1 (en) | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| US6506609B1 (en) | 1999-05-17 | 2003-01-14 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| US6472141B2 (en) | 1999-05-21 | 2002-10-29 | Caliper Technologies Corp. | Kinase assays using polycations |
| US6287774B1 (en) | 1999-05-21 | 2001-09-11 | Caliper Technologies Corp. | Assay methods and system |
| JP3417344B2 (ja) | 1999-05-26 | 2003-06-16 | 株式会社島津製作所 | 化学発光検出方法及びその方法を用いたマイクロチップ電気泳動装置 |
| US6649358B1 (en) | 1999-06-01 | 2003-11-18 | Caliper Technologies Corp. | Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities |
| DE19927534B4 (de) * | 1999-06-16 | 2008-01-31 | Merck Patent Gmbh | Vorrichtung zur Probenaufgabe |
| JP2001004628A (ja) * | 1999-06-18 | 2001-01-12 | Kanagawa Acad Of Sci & Technol | 免疫分析装置と免疫分析方法 |
| GB2351245B (en) * | 1999-06-21 | 2003-07-16 | Univ Hull | Method of controlling liquid movement in a chemical device |
| DE19928412C2 (de) * | 1999-06-22 | 2002-03-21 | Agilent Technologies Inc | Versorgungselement für einen Labor-Mikrochip |
| FR2795476B1 (fr) * | 1999-06-22 | 2001-07-27 | Biomerieux Sa | Vanne permettant de diriger un fluide dans une carte d'analyse |
| US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
| US7195670B2 (en) * | 2000-06-27 | 2007-03-27 | California Institute Of Technology | High throughput screening of crystallization of materials |
| US7052545B2 (en) * | 2001-04-06 | 2006-05-30 | California Institute Of Technology | High throughput screening of crystallization of materials |
| US7223364B1 (en) | 1999-07-07 | 2007-05-29 | 3M Innovative Properties Company | Detection article having fluid control film |
| DE19935433A1 (de) | 1999-08-01 | 2001-03-01 | Febit Ferrarius Biotech Gmbh | Mikrofluidischer Reaktionsträger |
| US7138254B2 (en) * | 1999-08-02 | 2006-11-21 | Ge Healthcare (Sv) Corp. | Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins |
| JP2003507162A (ja) * | 1999-08-12 | 2003-02-25 | ユーティー−バトル,エルエルシー | 小容積体を制御操作する方法及び微小流体デバイス |
| US6524456B1 (en) * | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| US6858185B1 (en) | 1999-08-25 | 2005-02-22 | Caliper Life Sciences, Inc. | Dilutions in high throughput systems with a single vacuum source |
| US6613581B1 (en) | 1999-08-26 | 2003-09-02 | Caliper Technologies Corp. | Microfluidic analytic detection assays, devices, and integrated systems |
| US6613211B1 (en) | 1999-08-27 | 2003-09-02 | Aclara Biosciences, Inc. | Capillary electrokinesis based cellular assays |
| US6468763B1 (en) | 1999-09-29 | 2002-10-22 | Caliper Technologies Corp. | Optical detection of transmembrane potential changes |
| JP2003511682A (ja) | 1999-10-08 | 2003-03-25 | カリパー・テクノロジーズ・コープ. | 膜透過電圧測定でのネルンスト電圧感知性染料の使用 |
| DE19949551C2 (de) * | 1999-10-14 | 2001-12-13 | Agilent Technologies Inc | Mikrofluidischer Mikrochip, Energieversorgungseinrichtung und Verfahren zum Betrieb eines mikrofluidischen Mikrochips |
| US6908594B1 (en) * | 1999-10-22 | 2005-06-21 | Aclara Biosciences, Inc. | Efficient microfluidic sealing |
| US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
| CA2290731A1 (en) | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
| US6271038B1 (en) | 1999-12-15 | 2001-08-07 | Glaxo Wellcome Inc. | Methods for high throughout determination and ranking of formulations and solubility |
| ATE340025T1 (de) * | 2000-01-06 | 2006-10-15 | Caliper Life Sciences Inc | Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse |
| ATE386815T1 (de) | 2000-01-06 | 2008-03-15 | Caliper Life Sciences Inc | Methoden und syteme zur überwachung intrazellulärer bindereaktionen |
| US6468761B2 (en) | 2000-01-07 | 2002-10-22 | Caliper Technologies, Corp. | Microfluidic in-line labeling method for continuous-flow protease inhibition analysis |
| US7037416B2 (en) | 2000-01-14 | 2006-05-02 | Caliper Life Sciences, Inc. | Method for monitoring flow rate using fluorescent markers |
| US6556923B2 (en) | 2000-01-26 | 2003-04-29 | Caliper Technologies Corp. | Software for high throughput microfluidic systems |
| US6589729B2 (en) | 2000-02-04 | 2003-07-08 | Caliper Technologies Corp. | Methods, devices, and systems for monitoring time dependent reactions |
| DE60032113T2 (de) * | 2000-02-11 | 2007-06-28 | Stmicroelectronics S.R.L., Agrate Brianza | Integrierte Vorrichtung zur mikrofluidischen Temperaturregelung und dessen Herstellungsverfahren |
| JP4753517B2 (ja) * | 2000-02-11 | 2011-08-24 | アクララ バイオサイエンシーズ, インコーポレイテッド | サンプル注入器を備えるマイクロ流体デバイスおよび方法 |
| US20020151040A1 (en) | 2000-02-18 | 2002-10-17 | Matthew O' Keefe | Apparatus and methods for parallel processing of microvolume liquid reactions |
| AU2001238606A1 (en) * | 2000-02-18 | 2001-08-27 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
| US6681616B2 (en) * | 2000-02-23 | 2004-01-27 | Caliper Technologies Corp. | Microfluidic viscometer |
| ATE382858T1 (de) | 2000-02-23 | 2008-01-15 | Caliper Life Sciences Inc | Mehrfach-reservoir-drucksteuersystem |
| US7040144B2 (en) * | 2000-02-23 | 2006-05-09 | Caliper Life Sciences, Inc. | Microfluidic viscometer |
| US7732192B2 (en) * | 2000-02-29 | 2010-06-08 | Stmicroelectronics S.R.L. | Integrated chemical microreactor with large area channels and manufacturing process thereof |
| US7230315B2 (en) * | 2000-02-29 | 2007-06-12 | Stmicroelectronics S.R.L. | Integrated chemical microreactor with large area channels and manufacturing process thereof |
| US7452713B2 (en) * | 2000-02-29 | 2008-11-18 | Stmicroelectronics S.R.L. | Process for manufacturing a microfluidic device with buried channels |
| WO2001066245A2 (en) | 2000-03-07 | 2001-09-13 | Symyx Technologies, Inc. | Parallel flow process optimization reactor |
| US7485454B1 (en) * | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
| JP4648513B2 (ja) * | 2000-03-15 | 2011-03-09 | 関東化学株式会社 | 濃度検知方法及び濃度検知装置並びに薬剤の希釈調合装置 |
| US20020012971A1 (en) | 2000-03-20 | 2002-01-31 | Mehta Tammy Burd | PCR compatible nucleic acid sieving medium |
| JP2001340753A (ja) * | 2000-03-29 | 2001-12-11 | Sumitomo Chem Co Ltd | 反応方法および反応装置 |
| US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
| US6436722B1 (en) * | 2000-04-18 | 2002-08-20 | Idexx Laboratories, Inc. | Device and method for integrated diagnostics with multiple independent flow paths |
| US6733645B1 (en) | 2000-04-18 | 2004-05-11 | Caliper Technologies Corp. | Total analyte quantitation |
| US6569607B2 (en) | 2000-05-03 | 2003-05-27 | Caliper Technologies Corp. | Multi depth substrate fabrication processes |
| AU2001261541B2 (en) | 2000-05-11 | 2004-10-14 | Caliper Life Sciences, Inc. | Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers |
| EP1297179B1 (en) | 2000-05-12 | 2008-09-24 | Caliper Life Sciences, Inc. | Detection of nucleic acid hybridization by fluorescence polarization |
| US6635487B1 (en) | 2000-05-17 | 2003-10-21 | Caliper Technologies Corp. | Fluorescence standard for use in microfluidic instruments |
| WO2001093930A1 (en) * | 2000-06-02 | 2001-12-13 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
| DE60023464T2 (de) * | 2000-06-05 | 2006-07-20 | Stmicroelectronics S.R.L., Agrate Brianza | Verfahren zur Herstellung integrierter chemischer Mikroreaktoren aus Halbleitermaterial sowie integrierter Mikroreaktor |
| US20050032051A1 (en) * | 2000-06-19 | 2005-02-10 | Hayes Mark A | Rapid flow-based immunoassay microchip |
| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| CA2635452A1 (en) | 2000-06-21 | 2001-12-27 | Bioarray Solutions, Ltd. | Looped probe design to control hybridization stringency |
| WO2002000343A2 (en) | 2000-06-27 | 2002-01-03 | Fluidigm Corporation | A microfluidic design automation method and system |
| US6885982B2 (en) | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
| US6627159B1 (en) * | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| JP2002022752A (ja) * | 2000-07-13 | 2002-01-23 | Suzuki Motor Corp | 検体試験装置 |
| WO2002011887A1 (en) | 2000-08-03 | 2002-02-14 | Caliper Technologies Corp. | Methods and devices for high throughput fluid delivery |
| AU2001290867A1 (en) * | 2000-09-14 | 2002-03-26 | Caliper Technologies Corp. | Microfluidic devices and methods for performing temperature mediated reactions |
| DE60032772T2 (de) * | 2000-09-27 | 2007-11-08 | Stmicroelectronics S.R.L., Agrate Brianza | Integrierter chemischer Mikroreaktor mit thermisch isolierten Messelektroden und Verfahren zu dessen Herstellung |
| US20100261159A1 (en) * | 2000-10-10 | 2010-10-14 | Robert Hess | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| CA2425476C (en) * | 2000-10-10 | 2011-02-01 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| WO2002030486A2 (en) | 2000-10-13 | 2002-04-18 | Fluidigm Corporation | Microfluidic device based sample injection system for analytical devices |
| US7105304B1 (en) | 2000-11-07 | 2006-09-12 | Caliper Life Sciences, Inc. | Pressure-based mobility shift assays |
| US20090118139A1 (en) * | 2000-11-07 | 2009-05-07 | Caliper Life Sciences, Inc. | Microfluidic method and system for enzyme inhibition activity screening |
| US20050221385A1 (en) * | 2000-11-07 | 2005-10-06 | Caliper Life Sciences, Inc. | Pressure based mobility shift assays |
| US8097471B2 (en) * | 2000-11-10 | 2012-01-17 | 3M Innovative Properties Company | Sample processing devices |
| AU2002230524A1 (en) | 2000-11-16 | 2002-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
| CA2697026A1 (en) * | 2000-12-12 | 2002-06-12 | Bayer Healthcare Llc | Method of making a capillary channel |
| US20020108860A1 (en) * | 2001-01-15 | 2002-08-15 | Staats Sau Lan Tang | Fabrication of polymeric microfluidic devices |
| US7070682B2 (en) | 2001-01-16 | 2006-07-04 | Cheng Lee | Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus |
| US20020166592A1 (en) * | 2001-02-09 | 2002-11-14 | Shaorong Liu | Apparatus and method for small-volume fluid manipulation and transportation |
| AU2002306486A1 (en) * | 2001-02-09 | 2002-08-28 | Microchem Solutions | Method and apparatus for sample injection in microfabricated devices |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US6913697B2 (en) * | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
| US20020180963A1 (en) * | 2001-02-15 | 2002-12-05 | Caliper Technologies Corp. | Microfluidic systems with enhanced detection systems |
| US7016560B2 (en) * | 2001-02-28 | 2006-03-21 | Lightwave Microsystems Corporation | Microfluidic control for waveguide optical switches, variable attenuators, and other optical devices |
| WO2002068821A2 (en) | 2001-02-28 | 2002-09-06 | Lightwave Microsystems Corporation | Microfluidic control using dieletric pumping |
| US6949377B2 (en) * | 2001-03-05 | 2005-09-27 | Ho Winston Z | Chemiluminescence-based microfluidic biochip |
| US20020127740A1 (en) * | 2001-03-06 | 2002-09-12 | Ho Winston Z. | Quantitative microfluidic biochip and method of use |
| US7118917B2 (en) | 2001-03-07 | 2006-10-10 | Symyx Technologies, Inc. | Parallel flow reactor having improved thermal control |
