JP2018524338A5 - - Google Patents
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- JP2018524338A5 JP2018524338A5 JP2017567489A JP2017567489A JP2018524338A5 JP 2018524338 A5 JP2018524338 A5 JP 2018524338A5 JP 2017567489 A JP2017567489 A JP 2017567489A JP 2017567489 A JP2017567489 A JP 2017567489A JP 2018524338 A5 JP2018524338 A5 JP 2018524338A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- ring
- optionally substituted
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 28
- 125000005843 halogen group Chemical group 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 16
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 10
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 7
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- 125000005103 alkyl silyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- -1 2,4-dioxothiazolidin-5-yl Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- IFKXGBGGICSDKX-WOJBJXKFSA-N 3-[(1R,2R)-2-hydroxycyclohexyl]-7-methyl-6-[(6-methylpyridin-3-yl)methyl]-2H-1,3-benzoxazin-4-one Chemical compound O[C@H]1[C@@H](CCCC1)N1COC2=C(C1=O)C=C(C(=C2)C)CC=1C=NC(=CC=1)C IFKXGBGGICSDKX-WOJBJXKFSA-N 0.000 claims 1
- ZUCIGCGJRYHGME-GOTSBHOMSA-N 3-[(3S,4S)-4-hydroxyoxan-3-yl]-7-methyl-6-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]-2H-1,3-benzoxazin-4-one Chemical compound O[C@@H]1[C@H](COCC1)N1COC2=C(C1=O)C=C(C(=C2)C)CC1=CC=C(C=C1)C1=NN(C=C1)C ZUCIGCGJRYHGME-GOTSBHOMSA-N 0.000 claims 1
- BWJHJLINOYAPEG-HOTGVXAUSA-N 8-chloro-6-[(6-chloropyridin-3-yl)methyl]-3-[(1S,2S)-2-hydroxycyclopentyl]-7-methyl-2H-1,3-benzoxazin-4-one Chemical compound ClC1=C(C(=CC=2C(N(COC=21)[C@@H]1[C@H](CCC1)O)=O)CC=1C=NC(=CC=1)Cl)C BWJHJLINOYAPEG-HOTGVXAUSA-N 0.000 claims 1
- WLYZHPHTBRFGML-OALUTQOASA-N 8-fluoro-3-[(1S,2S)-2-hydroxycyclopentyl]-7-methyl-6-[(6-pyrazol-1-ylpyridin-3-yl)methyl]-2H-1,3-benzoxazin-4-one Chemical compound FC1=C(C(=CC=2C(N(COC=21)[C@@H]1[C@H](CCC1)O)=O)CC=1C=NC(=CC=1)N1N=CC=C1)C WLYZHPHTBRFGML-OALUTQOASA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 102000007207 Muscarinic M1 Receptor Human genes 0.000 claims 1
- 108010008406 Muscarinic M1 Receptor Proteins 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 230000001713 cholinergic effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229940126027 positive allosteric modulator Drugs 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 125000005750 substituted cyclic group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015129043 | 2015-06-26 | ||
| JP2015129043 | 2015-06-26 | ||
| JP2015206797 | 2015-10-20 | ||
| JP2015206797 | 2015-10-20 | ||
| PCT/JP2016/069189 WO2016208775A1 (en) | 2015-06-26 | 2016-06-23 | 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524338A JP2018524338A (ja) | 2018-08-30 |
| JP2018524338A5 true JP2018524338A5 (https=) | 2019-07-25 |
| JP6745824B2 JP6745824B2 (ja) | 2020-08-26 |
Family
ID=56799518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567489A Active JP6745824B2 (ja) | 2015-06-26 | 2016-06-23 | 複素環化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US9878989B2 (https=) |
| EP (1) | EP3313836B1 (https=) |
| JP (1) | JP6745824B2 (https=) |
| KR (1) | KR20180019234A (https=) |
| CN (1) | CN107922403A (https=) |
| AU (1) | AU2016284654B9 (https=) |
| CA (1) | CA2988572A1 (https=) |
| CL (1) | CL2017003127A1 (https=) |
| CO (1) | CO2017012859A2 (https=) |
| CR (1) | CR20170568A (https=) |
| DO (1) | DOP2017000309A (https=) |
| EA (1) | EA201890152A1 (https=) |
| HK (1) | HK1248698A1 (https=) |
| IL (1) | IL256059A (https=) |
