JP2022516469A5 - - Google Patents
Info
- Publication number
- JP2022516469A5 JP2022516469A5 JP2021537781A JP2021537781A JP2022516469A5 JP 2022516469 A5 JP2022516469 A5 JP 2022516469A5 JP 2021537781 A JP2021537781 A JP 2021537781A JP 2021537781 A JP2021537781 A JP 2021537781A JP 2022516469 A5 JP2022516469 A5 JP 2022516469A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- nitrogen
- sulfur
- oxygen
- heteroatoms selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862785733P | 2018-12-28 | 2018-12-28 | |
| US62/785,733 | 2018-12-28 | ||
| PCT/US2019/068648 WO2020139988A1 (en) | 2018-12-28 | 2019-12-27 | Compositions for inhibiting ubiquitin specific protease 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022516469A JP2022516469A (ja) | 2022-02-28 |
| JP2022516469A5 true JP2022516469A5 (https=) | 2022-12-22 |
| JP7553450B2 JP7553450B2 (ja) | 2024-09-18 |
Family
ID=71126375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021537781A Active JP7553450B2 (ja) | 2018-12-28 | 2019-12-27 | ユビキチン特異的プロテアーゼ１を阻害するための組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220073525A1 (https=) |
| EP (1) | EP3902802A4 (https=) |
| JP (1) | JP7553450B2 (https=) |
| CN (1) | CN113474346B (https=) |
| WO (1) | WO2020139988A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108473495B (zh) | 2015-11-20 | 2022-04-12 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
| EP4291559A1 (en) * | 2021-02-15 | 2023-12-20 | Tango Therapeutics, Inc. | Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer |
| CA3214040A1 (en) * | 2021-04-07 | 2022-10-13 | Forma Therapeutics, Inc. | Inhibiting ubiquitin-specific protease 1 (usp1) |
| CN117136189A (zh) * | 2021-04-09 | 2023-11-28 | 先声再明医药有限公司 | 泛素特异性蛋白酶1（usp1）抑制剂 |
| CN121851016A (zh) * | 2021-04-21 | 2026-04-14 | 长春金赛药业有限责任公司 | 含咪唑稠环类衍生物、其制备方法及其在医药上的应用 |
| CN117412973A (zh) * | 2021-05-31 | 2024-01-16 | 上海瑛派药业有限公司 | 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用 |
| US20240409538A1 (en) * | 2021-10-19 | 2024-12-12 | Impact Therapeutics (Shanghai), Inc. | Substituted triazoloheteroaryl compounds as usp1 inhibitors and the use thereof |
| IL312642A (en) | 2021-11-12 | 2024-07-01 | Insilico Medicine Ip Ltd | Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof |
| US20250163049A1 (en) * | 2022-02-03 | 2025-05-22 | Exelixis, Inc. | Fused bicyclic heterocyclyl compounds as usp1 inhibitors |
| KR20250004854A (ko) * | 2022-04-29 | 2025-01-08 | 장슈 야홍 메디텍 코퍼레이션 리미티드 | 피리미딘 화합물, 이의 제조 방법 및 이의 약학적 용도 |
| US20240092779A1 (en) * | 2022-06-29 | 2024-03-21 | Zentaur Therapeutics Usa Inc. | Usp1 inhibitors and uses thereof |
| WO2024022519A1 (zh) * | 2022-07-28 | 2024-02-01 | 先声再明医药有限公司 | 杂环并嘧啶类化合物及其应用 |
| CN119790043A (zh) * | 2022-08-26 | 2025-04-08 | 海南先声再明医药股份有限公司 | 三环类化合物及其应用 |
| WO2024078436A1 (zh) * | 2022-10-09 | 2024-04-18 | 海南先声再明医药股份有限公司 | 杂环并嘧啶类化合物、药物组合物及其应用 |
| EP4605391A1 (en) | 2022-10-21 | 2025-08-27 | Exelixis, Inc. | 4,5,6,7-tetrahydro-1-pyrazolo[4,3-c]pyridine compounds and derivatives as usp1 inhibitors |
| CN120603835A (zh) * | 2023-01-20 | 2025-09-05 | 杭州英创医药科技有限公司 | 作为usp1抑制剂的化合物 |
| TW202509030A (zh) | 2023-05-08 | 2025-03-01 | 美商譚格醫療公司 | 化合物及使用方法 |
| WO2024233665A1 (en) | 2023-05-08 | 2024-11-14 | Tango Therapeutics, Inc. | Compounds and their use against cancer |
| TW202446379A (zh) * | 2023-05-18 | 2024-12-01 | 香港商英矽智能科技知識產權有限公司 | 泛素特異性蛋白酶１（ｕｓｐ１）之小分子抑制劑及其用途 |
| WO2025010245A1 (en) | 2023-07-06 | 2025-01-09 | Exelixis, Inc. | Fused pyrazole derivatives as usp1 inhibitors |
| CN119930633B (zh) * | 2023-11-06 | 2025-11-18 | 中国医学科学院药物研究所 | 一种吡咯并蝶啶酮类泛素特异性蛋白酶1抑制剂及其制备方法、用途和药物组合物 |
| CN119930632B (zh) * | 2023-11-06 | 2025-11-18 | 中国医学科学院药物研究所 | 一种三并环类泛素特异性蛋白酶1抑制剂及其制备方法、用途和药物组合物 |
| WO2025102016A1 (en) | 2023-11-10 | 2025-05-15 | Vrise Therapeutics, Inc. | Novel molecules as inhibitors of dna damage repair pathway |
| TW202539659A (zh) | 2024-01-10 | 2025-10-16 | 美商維瑞斯治療股份有限公司 | Ｄｎａ損傷修復途徑的新穎抑制劑 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4035893A (en) * | 1991-12-17 | 1993-07-19 | Upjohn Company, The | 3-substituted imidazo (1,5-a) and imidazo (1,5-a)-triazolo (1,5-c) quinoxalines and quinazolines with cns activity |
| CN101686989B (zh) * | 2007-06-21 | 2016-10-19 | 卡拉治疗学股份有限公司 | 取代的咪唑并杂环 |
| DK2334672T3 (da) * | 2008-09-16 | 2013-12-02 | Proximagen Ltd | 4,5,6,7-tetrahydroimidazo[4,5-c]pyridinforbindelser som inhibitorer af SSAO |
| CN101824036A (zh) * | 2009-03-05 | 2010-09-08 | 上海恒瑞医药有限公司 | 四氢咪唑并[1，5-a]吡嗪衍生物的盐,其制备方法及其在医药上的应用 |
| CN108473495B (zh) * | 2015-11-20 | 2022-04-12 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
-
2019
- 2019-12-27 US US17/417,805 patent/US20220073525A1/en not_active Abandoned
- 2019-12-27 WO PCT/US2019/068648 patent/WO2020139988A1/en not_active Ceased
- 2019-12-27 CN CN201980093028.5A patent/CN113474346B/zh active Active
- 2019-12-27 JP JP2021537781A patent/JP7553450B2/ja active Active
- 2019-12-27 EP EP19904923.0A patent/EP3902802A4/en not_active Withdrawn
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