| KR100916074B1 (ko) * | 2001-03-09 | 2009-09-08 | 바이오마이크로 시스템즈, 인크. | 어레이에 대한 마이크로유체 인터페이스 방법 및인터페이스용 시스템 |
| US7429354B2 (en) | 2001-03-19 | 2008-09-30 | Gyros Patent Ab | Structural units that define fluidic functions |
| US7759067B2 (en) | 2001-03-19 | 2010-07-20 | Gyros Patent Ab | Method for determining the amount of an analyte with a disc-shaped microfluidic device |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7314718B1 (en) | 2001-04-03 | 2008-01-01 | Bioarray Solutions Ltd. | Method and apparatus for maintaining multiple planar fluid flows |
| US6960437B2 (en) | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| CA2440785A1 (en) * | 2001-04-10 | 2002-10-24 | Bioprocessors Corporation | Microfermentor device and cell based screening method |
| WO2002085185A2 (en) * | 2001-04-19 | 2002-10-31 | Adhesives Research, Inc. | Hydrophilic diagnostic devices |
| US7476533B2 (en) * | 2002-04-19 | 2009-01-13 | Adhesives Research, Inc. | Diagnostic devices for use in the assaying of biological fluids |
| US6727479B2 (en) * | 2001-04-23 | 2004-04-27 | Stmicroelectronics S.R.L. | Integrated device based upon semiconductor technology, in particular chemical microreactor |
| US6974526B2 (en) * | 2001-05-01 | 2005-12-13 | Calibrant Biosystems, Inc. | Plastic microfluidics enabling two-dimensional protein separations in proteome analysis |
| US6929730B2 (en) * | 2001-05-01 | 2005-08-16 | Cheng Sheng Lee | Two dimensional microfluidic gene scanner |
| US7641780B2 (en) | 2001-05-01 | 2010-01-05 | Calibrant Biosystems, Inc. | Two-dimensional microfluidics for protein separations and gene analysis |
| JP4566456B2 (ja) * | 2001-05-31 | 2010-10-20 | 独立行政法人理化学研究所 | 微量液体制御機構および微量液体制御方法 |
| US7723123B1 (en) | 2001-06-05 | 2010-05-25 | Caliper Life Sciences, Inc. | Western blot by incorporating an affinity purification zone |
| US20030077570A1 (en) * | 2001-09-20 | 2003-04-24 | Coventor, Inc. | Small molecule substrate based enzyme activity assays |
| US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
| US20050149304A1 (en) * | 2001-06-27 | 2005-07-07 | Fluidigm Corporation | Object oriented microfluidic design method and system |
| EP2053406A3 (en) * | 2001-07-16 | 2009-06-24 | caprotec bioanalytics GmbH | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| US20060062696A1 (en) | 2001-07-27 | 2006-03-23 | Caliper Life Sciences, Inc. | Optimized high throughput analytical systems |
| US7019831B2 (en) * | 2001-08-24 | 2006-03-28 | Applera Corporation | Separation device substrate including non-fluorescent quencher dye |
| US7666661B2 (en) | 2001-08-27 | 2010-02-23 | Platypus Technologies, Llc | Substrates, devices, and methods for quantitative liquid crystal assays |
| WO2003025115A1 (en) * | 2001-09-20 | 2003-03-27 | Cytonome, Inc. | Small molecule substrate based enzyme activity assays |
| JP4377689B2 (ja) | 2001-10-15 | 2009-12-02 | バイオアレイ ソリューションズ リミテッド | 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析 |
| DE60200822T2 (de) * | 2001-10-18 | 2005-09-15 | Aida Engineering, Ltd., Sagamihara | Mikrodosier- und Probennahmevorrichtung sowie Mikrochip mit dieser Vorrichtung |
| US20030082632A1 (en) * | 2001-10-25 | 2003-05-01 | Cytoprint, Inc. | Assay method and apparatus |
| US8440093B1 (en) | 2001-10-26 | 2013-05-14 | Fuidigm Corporation | Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels |
| US6882500B2 (en) * | 2001-10-26 | 2005-04-19 | Seagate Technology Llc | Airflow channel within a disc drive housing |
| US20030085952A1 (en) * | 2001-11-05 | 2003-05-08 | Williams Roger O | Apparatus and method for controlling the free surface of liquid in a well plate |
| SE526185C2 (sv) | 2001-11-07 | 2005-07-19 | Prolight Diagnostics Ab | Metod och anordning för immunanalys |
| WO2003042697A1 (en) * | 2001-11-14 | 2003-05-22 | Genospectra, Inc. | Biochemical analysis system with combinatorial chemistry applications |
| US20030098661A1 (en) * | 2001-11-29 | 2003-05-29 | Ken Stewart-Smith | Control system for vehicle seats |
| WO2003048295A1 (en) | 2001-11-30 | 2003-06-12 | Fluidigm Corporation | Microfluidic device and methods of using same |
| US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
| US6889468B2 (en) | 2001-12-28 | 2005-05-10 | 3M Innovative Properties Company | Modular systems and methods for using sample processing devices |
| US7470518B2 (en) * | 2002-02-12 | 2008-12-30 | Cellectricon Ab | Systems and method for rapidly changing the solution environment around sensors |
| EP2368636A3 (en) * | 2002-02-12 | 2012-03-07 | Cellectricon Ab | Systems and methods for rapidly changing the solution environment around sensors |
| US6814859B2 (en) * | 2002-02-13 | 2004-11-09 | Nanostream, Inc. | Frit material and bonding method for microfluidic separation devices |
| JP3933058B2 (ja) | 2002-02-25 | 2007-06-20 | 日立化成工業株式会社 | マイクロ流体システム用支持ユニット及びその製造方法 |
| US7419821B2 (en) | 2002-03-05 | 2008-09-02 | I-Stat Corporation | Apparatus and methods for analyte measurement and immunoassay |
| CA2477702A1 (en) | 2002-03-05 | 2003-09-18 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems abstract of the disclosure |
| DK1502102T3 (da) * | 2002-03-11 | 2009-05-04 | Caprotec Bioanalytics Gmbh | Forbindelser og fremgangsmåder til analysering af proteomet |
| US20030215941A1 (en) * | 2002-03-12 | 2003-11-20 | Stewart Campbell | Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound |
| US7252928B1 (en) | 2002-03-12 | 2007-08-07 | Caliper Life Sciences, Inc. | Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels |
| US7524462B2 (en) * | 2002-03-29 | 2009-04-28 | Agilent Technologies, Inc. | Capillary flow for a heterogenous assay in a micro-channel environment |
| CA2480728A1 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US9943847B2 (en) | 2002-04-17 | 2018-04-17 | Cytonome/St, Llc | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
| AU2003225281A1 (en) | 2002-04-30 | 2003-11-17 | University Of South Florida | Materials and methods for prevention and treatment of rna viral diseases |
| EP2283917B1 (en) * | 2002-05-09 | 2021-12-15 | The University of Chicago | Device for pressure-driven plug transport and reaction |
| US20030208936A1 (en) * | 2002-05-09 | 2003-11-13 | Lee Charles Hee | Method for manufacturing embroidery decorated cards and envelopes |
| WO2005047863A2 (en) | 2003-11-10 | 2005-05-26 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| WO2004041061A2 (en) * | 2002-05-22 | 2004-05-21 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| US20030228566A1 (en) * | 2002-06-11 | 2003-12-11 | Biotechplex Corporation | Method of and apparatus for screening for drug candidates |
| JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| US7364647B2 (en) * | 2002-07-17 | 2008-04-29 | Eksigent Technologies Llc | Laminated flow device |
| US7517440B2 (en) | 2002-07-17 | 2009-04-14 | Eksigent Technologies Llc | Electrokinetic delivery systems, devices and methods |
| US7235164B2 (en) | 2002-10-18 | 2007-06-26 | Eksigent Technologies, Llc | Electrokinetic pump having capacitive electrodes |
| US7214348B2 (en) * | 2002-07-26 | 2007-05-08 | Applera Corporation | Microfluidic size-exclusion devices, systems, and methods |
| AU2003304163A1 (en) | 2002-08-21 | 2005-01-21 | Shell Oil Company | Method for measuring fluid chemistry in drilling and production operations |
| US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
| US7534601B2 (en) * | 2002-08-27 | 2009-05-19 | Vanderbilt University | Capillary perfused bioreactors with multiple chambers |
| AU2003262906A1 (en) * | 2002-08-27 | 2004-03-19 | Vanderbilt University | Bioreactors with multiple chambers |
| US7790443B2 (en) * | 2002-08-27 | 2010-09-07 | Vanderbilt University | Bioreactors with substance injection capacity |
| US7595303B1 (en) | 2002-09-05 | 2009-09-29 | University Of South Florida | Genetic adjuvants for immunotherapy |
| US7094345B2 (en) * | 2002-09-09 | 2006-08-22 | Cytonome, Inc. | Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system |
| US7279134B2 (en) * | 2002-09-17 | 2007-10-09 | Intel Corporation | Microfluidic devices with porous membranes for molecular sieving, metering, and separations |
| ITTO20020809A1 (it) * | 2002-09-17 | 2004-03-18 | St Microelectronics Srl | Micropompa, in particolare per un dispositivo integrato di analisi del dna. |
| ITTO20020808A1 (it) * | 2002-09-17 | 2004-03-18 | St Microelectronics Srl | Dispositivo integrato di analisi del dna. |
| WO2004027379A2 (en) * | 2002-09-20 | 2004-04-01 | Novus Molecular, Inc. | Methods and devices for active bioassay |
| CA2500283A1 (en) | 2002-09-25 | 2004-04-08 | California Institute Of Technology | Microfluidic large scale integration |
| US20040115830A1 (en) * | 2002-09-25 | 2004-06-17 | Igor Touzov | Components for nano-scale Reactor |
| EP1569510B1 (en) | 2002-09-27 | 2011-11-02 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| US8871446B2 (en) | 2002-10-02 | 2014-10-28 | California Institute Of Technology | Microfluidic nucleic acid analysis |
| AU2003278461A1 (en) | 2002-10-16 | 2004-05-04 | Cellectricon Ab | Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells |
| US20060183106A1 (en) * | 2002-10-18 | 2006-08-17 | Adam Siddiqui-Jain | Processes for identifying quadruplex-targeted antiviral molecules |
| US7179357B2 (en) * | 2002-10-25 | 2007-02-20 | Beckman Coulter, Inc. | Serial sample injection in capillary electrophoresis |
| GB2395006A (en) * | 2002-10-29 | 2004-05-12 | Micro Chemical Systems Ltd | Apparatus and method for performing an assay |
| JP4346893B2 (ja) * | 2002-11-01 | 2009-10-21 | 株式会社日立製作所 | 化学反応装置 |
| DE60314441T2 (de) * | 2002-11-04 | 2008-02-21 | Transform Pharmaceuticals, Inc., Lexington | Analyse pharmazeutischer löslichkeit und stabilität |
| US7108775B2 (en) * | 2002-11-08 | 2006-09-19 | Applera Corporation | Apparatus and method for confining eluted samples in electrophoresis systems |
| KR20020097093A (ko) * | 2002-11-09 | 2002-12-31 | 신세현 | 자연대류형 미소유체 혼합기 |
| WO2004047007A1 (en) | 2002-11-15 | 2004-06-03 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
| US6759713B2 (en) * | 2002-11-22 | 2004-07-06 | Xerox Corporation | Electronic device structures including interconnecting microfluidic channels |
| CN101158695A (zh) * | 2002-12-04 | 2008-04-09 | 斯宾克斯公司 | 流体的可程控微量控制用方法 |
| AU2003298938A1 (en) * | 2002-12-05 | 2004-06-30 | Protasis Corporation | Configurable microfluidic substrate assembly |
| US7507376B2 (en) * | 2002-12-19 | 2009-03-24 | 3M Innovative Properties Company | Integrated sample processing devices |
| US20050042639A1 (en) | 2002-12-20 | 2005-02-24 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of DNA length |
| CA2510166A1 (en) | 2002-12-20 | 2004-09-30 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of dna |
| AU2003302264A1 (en) | 2002-12-20 | 2004-09-09 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
