ATE419528T1 - Polyionische beschichtungen für analytische und sensor-vorrichtungen - Google Patents

Polyionische beschichtungen für analytische und sensor-vorrichtungen

Info

Publication number
ATE419528T1
ATE419528T1 AT00928641T AT00928641T ATE419528T1 AT E419528 T1 ATE419528 T1 AT E419528T1 AT 00928641 T AT00928641 T AT 00928641T AT 00928641 T AT00928641 T AT 00928641T AT E419528 T1 ATE419528 T1 AT E419528T1
Authority
AT
Austria
Prior art keywords
analyte
multifunctional
side chains
polyionic
copolymers
Prior art date
Application number
AT00928641T
Other languages
English (en)
Inventor
Jeffrey Hubbell
Marcus Textor
Donald Elbert
Stephanie Finken
Laurence Ruiz-Taylor
Nicholas Spencer
Rolf Hofer
Original Assignee
Eidgenoess Tech Hochschule
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoess Tech Hochschule, Univ Zuerich filed Critical Eidgenoess Tech Hochschule
Application granted granted Critical
Publication of ATE419528T1 publication Critical patent/ATE419528T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • Y10S435/815Enzyme separation or purification by sorption
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/961Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/969Multiple layering of reactants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/819Multifunctional antigen or antibody
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/823Immunogenic carrier or carrier per se
AT00928641T 1999-04-28 2000-04-28 Polyionische beschichtungen für analytische und sensor-vorrichtungen ATE419528T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13139199P 1999-04-28 1999-04-28
US13140299P 1999-04-28 1999-04-28
US18461600P 2000-02-24 2000-02-24

Publications (1)

Publication Number Publication Date
ATE419528T1 true ATE419528T1 (de) 2009-01-15

Family

ID=27384152

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00928641T ATE419528T1 (de) 1999-04-28 2000-04-28 Polyionische beschichtungen für analytische und sensor-vorrichtungen

Country Status (8)

Country Link
US (1) US6884628B2 (de)
EP (1) EP1190252B1 (de)
JP (1) JP4647792B2 (de)
AT (1) ATE419528T1 (de)
AU (1) AU769571B2 (de)
CA (1) CA2371011C (de)
DE (1) DE60041255D1 (de)
WO (1) WO2000065352A1 (de)