| MX (1) | MX2017016875A (https=) |
| PE (1) | PE20180500A1 (https=) |
| PH (1) | PH12017502351A1 (https=) |
| TN (1) | TN2017000508A1 (https=) |
| TW (1) | TW201710255A (https=) |
| UA (1) | UA121503C2 (https=) |
| UY (1) | UY36750A (https=) |
| WO (1) | WO2016208775A1 (https=) |
| ZA (1) | ZA201708387B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2988572A1 (en) * | 2015-06-26 | 2016-12-29 | Takeda Pharmaceutical Company Limited | 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor |
| WO2016206101A1 (en) | 2015-06-26 | 2016-12-29 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors |
| JP6787913B2 (ja) | 2015-10-20 | 2020-11-18 | 武田薬品工業株式会社 | 複素環化合物 |
| JP6860551B2 (ja) | 2016-03-11 | 2021-04-14 | 武田薬品工業株式会社 | 芳香環化合物 |
| EP3590936B1 (en) * | 2017-02-28 | 2021-09-01 | Takeda Pharmaceutical Company Limited | Method for producing heterocyclic compound |
| EP3612527B1 (en) * | 2017-04-18 | 2022-07-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds useful as modulators of acetylcholine receptors |
| WO2018212312A1 (ja) | 2017-05-19 | 2018-11-22 | 武田薬品工業株式会社 | スクリーニング方法 |
| KR102658949B1 (ko) | 2017-06-20 | 2024-04-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
| HUE063823T2 (hu) | 2017-06-20 | 2024-02-28 | Heterociklusos vegyület és annak alkalmazása a kolinerg muszkarin M1 receptor pozitív alloszterikus modulátoraként | |
| US11970483B2 (en) | 2018-09-28 | 2024-04-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2020067455A1 (ja) | 2018-09-28 | 2020-04-02 | 武田薬品工業株式会社 | 複素環化合物 |
| US12162864B2 (en) | 2018-09-28 | 2024-12-10 | Takeda Pharmaceutical Company Limited | Condensed-cyclic compound |
| KR102288434B1 (ko) * | 2018-10-18 | 2021-08-12 | 에이치케이이노엔 주식회사 | 신규한 (이소프로필-트리아졸릴)피리디닐 치환된 벤조옥사지논 또는 벤조티아지논 유도체 및 이의 용도 |
| WO2020086857A1 (en) | 2018-10-24 | 2020-04-30 | Vanderbilt University | Wdr5 inhibitors and modulators |
| WO2020247679A1 (en) * | 2019-06-04 | 2020-12-10 | Vanderbilt University | Wdr5 inhibitors and modulators |
| CN114539035B (zh) * | 2021-03-10 | 2023-08-18 | 山东新时代药业有限公司 | 一种七氟烷的合成方法 |
| WO2025227116A1 (en) * | 2024-04-25 | 2025-10-30 | The Board Of Regents Of The University Of Texas System | Eph-ephrin tetramerization inhibitors that target a previously unknown and very high-affinity chelator-type intermolecular protein-protein interaction |
| WO2025231259A1 (en) * | 2024-05-01 | 2025-11-06 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| WO2025231260A1 (en) * | 2024-05-01 | 2025-11-06 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
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| CA2988572A1 (en) * | 2015-06-26 | 2016-12-29 | Takeda Pharmaceutical Company Limited | 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor |
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| JP6787913B2 (ja) | 2015-10-20 | 2020-11-18 | 武田薬品工業株式会社 | 複素環化合物 |
| JP6860551B2 (ja) | 2016-03-11 | 2021-04-14 | 武田薬品工業株式会社 | 芳香環化合物 |
| CN110337289A (zh) | 2016-12-29 | 2019-10-15 | Rvx疗法有限公司 | 用于增强cns药物并减轻它们的副作用的方法和组合物 |
-
2016
- 2016-06-23 CA CA2988572A patent/CA2988572A1/en not_active Abandoned
- 2016-06-23 WO PCT/JP2016/069189 patent/WO2016208775A1/en not_active Ceased
- 2016-06-23 MX MX2017016875A patent/MX2017016875A/es unknown
- 2016-06-23 US US15/190,642 patent/US9878989B2/en active Active
- 2016-06-23 UA UAA201800653A patent/UA121503C2/uk unknown
- 2016-06-23 KR KR1020187002502A patent/KR20180019234A/ko not_active Withdrawn
- 2016-06-23 JP JP2017567489A patent/JP6745824B2/ja active Active
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