| US8275554B2 (en) | 2002-12-20 | 2012-09-25 | Caliper Life Sciences, Inc. | System for differentiating the lengths of nucleic acids of interest in a sample |
| US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
| EP1649045B1 (de) * | 2002-12-23 | 2008-06-25 | febit biotech GmbH | Einbau von hapten-gruppen bei der herstellung von trägern für die analytbestimmung |
| AU2003303594A1 (en) | 2002-12-30 | 2004-07-29 | The Regents Of The University Of California | Methods and apparatus for pathogen detection and analysis |
| WO2004059324A1 (en) * | 2002-12-31 | 2004-07-15 | Telaura Inc. | System and method for real-time detection and remote monitoring of pathogens |
| US20040129676A1 (en) * | 2003-01-07 | 2004-07-08 | Tan Roy H. | Apparatus for transfer of an array of liquids and methods for manufacturing same |
| US7122153B2 (en) * | 2003-01-08 | 2006-10-17 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| US20050221281A1 (en) * | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| US7332129B2 (en) * | 2003-01-09 | 2008-02-19 | 3M Innovative Properties Company | Sample processing device having process chambers with bypass slots |
| EP1583972B1 (en) * | 2003-01-16 | 2010-11-24 | caprotec bioanalytics GmbH | Methods for identifying drug non-target proteins |
| TW571101B (en) | 2003-01-21 | 2004-01-11 | Ind Tech Res Inst | Fluid analysis apparatus |
| US20040150217A1 (en) * | 2003-01-23 | 2004-08-05 | Heffelfinger David M. | Identifying indicia and focusing target |
| US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
| ATE452986T1 (de) * | 2003-03-17 | 2010-01-15 | Charles River Lab Inc | Methoden und zusammensetzungen für den nachweis mikrobieller verunreinigungen |
| SE0300823D0 (sv) | 2003-03-23 | 2003-03-23 | Gyros Ab | Preloaded Microscale Devices |
| SE0300822D0 (sv) | 2003-03-23 | 2003-03-23 | Gyros Ab | A collection of Micro Scale Devices |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20040223874A1 (en) * | 2003-03-31 | 2004-11-11 | Canon Kabushiki Kaisha | Biochemical reaction cartridge |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
| US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
| US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
| US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
| AU2004228678A1 (en) | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Microfluidic devices and methods of using same |
| EP2127736A1 (en) | 2003-04-10 | 2009-12-02 | The President and Fellows of Harvard College | Formation and control of fluidic species |
| US7422725B2 (en) * | 2003-05-01 | 2008-09-09 | Enplas Corporation | Sample handling unit applicable to microchip, and microfluidic device having microchips |
| US7217396B2 (en) * | 2003-05-05 | 2007-05-15 | The Board Of Trustees Of The University Of Illinois | Microfabricated micro fluid channels |
| DE10320869A1 (de) * | 2003-05-09 | 2004-12-16 | Evotec Technologies Gmbh | Verfahren und Vorrichtungen zur Flüssigkeitsbehandlung suspendierter Partikel |
| US7038472B1 (en) | 2003-05-12 | 2006-05-02 | Caliper Life Sciences, Inc. | Methods and systems for measuring internal dimensions of microscale structures |
| US20040228962A1 (en) * | 2003-05-16 | 2004-11-18 | Chang Liu | Scanning probe microscopy probe and method for scanning probe contact printing |
| US7578916B2 (en) * | 2004-05-25 | 2009-08-25 | Applied Biosystems, Llc | Emulsions of ionic liquids |
| US7572409B2 (en) * | 2003-05-23 | 2009-08-11 | Applied Biosystems, Llc | Ionic liquid apparatus and method for biological samples |
| JP2006526407A (ja) * | 2003-06-05 | 2006-11-24 | バイオプロセッサーズ コーポレイション | プロセス自動化のためのシステムおよび方法 |
| US20040248306A1 (en) * | 2003-06-09 | 2004-12-09 | Hernandez Juan J. | Microfluidic water analytical device |
| US7736889B2 (en) * | 2003-06-10 | 2010-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Fluidic force discrimination |
| US7672791B2 (en) * | 2003-06-13 | 2010-03-02 | International Business Machines Corporation | Method of performing three-dimensional molecular superposition and similarity searches in databases of flexible molecules |
| JP2005007529A (ja) * | 2003-06-19 | 2005-01-13 | Dainippon Screen Mfg Co Ltd | マイクロ流体デバイスおよびマイクロ流体デバイスの製造方法 |
| CN1795263A (zh) * | 2003-06-20 | 2006-06-28 | 日东电工株式会社 | 细胞微芯片 |
| CA2533659A1 (en) | 2003-07-25 | 2005-03-10 | Platypus Technologies, Llc | Liquid crystal based analyte detection |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US20050103713A1 (en) * | 2003-07-30 | 2005-05-19 | Ramsey J. M. | Devices with small-scale channels and the fabrication thereof by etching |
| WO2005011867A2 (en) | 2003-07-31 | 2005-02-10 | Handylab, Inc. | Processing particle-containing samples |
| US7413712B2 (en) | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
| US20050037508A1 (en) * | 2003-08-12 | 2005-02-17 | Juan Hernandez | Microfluidic titration apparatus |
| KR101135138B1 (ko) | 2003-08-13 | 2012-04-16 | 루미넥스 코포레이션 | 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의제어 방법 |
| JP4630870B2 (ja) | 2003-08-27 | 2011-02-09 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 流体種の電子的制御 |
| WO2005022147A1 (en) | 2003-08-28 | 2005-03-10 | Celula, Inc. | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
| WO2005074417A2 (en) * | 2003-09-03 | 2005-08-18 | Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| US7927796B2 (en) | 2003-09-18 | 2011-04-19 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
| US7407630B2 (en) * | 2003-09-19 | 2008-08-05 | Applera Corporation | High density plate filler |
| US20050226782A1 (en) * | 2003-09-19 | 2005-10-13 | Reed Mark T | High density plate filler |
| US7695688B2 (en) * | 2003-09-19 | 2010-04-13 | Applied Biosystems, Llc | High density plate filler |
| US20060233671A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
| US7998435B2 (en) * | 2003-09-19 | 2011-08-16 | Life Technologies Corporation | High density plate filler |
| US8277760B2 (en) * | 2003-09-19 | 2012-10-02 | Applied Biosystems, Llc | High density plate filler |
| US9492820B2 (en) | 2003-09-19 | 2016-11-15 | Applied Biosystems, Llc | High density plate filler |
| US20050220675A1 (en) * | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
| US20050237528A1 (en) * | 2003-09-19 | 2005-10-27 | Oldham Mark F | Transparent heater for thermocycling |
| US20060272738A1 (en) * | 2003-09-19 | 2006-12-07 | Gary Lim | High density plate filler |
| US20060233673A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
| CA2539824C (en) | 2003-09-22 | 2015-02-03 | Xinwen Wang | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
| AU2004276302B2 (en) | 2003-09-23 | 2011-02-03 | California Institute Of Technology | Photocurable perfluoropolyethers for use as novel materials in microfluidic devices |
| JP2007507721A (ja) * | 2003-09-30 | 2007-03-29 | クロンバ,インコーポレーテッド | クロマトグラフィー及びサンプル調製のためのマルチキャピラリーカラム |
| US20070017870A1 (en) * | 2003-09-30 | 2007-01-25 | Belov Yuri P | Multicapillary device for sample preparation |
| US20050069462A1 (en) * | 2003-09-30 | 2005-03-31 | International Business Machines Corporation | Microfluidics Packaging |
| US20050069949A1 (en) * | 2003-09-30 | 2005-03-31 | International Business Machines Corporation | Microfabricated Fluidic Structures |
| US7718133B2 (en) * | 2003-10-09 | 2010-05-18 | 3M Innovative Properties Company | Multilayer processing devices and methods |
| US7563569B2 (en) | 2003-10-28 | 2009-07-21 | Michael Seul | Optimization of gene expression analysis using immobilized capture probes |
| JP2007509629A (ja) | 2003-10-29 | 2007-04-19 | バイオアレイ ソリューションズ リミテッド | 二本鎖dnaの切断による複合核酸分析 |
| EP1535665A1 (en) * | 2003-11-28 | 2005-06-01 | STMicroelectronics S.r.l. | Integrated chemical microreactor with separated channels for confining liquids inside the channels and manufacturing process thereof |
| EP1541991A1 (en) * | 2003-12-12 | 2005-06-15 | STMicroelectronics S.r.l. | Integrated semiconductor chemical microreactor for real-time monitoring of biological reactions |
| KR100519672B1 (ko) * | 2003-12-22 | 2005-10-11 | 주식회사 디지탈바이오테크놀러지 | 유체 플로우를 포커싱하기 위한 채널 장치 |
| US20050161327A1 (en) * | 2003-12-23 | 2005-07-28 | Michele Palmieri | Microfluidic device and method for transporting electrically charged substances through a microchannel of a microfluidic device |
| EP1547688A1 (en) * | 2003-12-23 | 2005-06-29 | STMicroelectronics S.r.l. | Microfluidic device and method of locally concentrating electrically charged substances in a microfluidic device |
| EP1704405A1 (en) * | 2003-12-31 | 2006-09-27 | The President and Fellows of Harvard College | Assay device and method |
| JP3991034B2 (ja) * | 2004-01-23 | 2007-10-17 | キヤノン株式会社 | 検出方法 |
| WO2005072353A2 (en) | 2004-01-25 | 2005-08-11 | Fluidigm Corporation | Crystal forming devices and systems and methods for making and using the same |
| US8030057B2 (en) * | 2004-01-26 | 2011-10-04 | President And Fellows Of Harvard College | Fluid delivery system and method |
| SE0400181D0 (sv) * | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| US8158728B2 (en) | 2004-02-13 | 2012-04-17 | The University Of North Carolina At Chapel Hill | Methods and materials for fabricating microfluidic devices |
| US8058056B2 (en) * | 2004-03-12 | 2011-11-15 | The Regents Of The University Of California | Method and apparatus for integrated cell handling and measurements |
| CA2559171A1 (en) | 2004-03-12 | 2005-09-29 | Biotrove, Inc. | Nanoliter array loading |
| US7432106B2 (en) * | 2004-03-24 | 2008-10-07 | Applied Biosystems Inc. | Liquid processing device including gas trap, and system and method |
| US20050214737A1 (en) * | 2004-03-26 | 2005-09-29 | Dejneka Matthew J | Transparent filtered capillaries |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| KR100597870B1 (ko) * | 2004-04-01 | 2006-07-06 | 한국과학기술원 | 고속 스크리닝 또는 고속 분석을 위한 미소 유체 칩 |
| US7559356B2 (en) * | 2004-04-19 | 2009-07-14 | Eksident Technologies, Inc. | Electrokinetic pump driven heat transfer system |
| US20050266093A1 (en) * | 2004-04-27 | 2005-12-01 | Mohapatra Shyam S | Nanogene therapy for cell proliferation disorders |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| CA2994321C (en) | 2004-05-03 | 2023-08-08 | Handylab, Inc. | A microfluidic device and methods for processing polynucleotide-containing samples |
| JP4683538B2 (ja) | 2004-05-06 | 2011-05-18 | セイコーインスツル株式会社 | 分析用マイクロチップを含む分析システムと分析方法 |
| EP1746158A4 (en) * | 2004-05-07 | 2009-11-25 | Konica Minolta Med & Graphic | MICROREACTOR FOR TESTING, GENETIC TEST EQUIPMENT AND GENETIC TEST PROCEDURE |
| EP2093571B1 (en) * | 2004-05-21 | 2014-07-09 | Caliper Life Sciences, Inc. | Automated system for handling microfluidic devices |
| US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
| US7655470B2 (en) | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
| US9477233B2 (en) | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