Families Citing this family (241)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
CA2377739A1 (en) 1999-07-02 2001-01-11 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
US20030059809A1 (en) * 1999-12-17 2003-03-27 Todor Vujasinovic Biochips,preparation and uses
US7163712B2 (en) * 2000-03-03 2007-01-16 Duke University Microstamping activated polymer surfaces
US6406777B1 (en) * 2000-06-14 2002-06-18 The United States Of America As Represented By The Secretary Of The Navy Metal and glass structure for use in surface enhanced Raman spectroscopy and method for fabricating same
DE10036907B4 (de) * 2000-07-28 2012-03-22 Xantec Bioanalytics Gmbh Verfahren zur Herstellung einer Beschichtung auf einem mit Gold bedampften Glassubstrat, Beschichtung hergestellt nach diesem Verfahren und deren Verwendung
US7678539B2 (en) * 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
EP1316599B1 (de) * 2000-08-21 2014-03-26 National Institute of Advanced Industrial Science and Technology Magnetische teilchen und verfahren zur herstellung derselben
US7205161B2 (en) 2001-01-10 2007-04-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
DK1373573T3 (da) * 2001-03-09 2014-01-20 Trovagene Inc Konjugatsonder og optisk detektion af analytter
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7501157B2 (en) * 2001-06-26 2009-03-10 Accelr8 Technology Corporation Hydroxyl functional surface coating
US6844028B2 (en) 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
US6989267B2 (en) 2001-07-02 2006-01-24 Agilent Technologies, Inc. Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films
EP1411816A4 (de) * 2001-07-09 2005-09-28 Univ Arizona State Affinitäts-biosensor zur überwachung biologischer prozesse
AU2002338007A1 (en) * 2001-08-27 2003-03-18 Zeptosens Ag Surface for the immobilisation of nucleic acids
AU2002361223A1 (en) * 2001-08-27 2003-03-18 Zeptosens Ag Bioanalytical recognition surface with optimised recognition element density
US9671396B2 (en) * 2001-09-05 2017-06-06 Joon Won Park Solid substrate comprising array of dendrons and methods for using the same
US20050014151A1 (en) * 2001-09-12 2005-01-20 Marcus Textor Device with chemical surface patterns
EP1435520A4 (de) * 2001-09-21 2005-02-02 Takara Bio Inc Träger für die immobilisierung von liganden
FI118061B (fi) 2001-09-24 2007-06-15 Beanor Oy Menetelmä ja bioanturi analyysiä varten
EP1321761B1 (de) * 2001-12-21 2006-08-23 Interuniversitair Micro-Elektronica Centrum Verfahren zum Nachweis eines Analyten
EP1464069A2 (de) * 2001-12-21 2004-10-06 Sense Proteomic Limited Sonde für die massenspektrometrie
US8043868B2 (en) 2001-12-21 2011-10-25 Imec Method and apparatus for detecting an analyte
FI115166B (fi) 2001-12-31 2005-03-15 Biofons Oy Diagnostisia menetelmiä
US7635463B2 (en) 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
DE60335608D1 (de) * 2002-02-27 2011-02-17 Pharmain Corp Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung
AU2002233097A1 (en) * 2002-02-28 2003-09-09 Eidgenossische Technische Hochschule Zurich Oberflachentechnik Biomedical implant surfaces with osteogenic properties
CN1650166A (zh) * 2002-04-12 2005-08-03 迈克纳斯公司 将分子固定在表面上的方法
US7514150B2 (en) 2002-04-16 2009-04-07 Eidgenossische Technische Hochschule Zurich Environmentally compatible additives for aqueous lubricants
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
US7010182B2 (en) * 2002-07-31 2006-03-07 Luna Innovations Incorporated Biosensors having enhanced environmental sensitivity
US7998699B2 (en) 2002-08-15 2011-08-16 University Of South Florida Early detection of pathogens in blood
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US20090118605A1 (en) * 2002-08-30 2009-05-07 Northwestern University Surface-enhanced raman nanobiosensor
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
US20040062882A1 (en) * 2002-09-30 2004-04-01 Andrea Liebmann-Vinson Cell adhesion resisting surfaces
ES2208121B1 (es) * 2002-11-29 2005-08-16 Consejo Sup. Investig. Cientificas Anticuerpos y antigenos inmovilizados sobre particulas magneticas de silice como biosensores.
US7070922B2 (en) * 2002-12-04 2006-07-04 International Business Machines Corporation Surface treatment
US20040121339A1 (en) * 2002-12-19 2004-06-24 Jizhong Zhou Special film-coated substrate for bio-microarray fabrication and use thereof
CN100347545C (zh) * 2003-04-08 2007-11-07 成都夸常科技有限公司 一种对样品中的目标物进行定性和/或定量分析的方法及其检测装置
JP4006523B2 (ja) * 2003-04-10 2007-11-14 独立行政法人産業技術総合研究所 タンパク質アレイ及びその作製方法
EP1613962B1 (de) * 2003-04-14 2008-10-29 Caliper Life Sciences, Inc. Reduktion der migrations-shift-assay-interferenz
DE10320312A1 (de) * 2003-05-06 2004-12-02 Friz Biochem Gmbh Substrat als Träger von Ligaten
