JP2022501354A5 - - Google Patents

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JP2022501354A5
JP2022501354A5 JP2021515149A JP2021515149A JP2022501354A5 JP 2022501354 A5 JP2022501354 A5 JP 2022501354A5 JP 2021515149 A JP2021515149 A JP 2021515149A JP 2021515149 A JP2021515149 A JP 2021515149A JP 2022501354 A5 JP2022501354 A5 JP 2022501354A5
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alkynyl
alkenyl
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JP2021515149A
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JP2022501354A (ja
JP7450610B2 (ja
JPWO2020061255A5 (https=
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JP2021515149A 2018-09-19 2019-09-19 ピルビン酸キナーゼrの活性化 Active JP7450610B2 (ja)

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US201862733546P 2018-09-19 2018-09-19
US62/733,546 2018-09-19
PCT/US2019/051831 WO2020061255A1 (en) 2018-09-19 2019-09-19 Activating pyruvate kinase r

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JP2022501354A JP2022501354A (ja) 2022-01-06
JPWO2020061255A5 JPWO2020061255A5 (https=) 2022-09-27
JP2022501354A5 true JP2022501354A5 (https=) 2022-09-27
JP7450610B2 JP7450610B2 (ja) 2024-03-15

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EP (1) EP3852791B1 (https=)
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CN (1) CN113226356B (https=)
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SG11202102526QA (en) * 2018-09-19 2021-04-29 Forma Therapeutics Inc Inhibiting ubiquitin specific peptidase 9x
US20210346356A1 (en) * 2018-09-19 2021-11-11 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
US12053458B2 (en) 2018-09-19 2024-08-06 Novo Nordisk Health Care Ag Treating sickle cell disease with a pyruvate kinase R activating compound
US20220378756A1 (en) 2019-09-19 2022-12-01 Forma Therapeutics, Inc. Activating pyruvate kinase r
WO2022031735A1 (en) * 2020-08-03 2022-02-10 Global Blood Therapeutics, Inc. Urea derivatives as pyruvate kinase activators
US20220087983A1 (en) * 2020-09-18 2022-03-24 Forma Therapeutics, Inc. Activating pyruvate kinase r
US11566030B2 (en) 2021-02-08 2023-01-31 Global Blood Therapeutics, Inc. Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
US20240408107A1 (en) * 2021-10-06 2024-12-12 Global Blood Therapeutics, Inc. Lactam pyrrolidine-pyrazoles as pyruvate kinase activators
KR20240124324A (ko) 2021-12-21 2024-08-16 시노허브 파마슈티컬 씨오., 엘티디 비스(아자니릴리덴)설포닐 구조를 함유하는 화합물 및 약제에서의 이의 용도
CN115304605B (zh) * 2022-01-21 2023-10-03 陕西国际商贸学院 具有抗肿瘤活性的氧杂环丁烷衍生物及其制备方法和应用
EP4622958A1 (en) * 2022-11-21 2025-10-01 Novo Nordisk Health Care AG Synthesis of pyrrolo[3,4-c]pyrroles
WO2024158875A1 (en) * 2023-01-25 2024-08-02 The Rockefeller University Sulfone-1h-pyrrole-2-carboxamide inhibitors of sars-cov-2 nsp14 methyltransferase and derivatives thereof
WO2024230586A1 (zh) * 2023-05-05 2024-11-14 赛诺哈勃药业(成都)有限公司 含二氮杂亚基磺酰结构的化合物作为pkm2激动剂的新用途
CN121175042A (zh) 2023-05-26 2025-12-19 赛诺哈勃药业(成都)有限公司 含二氮杂亚基磺酰结构化合物的药物组合物在治疗贫血相关疾病中的用途
WO2026008051A1 (zh) * 2024-07-05 2026-01-08 广东东阳光药业股份有限公司 杂环并环类化合物、其药物组合物及其用途

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