| EP1810030A1 (en) * | 2004-07-16 | 2007-07-25 | Gyros Patent Ab | Sequential method |
| DE602004030678D1 (de) * | 2004-07-19 | 2011-02-03 | St Microelectronics Srl | Vorrichtung zur Detektion von biologischen Molekülen mit erhöhter Detektionsgeschwindigkeit und Verfahren zur schnellen Detektion von Biomolekülen |
| EP1622200A1 (en) | 2004-07-26 | 2006-02-01 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Solid-state photodetector pixel and photodetecting method |
| AU2005330267A1 (en) | 2004-07-28 | 2006-10-12 | Canon U.S. Life Sciences, Inc. | Methods for monitoring genomic DNA of organisms |
| US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
| US12070731B2 (en) | 2004-08-04 | 2024-08-27 | Life Technologies Corporation | Methods and systems for aligning dispensing arrays with microfluidic sample arrays |
| US20060105453A1 (en) | 2004-09-09 | 2006-05-18 | Brenan Colin J | Coating process for microfluidic sample arrays |
| US7932090B2 (en) * | 2004-08-05 | 2011-04-26 | 3M Innovative Properties Company | Sample processing device positioning apparatus and methods |
| US7618524B1 (en) | 2004-08-10 | 2009-11-17 | Sandia Corporation | Polymeric salt bridges for conducting electric current in microfluidic devices |
| US20060070880A1 (en) * | 2004-08-31 | 2006-04-06 | Applera Corporation | Methods and apparatus for manipulating separation media |
| US20070248958A1 (en) | 2004-09-15 | 2007-10-25 | Microchip Biotechnologies, Inc. | Microfluidic devices |
| US7745207B2 (en) | 2006-02-03 | 2010-06-29 | IntegenX, Inc. | Microfluidic devices |
| WO2006039293A2 (en) * | 2004-09-29 | 2006-04-13 | University Of Virginia Patent Foundation | Localized control of thermal properties on microdevices and applications thereof |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US7674545B2 (en) * | 2004-10-19 | 2010-03-09 | Korea Institute Of Science & Technology | Electrokinetic micro power cell using microfluidic-chip with multi-channel type |
| EP1832861B1 (en) | 2004-11-30 | 2020-04-29 | Hitachi Chemical Company, Ltd. | Analytical pretreatment device |
| WO2006060739A2 (en) | 2004-12-01 | 2006-06-08 | Proteologics, Inc. | Ubiquitin ligase assays and related reagents |
| EP1842069A2 (en) | 2004-12-02 | 2007-10-10 | Charles River Laboratories, Inc. | Methods and compositions for the detection and/or quantification of gram positive bacterial contaminants |
| US9260693B2 (en) | 2004-12-03 | 2016-02-16 | Cytonome/St, Llc | Actuation of parallel microfluidic arrays |
| US7479375B2 (en) * | 2005-01-13 | 2009-01-20 | Charles River Laboratories, Inc. | Method for classifying a microorganism in a biological sample |
| AU2006206426B2 (en) * | 2005-01-20 | 2012-03-15 | The Regents Of The University Of California | Cellular microarrays for screening differentiation factors |
| KR100738071B1 (ko) * | 2005-01-21 | 2007-07-12 | 삼성전자주식회사 | 농도구배발생부가 구비된 유전영동 장치, 그를 이용한물질의 분리방법 및 물질 분리의 최적 조건을 탐색하는 방법 |
| WO2006079007A2 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Microconcentrator/microfilter |
| WO2006081270A2 (en) * | 2005-01-25 | 2006-08-03 | Massachusetts Institute Of Technology | Electrokinetic concentration device and methods of use thereof |
| EP1871903B1 (en) * | 2005-02-18 | 2011-12-21 | Canon U.S. Life Sciences, Inc. | Devices and methods for identifying genomic dna of organisms |
| US20070054119A1 (en) * | 2005-03-04 | 2007-03-08 | Piotr Garstecki | Systems and methods of forming particles |
| WO2006096571A2 (en) | 2005-03-04 | 2006-09-14 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
| JP2008538077A (ja) * | 2005-03-16 | 2008-10-09 | ユニバーシティ オブ シカゴ | マイクロフルイディックシステム |
| JP4548174B2 (ja) * | 2005-03-24 | 2010-09-22 | コニカミノルタエムジー株式会社 | 検査用マイクロチップおよびそれを用いた検査装置 |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8501416B2 (en) | 2005-04-19 | 2013-08-06 | President And Fellows Of Harvard College | Fluidic structures including meandering and wide channels |
| US7300631B2 (en) | 2005-05-02 | 2007-11-27 | Bioscale, Inc. | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles |
| WO2006119280A2 (en) * | 2005-05-03 | 2006-11-09 | Handylab, Inc. | Lyophilized pellets |
| US20060286549A1 (en) * | 2005-05-06 | 2006-12-21 | The Regents Of The University Of California | Microfluidic system for identifying or sizing individual particles passing through a channel |
| KR101392106B1 (ko) | 2005-05-09 | 2014-05-07 | 테라노스, 인코포레이티드 | 현장진료 유체 시스템 및 그 용도 |
| CN101223101A (zh) * | 2005-05-12 | 2008-07-16 | 意法半导体股份有限公司 | 具有集成的微型泵尤其是生化微反应器的微流体装置及其制造方法 |
| US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
| US7263874B2 (en) * | 2005-06-08 | 2007-09-04 | Bioscale, Inc. | Methods and apparatus for determining properties of a fluid |
| FR2890578B3 (fr) * | 2005-09-09 | 2007-11-30 | Rhodia Chimie Sa | Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation |
| JP4892219B2 (ja) * | 2005-06-17 | 2012-03-07 | 凸版印刷株式会社 | 反応チップおよび反応装置および反応チップの製造方法 |
| US7763210B2 (en) | 2005-07-05 | 2010-07-27 | 3M Innovative Properties Company | Compliant microfluidic sample processing disks |
| US7754474B2 (en) | 2005-07-05 | 2010-07-13 | 3M Innovative Properties Company | Sample processing device compression systems and methods |
| USD564667S1 (en) | 2005-07-05 | 2008-03-18 | 3M Innovative Properties Company | Rotatable sample processing disk |
| US7323660B2 (en) * | 2005-07-05 | 2008-01-29 | 3M Innovative Properties Company | Modular sample processing apparatus kits and modules |
| US9354156B2 (en) * | 2007-02-08 | 2016-05-31 | Emd Millipore Corporation | Microfluidic particle analysis method, device and system |
| US9388374B2 (en) | 2005-07-07 | 2016-07-12 | Emd Millipore Corporation | Microfluidic cell culture systems |
| US8257964B2 (en) | 2006-01-04 | 2012-09-04 | Cell ASIC | Microwell cell-culture device and fabrication method |
| US9260688B2 (en) * | 2005-07-07 | 2016-02-16 | The Regents Of The University Of California | Methods and apparatus for cell culture array |
| US9637715B2 (en) | 2005-07-07 | 2017-05-02 | Emd Millipore Corporation | Cell culture and invasion assay method and system |
| EP1746410B1 (en) * | 2005-07-21 | 2018-08-22 | CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement | Apparatus and method for fluorescence lifetime imaging |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| WO2007022026A2 (en) * | 2005-08-11 | 2007-02-22 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| US9285297B2 (en) * | 2005-08-22 | 2016-03-15 | Applied Biosystems, Llc | Device, system, and method for depositing processed immiscible-fluid-discrete-volumes |
| US7662572B2 (en) | 2005-08-25 | 2010-02-16 | Platypus Technologies, Llc. | Compositions and liquid crystals |
| US7915030B2 (en) * | 2005-09-01 | 2011-03-29 | Canon U.S. Life Sciences, Inc. | Method and molecular diagnostic device for detection, analysis and identification of genomic DNA |
| US7281419B2 (en) * | 2005-09-21 | 2007-10-16 | The Board Of Trustees Of The University Of Illinois | Multifunctional probe array system |
| US8449837B2 (en) * | 2005-10-11 | 2013-05-28 | The Johns Hopkins University | Microfluidic device for high-throughput cellular gradient and dose response studies |
| WO2007044856A1 (en) * | 2005-10-11 | 2007-04-19 | The Johns Hopkins University | Device and method for high-throughput stimulation, immunostaining, and visualization of single cells |
| US8916375B2 (en) * | 2005-10-12 | 2014-12-23 | University Of Virginia Patent Foundation | Integrated microfluidic analysis systems |
| WO2007047606A2 (en) * | 2005-10-17 | 2007-04-26 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Electrokinetic thermal cycler and reactor |
| US20090291437A1 (en) * | 2005-11-02 | 2009-11-26 | O'brien Sean | Methods for targeting quadruplex sequences |
| WO2007062182A2 (en) | 2005-11-23 | 2007-05-31 | Eksigent Technologies, Llp | Electrokinetic pump designs and drug delivery systems |
| CA2636855C (en) | 2006-01-11 | 2016-09-27 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| EP2263787A3 (en) * | 2006-01-27 | 2012-02-22 | President and Fellows of Harvard College | Fluidic droplet coalescence |
| WO2007098065A2 (en) * | 2006-02-17 | 2007-08-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Human sodium channel isoforms |
| US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
| EP1830186A1 (en) * | 2006-03-01 | 2007-09-05 | ETH Zürich | High-throughput cell-based screening system |
| US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| WO2007112114A2 (en) | 2006-03-24 | 2007-10-04 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
| US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
| US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
| JPWO2007111274A1 (ja) * | 2006-03-24 | 2009-08-13 | 株式会社東芝 | 核酸検出カセット及び核酸検出装置 |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| GB2436616A (en) | 2006-03-29 | 2007-10-03 | Inverness Medical Switzerland | Assay device and method |
| US8293524B2 (en) * | 2006-03-31 | 2012-10-23 | Fluxion Biosciences Inc. | Methods and apparatus for the manipulation of particle suspensions and testing thereof |
| US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
| ATE540750T1 (de) * | 2006-05-11 | 2012-01-15 | Raindance Technologies Inc | Mikrofluidische vorrichtung und verfahren |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| CN101074963B (zh) * | 2006-05-17 | 2011-07-06 | 聿新生物科技股份有限公司 | 电化学胆固醇检测电极测试条和其制造方法 |
| US7674924B2 (en) * | 2006-05-22 | 2010-03-09 | Third Wave Technologies, Inc. | Compositions, probes, and conjugates and uses thereof |
| CA2653321A1 (en) | 2006-05-26 | 2007-12-06 | Althea Technologies, Inc. | Biochemical analysis of partitioned cells |
| US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| JP4292279B2 (ja) * | 2006-07-18 | 2009-07-08 | ファルマ・アクセス株式会社 | 結晶作製器具 |
| US7842499B2 (en) * | 2006-08-07 | 2010-11-30 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| EP3536396B1 (en) | 2006-08-07 | 2022-03-30 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| US8656949B2 (en) * | 2006-08-15 | 2014-02-25 | University Of Maryland College Park | Microfluidic devices and methods of fabrication |
| US20100178204A1 (en) * | 2006-08-21 | 2010-07-15 | Anp Technologies | Automated Self-Contained Liquid Handling and Detection System Device |
| US7674616B2 (en) * | 2006-09-14 | 2010-03-09 | Hemosense, Inc. | Device and method for measuring properties of a sample |
| EP2089016A4 (en) * | 2006-10-03 | 2014-10-08 | Univ Pennsylvania | METHOD FOR TREATING MACULAR AGENCY |
| US8012744B2 (en) | 2006-10-13 | 2011-09-06 | Theranos, Inc. | Reducing optical interference in a fluidic device |
| US8841116B2 (en) | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
| WO2008052168A2 (en) | 2006-10-26 | 2008-05-02 | Symyx Technologies, Inc. | High pressure parallel fixed bed reactor and method |
| US20080113391A1 (en) * | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
| WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
| US8202491B2 (en) | 2006-11-21 | 2012-06-19 | Bioscale, Inc. | Apparatus for analyte processing |
| US20080118402A1 (en) * | 2006-11-21 | 2008-05-22 | David Brancazio | Method and apparatus for analyte processing |
| US20080153152A1 (en) * | 2006-11-22 | 2008-06-26 | Akira Wakabayashi | Microfluidic chip |
| CN1996009B (zh) * | 2007-01-10 | 2010-05-19 | 博奥生物有限公司 | 一种用于多样品分析的微流体器件和使用方法 |
| US7867592B2 (en) | 2007-01-30 | 2011-01-11 | Eksigent Technologies, Inc. | Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces |
| CN101715483A (zh) | 2007-02-05 | 2010-05-26 | 微芯片生物工艺学股份有限公司 | 微流体和纳米流体装置、系统和应用 |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| CN102014871A (zh) * | 2007-03-28 | 2011-04-13 | 哈佛大学 | 乳液及其形成技术 |
| JP2010523115A (ja) | 2007-04-04 | 2010-07-15 | ネットワーク・バイオシステムズ・インコーポレーテッド | 集積化された核酸分析 |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US8691164B2 (en) * | 2007-04-20 | 2014-04-08 | Celula, Inc. | Cell sorting system and methods |
| ES2687620T3 (es) | 2007-05-04 | 2018-10-26 | Opko Diagnostics, Llc | Dispositivo y método para análisis en sistemas microfluídicos |
| US20080297169A1 (en) * | 2007-05-31 | 2008-12-04 | Greenquist Alfred C | Particle Fraction Determination of A Sample |
| US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
| EP2014761B1 (en) * | 2007-06-22 | 2016-09-28 | Sony Deutschland GmbH | A device for processing an analyte and a method of processing and/or detecting an analyte using said device |
| US8921121B2 (en) * | 2007-06-29 | 2014-12-30 | The Trustees Of Columbia University In The City Of New York | Methods, devices, and systems for chemiluminescence-based microfluidic cell counting |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| EP3222733B1 (en) | 2007-07-13 | 2021-04-07 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US8454906B2 (en) | 2007-07-24 | 2013-06-04 | The Regents Of The University Of California | Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions |
| US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
| EP2178641B1 (en) * | 2007-08-09 | 2018-04-11 | Progenity, Inc. | Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material |
| WO2009026359A2 (en) * | 2007-08-20 | 2009-02-26 | Platypus Technologies, Llc | Improved devices for cell assays |
| EP2193361A4 (en) * | 2007-09-26 | 2013-11-27 | Massachusetts Inst Technology | DEVICE FOR ELECTROKINETIC CONCENTRATION AND USE METHOD THEREFOR |
| BR122020017678B1 (pt) | 2007-10-02 | 2021-08-03 | Labrador Diagnostics Llc | Sistema para detecção automática de um analito em uma amostra de fluido corporal |
| WO2009058881A1 (en) * | 2007-10-29 | 2009-05-07 | The University Of California | Osteoarthritis gene therapy |
| JP5404638B2 (ja) | 2007-11-07 | 2014-02-05 | ザ ユニヴァーシティ オブ ブリティッシュ コロンビア | マイクロ流体デバイスおよびその使用方法 |
| WO2009076134A1 (en) * | 2007-12-11 | 2009-06-18 | Eksigent Technologies, Llc | Electrokinetic pump with fixed stroke volume |
| EP3173787B1 (en) | 2008-01-03 | 2021-06-02 | EMD Millipore Corporation | Cell culture array system for automated assays and methods of operation and manufacture thereof |
| US20090253181A1 (en) | 2008-01-22 | 2009-10-08 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
| JP4556194B2 (ja) * | 2008-02-01 | 2010-10-06 | セイコーエプソン株式会社 | 生体試料反応方法 |
| US8397762B2 (en) * | 2008-02-04 | 2013-03-19 | Bioscale, Inc. | Fluidic system with improved flow characteristics |
| WO2009121034A2 (en) * | 2008-03-28 | 2009-10-01 | Pelican Group Holdings, Inc. | Multicapillary sample preparation devices and methods for processing analytes |
| US20090286692A1 (en) * | 2008-04-15 | 2009-11-19 | Wainwright Norman R | Cartridge and Method for Sample Analysis |
| US8222049B2 (en) * | 2008-04-25 | 2012-07-17 | Opko Diagnostics, Llc | Flow control in microfluidic systems |
| WO2009131704A2 (en) | 2008-04-25 | 2009-10-29 | Northwestern University | Nanostructures suitable for sequestering cholesterol and other molecules |
| WO2009134395A2 (en) | 2008-04-28 | 2009-11-05 | President And Fellows Of Harvard College | Microfluidic device for storage and well-defined arrangement of droplets |
| US8472683B2 (en) * | 2008-05-09 | 2013-06-25 | General Electric Company | Motion correction in tomographic images |
| US9879360B2 (en) * | 2008-06-20 | 2018-01-30 | International Business Machines Corporation | Microfluidic selection of library elements |
| US9393566B2 (en) * | 2008-06-23 | 2016-07-19 | Canon U.S. Life Sciences, Inc. | System and method for temperature referencing for melt curve data collection |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| EP2315629B1 (en) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| KR101652780B1 (ko) * | 2008-08-11 | 2016-08-31 | 후지모리 고교 가부시키가이샤 | 혈소판 검사 방법 및 혈소판 검사 장치 |
| US8178355B2 (en) | 2008-09-15 | 2012-05-15 | Platypus Technologies, Llc. | Detection of vapor phase compounds by changes in physical properties of a liquid crystal |
| EP2952589B1 (en) | 2008-09-20 | 2018-02-14 | The Board of Trustees of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
| US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| WO2011120024A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet generation for droplet-based assays |
| EP2347245B1 (en) | 2008-09-23 | 2021-11-03 | Bio-Rad Laboratories, Inc. | Droplet-based assay method |
| US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
| US12090480B2 (en) | 2008-09-23 | 2024-09-17 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| US8633015B2 (en) | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
| US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
| US12162008B2 (en) | 2008-09-23 | 2024-12-10 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
| US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
| US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
| US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
| EP2376226B1 (en) | 2008-12-18 | 2018-09-12 | Opko Diagnostics, LLC | Improved reagent storage in microfluidic systems and related articles and methods |
| US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
| US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
| EP2391452B1 (en) * | 2009-01-30 | 2015-06-17 | Gen-Probe Incorporated | Systems and methods for detecting a signal and applying thermal energy to a signal transmission element |
| WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| DE202010018623U1 (de) | 2009-02-02 | 2018-12-07 | Opko Diagnostics, Llc | Strukturen zur Steuerung der Lichtwechselwirkung mit mikrofluidischen Vorrichtungen |
| WO2010089138A1 (en) * | 2009-02-09 | 2010-08-12 | Caprotec Bioanalytics Gmbh | Devices, systems and methods for separating magnetic particles |
| US9068921B2 (en) * | 2009-03-07 | 2015-06-30 | Hewlett-Packard Development Company, L.P. | Analyzer and method for sensing using the same |
| US20120058464A1 (en) * | 2009-03-16 | 2012-03-08 | Eugen Ermantraut | Assay Methods Using Array of Test Zones |
| EP3415235B1 (en) | 2009-03-23 | 2025-11-12 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
| US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| US9415392B2 (en) | 2009-03-24 | 2016-08-16 | The University Of Chicago | Slip chip device and methods |
| US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
| US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
| US8354080B2 (en) | 2009-04-10 | 2013-01-15 | Canon U.S. Life Sciences, Inc. | Fluid interface cartridge for a microfluidic chip |
| US8790916B2 (en) | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
| DE102009040151B4 (de) * | 2009-05-26 | 2013-09-12 | Analytik Jena Ag | Anordnung zur Detektion von Chemolumineszenz an Gasen |
| US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| WO2010141326A1 (en) | 2009-06-02 | 2010-12-09 | Integenx Inc. | Fluidic devices with diaphragm valves |
| WO2010141131A1 (en) | 2009-06-04 | 2010-12-09 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for dna analysis |
| EP3586945A3 (en) * | 2009-06-05 | 2020-03-04 | IntegenX Inc. | Universal sample preparation system and use in an integrated analysis system |
| WO2010147654A2 (en) | 2009-06-15 | 2010-12-23 | Netbio Inc. | Improved methods for forensic dna quantitation |
| JP5663574B2 (ja) | 2009-07-20 | 2015-02-04 | シロアム バイオサイエンシズ, インコーポレイテッドSiloam Biosciences, Inc. | 微小流体分析プラットホーム |
| WO2011028764A2 (en) | 2009-09-02 | 2011-03-10 | President And Fellows Of Harvard College | Multiple emulsions created using jetting and other techniques |
| CA2767056C (en) | 2009-09-02 | 2018-12-04 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| CN105740641A (zh) | 2009-10-19 | 2016-07-06 | 提拉诺斯公司 | 集成的健康数据采集和分析系统 |
| KR20120102674A (ko) | 2009-11-03 | 2012-09-18 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 중합체 분석물을 검출하는 다용도의 가시적인 방법 |
| EP2496700B1 (en) | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
| US8834792B2 (en) | 2009-11-13 | 2014-09-16 | 3M Innovative Properties Company | Systems for processing sample processing devices |
| USD638951S1 (en) | 2009-11-13 | 2011-05-31 | 3M Innovative Properties Company | Sample processing disk cover |
| USD667561S1 (en) | 2009-11-13 | 2012-09-18 | 3M Innovative Properties Company | Sample processing disk cover |
| USD638550S1 (en) | 2009-11-13 | 2011-05-24 | 3M Innovative Properties Company | Sample processing disk cover |
| WO2013134744A2 (en) * | 2012-03-08 | 2013-09-12 | Cyvek, Inc | Microfluidic assay assemblies and methods of manufacture |
| US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
| US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
| US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
| WO2011063408A1 (en) | 2009-11-23 | 2011-05-26 | Cyvek, Inc. | Method and apparatus for performing assays |
| US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
| US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
| US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
| MX336714B (es) | 2009-11-24 | 2016-01-28 | Opko Diagnostics Llc | Mezclado y entrega de fluidos en sistemas microfluidicos. |
| US8584703B2 (en) * | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
| EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
| JP5863670B2 (ja) | 2010-01-19 | 2016-02-17 | ノースウェスタン ユニバーシティ | 核酸および/または他の構成要素を含有している合成ナノ構造体 |
| US9353342B2 (en) | 2010-01-21 | 2016-05-31 | Emd Millipore Corporation | Cell culture and gradient migration assay methods and devices |
| CN102762991B (zh) | 2010-02-10 | 2015-08-19 | 藤森工业株式会社 | 血小板检测用微芯片及使用该微芯片的血小板检测装置 |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| CA2789425C (en) | 2010-02-12 | 2020-04-28 | Raindance Technologies, Inc. | Digital analyte analysis with polymerase error correction |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US8399198B2 (en) | 2010-03-02 | 2013-03-19 | Bio-Rad Laboratories, Inc. | Assays with droplets transformed into capsules |
| JP2013525087A (ja) * | 2010-03-17 | 2013-06-20 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 融解乳化 |
| EP2556170A4 (en) | 2010-03-25 | 2014-01-01 | Quantalife Inc | TRAPPING TRANSPORT AND DETECTION SYSTEM |
| CN101817495B (zh) * | 2010-03-25 | 2012-03-14 | 湖南大学 | 微流控芯片及其制备方法和应用 |
| EP2550351A4 (en) | 2010-03-25 | 2014-07-09 | Quantalife Inc | DETECTION SYSTEM FOR DROPLET-BASED ANALYZES |
| CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| JP2011220947A (ja) * | 2010-04-14 | 2011-11-04 | Hitachi Engineering & Services Co Ltd | 微生物検査装置及び微生物検査チップ |
| WO2011130625A1 (en) | 2010-04-16 | 2011-10-20 | Claros Diagnostics, Inc. | Feedback control in microfluidic systems |
| USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
| US20130203045A1 (en) | 2010-05-26 | 2013-08-08 | University Of Virginia Patent Foundation | Method for detecting nucleic acids based on aggregate formation |
| US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
| WO2012011074A2 (en) | 2010-07-22 | 2012-01-26 | Hach Company | Lab-on-a-chip for alkalinity analysis |
| WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
| EP2606242A4 (en) | 2010-08-20 | 2016-07-20 | Integenx Inc | MICROFLUIDIC DEVICES WITH MECHANICALLY SEALED MEMBRANE VALVES |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| US10114020B2 (en) | 2010-10-11 | 2018-10-30 | Mbio Diagnostics, Inc. | System and device for analyzing a fluidic sample |
| WO2012051529A1 (en) | 2010-10-15 | 2012-04-19 | Lockheed Martin Corporation | Micro fluidic optic design |
| EP4016086A1 (en) | 2010-11-01 | 2022-06-22 | Bio-Rad Laboratories, Inc. | System for forming emulsions |
| MX2013008339A (es) | 2011-01-21 | 2014-02-11 | Theranos Inc | Sistemas y metodos para maximizacion de uso de muestras. |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| US12097495B2 (en) | 2011-02-18 | 2024-09-24 | Bio-Rad Laboratories, Inc. | Methods and compositions for detecting genetic material |
| EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| WO2012129187A1 (en) | 2011-03-18 | 2012-09-27 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
| CN103649759B (zh) * | 2011-03-22 | 2016-08-31 | 西维克公司 | 微流体装置以及制造方法和用途 |
| JP5637300B2 (ja) * | 2011-03-28 | 2014-12-10 | 学校法人加計学園 | 試料溶液濃度測定方法及び試料溶液濃度測定装置 |
| US10526572B2 (en) | 2011-04-01 | 2020-01-07 | EMD Millipore Corporaticn | Cell culture and invasion assay method and system |
| EP3709025A1 (en) | 2011-04-15 | 2020-09-16 | Becton, Dickinson and Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
| AU2012249759A1 (en) | 2011-04-25 | 2013-11-07 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
| WO2012149285A1 (en) | 2011-04-28 | 2012-11-01 | Claire Mitchell | Method for treatment of macular degeneration by modulating p2y12 or p2x7 receptors |
| WO2012151268A1 (en) | 2011-05-02 | 2012-11-08 | University Of Virginia Patent Foundation | Method and system for high throughput optical and label free detection of analytes |
| WO2012151289A2 (en) | 2011-05-02 | 2012-11-08 | University Of Virginia Patent Foundation | Method and system to detect aggregate formation on a substrate |
| US8979511B2 (en) | 2011-05-05 | 2015-03-17 | Eksigent Technologies, Llc | Gel coupling diaphragm for electrokinetic delivery systems |
| CA2835620C (en) | 2011-05-12 | 2021-02-23 | Netbio, Inc. | Methods and compositions for rapid multiplex amplification of str loci |
| EP2709760B1 (en) | 2011-05-18 | 2019-06-05 | DiaSorin S.p.A. | Systems and methods for valving on a sample processing device |
| AU2012255151B2 (en) | 2011-05-18 | 2015-09-03 | Diasorin Italia S.P.A. | Systems and methods for detecting the presence of a selected volume of material in a sample processing device |
| KR20140022399A (ko) | 2011-05-18 | 2014-02-24 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법 |
| BR112013029729A2 (pt) | 2011-05-23 | 2017-01-24 | Basf Se | controle de emulsões, incluindo emulsões múltiplas |
| DE202012013668U1 (de) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | Enzymquantifizierung |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| WO2013066418A1 (en) * | 2011-06-14 | 2013-05-10 | Corning Incorporated | Hybrid microfluidic assemblies |
| US20140220350A1 (en) | 2011-07-06 | 2014-08-07 | President And Fellows Of Harvard College | Multiple emulsions and techniques for the formation of multiple emulsions |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| WO2013019751A1 (en) | 2011-07-29 | 2013-02-07 | Bio-Rad Laboratories, Inc., | Library characterization by digital assay |
| AU2012216792A1 (en) | 2011-09-12 | 2013-03-28 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies |
| CN103959070B (zh) | 2011-09-30 | 2017-05-10 | 贝克顿·迪金森公司 | 组合试剂条 |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
| US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| JP2015502337A (ja) | 2011-10-25 | 2015-01-22 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 限界サイズ脂質ナノ粒子および関連方法 |
| EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| EP3441142A1 (en) | 2011-11-16 | 2019-02-13 | Becton, Dickinson and Company | Methods and systems for detecting an analyte in a sample |
| ES2870857T3 (es) | 2011-12-03 | 2021-10-27 | Emd Millipore Corp | Sistema microfluídico para cultivo celular |
| JP6108657B2 (ja) * | 2011-12-28 | 2017-04-05 | 日本バイリーン株式会社 | 構造体及びその製造方法 |
| US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
| US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
| US9304065B2 (en) | 2012-02-29 | 2016-04-05 | Fluidigm Corporation | Methods, systems and devices for multiple single-cell capturing and processing using microfluidics |
| ES2978966T3 (es) | 2012-03-05 | 2024-09-23 | Oy Arctic Partners Ab | Métodos y aparatos para predecir el riesgo de cáncer de próstata y el volumen de la glándula prostática |
| WO2013155531A2 (en) | 2012-04-13 | 2013-10-17 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
| EP2838658A1 (en) * | 2012-04-16 | 2015-02-25 | QuNano AB | A nanocapillary device for biomolecule detection, a fluidic network structure and a method of manufacturing thereof |
| US9180449B2 (en) | 2012-06-12 | 2015-11-10 | Hach Company | Mobile water analysis |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| DE102012109026A1 (de) * | 2012-09-25 | 2014-03-27 | Eads Deutschland Gmbh | Detektionsvorrichtung und Detektionsverfahren zur automatischen Bestimmung von Biomasse |
| US10816550B2 (en) | 2012-10-15 | 2020-10-27 | Nanocellect Biomedical, Inc. | Systems, apparatus, and methods for sorting particles |
| EP2911791A4 (en) | 2012-10-29 | 2016-11-02 | Mbio Diagnostics Inc | BIOPARTICLE IDENTIFICATION SYSTEM, CARTRIDGE AND RELATED METHODS |
| USD768872S1 (en) | 2012-12-12 | 2016-10-11 | Hach Company | Cuvette for a water analysis instrument |
| ES2692407T3 (es) | 2013-01-11 | 2018-12-03 | Becton, Dickinson And Company | Dispositivo de ensayo de punto de cuidado de bajo coste |
| EP2962092A4 (en) * | 2013-03-01 | 2016-08-24 | Wave 80 Biosciences Inc | METHOD AND SYSTEMS FOR IMPROVED MICROFLUIDIC PROCESSING |
| US9995412B2 (en) | 2013-03-01 | 2018-06-12 | Wave 80 Biosciences, Inc. | Long-throw microfluidic actuator |
| EP2969156B1 (en) | 2013-03-13 | 2019-04-10 | Opko Diagnostics, LLC | Mixing of fluids in fluidic systems |
| EP3581641A1 (en) | 2013-03-15 | 2019-12-18 | Fluidigm Corporation | Methods and devices for analysis of defined multicellular combinations |
| CA2906732C (en) | 2013-03-15 | 2023-08-08 | The University Of British Columbia | Lipid nanoparticles for transfection and related methods |
| JP2014240065A (ja) * | 2013-05-15 | 2014-12-25 | 公立大学法人大阪府立大学 | 流路構造体および流路構造体の製造方法 |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9815059B2 (en) * | 2013-10-07 | 2017-11-14 | Devrim PESEN OKVUR | Microfluidic device for investigation of distance dependent interactions in cell biology |
| EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| US9797899B2 (en) | 2013-11-06 | 2017-10-24 | Becton, Dickinson And Company | Microfluidic devices, and methods of making and using the same |
| BR112016010721B1 (pt) | 2013-11-13 | 2021-06-01 | Becton, Dickinson And Company | Método e sistema de análise de uma amostra para um analito |
| US10191071B2 (en) | 2013-11-18 | 2019-01-29 | IntegenX, Inc. | Cartridges and instruments for sample analysis |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015097560A2 (en) | 2013-12-23 | 2015-07-02 | Basf Se | Methods for determining modulators of insect transient receptor potential v (trpv) channel |
| EP3090063B1 (en) | 2013-12-31 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Method for detection of latent retrovirus |
| WO2015179098A1 (en) | 2014-05-21 | 2015-11-26 | Integenx Inc. | Fluidic cartridge with valve mechanism |
| MX380586B (es) * | 2014-06-13 | 2025-03-12 | Gattaco Inc | Mecanismo para reiniciar presion capilar y aplicaciones. |
| US11305236B2 (en) | 2014-06-13 | 2022-04-19 | Gattaco Inc. | Surface tension driven filtration |
| US10539579B2 (en) | 2014-09-29 | 2020-01-21 | C A Casyso Gmbh | Blood testing system and method |
| EP3201596A4 (en) * | 2014-10-01 | 2018-07-11 | University of Tasmania | Extraction and concentration device |
| CA2935312C (en) | 2014-10-14 | 2022-11-22 | Becton, Dickinson And Company | Blood sample management using open cell foam |
| BR122020024283B1 (pt) | 2014-10-14 | 2023-02-23 | Becton, Dickinson And Company | Dispositivo de transferência de sangue adaptado para receber uma amostra de sangue |
| EP3209410B1 (en) | 2014-10-22 | 2024-12-25 | IntegenX Inc. | Electrophoresis cartridge and corresponding method for sample preparation, processing and analysis |
| US10210410B2 (en) | 2014-10-22 | 2019-02-19 | Integenx Inc. | Systems and methods for biometric data collections |
| EA038479B1 (ru) | 2014-12-12 | 2021-09-03 | Опкоу Дайагностикс, Ллк | Устройство для проведения анализа пробы и способ эксплуатации указанного устройства |
| EP3234576B1 (en) | 2014-12-18 | 2023-11-22 | Life Technologies Corporation | High data rate integrated circuit with transmitter configuration |
| EP3154697B1 (en) | 2015-03-10 | 2018-06-20 | Becton, Dickinson and Company | Biological fluid micro-sample management device |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| WO2016161081A1 (en) | 2015-04-03 | 2016-10-06 | Fluxion Biosciences, Inc. | Molecular characterization of single cells and cell populations for non-invasive diagnostics |
| JP6466775B2 (ja) * | 2015-04-30 | 2019-02-06 | シスメックス株式会社 | 検体分析カートリッジを用いた検体分析方法、検体分析カートリッジ、および、検体分析装置 |
| CN106248929A (zh) * | 2015-06-11 | 2016-12-21 | 宁波大学 | 一种以pdms作基片的艾滋病诊断用多通道芯片装置 |
| NL2015130B1 (en) * | 2015-07-09 | 2017-02-01 | Mimetas B V | Barrier function measurements. |
| USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
| JP2018536142A (ja) | 2015-09-01 | 2018-12-06 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 試料の相を分離するためのデプスフィルトレーションデバイス |