US20040228766A1 (en) * 2003-05-14 2004-11-18 Witty Thomas R. Point of care diagnostic platform
US7160867B2 (en) * 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
US9206414B2 (en) * 2003-08-13 2015-12-08 Axcelon Biopolymers Corporation Anisotropic nanocomposite hydrogel
PL2103694T3 (pl) 2003-08-15 2011-10-31 Univ South Florida Materiały i sposoby do wychwytywania patogenów i usuwania kwasu aurynotrikarboksylowego z próbki
US20050070027A1 (en) * 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
JP2006514299A (ja) * 2003-10-27 2006-04-27 センス プロテオミック リミテッド 酵素アレイ及びアッセイ
US20050244898A1 (en) * 2003-11-19 2005-11-03 Cohen Robert E Large-area two-dimensional non-adhesive cell arrays for sensing and cell-sorting applications
US7510942B2 (en) * 2003-11-25 2009-03-31 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Molecular modifications of metal/dielectric interfaces
US20050131513A1 (en) * 2003-12-16 2005-06-16 Cook Incorporated Stent catheter with a permanently affixed conductor
US20050180957A1 (en) * 2004-01-16 2005-08-18 Scharp David W. Method of using fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
US7723126B2 (en) * 2004-03-24 2010-05-25 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of inorganic oxide surfaces
JP4535490B2 (ja) * 2004-04-09 2010-09-01 株式会社資生堂 蛋白質吸着防止方法
WO2005108620A2 (en) 2004-05-03 2005-11-17 Handylab, Inc. Processing polynucleotide-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP2007538233A (ja) * 2004-05-21 2007-12-27 エムディーエス インコーポレイテッド ドゥーイング ビジネス スルー イッツ エムディーエス ファーマ サービシーズ ディビジョン 医療デバイスの細胞結合特性を定量する方法
EP1771214A2 (de) * 2004-06-16 2007-04-11 Affinergy Inc. Biofunktionale beschichtungen
US10150945B2 (en) * 2004-07-23 2018-12-11 Jnc Corporation Cell culture device and manufacturing method therof
US20060029961A1 (en) * 2004-08-04 2006-02-09 Goh M C Patterned surfaces and their use in diffraction-based sensing
US7595157B2 (en) * 2004-08-19 2009-09-29 Biocept, Inc. Microarrays utilizing hydrogels
EP1799626B1 (de) * 2004-10-12 2012-01-18 Schott AG Gemultiplexter proteinadsorptions-assay
US20060110594A1 (en) * 2004-11-24 2006-05-25 Frutos Anthony G Polymer-coated substrates for binding biomolecules and methods of making and using thereof
JP4585523B2 (ja) * 2004-12-28 2010-11-24 独立行政法人科学技術振興機構 自己組織化材料または微粒子を基板上に固定化する方法、および当該方法を用いて作製した基板
US7604984B2 (en) * 2004-12-29 2009-10-20 Corning Incorporated Spatially scanned optical reader system and method for using same
US20060141527A1 (en) * 2004-12-29 2006-06-29 Caracci Stephen J Method for creating a reference region and a sample region on a biosensor and the resulting biosensor
US7629173B2 (en) * 2004-12-29 2009-12-08 Corning Incorporated Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors
EP1696235B1 (de) * 2005-02-23 2009-10-28 FUJIFILM Corporation Biosensor
JP2006335912A (ja) * 2005-06-03 2006-12-14 Fujifilm Holdings Corp 生理活性物質固定化剤
JP2006271860A (ja) * 2005-03-30 2006-10-12 Japan Lifeline Co Ltd 医療用具及びその製造方法
WO2006102756A1 (en) * 2005-03-30 2006-10-05 University Western Ontario Anisotropic hydrogels
US20060234269A1 (en) * 2005-04-18 2006-10-19 Matthew Asplund Laser Modification and Functionalization of Substrates
AU2006239534B2 (en) 2005-04-26 2012-05-31 Bayer Intellectual Property Gmbh Novel equipment and method for coating substrates for analyte detection by way of an affinity assay method
US7723438B2 (en) * 2005-04-28 2010-05-25 International Business Machines Corporation Surface-decorated polymeric amphiphile porogens for the templation of nanoporous materials
US20070009568A1 (en) * 2005-06-03 2007-01-11 Bhatnagar Rajendra S Methods for immobilizing molecules on surfaces
US8475886B2 (en) * 2005-08-05 2013-07-02 Corning Incorporated Methods for producing surfaces that resist non-specific protein binding and cell attachment
US7713689B2 (en) * 2005-09-15 2010-05-11 Duke University Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
US7763423B2 (en) * 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
WO2007043498A1 (en) * 2005-10-07 2007-04-19 Canon Kabushiki Kaisha Substrate with binding functional group
JP4818056B2 (ja) * 2005-10-07 2011-11-16 キヤノン株式会社 標的物質を捕捉する捕捉分子を結合させるための結合用官能基を基体上に備えた構造体
US20090221441A1 (en) * 2005-11-01 2009-09-03 Rensselaer Polytechnic Institute Three-dimensional cellular array chip and platform for toxicology assays
US20070117152A1 (en) * 2005-11-08 2007-05-24 Fujifilm Corporation Biosensor
US8334140B2 (en) * 2005-11-08 2012-12-18 Smart Holograms Limited Boronate complex and its use in a glucose sensor
US20070224164A1 (en) * 2005-11-14 2007-09-27 Maciej Radosz Degradable nanogel for drug delivery
EP1948829A4 (de) * 2005-11-15 2009-08-26 Becton Dickinson Co Sers-basierte verfahren zur erkennung von biowirkstoffen
US20070110786A1 (en) * 2005-11-15 2007-05-17 Boston Scientific Scimed, Inc. Medical articles having enhanced therapeutic agent binding
KR100738083B1 (ko) * 2005-12-20 2007-07-12 삼성전자주식회사 마이크로어레이용 기판 및 그의 제조방법
US7723422B2 (en) * 2005-12-23 2010-05-25 Boston Scientific Scimed, Inc. Functionalized block copolymers
US8455088B2 (en) 2005-12-23 2013-06-04 Boston Scientific Scimed, Inc. Spun nanofiber, medical devices, and methods
US7674864B2 (en) * 2005-12-23 2010-03-09 Boston Scientific Scimed, Inc. Polymeric hybrid precursors, polymeric hybrid precursor composite matrices, medical devices, and methods
US7781203B2 (en) * 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
US8834912B2 (en) * 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
EP1808187A1 (de) * 2006-01-11 2007-07-18 Straumann Holding AG Zell-selektive Implantatoberflächen mit kontrollierter bioaktiver Freisetzung von Wirkstoffen
ES2601391T3 (es) * 2006-01-27 2017-02-15 Becton Dickinson And Company Inmunoensayo de flujo lateral con modalidad de detección encapsulada
US8835513B2 (en) 2006-02-28 2014-09-16 Covidien Lp Drug delivery devices
EP3050578B1 (de) * 2006-02-28 2020-08-05 Covidien LP Gewebeklebstoff und -versiegelungsmittel und verfahren zu deren verwendung
US8349349B2 (en) * 2006-02-28 2013-01-08 Covidien Lp Tissue adhesives and sealants and method for their use
EP1997877B1 (de) * 2006-03-17 2014-03-05 Sanyo Chemical Industries, Ltd. Zellkultursubstrat
WO2007108775A1 (en) * 2006-03-21 2007-09-27 Agency For Science, Technology And Research Cell-adhesive polyelectrolyte material for use as membrane and coating
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8545865B2 (en) * 2006-03-24 2013-10-01 Boston Scientific Scimed, Inc. Medical devices having polymer brushes
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US20080076189A1 (en) * 2006-03-30 2008-03-27 Visigen Biotechnologies, Inc. Modified surfaces for the detection of biomolecules at the single molecule level
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US20080050747A1 (en) * 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
EP2016391A1 (de) * 2006-04-19 2009-01-21 Universiteit Gent Integrierter oberflächenmodus-biosensor
US8330951B2 (en) * 2006-04-28 2012-12-11 Hewlett-Packard Development Company, L.P. Nano-enhanced Raman spectroscopy substrate packaging structure
US9790538B2 (en) 2013-03-07 2017-10-17 Apdn (B.V.I.) Inc. Alkaline activation for immobilization of DNA taggants
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
EP2620771B1 (de) * 2006-07-24 2017-08-30 Becton Dickinson and Company Testpartikelkonzentrationsvorrichtung und -verfahren
WO2008019381A1 (en) * 2006-08-07 2008-02-14 University Of Washington Mixed charge copolymers and hydrogels
JPWO2008018355A1 (ja) * 2006-08-08 2009-12-24 シャープ株式会社 バイオセンサ及びその製造方法並びに当該バイオセンサを用いた検出方法
JP5001015B2 (ja) 2006-09-28 2012-08-15 富士フイルム株式会社 非特異吸着を抑制した表面を有する生化学用器具
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
CA2661661A1 (en) * 2006-11-21 2008-05-29 Applied Biosystems, Llc Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby
US8029902B2 (en) * 2006-12-11 2011-10-04 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups
MX2009007101A (es) * 2006-12-29 2009-12-01 Univ Washington Superficies y materiales antibioincrustación bifuncionales.
JP2008185494A (ja) * 2007-01-31 2008-08-14 Fujifilm Corp 生理活性物質固定化基板
JP2010534461A (ja) * 2007-02-28 2010-11-11 コーニング インコーポレイテッド バイオセンサ細胞アッセイの表面および方法
JP2008249502A (ja) * 2007-03-30 2008-10-16 Fujifilm Corp 生理活性物質を固定化した固体基板
US8093039B2 (en) * 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
US8084077B2 (en) 2007-05-25 2011-12-27 Abbott Laboratories One-step phosphorylcholine-linked polymer coating and drug loading of stent
EP2165353B1 (de) * 2007-06-29 2017-08-30 Applied Biosystems, LLC Systeme und verfahren zur elektronischen erkennung mit nanofets
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
EP2176066A4 (de) * 2007-08-06 2011-08-24 Canon Kk Strukturelement und verfahren zur herstellung des strukturelements
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
WO2009031804A2 (en) * 2007-09-07 2009-03-12 Gwangju Institute Of Science And Technology Multi-functional polymeric layers and its uses
KR101050690B1 (ko) 2007-09-07 2011-07-20 광주과학기술원 다기능성 고분자막 및 그의 용도
WO2009039466A1 (en) 2007-09-20 2009-03-26 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
DE102007049013A1 (de) * 2007-10-11 2009-04-16 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Sensor mit Langzeitstabilität für Bio-Prozesse
US20090130746A1 (en) * 2007-10-25 2009-05-21 Canon U.S. Life Sciences, Inc. Microchannel surface coating
US20110092768A1 (en) * 2007-10-31 2011-04-21 Given Imaging Ltd. Device, system and method for in-vivo analysis
JP5345335B2 (ja) * 2007-12-03 2013-11-20 国立大学法人九州大学 新規双性イオン型多分岐樹脂、並びに、蛋白質チップ表面調節剤
WO2009076235A2 (en) 2007-12-05 2009-06-18 Zyomyx, Inc. Cell assay kit and method
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
US8815611B2 (en) 2008-04-10 2014-08-26 Corning Incorporated Surface for label independent detection and method thereof
US8877298B2 (en) * 2008-05-27 2014-11-04 The Hong Kong University Of Science And Technology Printing using a structure coated with ultraviolet radiation responsive material
JP2009286968A (ja) * 2008-05-30 2009-12-10 Canon Inc グラフトポリマー含有基体、その製造方法および磁気バイオセンサ
US20090311540A1 (en) * 2008-06-11 2009-12-17 Yoram Cohen Highly Sensitive and Selective Nano-Structured Grafted Polymer Layers
WO2010004568A1 (en) * 2008-07-10 2010-01-14 Given Imaging Ltd. Device, method and kit for in vivo detection of a biomarker
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
WO2010005444A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide capture materials, and methods of using same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8173198B2 (en) * 2008-07-23 2012-05-08 Life Technologies Corporation Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
US20100034704A1 (en) * 2008-08-06 2010-02-11 Honeywell International Inc. Microfluidic cartridge channel with reduced bubble formation
US8226603B2 (en) 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US8076529B2 (en) 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
WO2010039247A2 (en) * 2008-10-03 2010-04-08 Molecular Sensing, Inc. Substrates with surfaces modified with peg
DE102008053270A1 (de) 2008-10-27 2010-05-12 Medizinische Hochschule Hannover Vorrichtung und Verfahren zur Analyse von Zellen
US8580240B1 (en) 2008-11-19 2013-11-12 University Of Kentucky Research Foundation Compounds and methods for reducing the occurrence of post-surgical adhesions
EP2373355A4 (de) * 2008-11-25 2013-10-02 Univ California Funktionalisierte titanimplantate und zugehörige regenerationsmaterialien
EP2192410B1 (de) * 2008-11-26 2012-07-11 Corning Incorporated Erfassung der Nanoteilchenaffinität für etikettenunabhängige Detektionssysteme
EP2204650B1 (de) * 2008-12-31 2012-06-27 DWI an der RWTH Aachen e.V. Neuartiges Biosensorsystem basierend auf der Erkennung von induzierter Doppelbrechung (RIB)
US20100184056A1 (en) * 2009-01-12 2010-07-22 Molecular Sensing, Inc. Sample collection and measurement in a single container by back scattering interferometry
DE202010017793U1 (de) * 2009-03-20 2012-08-31 Attana Ab Analytische Methode und Sensor
WO2010117460A1 (en) * 2009-04-08 2010-10-14 Michigan Molecular Institute Surface modification of reverse osmosis membranes by hydrophilic dendritic polymers
WO2010123448A1 (en) * 2009-04-21 2010-10-28 Gyros Patent Ab Method for reducing adsorption losses on metal oxide surfaces
EP2424971A4 (de) * 2009-05-01 2013-07-31 Univ Utah Res Found Verfahren und zusammensetzungen zur messung von hochaffinen interaktionen mit kinetischer bildgebung einer einzelmolekülinteraktion (kismi)
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
US20120150015A1 (en) * 2009-09-02 2012-06-14 Mayo Foundation For Medical Education And Research System and method for detecting healing adjacent to implanted medical device
US20110225809A1 (en) * 2010-03-17 2011-09-22 Alan Francis Daher Apparatus for removably attaching an item to a surface
WO2011119536A1 (en) 2010-03-22 2011-09-29 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
ES2645210T3 (es) 2010-05-17 2017-12-04 Sentilus Holdco, Llc Dispositivos de detección y métodos de uso relacionados
WO2011156713A1 (en) 2010-06-11 2011-12-15 Vanderbilt University Multiplexed interferometric detection system and method
EP2409766A1 (de) * 2010-07-23 2012-01-25 F. Hoffmann-La Roche AG Verfahren zur Hydrophilisierung von Oberflächen fluidischer Komponenten und derartige Komponenten enthaltende Bauteile
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
EP2541250A1 (de) 2011-06-30 2013-01-02 Koninklijke Philips Electronics N.V. Molekulare Architektur von magnetischen Partikeln für Affinitätsprüfungen mit geringer nicht spezifischer Bindung
JP5564155B1 (ja) * 2011-07-13 2014-07-30 エンパイア テクノロジー ディベロップメント エルエルシー 再生可能な表面を伴う、表面プラズモンを用いる検体監視のための方法およびシステム
EP2731429A4 (de) * 2011-07-15 2015-03-04 Univ Georgia Verbindungen, herstellungsverfahren dafür und verwendungsverfahren dafür
CA2872378C (en) 2011-07-20 2016-01-12 University Of Washington Through Its Center For Commercialization Photonic blood typing
DK3273253T3 (da) 2011-09-30 2020-10-12 Becton Dickinson Co Forenet reagensstrimmel
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
IN2014KN01168A (de) 2011-11-02 2015-10-16 Univ Cape Town
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
US10031138B2 (en) * 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
CN107881219B (zh) 2012-02-03 2021-09-10 贝克顿·迪金森公司 用于分子诊断测试分配和测试之间兼容性确定的外部文件
US9572580B2 (en) 2012-03-16 2017-02-21 Covidien Lp Closure tape dispenser
US9161756B2 (en) 2012-03-16 2015-10-20 Covidien Lp Closure tape dispenser
JP5844195B2 (ja) * 2012-03-29 2016-01-13 三洋化成工業株式会社 磁性シリカ粒子並びにこれを用いた免疫測定法及び免疫測定用試薬
US20140102899A1 (en) * 2012-04-09 2014-04-17 Applied Dna Sciences, Inc. Plasma treatment for dna binding
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
WO2014014788A2 (en) * 2012-07-18 2014-01-23 President And Fellows Of Harvard College Modification of surfaces for simulataneous repellency and targeted binding of desired moieties
WO2014022365A1 (en) * 2012-07-31 2014-02-06 The Trustees Of Columbia University In The City Of New York Cyclopropenium polymers and methods for making the same
US9758606B2 (en) 2012-07-31 2017-09-12 The Trustees Of Columbia University In The City Of New York Cyclopropenium polymers and methods for making the same
US9266370B2 (en) 2012-10-10 2016-02-23 Apdn (B.V.I) Inc. DNA marking of previously undistinguished items for traceability
US9297032B2 (en) 2012-10-10 2016-03-29 Apdn (B.V.I.) Inc. Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings
US8994077B2 (en) * 2012-12-21 2015-03-31 International Business Machines Corporation Field effect transistor-based bio sensor
TWI535750B (zh) 2013-01-14 2016-06-01 國立臺灣大學 基材上的聚合物組成物以及表面改質方法
US10060851B2 (en) * 2013-03-05 2018-08-28 Plexense, Inc. Surface plasmon detection apparatuses and methods
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
US10359362B2 (en) 2013-04-15 2019-07-23 Plexense, Inc. Method for manufacturing nanoparticle array, surface plasmon resonance-based sensor and method for analyzing using same
US10544449B2 (en) 2013-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Bis-biotinylation tags
DE102013211837A1 (de) * 2013-06-21 2014-12-24 Gilupi Gmbh Katheter mit Detektionsvorrichtung zum Echtzeitnachweis eines Probenmaterials
DE102013211850A1 (de) * 2013-06-21 2014-12-24 Gilupi Gmbh Schnelltest zum Nachweisen von Erregermaterial, insbesondere zur Unterstützung der Diagnose einer Sepsis, sowie Kit und Vorrichtung zur Durchführung eines Sepsistests
US9366651B2 (en) 2013-07-03 2016-06-14 Matrix Sensors, Inc. Array of sensors with surface modifications
CA2926436A1 (en) 2013-10-07 2015-04-16 Judith Murrah Multimode image and spectral reader
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
WO2015142990A1 (en) 2014-03-18 2015-09-24 Apdn (B.V.I.) Inc. Encryped optical markers for security applications
KR102592368B1 (ko) 2014-07-02 2023-10-25 라이프 테크놀로지스 코포레이션 반도체 센서의 표면 처리
US11754563B2 (en) 2014-11-20 2023-09-12 Global Life Sciences Solutions Operations UK Ltd Porous membranes with a polymer grafting, methods and uses thereof
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
JP2018506715A (ja) 2015-01-23 2018-03-08 ヴァンダービルト ユニバーシティー 堅固なインターフェロメーター及びその使用方法
TWI585401B (zh) * 2015-12-17 2017-06-01 長庚大學 光定址電位感測元件
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
EP3442719B1 (de) 2016-04-11 2021-09-01 APDN (B.V.I.) Inc. Verfahren zur markierung von cellulosischen produkten
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
US9999899B2 (en) 2016-11-01 2018-06-19 International Business Machines Corporation Controlled exposure of in-vivo sensors
US10920274B2 (en) 2017-02-21 2021-02-16 Apdn (B.V.I.) Inc. Nucleic acid coated submicron particles for authentication
WO2018222034A1 (en) * 2017-05-30 2018-12-06 Jurriaan Huskens Surface with poly-cationic polymers and functionalized using coupling chemistry, biosensor comprising the same and use thereof in bio-sensing
EP3642348A1 (de) * 2017-06-22 2020-04-29 Paris Sciences et Lettres - Quartier Latin Redox-spaltbares kammcopolymer zur kontrollierten adhäsion zwischen zellen und substraten
CN111868096B (zh) 2018-03-28 2022-06-17 持田制药株式会社 反应性海藻酸衍生物
US11357542B2 (en) 2019-06-21 2022-06-14 Covidien Lp Valve assembly and retainer for surgical access assembly
EP4035735A4 (de) 2019-09-25 2023-10-18 Mochida Pharmaceutical Co., Ltd. Neuartige vernetzte alginsäurestruktur
CN114829669A (zh) 2019-10-11 2022-07-29 宽腾矽公司 气相表面改性
WO2021090787A1 (ja) * 2019-11-05 2021-05-14 国立大学法人東海国立大学機構 ポリペプチド
WO2023205353A1 (en) * 2022-04-21 2023-10-26 Ultima Genomics, Inc. Self assembly of beads on substrates
EP4299596A1 (de) * 2022-06-30 2024-01-03 betaSENSE GmbH Funktionalisiertes element einer molekularen sonde

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822867A (en) * 1987-02-02 1989-04-18 Semih Erhan Protein polymer grafts
US4886836A (en) * 1987-06-03 1989-12-12 Pall Corporation Activated medium with low non-specific protein adsorption
US5866322A (en) * 1988-01-29 1999-02-02 Abbott Laboratories Method for performing Rubella assay
EP0335308B1 (de) * 1988-03-31 1993-12-08 W.R. Grace & Co.-Conn. Mit Protein nichtabsorbierend polyureum-urethan-polymerbeschichtete Gegenstände
JP2570408B2 (ja) * 1988-11-29 1997-01-08 東ソー株式会社 抗原,抗体又は生理活性物質固定化用の担体
US5330911A (en) * 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
SE467308B (sv) * 1990-10-22 1992-06-29 Berol Nobel Ab Fast yta belagd med ett hydrofilt ytterskikt med kovalent bundna biopolymerer, saett att framstaella en saadan yta och ett konjugat daerfoer
US6093558A (en) * 1991-07-25 2000-07-25 Edge Biosystems, Inc. Binding protein of biologically active compositions to an adhesive formulation on a substrate
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
DE4208645A1 (de) 1992-03-18 1993-09-23 Bayer Ag Optischer festphasenbiosensor auf basis fluoreszenzfarbstoffmarkierter polyionischer schichten
US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
US6113946A (en) * 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
EP0565978B1 (de) * 1992-04-16 1997-06-18 MERCK PATENT GmbH Aktivierte Trägermaterialien, ihre Herstellung und Verwendung
CA2135769A1 (en) * 1992-05-29 1993-12-09 Kent C. Cochrum Coated transplant and method for making same
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
SE509662C2 (sv) * 1993-04-29 1999-02-22 Tetra Laval Holdings & Finance Förpackningslaminat belagt med en vattenolöslig chitosanförening samt sätt att tillverka förpackningslaminatet
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
ATE209782T1 (de) * 1993-05-18 2001-12-15 Univ Utah Res Found Vorrichtung und verfahren fuer homogene multianalyt-immuno-assays
US6284503B1 (en) * 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
US5543326A (en) * 1994-03-04 1996-08-06 Heller; Adam Biosensor including chemically modified enzymes
BR9508139A (pt) * 1994-06-28 1999-11-30 Tri Point Medical Corp Processo, processo de regular uma velocidade de biodegradação in vivo de um polìmero e de unir entre si duas superfìcies in vivo, composição biocompatìvel, adesivo, vedante e implante cirúrgico e sistema de liberação para um agente terapêutico
US5858747A (en) * 1994-07-20 1999-01-12 Cytotherapeutics, Inc. Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers
US5507804A (en) * 1994-11-16 1996-04-16 Alcon Laboratories, Inc. Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US6017577A (en) * 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US5629213A (en) * 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
DE19530078A1 (de) * 1995-08-16 1997-02-20 Bayer Ag Optischer Festphasenbiosensor auf Basis von Streptavidin und Biotin
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
WO1998000231A1 (en) * 1996-06-28 1998-01-08 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
CA2202424A1 (en) * 1997-04-11 1998-10-11 Donald E. Brooks A tethered polymer macromolecule-excluding surface, its mode of synthesis and use
ES2353840T3 (es) * 1997-04-21 2011-03-07 California Institute Of Technology Recubrimientos tisulares poliméricos multifuncionales.
US6287558B1 (en) * 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6348322B1 (en) * 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
WO1999052574A1 (en) * 1998-04-10 1999-10-21 Massachusetts Institute Of Technology Biopolymers resistant coatings
AU752942B2 (en) * 1998-04-13 2002-10-03 Massachusetts Institute Of Technology Comb copolymers for regulating cell-surface interactions
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6248127B1 (en) * 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6303179B1 (en) * 1999-02-08 2001-10-16 Medtronic, Inc Method for attachment of biomolecules to surfaces through amine-functional groups

Also Published As

Publication number Publication date
DE60041255D1 (de) 2009-02-12
AU769571B2 (en) 2004-01-29
US20020128234A1 (en) 2002-09-12
WO2000065352A1 (en) 2000-11-02
US6884628B2 (en) 2005-04-26
JP2003516519A (ja) 2003-05-13
CA2371011C (en) 2009-12-22
AU4684600A (en) 2000-11-10
EP1190252A1 (de) 2002-03-27
EP1190252B1 (de) 2008-12-31
JP4647792B2 (ja) 2011-03-09
CA2371011A1 (en) 2000-11-02

Similar Documents

Publication Publication Date Title
DE60041255D1 (de) Polyionische beschichtungen für analytische und sensor-vorrichtungen
Teengam et al. Electrochemical impedance-based DNA sensor using pyrrolidinyl peptide nucleic acids for tuberculosis detection
WO2006101798A3 (en) Polymer compound for biomedical use and biochip substrate using such a polymer compound
US20190285623A1 (en) Detection and assay devices and methods of making and using the same
EP1893979B1 (de) Molekular geprägte polymere und ihre verwendung bei diagnosevorrichtungen
Bi et al. Deposition of PEG onto PMMA microchannel surface to minimize nonspecific adsorption
EP1650565A4 (de) Oberfläche eines bei nichtspezifischer adsorption inhibierten basismaterials
Sung et al. Toward immunoassay chips: Facile immobilization of antibodies on cyclic olefin copolymer substrates through pre-activated polymer adlayers
WO2002056021A3 (en) Polymer brushes for immobilizing molecules to a surface
WO2006116111A3 (en) Interdigitated chemical sensors, and methods of making and using the same
WO2001042508A3 (en) Methods and compositions relating to electrical detection of nucleic acid reactions
Zhou et al. Potentiometric sensor for dipicolinic acid
WO2000039325A3 (de) Affinitätssensor für den nachweis spezifischer molekularer bindungsereignisse und dessen verwendung
WO2010151817A1 (en) Probe immobilization and signal amplification for polymer-based biosensor
CN104583765A (zh) 酶电极
Wang et al. Microfluidic immunosensor based on stable antibody-patterned surface in PMMA microchip
US10077379B2 (en) Silane copolymers and uses thereof
EP1798250A3 (de) Zur Bindung an Metallschichten geeignete Moleküle zur kovalenten Immobilisierung von Biomolekülen
WO2002079268A3 (en) Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform
Horsch et al. Fish and clips: A convenient strategy to identify tyrosinase substrates with rapid activation behavior for materials science applications
EP1726939A3 (de) Detektor für molekulare Interaktion und Molekülgewinnungsvorrichtung damit
WO2005059507A3 (en) Biosensor and method of making same
DE60037734D1 (de) Photo-pfropfungs-elektropolymere, ihre herstellung und deren verwendung als träger für erkennungssonden spezifisch in biosensorsystemen
Bi et al. Complexation of copper ions with histidine-containing tripeptides immobilized on solid surfaces
Liu et al. Surface-reactive acrylic copolymer for fabrication of microfluidic devices

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties