CN113226356B - 活化丙酮酸激酶r - Google Patents

活化丙酮酸激酶r Download PDF

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Publication number
CN113226356B
CN113226356B CN201980075930.4A CN201980075930A CN113226356B CN 113226356 B CN113226356 B CN 113226356B CN 201980075930 A CN201980075930 A CN 201980075930A CN 113226356 B CN113226356 B CN 113226356B
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alkyl
compound
independently selected
optionally substituted
ring
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Chinese (zh)
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CN113226356A (zh
Inventor
X.郑
A.埃里克森
N.格林
G.古斯塔夫森
D.R.小兰西亚
J.林
L.米歇尔
D.理查德
T.谢莱金
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Novo Nordisk Health Care AG
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Novo Nordisk Health Care AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201980075930.4A 2018-09-19 2019-09-19 活化丙酮酸激酶r Active CN113226356B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862733546P 2018-09-19 2018-09-19
US62/733,546 2018-09-19
PCT/US2019/051831 WO2020061255A1 (en) 2018-09-19 2019-09-19 Activating pyruvate kinase r

Publications (2)

Publication Number Publication Date
CN113226356A CN113226356A (zh) 2021-08-06
CN113226356B true CN113226356B (zh) 2025-03-04

Family

ID=69772664

Family Applications (1)

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CN201980075930.4A Active CN113226356B (zh) 2018-09-19 2019-09-19 活化丙酮酸激酶r

Country Status (6)

Country Link
US (3) US11001588B2 (https=)
EP (1) EP3852791B1 (https=)
JP (2) JP7450610B2 (https=)
CN (1) CN113226356B (https=)
ES (1) ES2989438T3 (https=)
WO (1) WO2020061255A1 (https=)

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US20210346356A1 (en) * 2018-09-19 2021-11-11 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
EP3853206B1 (en) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Treating sickle cell disease with a pyruvate kinase r activating compound
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
HRP20251148T1 (hr) 2019-09-19 2025-11-21 Novo Nordisk Health Care Ag Pripravci koji aktiviraju piruvat-kinazu r (pkr)
EP4188542A1 (en) * 2020-08-03 2023-06-07 Global Blood Therapeutics, Inc. Urea derivatives as pyruvate kinase activators
US20220087983A1 (en) * 2020-09-18 2022-03-24 Forma Therapeutics, Inc. Activating pyruvate kinase r
US11566030B2 (en) 2021-02-08 2023-01-31 Global Blood Therapeutics, Inc. Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
WO2023060134A1 (en) * 2021-10-06 2023-04-13 Global Blood Therapeutics, Inc. Lactam pyrrolidine-pyrazoles as pyruvate kinase activators
CN118510768A (zh) * 2021-12-21 2024-08-16 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构的化合物及其在医药上的用途
CN115304605B (zh) * 2022-01-21 2023-10-03 陕西国际商贸学院 具有抗肿瘤活性的氧杂环丁烷衍生物及其制备方法和应用
EP4622958A1 (en) * 2022-11-21 2025-10-01 Novo Nordisk Health Care AG Synthesis of pyrrolo[3,4-c]pyrroles
EP4654964A1 (en) * 2023-01-25 2025-12-03 The Rockefeller University Sulfone-1h-pyrrole-2-carboxamide inhibitors of sars-cov-2 nsp14 methyltransferase and derivatives thereof
CN121511081A (zh) * 2023-05-05 2026-02-10 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构的化合物作为pkm2激动剂的新用途
KR20260014544A (ko) 2023-05-26 2026-01-30 시노허브 파마슈티컬 씨오., 엘티디 빈혈 관련 질환의 치료에 있어서 비스(아자니릴리덴) 설포닐 구조 화합물을 함유하는 약학적 조성물의 용도
CN121270584A (zh) * 2024-07-05 2026-01-06 广东东阳光药业股份有限公司 杂环并环类化合物、其药物组合物及其用途

Citations (1)

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CN109311897A (zh) * 2017-03-20 2019-02-05 福马治疗股份有限公司 作为丙酮酸激酶(pkr)活化剂的吡咯并吡咯组合物

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