| US10227556B2 (en) | 2015-09-04 | 2019-03-12 | Wayne State University | Cell culture devices for biomimetic and pathomimetic cell cultures |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| JP6998863B2 (ja) | 2015-09-25 | 2022-02-04 | エフ.ホフマン-ラ ロシュ アーゲー | 深共融溶媒におけるソルターゼaを利用したアミド基転移 |
| CN108138204B (zh) | 2015-09-25 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 使用分选酶a生产硫酯的方法 |
| JP6998862B2 (ja) | 2015-09-25 | 2022-02-04 | エフ.ホフマン-ラ ロシュ アーゲー | 可溶性ソルターゼa |
| EP3359573B1 (en) | 2015-10-01 | 2023-01-04 | The Whitehead Institute for Biomedical Research | Labeling of antibodies |
| US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
| US10852310B2 (en) | 2015-12-11 | 2020-12-01 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| WO2017167712A1 (en) | 2016-03-30 | 2017-10-05 | F. Hoffmann-La Roche Ag | Improved sortase |
| US11426580B2 (en) | 2016-08-12 | 2022-08-30 | Health Discovery Labs Llc | Systems and methods for low intensity high efficiency electrical stimulation |
| CN106362811B (zh) * | 2016-08-29 | 2018-07-13 | 北京工业大学 | 一种测量壁面可变形通道中压力变化的微流控芯片 |
| US20210284998A1 (en) | 2016-10-03 | 2021-09-16 | Precision Nanosystems Inc. | Compositions for Transfecting Resistant Cell Types |
| CN110035810B (zh) * | 2016-11-29 | 2021-09-28 | 普诺森公司 | 用于同时检测大范围蛋白质浓度的方法和装置 |
| WO2018175411A1 (en) | 2017-03-20 | 2018-09-27 | Nanocellect Biomedical, Inc. | Systems, apparatuses, and methods for cell sorting and flow cytometry |
| US11525152B2 (en) | 2017-04-07 | 2022-12-13 | Acenxion Biosystems, Inc. | System and method for rapid detection of viable microorganisms in liquid media |
| JP7227568B2 (ja) | 2017-07-27 | 2023-02-22 | ユニバーシティー オブ サウザン カリフォルニア | 医薬品開発のための標的としてのオトペトリンプロトンチャネル |
| CN108181458B (zh) * | 2018-02-26 | 2019-05-14 | 北京华科泰生物技术股份有限公司 | 一种基于荧光免疫联合检测的微流控芯片及其制备方法和用途 |
| EP3566772A1 (en) * | 2018-05-11 | 2019-11-13 | Agilent Technologies, Inc. (A Delaware Corporation) | Immobilizing fluidic sample for inhibiting spatial broadening |
| CA3100019A1 (en) | 2018-05-11 | 2019-11-14 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| EP3797279A4 (en) * | 2018-07-11 | 2022-08-03 | The University of Hong Kong | Automatic microfluidic system for continuous and quantitive collection of droplets |
| GB201820870D0 (en) * | 2018-12-20 | 2019-02-06 | Cambridge Entpr Ltd | Detection of components |
| CN109647557B (zh) * | 2019-02-27 | 2021-04-02 | 哈尔滨工业大学 | 基于诱导电荷电渗微旋涡的直接颗粒分离芯片及其应用和分离方法 |
| EP4150336A4 (en) * | 2020-05-14 | 2024-06-26 | Bifrost Biosystems | MICROFLUIDIC DEVICE HAVING SPECIFICALLY DESIGNED DETECTION CHAMBERS |
| US20230405590A1 (en) * | 2020-11-22 | 2023-12-21 | Gattaco Inc. | Sample transfer devices, and components and methods thereof |
| US20230131266A1 (en) * | 2021-10-21 | 2023-04-27 | Hewlett-Packard Development Company, L.P. | Alignment and fusion of cells with an electrical field |
| WO2025197314A1 (ja) * | 2024-03-19 | 2025-09-25 | パナソニックIpマネジメント株式会社 | 製造装置 |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3018224A (en) | 1957-08-23 | 1962-01-23 | Technicon Instr | Analysis and production-monitoring methods and apparatus |
| NL235965A (enExample) | 1958-03-07 | |||
| US3065148A (en) | 1959-07-14 | 1962-11-20 | Technicon Instr | Method and apparatus for use in conducting studies on cells |
| US3701716A (en) | 1969-04-15 | 1972-10-31 | Beckman Instruments Inc | Liquid analysis apparatus |
| US3615241A (en) | 1970-02-27 | 1971-10-26 | Nasa | Firefly pump-metering system |
| US3700562A (en) | 1970-08-31 | 1972-10-24 | Technicon Instr | Method and apparatus for sample analysis on a continuous flow basis |
| US3918908A (en) | 1974-05-17 | 1975-11-11 | Geomet | Method for prothrombin testing |
| US4443408A (en) | 1981-07-09 | 1984-04-17 | International Technidyne, Inc. | Apparatus for analyzing the influence of additive reagents upon the coagulation of blood |
| US4390403A (en) | 1981-07-24 | 1983-06-28 | Batchelder J Samuel | Method and apparatus for dielectrophoretic manipulation of chemical species |
| US4629686A (en) | 1982-02-19 | 1986-12-16 | Endotronics, Inc. | Apparatus for delivering a controlled dosage of a chemical substance |
| US4618586A (en) | 1983-04-08 | 1986-10-21 | Endotronics, Inc. | Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber |
| US4554839A (en) | 1983-10-14 | 1985-11-26 | Cetus Corporation | Multiple trough vessel for automated liquid handling apparatus |
| US5171534A (en) | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
| JP2527933B2 (ja) | 1984-06-13 | 1996-08-28 | ユニリ−バ−・ナ−ムロ−ゼ・ベンノ−トシヤ−プ | 特異的反応性サンプルの収集及び試験デバイス並びにその製造方法 |
| US4952518A (en) | 1984-10-01 | 1990-08-28 | Cetus Corporation | Automated assay machine and assay tray |
| US5096807A (en) * | 1985-03-06 | 1992-03-17 | Murex Corporation | Imaging immunoassay detection system with background compensation and its use |
| US5144139A (en) | 1985-08-05 | 1992-09-01 | Biotrack, Inc. | Capillary flow device |
| US5164598A (en) | 1985-08-05 | 1992-11-17 | Biotrack | Capillary flow device |
| US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
| US5140161A (en) | 1985-08-05 | 1992-08-18 | Biotrack | Capillary flow device |
| US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US4675300A (en) | 1985-09-18 | 1987-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Laser-excitation fluorescence detection electrokinetic separation |
| US4737464A (en) * | 1985-09-26 | 1988-04-12 | Molecular Devices Corporation | Solid-state optical assay imaging apparatus |
| US5108703A (en) | 1986-03-26 | 1992-04-28 | Beckman Instruments, Inc. | Automated multi-purpose analytical chemistry processing center and laboratory work station |
| US4915812A (en) * | 1986-06-20 | 1990-04-10 | Molecular Devices Corporation | Zero volume cell |
| US4783413A (en) | 1986-07-30 | 1988-11-08 | Contraves Ag | Apparatus for supplying a medium to a reaction chamber |
| CA1296622C (en) * | 1986-08-12 | 1992-03-03 | Jeffrey E. Anderson | Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system |
| US4740708A (en) | 1987-01-06 | 1988-04-26 | International Business Machines Corporation | Semiconductor wafer surface inspection apparatus and method |
| US5079600A (en) * | 1987-03-06 | 1992-01-07 | Schnur Joel M | High resolution patterning on solid substrates |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| DE68922390T2 (de) * | 1988-10-21 | 1995-10-05 | Molecular Devices Corp | Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen. |
| US5278048A (en) * | 1988-10-21 | 1994-01-11 | Molecular Devices Corporation | Methods for detecting the effect of cell affecting agents on living cells |
| US5032381A (en) | 1988-12-20 | 1991-07-16 | Tropix, Inc. | Chemiluminescence-based static and flow cytometry |
| DK374889D0 (da) | 1989-07-28 | 1989-07-28 | Koege Kemisk Vaerk | Fremgangsmaade til procesovervaagning |
| SE464763B (sv) | 1989-10-05 | 1991-06-10 | Gunnar Engstroem | Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmedium |
| IE903930A1 (en) | 1989-11-06 | 1991-05-08 | Akzo Nv | Immunoassays for and monoclonal antibodies to prothrombin¹activation peptides and their degradation products |
| US5279936A (en) * | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium |
| KR910012538A (ko) | 1989-12-27 | 1991-08-08 | 야마무라 가쯔미 | 마이크로 펌프 및 그 제조 방법 |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5858188A (en) * | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
| US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
| US5104804A (en) | 1990-06-04 | 1992-04-14 | Molecular Devices Corporation | Cell assay device used in a microphysiometer |
| EP0491026B1 (en) | 1990-07-10 | 1995-03-01 | Westonbridge International Limited | Valve, method for producing said valve and micropump incorporating said valve |
| US5147606A (en) | 1990-08-06 | 1992-09-15 | Miles Inc. | Self-metering fluid analysis device |
| EP0498863B1 (en) | 1990-08-31 | 1995-07-26 | Westonbridge International Limited | A valve equipped with a position detector and a micropump incorporating said valve |
| GB2248891A (en) | 1990-10-18 | 1992-04-22 | Westonbridge Int Ltd | Membrane micropump |
| US5192405A (en) | 1991-01-11 | 1993-03-09 | Millipore Corporation | Process for effecting high efficiency separations by capillary electrophoresis |
| US5488469A (en) | 1991-08-30 | 1996-01-30 | Omron Corporation | Cell analyzing apparatus |
| GB9119382D0 (en) | 1991-09-11 | 1991-10-23 | Knight Scient Ltd | Apparatus for monitoring liquids |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| EP0544969B1 (de) * | 1991-12-06 | 1997-03-05 | Ciba-Geigy Ag | Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren |
| US5296144A (en) * | 1992-01-02 | 1994-03-22 | World Trade Corporation | Composite membrane of a hydrophilic asymmetric membrane coated with an organosiloxane block copolymer |
| US5451525A (en) | 1992-02-14 | 1995-09-19 | Coulter Corporation | Method and materials for determining particle count in a flow cytometer |
| SE500702C2 (sv) | 1992-04-07 | 1994-08-15 | Staffan Birnbaum | Sätt och anordning för optisk analys av prov separerade i tunna kapillärer |
| US5223219A (en) | 1992-04-10 | 1993-06-29 | Biotrack, Inc. | Analytical cartridge and system for detecting analytes in liquid samples |
| US5498392A (en) * | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| ATE174813T1 (de) | 1992-05-01 | 1999-01-15 | Univ Pennsylvania | Polynukleotide amplifikationsanalyse mit einer mikrofabrizierten vorrichtung |
| US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5296375A (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
| US5744366A (en) | 1992-05-01 | 1998-04-28 | Trustees Of The University Of Pennsylvania | Mesoscale devices and methods for analysis of motile cells |
| US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
| US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| US5486335A (en) * | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
| GB2266751A (en) | 1992-05-02 | 1993-11-10 | Westonbridge Int Ltd | Piezoelectric micropump excitation voltage control. |
| DE4220077A1 (de) | 1992-06-19 | 1993-12-23 | Bosch Gmbh Robert | Mikropumpe |
| US5598052A (en) | 1992-07-28 | 1997-01-28 | Philips Electronics North America | Vacuum microelectronic device and methodology for fabricating same |
| US5639423A (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
| US5547849A (en) | 1993-02-17 | 1996-08-20 | Biometric Imaging, Inc. | Apparatus and method for volumetric capillary cytometry |
| US5441894A (en) | 1993-04-30 | 1995-08-15 | Abbott Laboratories | Device containing a light absorbing element for automated chemiluminescent immunoassays |
| US5460709A (en) | 1993-06-21 | 1995-10-24 | Helena Laboratories Corporation | Automatic electrophoresis method and apparatus |
| US5395587A (en) * | 1993-07-06 | 1995-03-07 | Smithkline Beecham Corporation | Surface plasmon resonance detector having collector for eluted ligate |
| US5429734A (en) * | 1993-10-12 | 1995-07-04 | Massachusetts Institute Of Technology | Monolithic capillary electrophoretic device |
| JPH09508353A (ja) | 1993-11-02 | 1997-08-26 | アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ | 分子多様性の合成及びスクリーニング |
| DE4411268C2 (de) * | 1994-03-31 | 2001-02-01 | Danfoss As | Analyseverfahren und Analysevorrichtung |
| DE4411266C2 (de) * | 1994-03-31 | 2001-05-17 | Danfoss As | Analyseverfahren und Analysevorrichtung |
| US5540889A (en) | 1994-05-11 | 1996-07-30 | Whitehead Institute For Biomedical Research | Apparatus and method for a highly parallel pipetter |
| EP0695941B1 (en) | 1994-06-08 | 2002-07-31 | Affymetrix, Inc. | Method and apparatus for packaging a chip |
| US5637458A (en) | 1994-07-20 | 1997-06-10 | Sios, Inc. | Apparatus and method for the detection and assay of organic molecules |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US5645702A (en) | 1995-06-07 | 1997-07-08 | Hewlett-Packard Company | Low voltage miniaturized column analytical apparatus and method |
| US5571410A (en) * | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
| US5632876A (en) | 1995-06-06 | 1997-05-27 | David Sarnoff Research Center, Inc. | Apparatus and methods for controlling fluid flow in microchannels |
| US5744367A (en) | 1994-11-10 | 1998-04-28 | Igen International, Inc. | Magnetic particle based electrochemiluminescent detection apparatus and method |
| US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| KR100314996B1 (ko) | 1994-11-10 | 2002-01-15 | 윌리암 제이. 버크 | 액체분배시스템 |
| EP0739240B1 (en) | 1994-11-14 | 2004-06-16 | The Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| JP3909859B2 (ja) | 1994-11-14 | 2007-04-25 | トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 中規模ポリヌクレオチド増幅装置 |
| US5731212A (en) | 1994-12-20 | 1998-03-24 | International Technidyne Corporation | Test apparatus and method for testing cuvette accommodated samples |
| US5560811A (en) | 1995-03-21 | 1996-10-01 | Seurat Analytical Systems Incorporated | Capillary electrophoresis apparatus and method |
| US5607565A (en) | 1995-03-27 | 1997-03-04 | Coulter Corporation | Apparatus for measuring analytes in a fluid sample |
| US5650075A (en) * | 1995-05-30 | 1997-07-22 | Motorola, Inc. | Method for etching photolithographically produced quartz crystal blanks for singulation |
| US5605262A (en) | 1995-06-01 | 1997-02-25 | Bond; James R. | Adjustable wrist band |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5942433A (en) | 1995-07-31 | 1999-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Extension of a protein-protein interaction surface to inactivate the function of a cellular protein |
| US5716825A (en) | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| AU1059997A (en) | 1995-11-08 | 1997-05-29 | Trustees Of Boston University | Cellular physiology workstations for automated data acquisition and perfusion control |
| US5783397A (en) | 1995-12-11 | 1998-07-21 | Northeastern University | Screening natural samples for new therapeutic compounds using capillary electrophoresis |
| US6399023B1 (en) | 1996-04-16 | 2002-06-04 | Caliper Technologies Corp. | Analytical system and method |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US5824204A (en) * | 1996-06-27 | 1998-10-20 | Ic Sensors, Inc. | Micromachined capillary electrophoresis device |
| JP3361530B2 (ja) | 1996-06-28 | 2003-01-07 | カリパー・テクノロジーズ・コープ. | 電子ピペッタおよび電気泳動バイアスのための補償手段 |
| US5779868A (en) | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
| CN1173776C (zh) * | 1996-06-28 | 2004-11-03 | 卡钳技术有限公司 | 在微规模流体性设备里的高通过量的筛选分析系统 |
| US5800690A (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
| US5699157A (en) | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
| US5804436A (en) | 1996-08-02 | 1998-09-08 | Axiom Biotechnologies, Inc. | Apparatus and method for real-time measurement of cellular response |
| US5858187A (en) * | 1996-09-26 | 1999-01-12 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing electrodynamic focusing on a microchip |
| US6447727B1 (en) | 1996-11-19 | 2002-09-10 | Caliper Technologies Corp. | Microfluidic systems |
| US5964995A (en) | 1997-04-04 | 1999-10-12 | Caliper Technologies Corp. | Methods and systems for enhanced fluid transport |
| EP0972082A4 (en) | 1997-04-04 | 2007-04-25 | Caliper Life Sciences Inc | BIOCHEMICAL ANALYZERS OPERATING IN CLOSED LOOP |
| CN1105914C (zh) | 1997-04-25 | 2003-04-16 | 卡钳技术有限公司 | 改进了通道几何结构的微型流体装置 |
| US6090251A (en) | 1997-06-06 | 2000-07-18 | Caliper Technologies, Inc. | Microfabricated structures for facilitating fluid introduction into microfluidic devices |
| WO1998056956A1 (en) | 1997-06-09 | 1998-12-17 | Caliper Technologies Corporation | Apparatus and methods for correcting for variable velocity in microfluidic systems |
| US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
| US5882465A (en) | 1997-06-18 | 1999-03-16 | Caliper Technologies Corp. | Method of manufacturing microfluidic devices |
| US5959291A (en) | 1997-06-27 | 1999-09-28 | Caliper Technologies Corporation | Method and apparatus for measuring low power signals |
| US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
| US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
| CA2300203A1 (en) | 1997-09-02 | 1999-03-11 | Caliper Technologies Corporation | Microfluidic system with electrofluidic and electrothermal controls |
| US6012902A (en) | 1997-09-25 | 2000-01-11 | Caliper Technologies Corp. | Micropump |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| US5958694A (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
| US6022733A (en) | 1997-12-02 | 2000-02-08 | Tam; Yun K. | Simulated biological dissolution and absorption system |
| US6074725A (en) | 1997-12-10 | 2000-06-13 | Caliper Technologies Corp. | Fabrication of microfluidic circuits by printing techniques |
| US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
| US6132685A (en) | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
-
1997
- 1997-06-24 CN CNB971959544A patent/CN1173776C/zh not_active Expired - Fee Related
- 1997-06-24 US US09/214,035 patent/US6429025B1/en not_active Expired - Lifetime
- 1997-06-24 BR BR9710054-4A patent/BR9710054A/pt unknown
- 1997-06-24 CA CA002258489A patent/CA2258489C/en not_active Expired - Fee Related
- 1997-06-24 US US08/881,696 patent/US6267858B1/en not_active Expired - Lifetime
- 1997-06-24 JP JP50423798A patent/JP3788519B2/ja not_active Expired - Lifetime
- 1997-06-24 NZ NZ333346A patent/NZ333346A/xx unknown
- 1997-06-24 WO PCT/US1997/010894 patent/WO1998000231A1/en not_active Ceased
- 1997-06-24 EP EP97931337A patent/EP0907412B1/en not_active Expired - Lifetime
-
1998
- 1998-03-19 US US09/044,587 patent/US6413782B1/en not_active Expired - Lifetime
- 1998-03-19 US US09/044,557 patent/US6274337B1/en not_active Expired - Lifetime
- 1998-08-12 US US09/132,963 patent/US6479299B1/en not_active Expired - Lifetime
- 1998-11-20 US US09/196,535 patent/US6306659B1/en not_active Expired - Lifetime
-
2000
- 2000-07-07 US US09/612,587 patent/US6399389B1/en not_active Expired - Lifetime
- 2000-11-21 US US09/718,236 patent/US6630353B1/en not_active Expired - Lifetime
- 2000-11-21 US US09/718,235 patent/US6558960B1/en not_active Expired - Lifetime
-
2002
- 2002-10-24 US US10/279,496 patent/US7091048B2/en not_active Expired - Lifetime
-
2003
- 2003-08-07 US US10/637,730 patent/US20040028567A1/en not_active Abandoned
-
2004
- 2004-04-08 US US10/821,503 patent/US7067263B2/en not_active Expired - Fee Related
-
2005
- 2005-07-06 US US11/176,805 patent/US20050241941A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007524851A (ja) * | 2004-01-26 | 2007-08-30 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体送達のシステムおよび方法 |
| DE102024106741A1 (de) * | 2024-03-08 | 2025-09-11 | Schott Ag | Mikroarrays mit Nitrozellulosebeschichtung und Herstellungsverfahren |
| DE102024106741B4 (de) * | 2024-03-08 | 2025-10-09 | Schott Ag | Mikroarrays mit Nitrozellulosebeschichtung und Herstellungsverfahren |
Also Published As
| Publication number | Publication date |
|---|---|
| US6306659B1 (en) | 2001-10-23 |
| US6274337B1 (en) | 2001-08-14 |
| US6479299B1 (en) | 2002-11-12 |
| US6558960B1 (en) | 2003-05-06 |
| JP2001502790A (ja) | 2001-02-27 |
| US6413782B1 (en) | 2002-07-02 |
| US7067263B2 (en) | 2006-06-27 |
| CN1262629A (zh) | 2000-08-09 |
| NZ333346A (en) | 2000-03-27 |
| EP0907412B1 (en) | 2008-08-27 |
| US20040241733A1 (en) | 2004-12-02 |
| US6267858B1 (en) | 2001-07-31 |
| CA2258489A1 (en) | 1998-01-08 |
| US20030134431A1 (en) | 2003-07-17 |
| EP0907412A1 (en) | 1999-04-14 |
| US6630353B1 (en) | 2003-10-07 |
| BR9710054A (pt) | 2000-01-11 |
| CA2258489C (en) | 2004-01-27 |
| US7091048B2 (en) | 2006-08-15 |
| US20050241941A1 (en) | 2005-11-03 |
| US6399389B1 (en) | 2002-06-04 |
| CN1173776C (zh) | 2004-11-03 |
| US6429025B1 (en) | 2002-08-06 |
| WO1998000231A1 (en) | 1998-01-08 |
| US20040028567A1 (en) | 2004-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3788519B2 (ja) | 微小スケール流体装置の高処理能力スクリーニングアッセイシステム | |
| EP1271148B1 (en) | High-throughput screening assay systems in microscale fluidic devices | |
| WO1998000231A9 (en) | High-throughput screening assay systems in microscale fluidic devices | |
| AU729537B2 (en) | High throughput screening assay systems in microscale fluidic devices | |
| US20060000722A1 (en) | High throughput screening assay systems in microscale fluidic devices | |
| KR100453100B1 (ko) | 미세규모의유체장치내의고처리율스크리닝검정시스템 | |
| AU759505B2 (en) | High-throughput screening assay systems in microscale fluidic devices | |
| AU2003213516C1 (en) | High-throughput Screening Assay Systems in Microscale Fluidic Devices | |
| AU2005234635B2 (en) | High-throughput screening assay systems in microscale fluidic devices |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040225 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040225 |
|
| A72 | Notification of change in name of applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A721 Effective date: 20050217 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050802 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20051101 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20051212 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060110 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20060228 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20060322 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120407 Year of fee payment: 6 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120407 Year of fee payment: 6 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130407 Year of fee payment: 7 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130407 Year of fee payment: 7 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140407 Year of fee payment: 8 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |